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Scavenger Receptor Class B type 1(SR-B1)and the modifiable risk factors of stroke

Chinese Neurosurgical Journal 2020年第1期6卷 35-44页

作者： lenahan cameron Huang Lei Travis Zachary D. Zhang John H. Burrell College of Osteopathic Medicine Las CrucesNM 88003USA Center for Neuroscience Research School of MedicineLoma Linda UniversityLoma LindaCA 92324USA Department of Neurosurgery School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Physiology&Pharmacology School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Earth and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Anesthesiology School of MedicineLoma Linda UniversityLoma LindaCA 92324USA

Stroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured,consequently leading to deficits in neurological *** consistently ranked as one of the top causes of mortality,and with the mean age of incidence decreasing,there is renewed interest to seek novel therapeutic *** Scavenger Receptor Class B type 1(SR-B1)is a multifunctional protein found on the surface of a variety of *** has found that that SR-B1 primarily functions in an anti-inflammatory and antiatherosclerotic *** this review,we discuss the characteristics of SR-B1 and focus on its potential correlation with the modifiable risk factors of ***-B1 likely has an impact on stroke through its interaction with smoking,diabetes mellitus,diet,physical inactivity,obesity,hypercholesterolemia,atherosclerosis,coronary heart disease,hypertension,and sickle cell disease,all of which are critical risk factors in the pathogenesis of stroke.

关键词： Scavenger Receptor Class B type 1 SR-B1 Atherosclerosis Coronary heart disease Diabetes mellitus Sickle cell Obesity Physical inactivity Hypercholesterolemia Hypertension

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CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats

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Stroke & Vascular Neurology 2023年第1期8卷 4-16页

作者： Anke Zhang Yibo Liu Houshi Xu Zeyu Zhang Xiaoyu Wang Ling Yuan cameron lenahan Chuan Zhang Junkun Jiang Chaoyou Fang Yuanjian Fang Jianmin Zhang Sheng Chen Department of Neurosurgery Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina Clinical Research Center for Neurological Diseases of Zhejiang Province HangzhouZhejiangChina Department of Neurosurgery Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Biomedical Sciences Burrell College of Osteopathic MedicineLas CrucesNew MexicoUSA Department of Biology Tongji UniversityShanghaiChina

Background and purpose C-C motif chemokine ligand 17(CCL17)presents an important role in immune regulation,which is critical in the pathophysiology of brain injury after subarachnoid haemorrhage(SAH).There is rare evidence to illustrate the function of CCL17 towards *** this study,we try to reveal the therapeutic effects of CCL17 and its underlying mechanism in rat SAH *** SAH rat models were assigned to receive recombinant CCL17(rCCL17)or phosphate buffer saline(PBS).AZD2098 and JR-AB2-011 were applied to investigate the C-C motif chemokine receptor 4(CCR4)/mammalian target of rapamycin complex 2(mTORC2)axis in CCL17-mediated *** elucidate the underlying mechanism,the in vitro kinase assay was performed in primary ***-specific Rictor knockdown was administered via intracerebroventricular injection of adenovirus-associated *** water content,short-term neurobehavioural evaluation,western blot analysis,quantitative RT-PCR and histological staining were *** The expression of CCL17 was increased and secreted from neurons after oxyhaemoglobin *** rCCL17 significantly alleviated neuronal apoptosis,and alleviated short-term neurofunction after SAH in *** addition,rCCL17 increased M2-like polarisation of microglia in rats post-SAH and in primary microglia *** neuroprotection of rCCL17 was abolished via inhibition of either CCR4 or *** CCL17 activated the CCR4/mTORC2 axis in microglia,which can alleviate SAH-induced neurological deficits by promoting M2-like polarisation of microglia.

关键词： CCL17 CCR4 mTORC2

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