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卒中后疲劳研究进展

国际医药卫生导报 2024年第3期30卷 381-385页

作者：范乐乐马靓翟怀香施童连云港市第一人民医院重症医学科连云港222002 连云港市第一人民医院护理部连云港222002

卒中后疲劳是脑卒中后常见的并发症,对卒中患者的康复及生活质量均产生了严重的影响。现就卒中后疲劳的流行病学、常用评估工具、影响因素、病理生理学机制以及治疗作一综述。

关键词：卒中疲劳进展

Consecutive hybrid mechanism boosting Na+storage performance of dual-confined SnSe2 in N,Se-doping double-walled hollow carbon spheres

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Journal of Energy Chemistry 2022年第11期31卷 8-17,I0002页

作者： Xiaoyu Wu Zhenshan Yang Lin Xu JianHua Wang lele fan fanjie Kong Qiaofang Shi Yuanzhe Piao Guowang Diao Ming Chen School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina Key Laboratory for Advanced Technology in Environmental Protection of jiangsu Province Yancheng Institute of TechnologyYancheng 224051JiangsuChina Department of Physics Yancheng Institute of TechnologyYancheng 224051JiangsuChina Graduate School of Convergence Science and Technology Seoul National University145 Gwanggyo-roYeongtong-guSuwon-si 16229Gyeonggi-doRepublic of Korea Advanced Institutes of Convergence Technology 145 Gwanggyo-roYeongtong-guSuwon-siGyeonggi-do16229Republic of Korea

Rationally designed hierarchical structures and heteroatomic doping of carbon are effective strategies to enhance the stability and electrical conductivity of ***,SnSe_(2)flakes were generated in the double-walled hollow carbon spheres(DWHCSs),in which N and Se atoms were doped in the carbon walls,to construct SnSe_(2)@N,Se-DWHCSs by confined growth and in-situ *** N and Sedoped DWHCSs can effectively limit the size increase of SnSe_(2),promote ion diffusion kinetics,and buffer volume expansion,which can be proved by electron microscope observation and density functional theory ***,the SnSe_(2)@N,Se-DWHCSs as an anode material for sodium ion batteries(SIBs)demonstrated a distinguished reversible capacity of 322.8 mAh g^(-1)at 5 A g^(-1)after 1000 cycles and a superior rate ability of 235.3 m Ah g^(-1)at an ultrahigh rate of 15 A g^(-1).Furthermore,the structure evolution and electrochemical reaction processes of SnSe2@N,Se-DWHCSs in SIBs were analyzed by exsitu methods,which confirmed the consecutive hybrid mechanism and the phase transition process.

关键词： SnSe2 N,Se-doping Double-walled hollow carbon spheres Hybrid mechanism Sodium-ion battery

2013-2022年河南省焦作市手足口病流行特征及趋势

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现代疾病预防控制 2024年第6期35卷 428-431,449页

作者：田争孙慧彦闫皓樊乐乐张向娜任东焦作市疾病预防控制中心河南焦作454003

目的分析2013—2022年焦作市手足口病流行特征,为制定手足口病防控措施提供依据。方法通过中国疾病预防控制信息系统,收集2013—2022年焦作市手足口病病例资料,运用描述性流行病学方法进行分析。结果2013—2022年焦作市共报告手足口病病... 详细信息

目的分析2013—2022年焦作市手足口病流行特征,为制定手足口病防控措施提供依据。方法通过中国疾病预防控制信息系统,收集2013—2022年焦作市手足口病病例资料,运用描述性流行病学方法进行分析。结果2013—2022年焦作市共报告手足口病病例38772例,年均发病率为109.35/10万;重症病例747例,占1.93%;死亡5例,病死率0.01%。手足口病呈隔年高发趋势,2016年后手足口病发病率和重症病例所占比例均呈下降趋势(χ^(2)趋势=4422.00、2472.00,P均<0.05)。发病时间呈单峰模式,主要集中在4—7月份。男女发病性别比为1.39∶1,男性年均发病率为123.98/10万,女性为93.70/10万,男性高于女性(χ^(2)=218.00,P<0.05);以散居儿童为主(24761例,63.86%);发病主要集中0~<5岁年龄组儿童(93.57%),≥5岁人群随年龄增加,年均发病率呈下降趋势(χ^(2)趋势=2072.00,P<0.05)。年均发病率前3位是博爱县、解放区、马村区,分别为177.95/10万、174.81/10万、165.61/10万。病原学监测结果显示,优势病原由EV-A71转变为其他肠道病毒,EV-A71构成比由2013年的47.06%下降到2022年的0.70%,其他肠道病毒由2013年的34.64%上升到2022年的42.16%,CV-A16由2013年的18.30%上升到2022年的57.14%(χ^(2)趋势=90.00、1765.00、868.00,P均<0.05)。结论焦作市手足口病有明显的季节、地区和人群分布特征,应加强5岁以下重点人群及重点地区的手足口病防控工作,持续监测手足口病病原学变化。

