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Combination strategies for first-line treatment of patients with unresectable hepatocellular carcinoma:prospect of natural products

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Chinese Journal of Natural Medicines 2024年第1期22卷 1-3页

作者： ZHANG lele lu Jinjian School of Basic Medical Sciences Chengdu UniversityChengdu 610106China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao 999078China

Liver cancer stands as a significant global health concern,contributing substantially to cancer incidence and mortality,particularly in Asian countries[1].Hepatocellular carcinoma(HCC)accounts for approximately 90%of all liver cancer cases and is characterized by a high-risk profile and a generally poor prognosis[2].To address advanced HCC,systemic therapy has been recommended,leading to the approval of a range of treatment regimens in clinical ***,first-line therapy involved the use of multitargeted tyrosine kinase inhibitors(TKIs)such as sorafenib or lenvatinib,while cabozantinib,ramucirumab.

关键词： Unresectable hepatocellular carcinoma Combination strategies Immunotherapy PD-1/PD-L1 Natural products

外源GABA联合超声处理发芽绿豆淀粉的结构特性及血糖指标变化

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现代食品科技 2024年第2期40卷 205-212页

作者：路乐乐刘莹徐海军李晓强隋春光李晓红王立东黑龙江八一农垦大学食品学院黑龙江大庆163319 内蒙古伊利实业集团股份有限公司内蒙古呼和浩特010000 黑龙江农业经济职业学院食品药品工程系黑龙江牡丹江157041 国家杂粮工程技术研究中心黑龙江省普通高等学校谷物副产物综合利用重点实验室黑龙江大庆163319

研究外源γ-氨基丁酸(γ-Aminobutyric Acid,GABA)联合超声处理绿豆淀粉结构特性及血糖指标变化影响,获得低GI值绿豆淀粉制品,该文以不同萌发时间的绿豆淀粉为研究对象,通过扫描电镜、X-射线衍射、傅里叶红外光谱等分析方法,探讨外源GAB... 详细信息

研究外源γ-氨基丁酸(γ-Aminobutyric Acid,GABA)联合超声处理绿豆淀粉结构特性及血糖指标变化影响,获得低GI值绿豆淀粉制品,该文以不同萌发时间的绿豆淀粉为研究对象,通过扫描电镜、X-射线衍射、傅里叶红外光谱等分析方法,探讨外源GABA协同超声处理对绿豆淀粉萌发过程中结构特性和血糖指标影响。结果表明,处理后,绿豆中总淀粉含量从52.13%下降到发芽96h的21.18%;发芽12h时,抗性淀粉含量达到70.65%。发芽后绿豆淀粉颗粒形貌无显著变化。发芽后绿豆淀粉的相对结晶度由39.64%下降到96 h的12.72%,但发芽处理并未改变绿豆淀粉的结晶类型。发芽处理后绿豆淀粉没有产生新的基团,但淀粉晶体结构的有序性降低。发芽后绿豆淀粉的凝沉性增强,其抗消化能力也增强,在发芽12 h时,发芽绿豆淀粉的估计血糖生成指数达到了22.52,相较于未处理时的27.13,可起到减缓血糖升高的作用。外源GABA联合超声处理降低了总淀粉含量,提高了抗性淀粉含量,使绿豆淀粉的消化特性发生了显著变化,为其在功能食品中的应用提供了理论依据。

关键词：估计血糖生成指数发芽淀粉绿豆超声处理 γ-氨基丁酸

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Cluster modeling of the short-range correlation of acoustically emitted scattering signals

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International Journal of Coal Science & Technology 2021年第4期8卷 575-589页

作者： Dongjie Xue lele lu Jie Zhou Lan lu Yintong Liu School of Mechanics and Civil Engineering China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China Key Laboratory of Safety and High-efficiency Coal Mining Anhui University of Science and TechnologyHuainan 232001China

