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Superior antibody and membrane protein‑specific t‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang howard h.W.Wong leo c.h.t.ang Sara chaothai tsz chun Kwan John K.c.Li Karl c.K.chan leo L.h.Luk Jenson c.h.ho Wing Yan Li Amos M.t.Lee Jennifer h.Y.Lam Sau Man chan Wilfred h.S.Wong Issan Y.S.tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(Nct04800133)investigated the superiority of antibody and t-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNt90),PRNt50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** this is the first study to demonstrate superior antibody and M-specific t-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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Enhanced hoek-Brown(h-B)criterion for rocks exposed to chemical corrosion

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International Journal of Mining Science and technology 2024年第5期34卷 609-630页

作者： hao Li leo Pel Zhenjiang You David Smeulders Department of Mechanical Engineering Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhoven 5600 MBthe Netherlands center for Sustainable Energy and Resources School of EngineeringEdith Cowan UniversityJoondalupWA 6027Australia School of chemical Engineering The University of QueenslandBrisbaneQLD 4072Australia Gas and Energy transition Research centre The University of QueenslandBrisbaneQLD 4072Australia

Underground constructions often encounter water environments,where water–rock interaction can increase porosity,thereby weakening engineering ***,the failure criterion for chemically corroded rocks becomes essential in the stability analysis and design of such *** study enhances the applicability of the hoek-Brown(h-B)criterion for engineering structures operating in chemically corrosive conditions by introducing a kinetic porosity-dependent instantaneous mi(KPIM).A multiscale experimental investigation,including nuclear magnetic resonance(NMR),X-ray diffraction(XRD),scanning electron microscopy(SEM),ph and ion chromatography analysis,and triaxial compression tests,is employed to quantify pore structural changes and their linkage with the strength responses of limestone under coupled chemical-mechanical(c-M)*** employing ion chromatography and NMR analysis,along with incorporating the principles of free-face dissolution theory accounting for both congruent and incongruent dissolution,a kinetic chemical corrosion model is *** model aims to calculate the kinetic porosity alterations within rocks exposed to varying h+concentrations and ***,utilizing the generalized mixture rule(GMR),the kinetic porositydependent mi is *** of the KPIM-enhanced h-B criterion using compression test data from 5 types of rocks demonstrated a high level of consistency between the criterion and the experimental results,with a coefficient of determination greater than 0.96,a mean absolute percentage error less than 4.84%,and a root-mean-square deviation less than 5.95 ***,the physical significance of the porosity-dependent instantaneous mi is clarified:it serves as an indicator of a rock’s capacity to leverage the confining pressure effect.

关键词： hoek-Brown(h-B)criterion Instantaneous mi Kinetic porosity-dependency chemical corrosion compressive strength

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Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management

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World Journal of Gastroenterology 2010年第7期16卷 818-831页

作者： Nicolas c Buchs Michael chilcott Pierre-Alexandre Poletti leo h Buhler Philippe Morel clinic for Visceral and transplantation Surgery Department of SurgeryUniversity Hospitals of GenevaGeneva1211Switzerland Department of Radiology University Hospitals of GenevaGeneva1211Switzerland

Pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative *** the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major ***,surgical exploration with pathological examination remains the"gold standard"in terms of evaluation of resectability,especially from the point of view of vascular ***,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively ***,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular *** the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a *** of vascular invasion remains one of the most important challenges in pancreatic *** aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer.

关键词： Vascular invasion cancer Pancreas Management

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Nonlinear analysis of pile load-settlement behavior in layered soil

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Journal of central South University 2015年第9期22卷 3615-3623页

作者：吕述晖王奎华张鹏 c.J.leo Key Laboratory of Soft Soils and Geoenvironmental Engineering of Ministry of Education (Zhejiang University) cccc Fourth harbon Engineering Institute co. Ltd. School of computing Engineering and Mathematics University of Western Sydney Locked Bag 1797 Penrith Sydney NSW 2751 Australia

A simplified approach is presented to analyze the single pile settlement in multilayered soil. First, a fictitious soil-pile model is employed to consider the effect of layered soil beneath pile toe on pile settlement behavior. two approximation methods are proposed to simplify the nonlinear load transfer function and simulate the nonlinear compression of fictitious soil-pile, respectively. On this basis, an efficient program is developed. the procedures for determining the main parameters of mathematical model are discussed. comparisons with two well-documented field experimental pile loading tests are conducted to verify the rationality of the present method. Further studies are also made to evaluate the practicability of the proposed approach when a soft substratum exists, and the results suggest that the proposed method can provide a constructive means for assessing the settlement of a single pile for use in engineering design.

