检索结果-南通市图书馆

Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

引用

World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang howard h.W.Wong leo c.h.tsang Sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan leo L.h.Luk Jenson c.h.ho Wing Yan Li Amos M.T.Lee Jennifer h.Y.Lam Sau Man chan Wilfred h.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibody and T cell responses against wild-type and Omicron SARS-coV-2 after third-dose BNT162b2 in adolescents

引用

Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu carolyn A.cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.cheng Yuet chung howard h.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer h.Y.Lam Derek h.L.Lee Sau Man chan leo c.h.tsang Karl c.K.chan John K.c.Li leo L.h.Luk Sara chaothai Kelvin K.h.Kwan Nym coco chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina hKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia centre for Immunology&Infection c2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NcT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-coV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)cD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)cD4^(+)and cD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nonlinear analysis of pile load-settlement behavior in layered soil

引用

Journal of central South University 2015年第9期22卷 3615-3623页

作者：吕述晖王奎华张鹏 c.J.leo Key Laboratory of Soft Soils and Geoenvironmental Engineering of Ministry of Education (Zhejiang University) cccc Fourth harbon Engineering Institute co. Ltd. School of computing Engineering and Mathematics University of Western Sydney Locked Bag 1797 Penrith Sydney NSW 2751 Australia

A simplified approach is presented to analyze the single pile settlement in multilayered soil. First, a fictitious soil-pile model is employed to consider the effect of layered soil beneath pile toe on pile settlement behavior. Two approximation methods are proposed to simplify the nonlinear load transfer function and simulate the nonlinear compression of fictitious soil-pile, respectively. On this basis, an efficient program is developed. The procedures for determining the main parameters of mathematical model are discussed. comparisons with two well-documented field experimental pile loading tests are conducted to verify the rationality of the present method. Further studies are also made to evaluate the practicability of the proposed approach when a soft substratum exists, and the results suggest that the proposed method can provide a constructive means for assessing the settlement of a single pile for use in engineering design.

关键词： pile load-settlement behavior fictitious soil-pile layered soil soft substratum sediment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preserving the literary past, looking to the future: the first hong Kong Literature Database

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第11期6卷 1341-1347页

作者： MA leo F.h. WONG Rita LAU Paul University Library System The Chinese University of Hong Kong Hong Kong ChinaUniversity Library System The Chinese University of Hong Kong Hong Kong ChinaUniversity Library System The Chinese University of Hong Kong Hong Kong China

In the last two decades of the 20th century, there has been an increasing interest in and emphasis on the study of the hong Kong literature in both the academic and general public in hong Kong. Recognizing the emergent need of the resources on hong Kong literature, the University Library System of the chinese University of hong Kong set up the hong Kong Literature Database （the “Database”）, which was the first chinese literature database in the Internet in 2000. The paper will examine how the database is constructed using XML technology andometadata schema, The database also employs Unicode UTF-8 as the internal code. A mapping table for traditional and simplified chinese characters was created based on Unihan and is used behind the scene so that a user can either input traditional or simplified chinese characters and retrieval will give both traditional and simplified chinese characters. currently 65% of journals use OcR technology so that full-text searching is possible. The chinese OcR technology will be examined in greater detail. Special features of the Database such as, page-by-page browse mode, position-highlight for full-page newspaper, linking Table-Of-contents and book jackets from the Library catalogue, etc. are described. The paper will also bring out the problem of massive downloading and compare the state-of-the-art technology and their shortcomings. This paper shows how the hong Kong Literature Database facilitates future collaboration and data exchange by using open standard, shareable structure and the latest technology.

关键词： hong Kong Literature hong Kong Literature Database XML Metadata schema Database structure UnicodeUTF-8 OcR technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Superhydrophobic PVDF/TiO_2-SiO_2 Membrane with hierarchical Roughness in Membrane Distillation for Water Recovery from Phenolic Rich Solution containing Surfactant

引用

chinese Journal of Polymer Science 2019年第6期37卷 609-616页

作者： N.hamzah c.P.leo B.S.Ooi School of chemical Engineering Engineering Campus Universiti Sains Malaysia

Superhydrophobic poly(vinylidene fluoride)(PVDF) membrane incorporated with nanoparticles was applied in membrane distillation to recover water from phenolic rich solution containing surfactant. The membranes coated on woven support were fabricated using phase inversion with dual bath coagulation and post-modified using silane. The membranes incorporated with TiO_2, SiO_2, or a mixture of TiO_2-SiO_2 nanoparticles achieved the water contact angle higher than 160°. The addition of TiO_2-SiO_2 mixture into PVDF matrix further enhanced the hierarchical roughness of membrane. hence, PVDF/TiO_2-SiO_2 membrane achieved the highest permeation flux and rejected 99.9% of gallic acid in the feed(100 g/L). PVDF/TiO_2-SiO_2 membrane also maintained a relative flux(J/J0) higher than0.9 after 8 h of operation. Even with the presence of surfactant in phenolic rich solution, PVDF/TiO_2-SiO_2 membrane was able to exhibit relative flux above 0.8. The significant changes on the hydrophobicity and chemical properties of PVDF/TiO_2-SiO_2 membrane due to fouling were not observed after 50 h of static adsorption test.

