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Acute-on-chronic liver failure in patients with severe acute respiratory syndrome coronavirus 2 infection

World Journal of Hepatology 2023年第1期15卷 41-51页

作者： Peter Liptak lenka nosakova Robert Rosolanka Lubomir Skladany Peter Banovcin Clinic of Internal Medicine-Gastroenterology University Hospital in MartinJessenius Faculty of Medicine in MartinComenius UniversityMartin 03601Slovakia Clinic of Infectology and Travel Medicine University Hospital in MartinJessenius Faculty of Medicine in MartinComenius UniversityMartin 03601Slovakia Department of Internal Medicine Ⅱ Division HepatologyGastroenterology and Liver TransplantationFD Roosevelt University Hospital of Slovak Medical UniversityBanska Bystrica 97517Slovakia

The coronavirus disease 2019(COVID-19)pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has had a significant impact on the lives of millions of people,especially those with other concomitant diseases,such as chronic liver *** date,seven coronaviruses have been identified to infect *** main site of pathological action of these viruses is lung ***,a substantial number of studies have proven that SARSCoV-2 shows affinity towards several organs,including the gastrointestinal tract and the *** current state of evidence points to several proposed mechanisms of liver injury in patients with COVID-19 and their *** impairment is considered to be the result of the direct effect of the virus on the hepatic tissue cells,a systemic reaction consisting of inflammation,hypoxia and cytokine storm,drug-induced liver injury,with the possible contribution of a perturbed gut-liver *** of chronic hepatic disease could be another factor for liver impairment in patients with SARS-CoV-2 ***-onchronic liver failure(ACLF)is a relatively new syndrome that occurs in 10%–30%of all hospitalized patients with chronic liver *** is crucial to recognize high-risk patients due to the increased morbidity and mortality in these *** published studies have reported virus infection as a trigger factor for ***,to date,there are few relevant studies describing the presence of ACLF in patients with acute SARS-CoV-2 *** this minireview we summarize the current state of knowledge regarding the relation between ACLF and acute SARS-CoV-2 infection.

关键词： SARS-CoV-2 COVID-19 Acute-on-chronic liver failure ACLF,Liver Coronavirus

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