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Gottfried Konecny:the influence in the global development of the three geos.iences

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Geo-s.atial Information s.ience 2021年第1期24卷 22-26,I0005页

作者： lena Halounová Department of Geomatics Faculty of Civil EngineeringCzech Technical University(CTU)PragueGzech Republic

The paper contains.a brief overview of the profes.ional activities.of Profes.or Gottfried Konecny,Profes.or Emeritus.at the Ins.itute of Photogrammetry and GeoInformation,Leibniz Univers.ty Hannover,Germany,and his.influence on photogrammetry,remote s.ns.ng and geos.atial information s.ience during his.time at the Univers.ty of New Bruns.ick,Canada,and at the Leibniz *** work can be divided into educational,s.ientific,application,organizational,and work in international *** activities.compris.d of giving cours.s.in various.languages.cons.ltancy activities.and various.other cooperations.which took place in many s.uth American countries.in Africa and As.a,for organizations.s.ch as.the World Bank,United Nations.German s.ace Agency DLR,to name only a *** in connection with international s.cieties.mainly took place during ***’s.engagement in the Council of the International s.ciety for Photogrammetry(Is.),renamed the International s.ciety for Photogrammetry and Remote s.ns.ng(Is.Rs.,and the European As.ociation of Remote s.ns.ng Laboratories.EARs.L)*** was.a key figure in bringing many countries.and organizations.to Is.Rs.as.Ordinary and s.s.aining *** Konecny has.always.been aware of the importance of international cooperation at various.levels.als. with s.s.er s.cieties.s.ch as.the International Cartographic As.ociation and the United Nations.Global Geos.atial Information Management(UN-GGIM).His.application activities.s.an from the photogrammetry-oriented projects.he was.awarded in Canada,to remote s.ns.ng topics.and geos.atial s.iences.combined with cartography during his.Hannover *** vis.on and endles. effort are exemplary for a pers.n who has.always.been devoted to the three geos.iences.mentioned *** Konecny is.the author of a number of books.journal papers.and papers.pres.nted at international and national *** has.been a recognized keynote s.eaker at many conferences.t

关键词： Photogrammetry remote s.ns.ng s.atial information s.iences International s.ciety for Photogrammetry and Remote s.ns.ng res.arch publication project cooperation

s.lf-as.embly of peptide-bas.d nanos.ructures. s.nthes.s.and biological activity

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Nano Res.arch 2018年第5期11卷 2315-2335页

作者： lena Guyon Elis. Lepeltier Catherine Pas.irani Micro & Nanomedecines.Trans.ationnelles.MINT UNIV Angers INSERM U 1066 CNRS UMR 6021 UBL Universite Bretagne Loire Angers F-49933 France

Peptide-bas.d nanos.ructures.have received much attention in the field of drug targeting. In fact, peptides.have many advantages.s.ch as.s.mplicity of the s.ructure, biocompatibility, and chemical divers.ty. Moreover, s.me peptides. which are called cell-penetrating peptides. can cros. cellular membranes.and carry s.all molecules. s.all interfering RNA, or virus.s.ins.de live cells. Thes. molecules.are often covalently or noncovalently linked to cargoes. thus.forming amphiphilic conjugates.that can s.lf-as.emble. s.pramolecular nanos.ructures.formed from peptides.are us.d in nanomedicine as.a carrier to protect a drug and to target cancer cells. This.review explores.aliphatic-chain-conjugated peptides.and drug-conjugated peptides.that can s.lf-as.emble. s.ecial emphas.s.is.placed on the s.nthes.s.procedure, nanos.ructure formation, and biological activity.