As a widely used measurement technique in rock mechanics,spatial correlation modeling of acoustic emission(AE)scattering signals is attracting increasing focus for describing mechanical behavior *** the statistical description of the spatial distribution of randomly generated AE signals,spatial correlation modeling is based mainly on short-range correlation considering the interrelationship of adjacent *** a new idea from percolation models,the covering strategy is used to build the most representative cube cluster,which corresponds to the critical scale at peak *** modeling process of critical cube cluster depends strongly on the full connection of the main fracture network,and the corresponding cube for coverage is termed the critical *** criticality pertains to not only the transition of local-to-whole connection of the fracture network but also the increasing-to-decreasing transition of the deviatoric stress with an obvious stress drop in the brittle failure of *** a reasonable critical cube guarantees the best observation scale for investigating the failure ***,the topological connection induces the geometric criticality of three descriptors,namely anisotropy,pore fraction,and specific surface area,which are evaluated separately and *** results show that cluster modeling based on the critical cube is effective and has criticality in both topology and geometry,as well as the triaxial ***,the critical cube length presents a high confidence probability of being correlated to the mineral particle ***,its pore fraction of cube cluster is influenced strongly by the critical cube length and confining pressure.

关键词： Acoustic emission Spatial correlation modeling Cover strategy Criticality Critical cube Cluster modeling

Prediction of fracture and dilatancy in granite using acoustic emission signal cloud

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 1059-1077页

作者： Dongjie Xue Lan lu Lie Gao lele lu Cheng Chen School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing100083China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400030China Key Laboratory of Safety and High-efficiency Coal Mining Anhui University of Science and TechnologyHuainan232001China

The invisibility of fracture network evolution in the rock under triaxial compression seriously restricts the correlation modeling between dilatancy behavior and fracture *** key to solving such a challenge is strongly dependent on the accurate modeling of the spatial correlation in fracture network,which could be indirectly re-constructed by the acoustic emission(AE)signal *** the interaction of local fractures,a cube cluster approach is established to describe the spatial *** evolutional cube clusters effectively present the geometric characteristics induced by the increasing dilatancy of *** descriptors(***-axis length sum and pore fraction)are introduced to correlate cluster model with dilatancy *** fitting results support the linear correlation between two descriptors and volumetric strain,which verifies the sensitiveness of the cube cluster model to *** importantly,by the statistical analysis of cluster structure,the cluster model shows the potential of calculating fracture ***,a comparison between dilatancybased damage and porosity-based damage is made not to prove the best but provide an AE-based prediction of local damage ***,four classical models for calculating fracture angle are *** deviations prove the huge difficulty of describing the development of the fracture network uniquely dependent on a fracture *** proximity of measured angle and cluster-based angle supports the effectiveness of predication by the cube cluster approach.

关键词： Fracture network Acoustic emission(AE) Spatial correlation Dilatancy Damage Fracture angle

Two-dimensional bimetallic coordination polymers as bifunctional evolved electrocatalysts for enhanced oxygen evolution reaction and urea oxidation reaction

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Journal of Energy Chemistry 2021年第12期30卷 230-238,I0005页

作者： Qiang Li lele lu Jingwei Liu Wei Shi Peng Cheng Key Laboratory of Advanced Energy Materials Chemistry(MOE) College of ChemistryNankai UniversityTianjin 300071China

Two-dimensional coordination polymers(CPs) have aroused tremendous interest as electrocatalysts because the catalytic performance could be fine-tuned by their well-designed coordination layers with highly accessible and active metal ***,it remains great challenge for CP-based catalysts to be utilized for electrocatalytic oxidation reactions due to their inefficient activities and low catalytic ***,we applied a mixed-metal strategy to fabricate two-dimensional Co_xNi_(1-x)-CPs with dual active sites for electrocatalytic water and urea *** metal ratio regulation in the twodimensional layer,an optimized Co_(2/3)Ni_(1/3)-CP exhibits a water oxidation performance with an overpotential of 325 mV at a current density of 10 mA cm^(-2) and a Tafel slope of 86 mV dec^(-1) in alkaline solution for oxygen evolution ***,a lower potential than that of commercial RuO_(2) is observed over20 mA cm^(-2).Co_(2/3)Ni_(1/3)-CP also displays a potential of 1.381 V at 10 mA cm^(-2) for urea oxidation reaction and a Tafel slope of 124 mV dec^(-1).This mixed-metal strategy to maximize synergistic effect of different metal centers may ultimately lead to promising electrocatalysts for small molecule oxidation reaction.

