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What Tool for diagnosis of Latent Tuberculosis Infection in developing Country with Tuberculosis High burden: Interferon Gamma Release Assays versus Tuberculin Skin Test in burkina Faso

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Advances in Infectious diseases 2022年第4期12卷 668-684页

作者： diakourga Arthur djibougou Gloria Ivy Mensah Tibila Kientega leon Tinnoaga Sawadogo Hervé Hien Clément Ziemlé Meda Adrien Marie-Gaston belem Roch Konbobr dabiré bassirou bonfoh Kennedy Kwasi Addo Potiandi Serge diagbouga Université Nazi bONI Bobo-Dioulasso Burkina Faso Centre MURAZ/Institut National de Santé Publique Bobo-Dioulasso Burkina Faso Centre National de Recherche Scientifique et Technologique/Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso department of bacteriology Noguchi Memorial Institute for Medical Research College of Health Sciences University of Ghana Legon Accra Ghana Université de Montréal Centre de recherche du Centre hospitalier de l’universitaire de Montréal (CRCHUM) Montréal Canada Programme National Tuberculose Ministry of Health Ouagadougou Burkina Faso Centre Suisse de Recherches Scientifique de Cô te d’Ivoire Abidjan C&#244 te d’Ivoire Etudes Formation et Recherches développement en Santé (EFORdS) Ouagadougou Burkina Faso

background: The diagnosis and treatment of active tuberculosis and the detection/management of latent tuberculosis infection (LTbI) cases are the two main strategies for the Tb control, particularly in endemic countries. Tuberculin skin test (TST) and Interferon Gamma Release Assays (IGRAs) are tools for detection of LTbI. The objective of this study was to evaluate the performance of the TST and QuantiFERON-Tb Gold Plus® (QTF-Plus) and to identify a threshold for TST in best agreement with QTF-Plus for LTbI detection in a high Tb burden setting. Methods: In July 2020, a cross-sectional analytical study was performed for QFT-Plus using blood samples and TST in 101 individuals with a high risk of Tb living in bobo-dioulasso, burkina Faso. A crude comparison between both tests was done and receiver operating characteristic curve was generated to determine TST’s threshold. TST sensitivity, specificity, predictive values and accuracy were calculated. Adjusted agreement between TST and QFT-Plus was evaluated. Results: With the minimum threshold of positivity set at 5 mm for TST, the overall agreement between the latter and QFT-Plus was poor with a Kappa coefficient (κ) rated at 0.319 (95% CI: 0.131 - 0.508). This cut-off yielded a sensitivity of 94.12% (95% CI: 88.53 - 99.71), and very poor specificity of 36.4% (95% IC: 25.0 - 47.80). However, an adjusted cut-off set at 11 mm gave a better specificity of 72.73% (95% CI: 62.1 - 83.30) of TST and improved the PPV (86%). Moreover, concordance between both tests was improved with κ at 0.56 (95% CI: 0.385 - 0.728) and 80.20% of accuracy. Factors associated with discordance between TST (11 mm) and QFT-Plus results were bCG vaccination, OR = 7.53 (95% CI: 1.43 - 139.25), p = 0.05 and chronic cough, OR = 5.07 (95% CI: 1.27 - 20.43), p = 0.01. Conclusions: This study showed that using a minimal cut-off of 11mm for TST significantly improved the concordance between QTF-Plus (IGRA) and TST. Using the cut-off TST of

关键词： LTbI diagnosis IGRA TST Threshold Concordance burkina Faso

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激光诊断医学的发展

中国激光 1980年第Z1期 127-127页

作者： leon Goldman,M.d. 辛辛那提大学医学中心激光实验室辛辛那提大学医学中心激光实验室主任主任

自从早期实验激光微发射光谱学以来,激光诊断医学有了很大的发展.当前,由于种种新技术的使用,尤其是红外激光器的使用,激光诊断光谱学领域有了很大的扩展.不论在目前与将来激光对免疫学都是重要的,特别是由于有了悬胶体光散射法与细胞... 详细信息

自从早期实验激光微发射光谱学以来,激光诊断医学有了很大的发展.当前,由于种种新技术的使用,尤其是红外激光器的使用,激光诊断光谱学领域有了很大的扩展.不论在目前与将来激光对免疫学都是重要的,特别是由于有了悬胶体光散射法与细胞筛选技术.激光技术在心血管动力学研究中也开始使用.诊断乳房癌的激光透照法正在研究.激光通讯信息

关键词：激光诊断医学现代医药学

Cystic fibrosis and the relevance of the whole-body vibration exercises in oscillating platforms: a short review