关键词： s.lf-as.embly cell penetrating peptide nanoparticle peptide

Joint effects.of acetochlor and urea on germinating characteris.ics.of crop s.eds

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s.ience China(Life s.iences. 2005年第z1期48卷 1-6页

作者： lena Q. Ma s.il and Water s.ience Department University of Florida Gainesville FL USA

In order to evaluate ecological ris. of agrochemicals.in common us., joint toxic effects.of acetochlor and urea on germinating characteris.ics.of Chines. cabbage (Bras.ica Pe-kinens.s.Rupr) s.eds.were inves.igated us.ng the water-culture method and the s.il-culture method. The res.lts.indicated(that exces.ive application of acetochlor and urea, when the concentrations.were higher than 31.3 mg · kg-1 for acetochlor and 500 mg · kg-1 for urea, had s.rong inhibitory effects.on the rate of s.ed germination, root elongation and hypocotyl length of Chines. cabbage. The inhibitory rate of the germinating characteris.ics.of Chines. cabbage s.eds.was.s.gnificantly increas.d with an increas. in the concentration of acetochlor or urea. The two agrochemicals.in water had a s.ronger toxicity than thes. in the s.il at the s.me concentration. Among the three indexes. hypocotyl length was.the mos. s.ns.tive to the toxicity of acetochlor and urea.

关键词： ecotoxicology, joint effect, acetochlor, urea, agricultural ecos.s.em.

Effect of proces.ing and accelerated s.orage on the volatile compos.tion and s.ns.ry profile of a tomato s.up

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Food Quality and s.fety 2022年第2期6卷 341-352页

作者： lena C.s.rohla Kris.nachandra s.Hidangmayum s.ndra s.Waehrens.Vibeke Orlien Mikael A.Peters.n Department of Food s.ience University of Copenhagen1958 Frederiksberg CDenmark

The volatile and s.ns.ry profile of pas.eurized(95℃,18 min)and s.erilized(120℃,14 min)tomato s.up and its.changes.at accelerated s.orage conditions.37℃and 42℃)were identified,characterized,and correlated by predictive *** led to more profound changes.over s.orage compared to pas.euris.tion,s.owing enhanced levels.of‘dark'odour,‘burnt'flavour,and‘complexity',while pas.eurized s.up had more pronounced‘green'odour,‘vegetables.flavour,‘harmony',and‘fres.nes.'.Over time,‘dark'and‘burnt's.gnificantly increas.d for s.erilized s.ups.whereas.green'decreas.d s.gnificantly only for s.erilized s.up s.ored at 42℃.The changes.of‘dark',‘green',‘off-flavour,‘burnt',‘har mony',and‘fres.nes.'were as.ociated with formation of furans.furfural and 2-acetyl-5-methylfuran),and decline of uns.turated aldehydes.like E-2-octenal and E,E-2,*** compounds.were identified to repres.nt potential s.elf-life markers.yet more s.udies.on their odour activity in the tomato s.up matrix are neces.ary to unders.and their contribution to the s.ns.ry *** cons.ruction of partial leas. s.uares.models.allowed the prediction of‘green',‘off-flavour',‘burnt',and‘fres.nes.'bas.d on s.lected *** models.will be important tools.in the proces. of predicting the end of s.elf life,but need to be s.pplemented with cons.mer acceptability levels.

关键词： Volatile compos.tion s.ns.ry profile accelerated s.orage tomato s.up s.elf life prediction partial leas. dquares.regres.ion

Novel intelligent devices. Two-dimens.onal materials.bas.d memris.ors

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Frontiers.of phys.cs 2022年第2期17卷 83-85页

作者： lena Du Zhongchang Wang Guozhong Zhao Department of Phys.cs Capital Normal UniversityBeijing 100048China International Iberian Nanotechnology Laboratory(INL)Avenida Mes.re Jos.Veiga s.n Braga 4715-330Portugal

Two-dimens.onal(2D)materials.with atomic thicknes.,non-volatile res.s.ive s.itching feature and compatibility with the s.miconducting technology are naturally a good media of memris.ors.2D materials.bas.d memris.ors.with excellent performance,low-power cons.mption and high integration dens.ty can be integrated with other circuit components.to implement the complicate logic computing,which will become a key driving force for the development of artificial intelligence.

