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儿童神经母细胞瘤自然杀伤细胞扩增和激活的免疫治疗研究

中国生物化学与分子生物学会第八届会员代表大会暨全国学术会议

作者： E.Arnold K.Das A.D.Clark.j.. D.Ludovici M.Kukla B.DeCorte K.Andries R.Pauwels M.-P.Bethune P.Lewi S.H.Hughes P.A.j.j.nssen Center for Advanced Biotechnology and Medicine and Rutgers University Department of Chemistry PiscatawayNJ j.nssen Research Foundation SpringhousePA j.nssen Research Foundation BeerseBelgium Tibotec.Mechelen.Belgium Center for Molecular Design Janssen Research FoundationVosselaarBelgium HIV Drug Resistance Program NIH National Cancer Institute-Frederick FrederickMD

A multidisciplinary approach has led to the discovery of novel non-nucleoside HIV-1 reverse transcriptaseinhibitors(NNRTIs)that show great promise as drug candidates for the treatment of *** the design

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儿童神经母细胞瘤自然杀伤细胞扩增和激活的免疫治疗研究

心肌CT灌注成像与SPECT在冠状动脉疾病诊断中准确性的直接比较:一项来自“CORE320”的多中心研究

2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者：刘茵 Hong-Wei Wu Michael A. Sheard Richard Sposto Robert C. Seeger Laurence j.N. Cooper Dean A. Lee Division of Hematology/Oncology and Saban Research Institute Children’s Hospital Los Angeles Keck School of Medicine University of Southern California 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 Department of Preventive Medicine Keck School of Medicine University of Southern California Division of Pediatrics MD Anderson Cancer Center University of Texas

目的自然杀伤细胞(NK细胞)及抗肿瘤细胞膜受体可应用于一系列肿瘤的免疫治疗。本研究旨在探讨体外扩增高危神经母细胞瘤(NB)患儿外周血获得大量高肿瘤细胞杀伤能力NK细胞的方法,NK细胞杀伤肿瘤细胞过程中释放的细胞因子和趋化因子,以及... 详细信息

目的自然杀伤细胞(NK细胞)及抗肿瘤细胞膜受体可应用于一系列肿瘤的免疫治疗。本研究旨在探讨体外扩增高危神经母细胞瘤(NB)患儿外周血获得大量高肿瘤细胞杀伤能力NK细胞的方法,NK细胞杀伤肿瘤细胞过程中释放的细胞因子和趋化因子,以及小鼠体内NK细胞杀伤NB肿瘤细胞的能力。方法K562

关键词：儿童神经母细胞瘤杀伤能力细胞扩增免疫治疗

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国际医学放射学杂志 2014年第5期 481-482页

作者： R.T.George V.C.Mehra M.Y.Chen K.Kitagawa A.Arbab-Zadeh j.M.Miller 陈国中 The School of Medicine Johns Hopkins University600 N Wolfe StBlalock 524D2BaltimoreMD 21287

摘要目的以有创的冠状动脉血管成像为金标准,比较心肌CT灌注成像和SPECT灌注成像对解剖学上有意义的冠状动脉疾病(CAD)诊断的准确性。材料与方法本研究经

关键词：灌注成像 SPECT CORE320 CT 心肌冠状动脉疾病

Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

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Signal Transduction and Targeted Therapy 2022年第3期7卷 790-801页

作者： Hernando Lopez-Bertoni Amanda j.hnson Yuan Rui Bachchu Lai Sophie Sail Maureen Malloy j.nathan BCoulter Maria Lugo-Fagundo Sweta Shudir Harmon Khela Christopher Caputo j.rdan j.Green j.hn Laterra Hugo W.Moser Research Institute at Kennedy Krieger BaltimoreMDUSA Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Biomedical Engineering Institute for NanoBioTechnologyand the Translational Tissue Engineering CenterJohns Hopkins University School of MedicineBaltimoreMDUSA Bloomberg School of Public Health Department of Environmental Health and EngineeringThe Johns Hopkins University School of MedicineBaltimoreMDUSA The Department of Radiation Oncology and Molecular Radiation Sciences The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Ophthalmology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Materials Science&Engineering and Chemical&Biomolecular Engineering Johns Hopkins UniversityBaltimoreMDUSA Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5m... 详细信息

关键词： TET2 5hmC convert

多杆菌麻风病患者多种药物联合治疗2年后眼部并发症的发病率

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 36-36页

作者： Daniel E. Ffytche T.j. Kempen j.H. 闫丽 Division of Ocular Immunology Department of Ophthalmology Johns Hopkins University School of Medicine 1620 McElderry Street Baltimore MD 21205 United StatesDr.

Aim: To evaluate the incidence of and risk factors for ocular complications in multibacillary (MB) leprosy patients following completion of 2 year, fixed duration, multidrug therapy (mdT). Methods: Biannual eye examinations were conducted prospectively on a cohort of MB patients who had completed mdT and followed up for 5 years. The incidence of ocular pathology was calculated as the number of events per person year of event free follow up of patients who did not have the specific finding before completion of mdT. Results: 278 patients had one or more follow up visits after completion of mdT. The incidence of lagophthalmos was 0.24%/patient year (95%CI 0.10%to 0.37%); corneal opacity, 5.35%/patient year (95%CI 4.27%to 6.70%); uveal involvement, 3.78%/patient year (95%CI 2.96%to 4.83%); and cataract that reduced vision to 6/18 or less, 2.4%/patient year (95%CI 1.77%to 3.26%). Overall, 5.65%/patient year (95%CI 4.51 %to 7.09%) developed leprosy related ocular disease and 3.86%/patient year (95%CI 3.00%to 4.95%) developed leprosy related, potentially blinding ocular pathology during the period following *** and otfier disability also predicted incident eye disease. Conclusions: Every year, approximately 5.6%of patients with MB who have completed mdT can be expected to develop new ocular complications of leprosy, which often (3.9%) are potentially vision threatening. Because many of these complications cannot be detected without slit lamp examination, periodic monitoring, particularly of older patients and those with other disability, is recommended, in order to detect and treat ocular complications satisfactorily.

