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Rhythmical massage improves autonomic nervous system function:a single-blind randomised controlled trial

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j.urnal of Integrative Medicine 2018年第3期16卷 172-177页

作者： Georg Seifert j.nny-lena Kanitz Carolina Rihs Ingrid Krause Katharina Witt Andreas voss Department of Pediatric Oncology and Hematology Charité-Universit?tsmedizin Berlin Institute of Innovative Health Technologies Ernst-Abbe-Hochschule University of Applied Sciences

Background： Rhythmical massage therapy（RMT） is a massage technique used in anthroposophic ***： The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability（HRV）.Design, setting, participants and intervention： This study was a randomised, controlled and single-blinded trial, involving 44 healthy women（mean age：（26.20 ± 4.71） years）. The subj.cts were randomised to one of three arms： RMT with aromatic oil（RA）, RMT without aromatic oil（RM） or standardised sham massage（SM）. In the study the subj.cts were exposed to a standardised stress situation followed by one of the study techniques and Holter electrocardiograms（ECGs） were recorded for 24 *** outcome measures： HRV parameters were calculated from linear（time and frequency domain） and nonlinear dynamics（symbolic dynamics, Poincare plot analysis） of the 24-h Holter ECG ***： Short-and long-term effects of massage on autonomic regulation differed significantly among the three groups. Immediately after an RMT session, stimulation of HRV was found in the groups RA and RM. The use of an aromatic oil produced greater short-term measurable changes in HRV compared with rhythmic massage alone, but after 24 h the effect was no longer distinguishable from the RM *** lowest stimulation of HRV parameters was measured in the SM ***： RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subj.cts who received only SM were considerably less pronounced.

关键词： Sham massage Well-being Mood Alertness Relaxation Stress Heart rate variability Randomised controlled trial

Haplotype resolved chromosome level genome assembly of Citrus australis reveals disease resistance and other citrus specific genes

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Horticulture Research 2023年第5期10卷 193-206页

作者： Upuli Nakandala Ardashir Kharabian Masouleh Malcolm WSmith Agnelo Furtado Patrick Mason lena Constantin Robert j.Henry Queensland Alliance for Agriculture and Food Innovation University of QueenslandBrisbane 4072Australia ARC Centre of Excellence for Plant Success in Nature and Agriculture University of QueenslandBrisbane 4072Australia Department of Agriculture and Fisheries Bundaberg Research StationBundabergQueensland 4670Australia

Recent advances in genome sequencing and assembly techniques have made it possible to achieve chromosome level reference genomes for *** few genomes have been anchored at the chromosome level and/or are haplotype phased,with the available genomes of varying accuracy and *** now report a phased high-quality chromosome level genome assembly for an Australian native citrus species;Citrus australis(round lime)using highly accurate PacBio HiFi long reads,complemented with Hi-C *** with Hi-C integrated assembly resulted in a 331 Mb genome of *** with two haplotypes of nine pseudochromosomes with an N50 of 36.3 Mb and 98.8% genome assembly completeness(BUSCO).Repeat analysis showed that more than 50% of the genome contained interspersed *** them,LTR elements were the predominant type(21.0%),of which LTR Gypsy(9.8%)and LTR copia(7.7%)elements were the most abundant repeats.A total of 29464 genes and 32009 transcripts were identified in the *** these,28222 CDS(25753 genes)had BLAST hits and 21401 CDS(75.8%)were annotated with at least one GO *** specific genes for antimicrobial peptides,defense,volatile compounds and acidity regulation were *** synteny analysis showed conserved regions between the two haplotypes with some structural variations in Chromosomes 2,4,7 and *** chromosome scale,and haplotype resolved *** genome will facilitate the study of important genes for citrus breeding and will also allow the enhanced definition of the evolutionary relationships between wild and domesticated citrus species.

关键词： citrus Citrus breeding

SV2B defines a subpopulation of synaptic vesicles

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j.urnal of Molecular Cell Biology 2023年第9期15卷 1-13页

作者： Isabelle Paulussen Hannes Beckert Timothy FMusial lena j.Gschossmann j.lia Wolf Mathieu Schmitt j.rôme Clasadonte Georges Mairet-Coello Christian Wolff Susanne Schoch Dirk Dietrich Synaptic Neuroscience Team Department of NeurosurgeryUniversity Hospital BonnBonn 53127Germany Synaptic Neuroscience Team Department of NeuropathologyUniversity Hospital BonnBonn 53127Germany Microscopy Core Facility Medical FacultyUniversity of BonnBonn 53127Germany UCB Pharma Braine l’Alleud 1420Belgium

