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搭桥之谜

少儿科技 2025年第Z1期 64-65+47页

作者： leo

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11枚铜钱

少儿科技 2025年第Z1期 66-67+47页

作者： leo

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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Triboelectric Nanogenerator Enabled Smart Shoes for Wearable Electricity Generation

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Research 2020年第1期2020卷 1202-1221页

作者： Yongjiu Zou Alberto Libanori Jing Xu ardo Nashalian Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The parallel evolution of wearable electronics,artificial intelligence,and fifth-generation wireless technology has created a technological paradigm with the potential to change our lives *** this,addressing limitations linked to continuous,sustainable,and pervasive powering of wearable electronics remains a bottleneck to overcome in order to maximize the exponential benefit that these technologies can bring once synergized.A recent groundbreaking discovery has demonstrated that by using the coupling effect of contact electrification and electrostatic induction,triboelectric nanogenerators(TENGs)can efficiently convert irregular and low-frequency passive biomechanical energy from body movements into electrical energy,providing an infinite and sustainable power source for wearable electronics.A number of human motions have been exploited to properly and efficiently harness this energy potential,including human *** are an indispensable component of daily wearing and can be leveraged as an excellent platform to exploit such kinetic *** this article,the latest representative achievements of TENG-based smart electricity-generating shoes are comprehensively *** summarize ways in which not only can biomechanical energy be scavenged via ambulatory motion,but also biomonitoring of health parameters via tracking of rhythm and strength of pace can be implemented to aid in theranostic *** work provides a systematical review of the rational structural design,practical applications,scenario analysis,and performance evaluation of TENG-based smart shoes for wearable electricity *** addition,the perspective for future development of smart electricity-generation shoes as a sustainable and pervasive energy solution towards the upcoming era of the Internet of Things is discussed.

关键词： smart generator overcome

Automatic Classification of Swedish Metadata Using Dewey Decimal Classification:A Comparison of Approaches

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Journal of Data and Information Science 2020年第1期5卷 18-38页

作者： Koraljka Golub Johan Hagelback Anders ardo Department of Cultural Sciences Faculty of Arts and HumanitiesLinnaeus UniversityVaxjoSweden Department of Computer Science and Media Technology Faculty of TechnologyLinnaeus UniversityKalmarSweden Department of Electrical and Information Technology Lund UniversityLundSweden

Purpose:With more and more digital collections of various information resources becoming available,also increasing is the challenge of assigning subject index terms and classes from quality knowledge organization *** the ultimate purpose is to understand the value of automatically produced Dewey Decimal Classification(DDC)classes for Swedish digital collections,the paper aims to evaluate the performance of six machine learning algorithms as well as a string-matching algorithm based on characteristics of ***/methodology/approach:State-of-the-art machine learning algorithms require at least 1,000 training examples per *** complete data set at the time of research involved 143,838 records which had to be reduced to top three hierarchical levels of DDC in order to provide sufficient training data(totaling 802 classes in the training and testing sample,out of 14,413 classes at all levels).Findings:Evaluation shows that Support Vector Machine with linear kernel outperforms other machine learning algorithms as well as the string-matching algorithm on average;the string-matching algorithm outperforms machine learning for specific classes when characteristics of DDC are most suitable for the *** embeddings combined with different types of neural networks(simple linear network,standard neural network,1 D convolutional neural network,and recurrent neural network)produced worse results than Support Vector Machine,but reach close results,with the benefit of a smaller representation *** of features in machine learning shows that using keywords or combining titles and keywords gives better results than using only titles as *** only marginally improves the *** stop-words reduced accuracy in most cases,while removing less frequent words increased it *** greatest impact is produced by the number of training examples:81.90%accuracy on the training set is achieved when at least 1,000 records per class are available

关键词： LIBRIS Dewey Decimal Classification Automatic classification Machine learning Support Vector Machine Multinomial Naive Bayes Simple linear network Standard neural network 1D convolutional neural network Recurrent neural network Word embeddings String matching

Estimating the Lost Economic Production Caused by Internal Displacement Because of Disasters

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International Journal of Disaster Risk Science 2018年第4期9卷 496-506页

作者： Mario A.salgado-Gálvez Centre Internacional de Metodes Numerics en Enginyeria(CIMNE) 08034 BarcelonaSpain

Disasters are a large cause of internal displacement at the global level, in 2017 alone affecting more than19 million people. This dimension of disaster risk is usually overlooked in many disaster risk management strategies and assessments. It is only very recently that efforts to quantify displacement risk and integrate that dimension into existing physical risk models have been made. A key component of internal displacement assessment is the quantification of its economic impacts, both direct and indirect, not only to make a figure available but to raise awareness and increase accountability among governments, stakeholders, policymakers, and decision *** article presents a novel and peril-agnostic methodology with which to estimate, using a scenario-based approach, the economic production lost because of internal population displacement. The methodology is applied by using as a triggering event the April 2015 Gorkha, Nepal M7.8 earthquake. The method quantifies the indirect cost caused by internal population displacement because of that event in terms of lost economic production and estimates the loss to be between USD 400 and 850 million.

关键词： Disability adjusted life years Disaster risk Internally displaced people Lost economic production Disaster risk assessment

Metcalfe＇s Law and Network Quality： An Extension of Zhang et al.

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Journal of Computer Science & Technology 2016年第1期31卷 117-123页

作者： leo Van Hove Department of Applied Economics (APEC) Vrije Universiteit Brussel (Free University of Brussels) Brussels 1050 Belgium

Zhang et al. exploited data on Facebook and Tencent to validate Metcalfe＇s law, which states that the aggregate value of a communications network is proportional to the square of the number of users. This note points out that the value of a social network may be driven not only by its size, but also by increases in the variety and quality of the services offered. I therefore extend Zhang et al.＇s approach by explicitly controlling for changes in network quality over time. For the case of Tencent, I also filter out revenues and costs that are unrelated to Tencent＇s core （social network） services. I find that these two extensions only strengthen Zhang et al.＇s conclusions： Metcalfe＇s law now outperforms the other laws even more clearlv.

关键词： Metcalfe's law network value Facebook Tencent quality cost of revenue

Reproductive Biology of a Blue-tail Skinks(Plestiodon)Population from a Temperate Forest,East-central Puebla,México

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Asian Herpetological Research 2024年第3期15卷 183-193页

作者： Manuel FERIA-ORTIZ Isaías hazarmabeth salgado-UGARTE Museo de Zoología Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoIztapalapaMéxico Laboratorio de Biometría y Biología Pesquera Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoIztapalapaMéxico

We studied the cycles of reproduction and fat bodies of a blue-tailed skink population of an undescribed species of the Plestiodon brevirostris *** maturity is attained by females and males as they both reach about 59 mm of *** started in June-July,with ovulation occurring during late-October to mid-November,and parturition in *** size varied from two to six,with a mean of 3.86±0.15 embryos in uterus,and showed a positive correlation with female body mass and *** gestation,a significant increase in the average wet mass of embryos in uterus was *** comparison,there were no notable changes in the average dry *** growth data suggest that sexual maturity,both males and females,is reached at 16-17 months of *** and epididymides exhibited maximal weight during *** regression occurred in *** apparently takes place from mid-summer to early *** stored in female fat bodies are used for vitellogenesis and for nutrition during the winter *** males,the stored lipids appear to be used in reproductive activities during the mating season.

关键词： growth litter size minimum size at maturity reproduction Scincidae viviparity