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搭桥之谜

少儿科技 2025年第Z1期 64-65+47页

作者： leo

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11枚铜钱

少儿科技 2025年第Z1期 66-67+47页

作者： leo

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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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天安·千树

建筑实践 2019年第11期 76-81页

作者：托马斯·赫斯维克 Lisa Finlay Dani Rossello Diez Jimmy Hung Thomas Impiglia leo cheung Claudia Orsetti Dimitrije Miletic Shan Li Vichayuth Meenaphant Vincenzo D'Auria Yuxiang Cao Chris Tsui Nicolas Leuina Osbert So Philipp Nedomlel Philip Hall-Patch Kelin Yue 朱清言 Noah Sheldon 托马斯·赫斯维克事务所

"千树"场地距上海市中心仅20分钟路程,毗邻苏州河,四通八达,也曾是工业历史的核心地带。如今,它已崛起为当代艺术的繁荣之地。天安中国投资有限公司将此地块开发,希望在融合滨水自然元素的同时,让新与旧和谐共存。规定中,新设计需要保... 详细信息

"千树"场地距上海市中心仅20分钟路程,毗邻苏州河,四通八达,也曾是工业历史的核心地带。如今,它已崛起为当代艺术的繁荣之地。天安中国投资有限公司将此地块开发,希望在融合滨水自然元素的同时,让新与旧和谐共存。规定中,新设计需要保留历史建筑的部分,并需包含住宅、酒店、零售和商业的功能。

关键词： MLA 面粉厂

Metcalfe＇s Law and Network Quality： An Extension of Zhang et al.

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Journal of Computer Science & Technology 2016年第1期31卷 117-123页

作者： leo Van Hove Department of Applied Economics (APEC) Vrije Universiteit Brussel (Free University of Brussels) Brussels 1050 Belgium

Zhang et al. exploited data on Facebook and Tencent to validate Metcalfe＇s law, which states that the aggregate value of a communications network is proportional to the square of the number of users. This note points out that the value of a social network may be driven not only by its size, but also by increases in the variety and quality of the services offered. I therefore extend Zhang et al.＇s approach by explicitly controlling for changes in network quality over time. For the case of Tencent, I also filter out revenues and costs that are unrelated to Tencent＇s core （social network） services. I find that these two extensions only strengthen Zhang et al.＇s conclusions： Metcalfe＇s law now outperforms the other laws even more clearlv.

关键词： Metcalfe's law network value Facebook Tencent quality cost of revenue

INTERACTION OF SIMILARLY CHARGED SURFACES MEDIATED BY NANOPARTICLES

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Chinese Journal of Polymer Science 2011年第4期29卷 414-420页

作者： Klemen Bohinc leo Lue Faculty of Health Sciences University of LjubljanaSI-1000 LjubljanaSlovenia Department of Chemical and Process Engineering University of StrathclydeJames Weir Building75 Montrose StreetGlasgow G1 1XJUK

We study the interaction between two like charged surfaces embedded in a solution of oppositely charged multivalent rod-like counterions. The counterions consist of two rigidly bonded point charges, each of valency Z. The strength of the electrostatic coupling increases with increasing surface charge density or valency of the charges. The system is analyzed by employing a self-consistent field theory, which treats the short and long range interactions of the counterions within different approximations. We find that in the weak coupling limit, the interactions are only repulsive. In the intermediate coupling regime, the multivalent rod-like counterions can mediate attractive interactions between the surfaces. For sufficiently long rods, bridging contributes to the attractive interaction. In the strong coupling limit, the charge correlations can contribute to the attractive interactions at short separations between the charged surfaces. Two minima can then appear in the force curve between surfaces.

关键词： Electrostatics Nanoparticle interactions Theory.

Comparison of undrained behaviors of granular media using fluidcoupled discrete element method and constant volume method

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第6期12卷 1272-1289页

作者： Wei Zhang leo Rothenburg Department of Civil and Environmental Engineering University of WaterlooWaterlooN2L 3G1Canada

The fluid-coupled discrete element method(DEM)and the constant volume method as two types of discrete modeling methods for fundamental study of undrained responses of granular materials,have been discussed by many *** fluid-coupled DEM,which couples the motions of discrete particles with pore fluid movements,is theoretically robust although it requires a large amount of computation *** a substitution for the complex fluid-coupled DEM,the constant volume method simulates an undrained condition for a saturated granular material by simply preserving the total volume of a granular assembly without considering interactions between fluids and particles;hence,the validity of its results is *** this paper,the undrained behaviors of granular assemblies simulated using the aforementioned two methods are *** on a comparison of both macroscopic and microscopic responses given by the two methods,it is demonstrated that the constant volume method may reasonably simulate the responses of a loose saturated granular material with very coarse grains,which has a high permeability,and thus a rapid pore pressure ***,it is ineffective in simulating the responses of a loose material with fine components due to its failure to capture the process of a slow dissipation of the excess pore pressure among the individual *** regard to the dense material adopted,similar behaviors at the early and intermediate shearing stages given by the two methods are displayed.

关键词： Micromechanics Constant volume method Fluid-coupled discrete element method (DEM) Undrained behavior

Fouling evaluation on membrane distillation used for reducing solvent in polyphenol rich propolis extract

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Chinese Journal of Chemical Engineering 2018年第3期26卷 477-483页

作者： Norhaziyana Hamzah Choe Peng leo School of Chemical Engineering Engineering Campus Universiti Sains Malaysia

Membrane distillation(MD) has not been widely studied in the concentrate of phenolic rich solution in comparison to osmotic distillation. In this work, the potential of MD to reduce solvent in the polyphenol rich propolis extract was further investigated. Polyvinylidene fluoride(PVDF) membranes were engineered with the smaller pore size for the less hydrophobic surface in order to avoid wetting, allowing only the solvent vapor to be transferred from the warm feed into the cold permeate. All the membranes exhibited more than 95% rejection of phenolic and flavonoid compounds. Although the hydrophilic membranes exhibited less fouling, they displayed a lower flux than the hydrophobic membrane due to the hindrance in the wetted pores. The hydrophobic membrane was seriously fouled by the phenolic acid as shown in the Fourier transform infrared spectroscopy spectrum. Pore plugging occurred on these hydrophobic membranes as confirmed in the scanning electron microscope images.

关键词： Membrane distillation Propolis Fouling

Convergence of Impact Measures and Impact Bundles

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Journal of Data and Information Science 2022年第3期7卷 5-19页

作者： leo Egghe Hasselt University Campus DiepenbeekDiepenbeek 3590Belgium

Purpose:A new point of view in the study of impact is ***/methodology/approach:Using fundamental theorems in real analysis we study the convergence of well-known impact ***:We show that pointwise convergence is maintained by all well-known impact bundles(such as the h-,g-,and R-bundle)and that theμ-bundle even maintains uniform *** on these results,a classification of impact bundles is *** limitations:As for all impact studies,it is just impossible to study all measures in *** implications:It is proposed to include convergence properties in the study of impact ***/value:This article is the first to present a bundle classification based on convergence properties of impact bundles.

关键词： Pointwise and uniform convergence of impact measures and bundles Second Dini theorem Arzelà’s theorem Bundle classification Generalized h-and g-indices percentiles