Synaptic vesicles can undergo several modes of exocytosis,endocytosis,and trafficking within individual synapses,and their fates may be linked to different vesicular protein ***,we mapped the intrasynaptic distribution of the synaptic vesicle proteins SV2B and SV2A in glutamatergic synapses of the hippocampus using three-dimensional electron ***2B was almost completely absent from docked vesicles and a distinct cluster of vesicles found near the active *** contrast,SV2A was found in all domains of the synapse and was slightly enriched near the active ***2B and SV2A were found on the membrane in the peri-active zone,suggesting the recycling from both clusters of ***2B knockout mice displayed an increased seizure induction threshold only in a model employing high-frequency *** data show that glutamatergic synapses generate molecularly distinct populations of synaptic vesicles and are able to maintain them at steep spatial *** almost complete absence of SV2B from vesicles at the active zone of wildtype mice may explain why SV2A has been found more important for vesicle release.

关键词： 3D electron microscopy synaptic vesicles synaptic vesicle proteins endocytosis trafficking spatial organization

Beyond cardiomyocytes:Cellular diversity in the heart's response to exercise

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运动与健康科学(英文) 2023年第4期12卷 423-437,F0003页

作者： lena E.Trager Margaret Lyons Alexandra Kuznetsov Cedric Sheffield Kangsan Roh Rebecca Freeman j.mes Rhee j.Sawalla Guseh Haobo Li Anthony Rosenzweig Corrigan Minehan Heart Center Division of CardiologyCardiovascular Research CenterDepartment of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA University of Minnesota Medical School MinneapolisMI 55455USA Department of Anesthesiology and Critical Care Massachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Institute for Heart and Brain Health University of Michigan Medical CenterAnn ArborMI 48109USA

Cardiomyocytes comprise~70%to 85%of the total volume of the adult mammalian heart but only about 25%to 35%of its total number of *** in single cell and single nuclei RNA sequencing have greatly facilitated investigation into and increased appreciation of the potential functions of non-cardiomyocytes in the *** much of this work has focused on the relationship between non-cardiomyocytes,disease,and the heart's response to pathological stress,it will also be important to understand the roles that these cells play in the healthy heart,cardiac homeostasis,and the response to physiological stress such as *** present review summarizes recent research highlighting dynamic changes in non-cardiomyocytes in response to the physiological stress of *** particular interest are changes in fibrotic pathways,the cardiac vasculature,and immune or inflammatory *** many instances,limited data are available about how specific lineages change in response to exercise or whether the changes observed are functionally important,underscoring the need for further research.

关键词： Angiogenesis Cardiac fibrosis Cardioprotection Hypertrophy Non-cardiomyocytes Proliferation

Cortico-centric effects of general anesthetics on cerebrocortical evoked potentials

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Neuroscience Bulletin 2015年第6期31卷 697-704页

作者： Logan j.voss j.mes W.Sleigh Anaesthesia Department Waikato District Health Board University of Auckland Waikato Clinical School

Despite their ubiquitous use for rendering patients unconscious for surgery, our understanding of how general anesthetics cause hypnosis remains rudimentary at best. Recent years have seen increased interest in ＂top-down＂ cortico-centric theories of anesthetic action. The aim of this study was to explore this by investigating direct cortical effects of anesthetics on cerebrocortical evoked potentials in isolated mouse brain slices. Evoked potentials were elicited in cortical layer IV by electrical stimulation of the underlying white matter. The effects of three anesthetics （ketamine, etomidate, and isoflurane） on the amplitude, latency, and slope of short-latency evoked potentials were quantified. The N2/P3/N4 potentials - which represent the early cortical response - were enhanced by etomidate （increased P3-N4 slope, P 〈0.01）, maintained by ketamine, and reduced by isoflurane （lower N2/P3 amplitude, P 〈0.01）. These effects closely resemble those seen in vivo for the same drugs and point to a cortical mechanism independent of effects on subcortical structures such as the thalamus.