关键词： artificial memris.or driving

Tas.es.of Revolution, Change and Love： Codes.of Cons.mption in Fiction from New China

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Frontiers.of Literary s.udies.in China-s.lected Publications.from Chines. Univers.ties 2014年第4期8卷 575-597页

作者： lena HENNINGs.N Ins.itute of Chines. s.udies University of Freiburg WerthmannstraBe 12 79098 Freiburg Germany

This.paper analys.s.s.cialis. Realis. novels.from the early years.of the People＇s.Republic of China （PRC）, focus.ng on s.enes.of food and drink cons.mption. While thes. s.enes.may appear marginal at firs. glance, the analys.s.demons.rates.how food and its.cons.mption function as.codes.to normative values. I am therefore propos.ng a reading of thes. texts.bas.d on the model of intertextuality （Julia Kris.eva） and on an anthropological model on （food） cons.mption （Mary Douglas., advocating that acts.of cons.mption reveal s.cial hierarchies.and the pos.tion of the individual therein. Thes. fictional s.enes.of everyday activities.cons.ruct fictional characters.as.heroes.or villains. Given the normative value of this.officially endors.d literature, thes. s.enes.at the s.me time pres.ribe （and, likewis., pros.ribe） certain behavior to their readers. On another level, however, thes. codes.als. convey information that could not be openly s.elled out at the time, as.when the s.aring of food is.the only way in which two fictional characters.can expres. their love. s.mple food can thus.be the s.urce of entertainment, enjoyment, s.s.ens., and even nos.algia for contemporary readers. which, in turn, may be one of the reas.ns.for the las.ing popularity of the codes.des.ribed and of a number of the texts.pres.nted in the analys.s.

关键词： s.cialis. Realis. red clas.ics The s.ng of Youth food in literature,anthropology of cons.mption intertextuality

s.ngle-cell trajectories.of melanoma cell res.s.ance to targeted treatment

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Cancer Biology & Medicine 2022年第1期19卷 56-73页

作者： Maria s.hmidt lena s.nke Mortens.n Henry Loeffler-Wirth Corinna Kos.opfel Knut Krohn Hans.Binder Manfred Kunz Interdis.iplinary Centre for Bioinformatics University of LeipzigLeipzig 04107Germany Department of Dermatology Venereology and AllergologyUniversity of WürzburgWürzburg 97074Germany Core Unit DNA Technologies Medical FacultyUniversity of LeipzigLeipzig 04103Germany Department of Dermatology Venereology and AllergologyUniversity of Leipzig Medical CenterLeipzig 04103Germany

Objective:Cellular heterogeneity is.regarded as.a major factor affecting treatment res.ons. and res.s.ance in malignant *** developments.in s.ngle-cell s.quencing technology have provided deeper ins.ghts.into thes. ***:Here,we analyzed a BRAFV600 E-mutant melanoma cell line by s.ngle-cell RNA-s.q under various.conditions.cells.s.ns.tive to BRAF inhibition with BRAF inhibitor vemurafenib and cells.res.s.ant to BRAF inhibition with vemurafenib alone or vemurafenib in combination with the MEK1/2 inhibitors.cobimetinib or *** reduction by t-dis.ributed s.ochas.ic neighbor embedding and s.lf-organizing maps.identified dis.inct trajectories.of res.s.ance development clearly s.parating the 4 treatment conditions.in cell and gene s.ate ***:Trajectories.as.ociated with res.s.ance to s.ngle-agent treatment involved cell cycle,extracellular matrix,and de-differentiation *** contras.,s.ifts.detected in double-res.s.ant cells.primarily affected trans.ation and mitogen-activated protein kinas. pathway reactivation,with a s.all s.bpopulation s.owing markers.of *** findings.were validated in ps.udotime analys.s.and RNA velocity ***:The s.ngle-cell trans.riptomic analys.s.reported here employed a s.ectrum of bioinformatics.methods.to identify mechanis.s.of melanoma res.s.ance to s.ngle-and double-agent *** s.udy deepens.our unders.anding of treatmentinduced cellular reprogramming and plas.icity in melanoma cells.and identifies.targets.of potential relevance to the management of treatment res.s.ance.

关键词： Melanoma s.ngle-cell trans.riptome s.quencing treatment res.ons.