关键词： Coordination Polymers Electrocatalysis Oxygen Evolution Reaction Urea Oxidation Reaction

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移动应用权限设计对其市场表现的影响

管理工程学报 2024年第3期38卷 29-45页

作者：陈璐刘鑫慧康乐乐上海交通大学安泰经济与管理学院上海200030 南京大学数据智能与交叉创新实验室、信息管理学院江苏南京210093

移动应用权限的调用涉及用户个人信息,会影响用户对于隐私风险的判断,进而影响用户下载决策。本文基于隐私关注理论和隐私计算理论,提出移动应用设计中调用权限的合理度和敏感度会影响其市场绩效,而这一效应被移动应用的功能丰富性所调... 详细信息

移动应用权限的调用涉及用户个人信息,会影响用户对于隐私风险的判断,进而影响用户下载决策。本文基于隐私关注理论和隐私计算理论,提出移动应用设计中调用权限的合理度和敏感度会影响其市场绩效,而这一效应被移动应用的功能丰富性所调节。权限合理度以同类别应用的平均权限水平为依据,敏感度以调用危险权限的程度为度量标准。低于正常合理水平的移动应用可能存在功能缺陷,而高于正常敏感水平的应用则可能引发用户的隐私担忧,合理性和敏感度交互作用,最终影响用户的下载决策和应用市场绩效。为识别移动应用的权限合理性及敏感性,本研究利用移动应用权限说明文本构建了权限向量,再以类别平均水平和危险权限调用程度为分类依据将应用权限划分为四类,确定了移动应用的正常权限过度系数、正常权限不足系数、危险权限过度系数、危险权限不足系数。通过采集小米应用市场中移动应用的权限说明、市场表现等相关数据,构建了包含33772条记录的面板数据进行了实证检验。实证研究的结果显示:危险权限申请略低于类别平均水平能正向促进应用绩效,相反,权限申请量超出“最优权限”则会降低应用排名,尤其是危险权限。对于功能较为丰富的应用而言,权限属性对用户隐私风险感知的影响程度更高。本研究一方面拓展了移动应用隐私保护的相关理论,另一方面对于开发者开展移动应用权限设计有着重要的参考意义。

关键词：最优化权限移动应用隐私安全固定效应 rologit模型

秩序与规则:清代徽州民间土地契约与乡村治理的多维互动研究

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淮南师范学院学报 2024年第4期26卷 102-107页

作者：和乐乐卢语云南师范大学历史与行政学院云南昆明650500 抗美援朝纪念馆丹东市抗美援朝研究中心辽宁丹东118000

土地契约作为徽民社会生活中的组成部分,至清代已进入较为成熟化、完备化的阶段。契约中蕴含的诚信、自由与法理价值观对调节徽州土地市场秩序、维护人与自然的生态平衡以及规范社会秩序等方面发挥良好的导向作用,是徽州乡村社会稳定运... 详细信息

土地契约作为徽民社会生活中的组成部分,至清代已进入较为成熟化、完备化的阶段。契约中蕴含的诚信、自由与法理价值观对调节徽州土地市场秩序、维护人与自然的生态平衡以及规范社会秩序等方面发挥良好的导向作用,是徽州乡村社会稳定运行的重要基础。契约秩序的良好运行同样离不开乡村治理中各主体对契约秩序的维系。良好的乡村治理环境是契约秩序运行的重要保障,契约规则是乡村秩序稳定的基础。两者的良性互动对徽州民间社会和谐、有序发展起着一定作用。