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Health 2011年第10期3卷 656-662页

作者： Adalgisa Ieda Maiworm Milena b.Monteiro Sebastiao d.Santos-Filho Agnaldo J.Lopes Leandro Azeredo Sotiris Missailidis Pedro J.Marin Mario bernardo-Filho Hospital Universitario Pedro Ernesto Setor de FisioterapiaUniversidade do Estado do Rio de JaneiroRio de JaneiroBrazil Clinica de Fisioterapia e biomedicina Rio de JaneiroBrazil Universidade do Estado do Rio de Janeiro Instituto de Biologia Roberto Alcantara GomesDepartamento de Biofisica e BiometriaRio de JaneiroBrazil departamento de Pneumologia e Coordenacao do Centro de Referencia de Fibrose Cistica em Adultos do Estado do Rio de Janeiro Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Hospital da Policia Militar NiteroiBrazil The Open University Milton KeynesUK Laboratory of Physiology European University Miguel de CervantesValladolidSpain Research Center on Physical disability ASPAYMCastilla y LeonSpain Coordenadoria de Pesquisa Instituto Nacional do CancerINCaRio de Janeiro Brazil.

Objective: The aim is to present a review about the whole-body vibration (WbV) exercises in the management of cystic fibrosis (CF). Methods: Computerized literature searches were performed using the PubMed databases. Results: A strong interest in studies, considering the number of publications, involving CF and lung was found. Although, the exercises and physical activities seem to have a high relevance in the management of the patients with CF, the number of publications involving these procedures is limited. Moreover, a modality of exercise involving WbV seems to be poorly utilized by the patients with CF and only two papers were found with positive actions. Conclusion: Oscillating platform is a promising technique to manage patients with CF. Moreover, as (i) the use of the oscillating platforms is inexpensive, (ii) the vibration exercise requires less technical abilities as compared to the performance of conventional resistance training and (iii) positive clinical findings have been noticed with the use of WbV in CF, it is suggested to implement the studies involving the application of the exercises with WbV in oscillating platforms to manage the patients with CF.

关键词： Cystic fibrosis whole body vibration PubMed

Inflammation, oxidative stress and renin angiotensin system in atherosclerosis

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World Journal of biological Chemistry 2015年第3期6卷 209-217页

作者： Kazim Husain Wilfredo Hernandez Rais A Ansari leon Ferder department of Physiology Pharmacology and Toxicology Ponce School of Medicine department of biochemistry Ponce School of Medicine department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University

Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin d analogs paricalcitol in Apo E-deficient atherosclerotic mice.

关键词： Atherosclerosis Renin-angiotensin system Inflammation Oxidants/antioxidants imbalance Antiinflammatory drugs Renin-angiotensin system blockers

Nitric oxide production is associated to increased lipoperoxidation and active caspase-3 in demyelinated brain regions of the taiep rat

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Advances in bioscience and biotechnology 2012年第6期3卷 695-704页

作者： Guadalupe Soto-Rodríguez daniel Martínez-Fong Rosa Arroyo Patricia Aguilar-Alonso Hector Rubio José Ramón Eguibar Araceli Ugarte Maricela Torres-Soto Juan Antonio González-barrios Jorge Cebada Eduardo brambila bertha Alicia leon-Chavez departamento de Fisiología Biofísica y Neurociencias Cinvestav Apdo. Postal 14-740 México D.F. 07000 México división de Medicina Genómica del Hospital regional 1o de Octubre ISSSTE Avenida Instituto Politécnico Nacional 1669 México D. F. 07760 México Escuela de biología BUAP Puebla Pue. Mexico Facultad de Ciencias Químicas BUAP 14 sur y Av. Edif. 138 San Claudio 72570 Puebla Pue. México Facultad de Medicina Universidad Autónoma de Yucatán Mexico Instituto de Fisiología BUAP 14 sur 6301 Puebla Pue. México

We previously showed that the increase in nitric oxide (NO) levels and NO synthase (NOS) expression correlate with the progression of reactive astrocytosis and demyelination in the brains of 6-month-old taiep rats. Increased levels of NO can result in high concentration of peroxynitrite and thus cause tissue damage, which consists of lipoperoxidation of the cytoplasmic membrane, such as the myelin, and of apoptotic and necrotic cell-death. On this basis, we studied whether the increased NO production is associated with lipoperoxidation and cell death in the cerebellum and brainstem over the age (1, 3, 6, and 8 months) of taiep rats. The results were compared with those obtained in matched Sprague-dawley (Sd) rats. We measured the levels of nitrites (NO production), malonyldialdehyde, and 4-hydroxyalkenal (lipoperoxidation) in brain tissue homogenates. The three NOS isoforms and cleaved caspase-3 were evaluated by using ELISA and immunostaining techniques. Our results showed that NO production and lipoperoxidation increased in the cerebellum and brainstem as the age of the taiep rats increased compared to Sd rats. The overexpression of nNOS and iNOS were in the Purkinje cells, magnocellular neurons, and in oligodendrocytes, whereas the glial cells showed strong cleaved-caspase-3 immunoreactivity. In summary our results suggest that NO plays a role in the demyelination and cell death in the taiep rat.

