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Breast Milk Application as a Natural Method for Umbilical Cord Care:A Community-Label 3-Arm Pilot Clinical Trial

Maternal-Fetal Medicine 2024年第4期6卷 203-210页

作者： Bekalu Kassie Alemu leltework yismaw wondimagegn Yibelu Bazezew Tewachew Muche Liyeh Abebaw Abeje Muluneh Gedefaye Nibret Mihretie Alekaw Sema Melese Linger Endalifer Getnet Gedefaw Azeze Gashaw Garedew Woldeamanuel Kenean Getaneh Tiaye Wing Fong Lee Yao Wang Chi Chiu Wang Department of Midwifery College of Medicine and Health SciencesDebre Markos UniversityDebre Markos 269Ethiopia Department of Obstetrics and Gynaecology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Public Health College of Medicine and Health SciencesDebre Markos UniversityDebre Markos 269Ethiopia Department of Midwifery College of Medicine and Health SciencesDebre Tabor UniversityDebre Tabor 272Ethiopia School of Public Health Faculty of HealthUniversity of Technology SydneyNSW 123Australia Department of Midwifery College of Medicine and Health SciencesDire-Dawa UniversityDire-Dawa 1362Ethiopia Department of Human Nutrition College of Medicine and Health SciencesDebre Markos UniversityDebre Markos 269Ethiopia Department of Midwifery College of Medicine and Health SciencesInjibara UniversityInjibara 40Ethiopia Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong Kong 999077China School of Biomedical Sciences Chinese University of Hong Kong-Sichuan University Joint Laboratory for Reproductive MedicineThe Chinese University of Hong KongHong Kong 999077China

Objective To compare the effects of human breast milk with those of chlorhexidine and the dry method on umbilical cord separation in *** This open-label 3-arm nonrandomized pilot clinical trial was conducted among 45 neonates(15 in each arm)with more than 630 home *** a standard cord cut,human breast milk,chlorhexidine,or nothing was applied once per day for 7 *** primary outcome was the duration of cord separation,while the secondary outcomes were umbilical cord infection,neonatal fever,jaundice,feeding and breathing difficulty,and persistent *** There were statistically significant differences in the time-to-cord separation between the human breast milk group and the chlorhexidine(P<0.001)and dry alone(P=0.038)*** to those of chlorhexidine,the rates of cord separation among human breast milk and the dry-alone group were 16.02,with 95%confidence intervals(3.81,37.43;P<0.001)and 3.15(0.99,10.00;P=0.052),***(6.7%)cord site infection was observed in the dry-alone groups *** This community-label study indicated that human breast milk application significantly shortened the length of umbilical cord separation time compared to chlorhexidine and dry methods.A large-scale randomized controlled trial is needed to confirm these results.

关键词： Chlorhexidine Human breast milk Neonatal care Trial Umbilical cord

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