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Comparison of intraocular pressure readings with Perkins,Tonopen,iCare 200,and iCare Home to manometry in cadaveric eyes

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2022-2027页

作者： Monica K Ertel leonard K Seibold Jennifer L Patnaik Malik Y Kahook Department of Ophthalmology University of ColoradoUC Health Sue Anschutz-Rodgers Eye CenterAuroraColorado 80045USA

AIM:To compare intraocular pressure(IOP)readings obtained with Perkins tonometry,i Care Home,i Care 200,and Tonopen to IOP readings obtained with the manometer of a perfusion system to assess the accuracy and reproducibility of each method of tonometry at set ***:The IOP of human cadaveric eyes(n=2)was measured using a manometer inserted into the eye through the optic *** measurements were obtained using a Perkins tonometer,i Care Home,i Care 200,and *** measurements were compared to set point IOP measurements of a manometer to determine accuracy and reproducibility of each ***:Mean IOP readings obtained with the Perkins tonometer compared to manometer readings demonstrated a difference of-1.0±5.0 mm Hg(P=0.45),indicating a lower reading on average than manometery although not *** IOP difference between iCare 200 and manometer was 5.3±2.2 mm Hg(P<0.0001).Mean difference in IOP between iCare Home and manometer was 3.5±2.4 mm Hg(P=0.0004).Mean IOP difference compared to manometer was 4.6±4.0 mm Hg for the Tonopen(P<0.0001).IOP measurements obtained with the Perkins tonometer demonstrated a standard deviation of 5.0 mm Hg while the Tonopen measurements demonstrated a 4.0 mm Hg standard *** comparison,iCare 200 and iCare Home demonstrated 2.2 and 2.4 mm Hg standard deviation,***:Applanation tonometry produces more accurate IOP readings than rebound tonometry or Tonopen,however it demonstrates greater variability than the other forms of *** tonometry is more reproducible but tends to over-estimate IOP.

关键词： intraocular pressure ocular tonometry manometry

A Comparison of Technology Firms in Beijing and Shenzhen

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2012年第3期7卷 434-464页

作者： Zhaoming Cui leonard K.Cheng Lian Zhou School of Economics Shanghai University of Finance and EconomicsShanghai 200433China Department of Economics Hong Kong University of Science and TechnologyHong KongChina Guanghua School of Management Peking UniversityBeijing 100871China

Beijing and Shenzhen are both well known for their high-tech industries. This paper compares the financial performance of the two cities＇ technology firms and explores the effects of the firms＇ operating characteristics and strategy choices on their performance. We find that when comparable samples are used, the firms in Beijing performed better than those in Shenzhen. In addition, for firms both in Beijing and Shenzhen, the ratio of current asset to total asset had a significantly positive effect while both short-term and long-term debt-asset ratios had a significantly negative effect on the performance. The strategy variable sales expenses as a fraction of the cost of goods sold had a significantly positive effect on the performance of firms in Beijing, but the positive effect on firms in Shenzhen was not significant. R＆D inputs contributed significantly to the pre-tax profitability of Beijing firms, but bad no significant effect whatsoever on Shenzhen firms.

关键词： Chinese technology firms comparison of performance operating characteristics

Advances in radiotherapy and targeted therapies for rectal cancer

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World Journal of Gastroenterology 2014年第1期20卷 1-5页

作者： Alexandra Sermeus Wim leonard Benedikt Engels Mark De Ridder UZ Brussel Vrije Universiteit BrusselDepartment of GastroenterologyB-1090 BrusselsBelgium UZ Brussel Vrije Universiteit BrusselDepartment of RadiotherapyB-1090 BrusselsBelgium

The last decade witnessed a significant progress in understanding the biology and immunology of colorectal cancer alongside with the technical innovations in *** stepwise implementation of intensitymodulated and image-guided radiation therapy by means of megavolt computed tomography and helical tomotherapy enabled us to anatomically sculpt dose delivery,reducing treatment related *** addition,the administration of a simultaneous integrated boost offers excellent local control *** novel challenge is the development of treatment strategies for medically inoperable patient and organ preserving ***,distant control remains unsatisfactory and indicates an urgent need for biomarkers that predict the risk of tumor *** expected benefit of target?ed therapies that exploit the tumor genome alone is so far hindered by high cost techniques and pharmaceuticals,hence hardly justifying rather modest improvements in patient *** the other hand,the immune landscape of colorectal cancer is now better clarified with regard to the immunosuppressive network that promotes immune *** N2 neutrophils and myeloid-derived suppressor cells(MDSC)emerge as useful clinical biomarkers of poor prognosis,while the growing list of anti-MDSC agents shows promising ability to boost antitumor T-cell immunity in preclinical ***,integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment.