关键词： Hypomyelination Nitrite Malonyldialdehyde Apoptosis Necrosis

dispersion of niquel on the microstructure in magnesium based alloys for hydrogen storage

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Journal of Magnesium and Alloys 2013年第4期1卷 292-296页

作者： A.A.Zaldıvar-Cadena I.dıaz-Pena J.G.Cabanas-Moreno Universidad Autonoma de Nuevo leon Av.Universidad s/nFacultad de Ingenierıa CivilSan Nicolas de los Garza N.L.C.P.66451Mexico Instituto Politecnico Nacional UPALMCol.LindavistaC.P.07338 Mexico D.F.Mexico

Mg–Xwt.%Ni(X=5 and 20)alloys have been prepared by mechanical alloying using milling times of 15 and 30 h in a planetary ball milling to know the effects of magnesium with the addition of Ni as catalyst,dispersion on the microstructure,area surface and the efficiency of hydrogen ***-EdS,XRd and ImageJ^(■)software have been used to characterize the microstructure and chemical composition of the *** experiments were performed as batch-type tests at 200,250 and 300℃ under 2 MPa H2 pressure during 30 *** experiments resulted in varying amounts of MgH2 in the hydrided powders depending on composition and hydriding *** best results point to an optimum Ni dispersion,which in turn depends on Ni content and milling time.

关键词： Hydrogen storage Magnesium Niquel Alloy Characterization

Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

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分子细胞生物学报:英文版 2016年第2期8卷 174-177页

作者： Yi Yang Kepin Wang Han Wu Qin Jin degong Ruan Zhen Ouyang bentian Zhao Zhaoming Liu yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai Key Laboratory of Regenerative biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China School of Life Sciences University of Science and Technology of ChinaHefei 230027China leon H Charney division of Cardiology New York University School of Medicine522 First AvenueNew YorkNY 10016USA Key Laboratory for Major Obstetric diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education InstitutesThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130062China

dear Editor,Type1diabetes(T1d)isa lifelong(chronic)disease and a major health problem throughout the *** disease can be treatedby either insulin injection or islet *** transplantation is considered as a better treatment for T1d patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control.

关键词： islet injection expressing

紫花苜蓿与百脉根原生质体培养及不对称体细胞杂交

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核农学报 2015年第1期29卷 40-48页

作者：李玉珠师尚礼甘肃农业大学草业学院/草业生态系统教育部重点实验室/甘肃省草业工程实验室/中美草地畜牧业可持续发展研究中心甘肃兰州730070

本研究拟通过原生体培养和不对称细胞杂交实现白脉根与苜蓿种间基因重组,为改良苜蓿饲用品质提供新的技术手段,用酶解法分离清水紫花苜蓿（Medicago sativa ***.‘Qingshui’）及里奥百脉根（Lotus corniculatus ***.‘leon’）愈伤组... 详细信息

本研究拟通过原生体培养和不对称细胞杂交实现白脉根与苜蓿种间基因重组,为改良苜蓿饲用品质提供新的技术手段,用酶解法分离清水紫花苜蓿（Medicago sativa ***.‘Qingshui’）及里奥百脉根（Lotus corniculatus ***.‘leon’）愈伤组织来源的原生质体,研究了酶解时间、酶液组合、甘露醇浓度、预处理条件、继代时间及培养方法等对原生质体分离和培养效果的影响。采用改良的PEG-高Ca2＋-高p H法进行了不对称体细胞杂交,通过荧光染色鉴别异核体并测定融合率。结果表明,采用继代培养第8~12天的苜蓿和百脉根愈伤组织,0.55 mol·L-1CPW溶液中预处理1h或预暗培养24 h,甘露醇浓度为0.55~0.6 mol·L-1时,清水紫花苜蓿在2%纤维素酶＋0.5%果胶酶＋0.3%崩溃酶的酶液中酶解10 h,里奥百脉根在2%纤维素酶＋0.5%果胶酶＋0.3%半纤维素酶的酶液中酶解12 h,经2~3个月的固液＋固体培养模式可分别获得较好的原生质体分离效果及愈伤组织再生植株。清水紫花苜蓿原生质体经3 mmol·L-1IOA处理10 min,里奥百脉根经50μg·m L-1R-6G处理10 min后融合,PEG（6000）最适浓度为35%,异源融合率为3.1%,最终获得了苜蓿与百脉根的杂种愈伤组织,为进一步培育抗臌胀病型苜蓿种质提供了新的材料。

关键词：紫花苜蓿百脉根原生质体培养不对称体细胞杂交

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什么是3d立体画?

小哥白尼（趣味科学） 2019年第11期 F0003-F0003页

作者： leon Keer

3d立体画与普通绘画的最大区别就在于,它参考了欣赏者站立的位置,为欣赏者营造了一个真实的视觉空间,而不仅仅是一幅画。眼睛骗了你你只有在特定角度才能看到3d立体画的最佳效果,在其他位置看到的可能只是一幅线条拉长了的变形图画。

关键词：立体画

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