关键词：麻风病麻风眼部并发症并发病疾病药物联合患者发病率杆菌

Barrett食管的冷冻消融术:一项先导性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 26-26页

作者： j.hnston M.H Eastone j.A Horwhat j.D. 尹勇 Gastroenterology GIClinicNationl Naval Medical Center 8901 Wisconsin Ave Bethesda MD 20889 United StatesDr.

Background: Numerous ablative modalities have demonstrated varying degrees of efficacy in the eradication of Barrett‘s esophagus (BE). However, they are associated with either high cost, patient discomfort, complications, tedious applica tion, residual underlying BE, or some combination of the above. The aim of this study was to evaluate the safety and the efficacy of a new cryogenic device by u sing liquid nitrogen sprayed through an open tipped cryogenic catheter placed th rough the accessory channel of an upper endoscope. Methods: A prospective, singl e center studywas performed on patients with a long-standing history of BE foll owed in a Barrett‘s registry. Patients with degrees of dysplasia ranging from n one to multifocal high-grade dysplasia were treated. All patients were treated with 40 mg rabeprazole 3 times per day during the treatment period. Elimination of acid reflux was confirmed via 24-hour esophageal pH studies. Cryoablation wa s applied hemicircumferentially to 4-cm-long segments at monthly intervals, un til the entire segment of BE was eliminated. Results: Eleven patients were treat ed. There was reversal of BE in all patients. In 9 of 11 (78%) patients who com pleted the protocol, there was complete endoscopic and histologic reversal of BE . There was no subsquamous specialized intestinal metaplasia at the 6-month fol low-up. No complications occurred. Conclusions: Based on preliminary results, l ow-pressure spray cryoablation of BE under direct endoscopic visualization is s afe and easy to perform. Its relative lack of patient discomfort and its simplic ity and demonstrated efficacy make it a modality that should be further explored in the ablation of GI mucosal lesions such as BE and perhaps early esophageal c ancer.

关键词： Barrett 冷冻消融术酸反流早期食管癌雷贝拉唑不典型增生喷洒液操作时间低温射频胃

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帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析

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中华肿瘤防治杂志 2021年第24期28卷 1841-1850页

作者：陈大卫(翻译) 于金明(校对) Willemij. S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen j.achim G j.V Aerts Idris Bahce Anna Larissa N Niemeij.r j.e Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel j.hn Heymach Paul Baas j.mes W Welsh 山东省肿瘤防治研究院(山东省肿瘤医院) 山东第一医科大学(山东省医学科学院)山东济南250117 不详 Department of Radiation Oncology The University of Texas M D Anderson Cancer CenterHoustonTX 77030USA

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期mdACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,... 详细信息

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期mdACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和mdACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,mdACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为mdACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在mdACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和mdACC研究(NCT02444741)均在***上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。

关键词：帕博利珠单抗非小细胞肺癌放疗汇总分析

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Traumatic brain inj.ry induced by exposure to blast overpressure via ear canal

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Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton j.nghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen j.n Huang Yue Yu j.rome Allison Fan Fan Richard j.oman j.mes Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences md Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain inj.ry in military and civilian *** ears are most often damaged following exposure to *** there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear *** present study investigated whether exposure to blasts directed through the ear canal causes brain inj.ry in LongEvans *** were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain inj.ry was evaluated by histological and behavioral outcomes at multiple *** exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of *** blast-induced inj.ry was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive ***,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast *** results suggest that the unprotected ear canal provides a locus for blast waves to cause *** study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain inj.ry

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Search for the doubly heavy baryons Ω^(0)_(bc) and E^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and E^(+)_(c)π^(-)

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Chinese Physics C 2021年第9期45卷 10-21页

作者： R.Aaij.C.Abelian Beteta T.Ackernley B.Adeva M.Adinolfi H.Afshamia C.A.Aidala S.Aiola Z.Aj.ltouni S.Aka j.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelie S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer j.j.Back P.Baladron Rodriguez V.Balagura W.Baldini j.Baptista Leite R.j.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov j.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Beminghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin j.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bj.rn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska j.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato j.T.Borsuk S.A.Bouchiba T.j.V.Bowcock A.Boyer C.Bozzi M j.Bradley S.Braun A.Brea Rodriguez M.Brodski j.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich j.S.Butter j.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Camiti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani j.Cerasoli A.j.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Baraj.s M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff j.Closier j.L.Cobbledick V.Coco j.A.B.Coelho j.Cogan E.Cogneras L.Coj.cariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik j.Crkovska M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo j.Dalseno C.D'Ambrosi Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de j.neiro(UFRj. Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofChinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

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涎腺基因转导的临床应用

中华口腔医学杂志 2009年第Z1期44卷 14-14页

作者： Bruce j.Baum Changyu Zheng Llias Alevizos Ana P Cotrim Corinne M Goldsmith Shuying Liu Linda McCullagh Nikolay Nikolov Gabor G Illei MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda md2190USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda9USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda md2190USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda9USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda md2190USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda9USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda md2190USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda9USA MolecularPhysiologyandTherapeuticsBranch NationalInstituteofDentalandCraniofacialResearch NIH DHHS Bethesda md2190USA