关键词： Rectal cancer Image-guided radiotherapy Intensity-modulated radiotherapy Biomarkers Targeted therapies Myeloid-derived suppressor cells

Neutrophils in cancer—unresolved questions

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Science China(Life Sciences) 2021年第11期64卷 1829-1841页

作者： Melissa S.F.Ng leonard Tan Quanbo Wang Charles R.Mackay Lai Guan Ng Singapore Immunology Network(SIgN) A*STAR(Agency for ScienceTechnology and Research)Biopolis 138648Singapore School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China State Key Laboratory of Experimental Hematology Institute of HematologyChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

There is growing recognition that neutrophils play an important role in cancer initiation, progression and metastasis. Although they are typically characterized as short-lived effector cells, neutrophils have been shown to acquire immunosuppressive and pro-tumorigenic functions that promote tumor progression and escape. As such, inhibition of their function or depletion of neutrophils are being explored as potential cancer therapies. However, growing evidence of neutrophil diversification in cancer and their potential anti-tumor roles raise many unresolved questions. Here, we review recent advances that address the definition,origin and function of neutrophils in cancer, and elaborate on obstacles that make the study of neutrophils challenging. We envision that this review will provide the groundwork for focused design of therapeutics that will specifically target "tumorreprogrammed" neutrophils while sparing normal neutrophils to improve patient outcomes.

关键词： neutrophils cancer myeloid-derived suppressor cells(MDSCs) immunotherapy

Study of galvanic corrosion and mechanical joint properties of AZ31B and carbon-fiber–reinforced polymer joined by friction self-piercing riveting

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Journal of Magnesium and Alloys 2022年第2期10卷 434-445页

作者： Yong Chae Lim Jiheon Jun Donovan N.leonard Yuan Li Jian Chen Michael P.Brady Zhili Feng Materials Science and Technology Division Oak Ridge National LaboratoryOne Bethel Valley RoadOak RidgeTN 37831USA

A new testing methodology was developed to quantitively study galvanic corrosion of AZ31B and thermoset carbon-fiber–reinforced polymer spot-joined by a friction self-piercing riveting ***-defined areas of AZ31B in the joint were exposed in 0.1 M NaCl solution over *** galvanic corrosion of AZ31B was observed as exposure time *** measured volume loss was converted into corrosion current that was at least 48 times greater than the corrosion current of AZ31B without galvanic *** percent of the mechanical joint integrity was retained for corroded F-SPR joints to 200 h and then decreased because of the massive volume loss of AZ31B。

关键词： Multi-material joining Carbon fiber–reinforced polymer AZ31B Friction self-piercing riveting Galvanic corrosion Mechanical joint strength

Synthesis and characterisation of potassium polytitanate for photocatalytic degradation of crystal violet

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Journal of Environmental Sciences 2014年第11期26卷 2348-2354页

作者： Mohammad Shahid Ibrahim El Saliby Andrew Mc Donagh leonard D.Tijing Jong-Ho Kim Ho Kyong Shon School of Civil and Environmental Engineering University of Technology Sydney (UTS) P.O. Box 123 Broadway Sydney NSW 2007Australia School of Chemistry and Forensic Science University of Technology Sydney (UTS) P.O. Box 123 Broadway Sydney NSW 2007 Australia School of Applied Chemical Engineering The Research Institute for Catalysis Chonnam National University Gwangju 500-757 South Korea Photo & Environmental Technology Co. Ltd. Gwangju 500-460 South Korea

Potassium titanate nanostructures were synthesised by hydrothermal treatment of TiO2 （P25） in KOH and H2O2. As-produced powders were characterised by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, X-ray diffraction, and nitrogen adsorption-desorption methods. Longitudinally-oriented-wire-like structures with a length up to several micrometres and diameters ranging from 10 to 30 nm were obtained. Larger size fibrous nanowires resulting from the hydrotherrnal treatment showed high affinity in adsorbing crystal violet （CV）, which was mainly due to their high surface area. The photocatalytic bleaching of CV solution revealed that the wires are photoactive under ultraviolet light irradiation. Macroporous nanowires are considered as effective adsorbents of CV, capable of photocatalvtic degradation, and they can be easily separated from the solution by settling.