关键词：土地契约乡村治理秩序调节生态平衡

基于贝叶斯模型平均法和逐步回归法构建杉木单木胸径生长模型

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林业科学 2021年第9期57卷 87-97页

作者：鲁乐乐王震张雄清张建国中国林业科学研究院林业研究所国家林业和草原局林木培育重点实验室北京100091 南京林业大学南方现代林业协同创新中心南京210037

【目的】探索杉木人工林单木胸径生长量变化的驱动因子,比较不同驱动因子的重要性,构建不确定性单木胸径生长模型,为杉木经营管理者科学经营管理杉木人工林提供参考。【方法】以福建省邵武市卫闽林场杉木密度试验林为研究对象,采用贝叶... 详细信息

【目的】探索杉木人工林单木胸径生长量变化的驱动因子,比较不同驱动因子的重要性,构建不确定性单木胸径生长模型,为杉木经营管理者科学经营管理杉木人工林提供参考。【方法】以福建省邵武市卫闽林场杉木密度试验林为研究对象,采用贝叶斯模型平均法(BMA)和逐步回归法(SR)分析杉木单木胸径生长量与内部因子(林分变量因子)和气候因子的关系,构建杉木单木胸径生长模型。【结果】杉木单木胸径年均生长量受气候因子影响较小,主要受竞争因子和单木大小因子影响。单木胸径生长量随林分密度、林分平方平均胸径、大于对象木的断面积和、年龄、冬季平均最低温度增加而减小,随期初胸径、胸高断面积、优势木平均高、最冷月平均温度、最热月平均温度、年均降雨量增加而增加。基于SR获得模型的后验概率小于BMA获得最佳模型(最高后验概率)或SR模型不在BMA模型空间前几个后验概率高的模型中。【结论】杉木单木胸径生长量随竞争增加而减小,随温度和降雨增加而增加。贝叶斯模型平均法考虑所有可能变量的组合,能够反映出模型的不确定性。

关键词：单木胸径生长量气候变量贝叶斯模型平均法逐步回归法林分变量因子

STEAM教育理念下“线上+线下”混合教学模式初探:以微生物学实验为例

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微生物学通报 2022年第4期49卷 1472-1482页

作者：鲁乐乐李林珂李文华郝越董海亭汤欣妍苏春陕西师范大学生命科学学院陕西西安710062

随着信息化手段的不断丰富,新型教育理念结合线上学习平台的新信息化教学模式成为高校课堂的改革新趋势。本次教学改革利用科学(Science)、技术(Technology)、工程(Engineering)、艺术(Art)和数学(Mathematics)多学科融合的超学科教育理... 详细信息

随着信息化手段的不断丰富,新型教育理念结合线上学习平台的新信息化教学模式成为高校课堂的改革新趋势。本次教学改革利用科学(Science)、技术(Technology)、工程(Engineering)、艺术(Art)和数学(Mathematics)多学科融合的超学科教育理念(简称STEAM教育)对教师教学过程进行了整体设计,同时借助“线上+线下”教学平台对学生学习过程进行了全面优化。将原本分散的验证型、操作型实验重新整合串联成以多角度“项目式”任务为主线、以Blackboard线上平台为辅线的自主研究型实验项目。新型教学模式以学生为主体,给学生提供更多自我展示和讨论互动的平台。从学生的课堂表现、知识测验、课后反馈、实验操作及实验报告4个方面对新型模式下的教学效果进行了分析和评价。结果表明,此模式不仅提高了学生在微生物学实验中的学习质量,增强了其学习主观能动性,而且有利于培养和提升学生的问题探究及实践创新能力。这一新型教学模式对其他生物学科实验课程的教学具有一定的借鉴意义。

关键词： STEAM教育理念微生物学实验 Blackboard线上平台混合教学模式