关键词： pile load-settlement behavior fictitious soil-pile layered soil soft substratum sediment

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Oncogenic Signaling Adaptor Proteins

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Journal of Genetics and Genomics 2015年第10期42卷 521-529页

作者： leo Y.Luo William c.hahn health Sciences and technology Program Harvard Medical School Department of Medical Oncology Dana-Farber Cancer Institute Broad Institute of harvard and Massachusetts Institute of technology center for cancer Genome Discovery Dana-Farber Cancer Institute Department of Medicine Brigham and Women's Hospital

Signal transduction pathways activated by receptor tyrosine kinases （RtK） play a critical role in many aspects of cell function. Adaptor proteins serve an important scaffolding function that facilitates key signaling transduction events downstream of RtKs. Recent work integrating both structural and functional genomic approaches has identified several adaptor proteins as new oncogenes. In this review, we locus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes. cRKL. GAB2, and FRS2. Each of the three genes is recurrently amplified in lung adenocarcinoma or ovarian cancer, and is essential to cancer cell lines that harbor such amplification. Overexpression of each gene is able to transform immortalized human cell lines in in vitro or in vivo models. these observations identify adaptor protein as a distinct class of oncogenes and potential therapeutic targets.

关键词： Adaptor protein cancer: Oncogene

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Superhydrophobic PVDF/tiO_2-SiO_2 Membrane with hierarchical Roughness in Membrane Distillation for Water Recovery from Phenolic Rich Solution containing Surfactant

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chinese Journal of Polymer Science 2019年第6期37卷 609-616页

作者： N.hamzah c.P.leo B.S.Ooi School of chemical Engineering Engineering Campus Universiti Sains Malaysia

Superhydrophobic poly(vinylidene fluoride)(PVDF) membrane incorporated with nanoparticles was applied in membrane distillation to recover water from phenolic rich solution containing surfactant. the membranes coated on woven support were fabricated using phase inversion with dual bath coagulation and post-modified using silane. the membranes incorporated with tiO_2, SiO_2, or a mixture of tiO_2-SiO_2 nanoparticles achieved the water contact angle higher than 160°. the addition of tiO_2-SiO_2 mixture into PVDF matrix further enhanced the hierarchical roughness of membrane. hence, PVDF/tiO_2-SiO_2 membrane achieved the highest permeation flux and rejected 99.9% of gallic acid in the feed(100 g/L). PVDF/tiO_2-SiO_2 membrane also maintained a relative flux(J/J0) higher than0.9 after 8 h of operation. Even with the presence of surfactant in phenolic rich solution, PVDF/tiO_2-SiO_2 membrane was able to exhibit relative flux above 0.8. the significant changes on the hydrophobicity and chemical properties of PVDF/tiO_2-SiO_2 membrane due to fouling were not observed after 50 h of static adsorption test.

关键词： Superhydrophobic PVDF Nano particles Roughness Membrane distillation

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Longitudinal vibration of pile in layered soil based on Rayleigh-Love rod theory and fictitious soil-pile model

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Journal of central South University 2015年第5期22卷 1909-1918页

作者：吕述晖王奎华吴文兵 c.J.leo Key Laboratory of Soft Soils and Geoenvironmental Engineering of Ministry of Education(Zhejiang University) Engineering Faculty China University of Geosciences School of computing Engineering and Mathematics University of Western SydneyLocked Bag 1797 Penrith Sydney NSW 2751 Australia

the dynamic response of pile in layered soil is theoretically investigated when considering the transverse inertia ***, the fictitious soil-pile model is employed to simulate the dynamic interaction between the pile and the soil layers beneath pile toe. the dynamic interactions of adjacent soil layers along the vertical direction are simplified as distributed Voigt ***, the pile and fictitious soil-pile are assumed to be viscoelastic Rayleigh-Love rods, and both the radial and vertical displacement continuity conditions at the soil-pile interface are taken into consideration. On this basis, the analytical solution for dynamic response at the pile head is derived in the frequency domain and the corresponding quasi-analytical solution in the time domain is then obtained by means of the convolution theorem. Following this, the accuracy and parameter value of the hypothetical boundaries for soil-layer interfaces are discussed. comparisons with published solution and measured data are carried out to verify the rationality of the present solution. Parametric analyses are further conducted by using the present solution to investigate the relationships between the transverse inertia effects and soil-pile parameters.

