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Associations between C-Reactive Protein and Apolipoproteins, Lipoprotein (a) and Conventional Serum Lipids in Outpatients: Correlations and Time Trends

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Open Journal of Clinical Diagnostics 2015年第2期5卷 33-40页

作者： Christian Lowbeer lena martensson Elisabeth Berg Hans Wallinder Department of Clinical Chemistry Aleris MedilabTabySweden Division of Clinical Chemistry Department of Laboratory MedicineKarolinska InstitutetStockholmSweden Medical Statistics Unit Department of LearningInformaticsManagement and EthicsKarolinska InstitutetStockholmSweden

Background: Correlations between CRP and serum lipids are weak, and there are conflicting and incomplete results in the literature. The aim of the present study was to clarify the strength and independence of relationships between CRP and serum lipids in outpatients. Methods: Inclusion criteria were outpatients where all the following analyses were requested in clinical routine: high sensitivity CRP, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, ApoB, ApoA-1 and Lp(a). Data for patients meeting the above criteria during a period of six years (2004-2010) were copied from Aleris Medilab’s Laboratory Information System to the software Statistica. Basic statistics and correlations were calculated for 2771 patients. In patients with two (n = 959) or more sampling times changes over time were calculated. The study was a quality assurance project without access to patient files. Results: Median age was 59 years and median serum CRP concentration was 1.5 mg/L. The strongest correlations (Spearman R) were seen between CRP and triglycerides (0.25), ApoB/ApoA-1 ratio (0.21) and HDL-cholesterol (−0.18). Stepwise regression analysis showed that ApoB, total cholesterol, log triglycerides and log Lp(a) together explained 8% of the variation in log CRP. Unfavourable time trends for CRP and triglycerides counteracted a significant decrease in LDL-cholesterol and total cholesterol. Conclusion: In a large cohort of outpatients CRP showed stronger correlation with triglycerides and ApoB/ApoA-1 ratio than with LDL-cholesterol and Lp(a). LDL-cholesterol concentrations changed favorably over time whereas CRP and triglycerides did not.

关键词： CRP Cholesterol LDL HDL ApoB ApoA-1 Triglycerides Lp(a) Outpatients Risk Factors

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