关键词： Potassium titanate Adsorption Crystal violet Macroporous Titanium dioxide Photocatalysis

Impact of spiritual beliefs and faith-based interventions on diabetes management

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World Journal of Diabetes 2021年第5期12卷 630-641页

作者： Charity Neejide Onyishi leonard Chidi Ilechukwu Vera Victor-Aigbodion Chiedu Eseadi Department of Educational Psychology University of JohannesburgGauteng2006South Africa Department of Educational Foundations University of NigeriaNsukkaEnugu 410001Nigeria Department of Arts Education University of NigeriaNsukkaEnugu 410001Nigeria

Management of diabetes constitutes significant social and economic burdens *** is a shortage of empirical studies on the management of diabetes and the associated mental health issues through spiritual beliefs and faith-based interventions(FBIs).It is not also clear how spiritual beliefs and FBIs account for the effective management of diabetic *** article discusses the impact of spiritual beliefs and FBIs in the management of diabetes,from relationship and efficacy studies that report outcomes from experimental procedures of related *** majority of the relationship studies showed positive relationships,while efficacy studies showed a high efficacy of interventions in faith-based ***,none of the studies clearly reported the mechanisms of change or modality of operation in a FBI that can serve as a model across culture and *** mechanisms of change were discussed for further development of a standard faith-based model,and finally,suggestions for future research were also highlighted by the authors.

关键词： Comorbid health conditions Diabetes Faith-based interventions Diabetes management Spirituality Coping strategies

The Health Benefits of a Pedometer-Based 100,000 Steps/Week Physical Activity Program

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Journal of Science in Sport and Exercise 2019年第2期1卷 176-183页

作者： Earlene Masi James E.Peterman leonard A.Kaminsky Department of Kinesiology Kardatzke Wellness CenterAnderson UniversityAndersonIN 46012USA Fisher Institute of Health and Well-Being Health and Physical Activity BuildingRoom 302Ball State UniversityMuncieIN 47306USA

Purpose Pedometers can be an effective tool to increase step counts in a physically inactive *** a more active population,pedometers may also be useful for further increasing physical activity and improving cardiovascular disease risk *** purpose was to assess the adherence and determine the health impact of a 100,000 steps/week(14,286 steps/day)goal in a somewhat-active(7500-9999 steps/day)to active(10,000-12,500 steps/day)*** Thirty-two apparently healthy subjects,13 males(age 44±14 years)and 19 females(age 39±13 years)who had a baseline activity level between 7500 and 12,500 steps/day,were *** were assessed prior to and 16 weeks after completing a 100,000 steps/week ***-and post-assessments of health included body composition,rest-ing blood pressure,blood lipid profile,fasting blood glucose,and a 3-min walk test to estimate cardiorespiratory *** Fifty-three percent of participants adhered(≥90,000 steps/week)to the 100,000 steps/week physical activity program yet all participants increased their stepping by 23,303±11,480 steps/*** increased stepping,significant improvements in body composition were *** included reduced body mass index(pre:27.2±3.6 kg/m^(2);post:26.9±3.6 kg/m^(2);P=0.026),reduced total percent body fat(pre:35.7±9.9%;post:34.3±10.4%;Pek with the use of a pedometer.

关键词： Physical activity Pedometer Body composition Adherence Dose-response

Nanotrains and Self-Assembled Two-Dimensional Arrays Built from Carboranes Linked by Hydrogen Bonding of Dipyridones

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Nano Research 2008年第5期1卷 412-419页

作者： Takashi Sasaki Jason M.Guerrero Ashley D.leonard James M.Tour Department of Chemistry Department of Mechanical Engineering and Materials ScienceRice UniversityMS 2226100 Main St.HoustonTexas 77005USA

The strong hydrogen bonding ability of 2-pyridones were exploited to build nanotrains on *** wheels on axles difunctionalized with 2-pyridone hydrogen bonding units were synthesized and displayed spontaneous formation of linear nanotrains by self-assembly on SiO_(2)or mica *** using atomic force microscopy confi rmed linear formations with lengths up to 5μm and heights within the range of the molecular height of the carborance-tipped axles.

关键词： Nanovehicles nanotrains 2-pyridone hydrogen bonding self-assembly