关键词： viscoelastic pile layered soil longitudinal vibration fictitious soil-pile transverse inertia effect

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Get it white: color-tunable Ac/Dc OLEDs

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Light(Science & Applications) 2015年第1期4卷 492-497页

作者： Markus Frobel tobias Schwab Mona Kliem Simone hofmann Karl leo Malte c Gather Institute for Applied Photophysics(IAPP) Dresden University of TechnologyD-01069 DresdenGermany School of Physics and Astronomy University of St AndrewsSt Andrews KY169SSUK

Organic light-emitting diodes(OLEDs)have gained considerable attention because of their use of inherently flexible materials and their compatibility with facile roll-to-roll and printing *** addition to high efficiency,flexibility and transparency,reliable color tunability of solid state light sources is a desirable feature in the lighting and display ***,we demonstrate a device concept for highly efficient organic light-emitting devices whose emission color can be easily adjusted from deep-blue through cold-white and warm-white to saturated *** approach exploits the different polarities of the positive and negative half-cycles of an alternating current(Ac)driving signal to independently address a fluorescent blue emission unit and a phosphorescent yellow emission unit which are vertically stacked on top of each *** electrode design is optimized for simple fabrication and driving and allows for two-terminal operation by a single *** presented concept for color-tunable OLEDs is compatible with application requirements and versatile in terms of emitter combinations.

关键词： alternating current color mixing color tuning vertical stacking white organic light-emitting devices

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Living electronics

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Nano Research 2020年第5期13卷 1205-1213页

作者： Yixin Zhang leo(huan-hsuan)hsu Xiaocheng Jiang Department of Biomedical Engineering Tufts UniversityMedfordMA 02155USA

Living electronics that converges the unique functioning modality of biological and electrical circuits has the potential to transform both fundamental biophysical/biochemical inquiries and translational biomedical/engineering *** article will review recent progress in overcoming the intrinsic physiochemical and signaling mismatches at biological/electronic interfaces,with specific focus on strategic approaches in forging the functional synergy through:(1)biohybrid electronics,where genetically encoded bio-machineries are hybridized with electronic transducers to facilitate the translation/interpretation of biologically derived signals;and(2)biosynthetic electronics,where biogenic electron pathways are designed and programmed to bridge the gap between internal biological and external electrical *** efforts are reconstructing the way that artificial electronics communicate with living systems,and opening up new possibilities for many cross-disciplinary applications in biosynthesis,sensing,energy transduction,and hybrid information processing.

关键词： bioelectronics signaling biohybrid synthetic biology extracellular electron transfer electrochemically active bacteria

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Degradation:A critical challenge for M-N-c electrocatalysts

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Journal of Energy chemistry 2021年第12期30卷 667-674,I0016页

作者： Yongchao Yang leo Lai Li Wei Yuan chen School of chemical and Biomolecular Engineering The University of Sydney.DarlingtonNew South Wales 2006Australia

Atomically dispersed transition metal(M)and nitrogen(N)co-doped carbon(M-N-c)electrocatalysts hold excellent application potentials for several critical reactions required in electrochemical conversion processes and energy storage devices,including oxygen reduction reaction,oxygen evolution reaction,hydrogen evolution reaction,carbon dioxide reduction reaction and nitrogen reduction *** significant progress achieved in the past few decades,their commercialization is hindered by their fast *** perspective article outlines the historical development of M-N-c electrocatalysts,the current understanding of their active catalytic sites,and crucial degradation *** highlight that many methods used to tailor M-N-c electrocatalysts likely cause contradictory effects on activity and *** emphasis is needed to address their degradation issues under industryrelevant working conditions.

关键词： M-N-c transition metal Electrocatalyst Degradation

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