关键词： Superhydrophobic PVDF Nano particles Roughness Membrane distillation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Which chinese Markets to Diversify into？

引用

Frontiers of Economics in china-Selected Publications from chinese Universities 2013年第2期8卷 220-232页

作者： leo h. chan Department of Finance and Economics Woodbury School of Business Utah Valley UniversityOrem UT 84058 USA

t This paper investigates the correlation and feedback relationships between the hong Kong hang Seng Index （hSI）, the hang Seng chinese Enterprise Index （cEI） and the S＆P 500 Index （SP）. We divide the indexes into two separate periods, from the inception of the cEI in 1994 to the stock market crash in 2000, and from 2001 to 2011. Our results show that the feedback relationship between the cEI and the SP is stronger after 2000. As the feedback relationship grows stronger, the diversification benefit reduces for US investors who utilizes the cEI as a tool for diversifying into chinese markets.

关键词： market correlation diversification chinese stock market

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Longitudinal vibration of pile in layered soil based on Rayleigh-Love rod theory and fictitious soil-pile model

引用

Journal of central South University 2015年第5期22卷 1909-1918页

作者：吕述晖王奎华吴文兵 c.J.leo Key Laboratory of Soft Soils and Geoenvironmental Engineering of Ministry of Education(Zhejiang University) Engineering Faculty China University of Geosciences School of computing Engineering and Mathematics University of Western SydneyLocked Bag 1797 Penrith Sydney NSW 2751 Australia

The dynamic response of pile in layered soil is theoretically investigated when considering the transverse inertia ***, the fictitious soil-pile model is employed to simulate the dynamic interaction between the pile and the soil layers beneath pile toe. The dynamic interactions of adjacent soil layers along the vertical direction are simplified as distributed Voigt ***, the pile and fictitious soil-pile are assumed to be viscoelastic Rayleigh-Love rods, and both the radial and vertical displacement continuity conditions at the soil-pile interface are taken into consideration. On this basis, the analytical solution for dynamic response at the pile head is derived in the frequency domain and the corresponding quasi-analytical solution in the time domain is then obtained by means of the convolution theorem. Following this, the accuracy and parameter value of the hypothetical boundaries for soil-layer interfaces are discussed. comparisons with published solution and measured data are carried out to verify the rationality of the present solution. Parametric analyses are further conducted by using the present solution to investigate the relationships between the transverse inertia effects and soil-pile parameters.

关键词： viscoelastic pile layered soil longitudinal vibration fictitious soil-pile transverse inertia effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Get it white: color-tunable Ac/Dc OLEDs

引用

Light(Science & Applications) 2015年第1期4卷 492-497页

作者： Markus Frobel Tobias Schwab Mona Kliem Simone hofmann Karl leo Malte c Gather Institute for Applied Photophysics(IAPP) Dresden University of TechnologyD-01069 DresdenGermany School of Physics and Astronomy University of St AndrewsSt Andrews KY169SSUK

Organic light-emitting diodes(OLEDs)have gained considerable attention because of their use of inherently flexible materials and their compatibility with facile roll-to-roll and printing *** addition to high efficiency,flexibility and transparency,reliable color tunability of solid state light sources is a desirable feature in the lighting and display ***,we demonstrate a device concept for highly efficient organic light-emitting devices whose emission color can be easily adjusted from deep-blue through cold-white and warm-white to saturated *** approach exploits the different polarities of the positive and negative half-cycles of an alternating current(Ac)driving signal to independently address a fluorescent blue emission unit and a phosphorescent yellow emission unit which are vertically stacked on top of each *** electrode design is optimized for simple fabrication and driving and allows for two-terminal operation by a single *** presented concept for color-tunable OLEDs is compatible with application requirements and versatile in terms of emitter combinations.

关键词： alternating current color mixing color tuning vertical stacking white organic light-emitting devices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

convergence of Impact Measures and Impact Bundles

引用

Journal of Data and Information Science 2022年第3期7卷 5-19页

作者： leo Egghe hasselt University Campus DiepenbeekDiepenbeek 3590Belgium

Purpose:A new point of view in the study of impact is ***/methodology/approach:Using fundamental theorems in real analysis we study the convergence of well-known impact ***:We show that pointwise convergence is maintained by all well-known impact bundles(such as the h-,g-,and R-bundle)and that theμ-bundle even maintains uniform *** on these results,a classification of impact bundles is *** limitations:As for all impact studies,it is just impossible to study all measures in *** implications:It is proposed to include convergence properties in the study of impact ***/value:This article is the first to present a bundle classification based on convergence properties of impact bundles.

关键词： Pointwise and uniform convergence of impact measures and bundles Second Dini theorem Arzelà’s theorem Bundle classification Generalized h-and g-indices percentiles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Living electronics

引用

Nano Research 2020年第5期13卷 1205-1213页

作者： Yixin Zhang leo(huan-hsuan)hsu Xiaocheng Jiang Department of Biomedical Engineering Tufts UniversityMedfordMA 02155USA

Living electronics that converges the unique functioning modality of biological and electrical circuits has the potential to transform both fundamental biophysical/biochemical inquiries and translational biomedical/engineering *** article will review recent progress in overcoming the intrinsic physiochemical and signaling mismatches at biological/electronic interfaces,with specific focus on strategic approaches in forging the functional synergy through:(1)biohybrid electronics,where genetically encoded bio-machineries are hybridized with electronic transducers to facilitate the translation/interpretation of biologically derived signals;and(2)biosynthetic electronics,where biogenic electron pathways are designed and programmed to bridge the gap between internal biological and external electrical *** efforts are reconstructing the way that artificial electronics communicate with living systems,and opening up new possibilities for many cross-disciplinary applications in biosynthesis,sensing,energy transduction,and hybrid information processing.

关键词： bioelectronics signaling biohybrid synthetic biology extracellular electron transfer electrochemically active bacteria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：