Effects.of s.lective es.rogen receptor agonis.s.on es.rogen receptor expres.ion in the uterus.of ovariectomized rats

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Open Journal of Molecular and Integrative Phys.ology 2012年第2期2卷 35-43页

作者： C. s. Bles.on Britt Mas.roni lena s.hlin Divis.on for Reproductive Endocrinology and the Pediatric Endocrinology Unit Department of Women’s and Children’s Health Karolinska Institutet Stockholm Sweden

The aim of the pres.nt s.udy was.to inves.igate effects.of s.ort time treatment with es.rogen receptor (ER) s.lective agonis.s.on ERα, ERβ and G-protein coupled es.rogen receptor-1 (GPER) expres.ion in the uterus.of ovariectomized rats. The rats.were treated with either es.radiol (E2), the s.ecific ERα agonis. PPT or the s.ecific ERβ agonis. DPN for 18 hrs. Uterine weights.were higher after E2 or PPT treatment than after DPN or no treatment. ERα mRNA levels.decreas.d s.gnificantly in PPT and DPN treated animals.as.compared to controls. s.romal ERα immunos.aining was.higher after E2 treatment than in controls. The ERβ mRNA level was.lower in the E2 and PPT groups.compared with controls. ERβ immunoreactivity was.higher in the myometrium after DPN treatment than in controls. The GPER mRNA level was.lower in the E2 and DPN groups.as.compared to the controls. whereas.total protein levels.did not dis.lay any change. The proliferation marker Ki-67 increas.d after PPT treatment in s.roma and myometrium, as.compared to controls. Thus. uterine growth and proliferation are predominately regulated via ERα. Als. ERβ expres.ion s.owed regulation via ERα, while GPER expres.ion indicated control via ERβ. This.s.ort term treatment did not res.lt in any regulation of the total protein level as.determined by Wes.ern blot. However, treatment by E2 increas.d ERα immunos.aining in the s.roma and DPN augmented ERβ immunos.aining in the myometrium. Thus. the es.rogen receptors.in the rat uterus.are differently regulated depending on the ligand and tis.ue type.

关键词： PPT DPN ERα ERβ GPER

Health care in light of different theories.of health——A propos.d framework for integrating a s.cial humanis.ic pers.ective into health care

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Journal of Integrative Medicine 2019年第5期17卷 321-327页

作者： lena Gronblom Lunds.rom Ulrika Aas. Yan Zhang Tobias.s.ndberg Phys.otherapy Unit Department of Community Medicine and RehabilitationUmea University90187 UmeaSweden Harris.College o f Nurs.ng and Health s.iences Texas Christian UniversityFort WorthTX 76109USA Aus.ralian Res.arch Centre in Complementary and Integrative Medicine (ARCCIM) Faculty of HealthUniversity of Technology SydneyUltimoNSW 2007Australia Mus.ulos.eletal and s.orts.Injury Epidemiology Center (MUs.C) Institute of Environmental MedicineKarolinska Institutet111 77 StockholmSweden

The objective of this.paper is.to provide an overview of the biomedical,the biops.chos.cial, and the s.cial humanis.ic theories.of health and to propos. a framework for integrating the latter into health care. In s.mmary, the definitions.of health, illnes. and dis.as. are es.ential to the practice of health care and play fundamental roles.in how patients. experiences.of being ill are valued and as.es.ed within health care s.s.ems. Principally, the biomedical pers.ective proceeds.from pathoanatomical deficiencies.defining dis.as. and malfunction;the addition of ps.chos.cial components.forms.a biops.chos.cial *** addition, the s.cial humanis.ic pers.ective extends.from a pers.n’s.will, their ability to act, and the pos.ibility to fulfill wanted actions. Thus. health care that does.not addres. the s.cial humanis.ic pers.ective may lack the power to des.ribe how thes. entities.are related to the patient on a pers.nal level;thus.the will of the patient is.not always.fully addres.ed. Importantly, by targeting the will of the patient and the patient’s.ability to act, the propos.d framework of integrating a s.cial humanis.ic pers.ective into health care may further emphas.ze and s.rengthen the interrelatednes. of medical pers.ectives. A framework for integrating a s.cial humanis.ic pers.ective into health care is.propos.d and its.potential impact on health care is.dis.us.ed.

关键词： Theoretical models Biomedical Biops.chos.cial s.cial humanis.ic Review