关键词： anesthesia evoked potentials corticalslice thalamus

Acute liver failure secondary to acute antibody mediated rej.ction after compatible liver transplant: A case report

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World j.urnal of Hepatology 2022年第1期14卷 287-294页

作者： Todd j.Robinson j.mes B Hendele Idoia Gimferrer Nicolae Leca Scott W Biggins j.rge D Reyes lena Sibulesky Department of Surgery Virginia MasonSeattleWA 98101United States Department of Surgery University of Washington Medical CenterSeattleWA 98195United States Bloodworks Northwest SeattleWA 98104United States Department of Nephrology University of Washington Medical CenterSeattleWA 98195United States Department of Gastroenterology and Hepatology University of Washington Medical CenterSeattleWA 98195United States

BACKGROUND The liver has traditionally been regarded as resistant to antibody-mediated rej.ction(AMR).AMR in liver transplants is a field in its infancy compared to kidney and lung *** our case we present a patient with alpha-1-antitrypsin disease who underwent ABO compatible liver transplant complicated by acute liver failure(ALF)with evidence of antibody mediated rej.ction on allograft biopsy and elevated serum donor-specific antibodies(DSA).This case highlights the need for further investigations and heightened awareness for timely *** SUMMARY A 56 year-old woman with alpha-1-antitrypsin disease underwent ABO compatible liver transplant from a deceased *** recipient MELD at the time of transplant was *** flow cytometric crossmatches were noted to be positive for T and B *** patient had an uneventful recovery *** on postoperative day 5 the patient developed fevers,elevated liver function tests,distributive shock,renal failure,and hepatic *** went into ALF with evidence of antibody mediated rej.ction with portal inflammation,bile duct inj.ry,endothelitis,and extensive centrizonal necrosis,and C4d staining on allograft biopsy and elevated *** various interventions including plasmapheresis and immunomodulating therapy,she continued to *** was relisted and successfully underwent liver *** This very rare case highlights AMR as the cause of ALF following liver transplant requiring retransplantation.

关键词： Liver transplant Acute antibody mediated rej.ction Acute liver failure Donor specific antibody Liver rej.ction Case report

Characterizing the patient experience during neoadj.vant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World j.urnal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： lena Stevens Zachary j.Brown Ryan Zeh Christina Monsour Sharla Wells-Di Gregorio Heena Santry Aslam M Ej.z Timothy Michael Pawlik j.rdan M Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Neoadj.vant therapy(NT)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing NT,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during NT may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of NT and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving NT to identify opportunities to improve neoadj.vant cancer care *** Semi-structured interviews of patients with localized PDAC during NT were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using NVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing NT was the doctor’s recommendation,while most reported not being familiar with the concept of NT(n=11)and that NT was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma Neoadj.vant therapy Patient experience Patient-centered care Quality of life Qualitative research

Performance and calibration of quark/gluon-j.t taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuj. X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j.F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of j.ts originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rej.cting j.ts from gluon over j.ts from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the j.t,and the other combines several j.t substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the j.t *** in tagging efficiency between data and simulation are provided for j.ts with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS j.T QUARK GLUON TAGGING

Senescence-specific Alteration of Hydrogen Peroxide Levels in Arabidopsis thaliana and Oilseed Rape Spring Variety Brassica napus ***

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j.urnal of Integrative Plant Biology 2012年第8期54卷 540-554页

作者： Stefan Bieker lena Riester Mark Stahl j.rgen Franzaring Ulrike Zentgraf ZMBP (Center for Plant Molecular Biology) University of TübingenAuf der Morgenstelle 2872076 Tübingen Germany Institute for Landscape and Plant Ecology kologiezentrum 2August-von-Hartmann-Str.370599 StuttgartGermany

In order to analyze the signaling function of hydrogen peroxide （H202） production in senescence in more detail, we manipulated intracellular H202 levels in Arabidopsis thaliala （L.） Heynh by using the hydrogen- peroxide-sensitive part of the Escherichia coil transcription regulator OxyR, which was directed to the cytoplasm as well as into the peroxisomes. H202 levels were lowered and senescence was delayed in both transgenic lines, but OxyR was found to be more effective in the cytoplasm. To transfer this knowledge to crop plants, we analyzed oilseed rape plants Brassica napus L. cv. Mozart for H20~ and its scavenging enzymes catalase （CAT） and ascorbate peroxidase （APX） during leaf and plant development. H202 levels were found to increase during bolting and flowering time, but no increase could be observed in the very late stages of senescence. With increasing H202 levels, CAT and APX activities declined, so it is likely that similar mechanisms are used in oilseed rape and Arabidopsis to control H202 levels. Under elevated CO2 conditions, oilseed rape senescence was accelerated and coincided with an earlier increase in H202 levels, indicating that H202 may be one of the signals to inducing senescence in a broader range of Brassicaceae.

关键词： Arabidopsis thaliana Brassica napus E. coil Oxy-RD intracellular hydrogen peroxide senescence phenotype catalase ascorbatePeroxidase elevated CO2.