关键词：手足口病流行特征趋势病原学特征

Nanoscale Precise Editing of Multiple Immune Stimulating Ligands on DNA Origami for T Cell Activation and Cell-Based Cancer Immunotherapy

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CCS Chemistry 2024年第3期6卷 719-732页

作者： lele Sun Fengyun Shen Zijian Xiong Yu Chao Chunhai fan Zhuang Liu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu School of Life Sciences Shanghai UniversityShanghai 200444 School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 201240

The spatial arrangement of activating ligands is known to have great influence on T cell ***,independently studying each ligand’s spatial organization parameter that affects T cell activation remains a great ***,with DNA origami,we precisely organized the CD3ɛantibodies simulating T cell receptor(TCR)ligands and CD28 antibodies simulating co-stimulatory ligands to interrogate the independent role of TCR-ligand spacing and local copy numbers as well as the spacing between TCR ligands and co-stimulatory ligands on T cell *** found that T cell activation benefited fromlocally concentrated TCR ligands with a shorter spacing and was maximized by an∼38 nm spacing between TCR ligands and co-stimulatory *** T cell expander constructed based on our findings could efficiently expand CD8+T cells for tumor ***,the DNA nanostructurebased ligands’precise arrangement can be a unique tool in studying immune cell activations and cellbased immunotherapies.

关键词： DNA origami T cell activation T cell receptor immune cancer immunotherapy

MicroRNA-206 functions as a potential oligonucleotide therapeutics in preterm birth

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Chinese Medical Journal 2024年第8期137卷 1000-1002页

作者： Wenfeng Deng Lina Chen Bolun Wen Xiaodi Wang lele Wang fan Yang Yunshan Chen Junjie Bao Guozheng Zhang Kaiyuan Ji Huishu Liu Guangzhou Key Laboratory of Maternal-Fetal Medicine Department of Obstetrics and GynecologyGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdong 510623China School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China

To the Editor:Spontaneous preterm labor(PTL)causes infant morbidity and *** uterine contractions were the common characteristics in spontaneous labor at term or ***,effective decrease or suppression of myometrial contraction could prevent preterm *** discovered that microRNA-206(miR-206)was a myometrium contraction-associated miRNA based on the transcriptome data of human laboring myometrium and indicated that miR-206 suppressed myometrial contractility by targeting junction protein alpha 1(GJA1)in the myometrium and would be a new potential therapeutic for preterm *** of miR-206 in RU486-induced PTL decreased myometrial contractility,prolonged pregnancy,reversed PTL to term labor,and improved perinatal outcomes.

关键词： mortality contraction RU486

地铁车站站厅排烟口位置对乘客安全疏散的影响

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城市轨道交通研究 2020年第5期23卷 183-188页

作者：范乐乐中铁第四勘察设计院集团有限公司武汉430063

为改善地铁车站站厅层公共区的排烟效果,以郑州某地铁车站为研究对象,利用FDS(火灾数值模拟)软件对不同的排烟工况下的火灾数据进行数值模拟计算,得出以下结论:在安全疏散时间内,除了着火点周围3 m区域范围,其他位置均能够满足乘客的安... 详细信息

为改善地铁车站站厅层公共区的排烟效果,以郑州某地铁车站为研究对象,利用FDS(火灾数值模拟)软件对不同的排烟工况下的火灾数据进行数值模拟计算,得出以下结论:在安全疏散时间内,除了着火点周围3 m区域范围,其他位置均能够满足乘客的安全疏散要求;火灾时,相比排烟管道设置在站厅层公共区围护结构两侧区域,排烟管道在站厅层公共区中部区域时更有利于乘客的安全疏散;在进行排烟设计时,站厅层公共区易发生火灾部位周围沿站厅层长度方向上12.6 m范围内、宽度方向上6.45 m范围内不应设置排烟防火阀。

关键词：地铁站厅火灾排烟模式仿真模拟

Effect of turbulent fluctuation on the ignition of millimeter particle:Experimental studies and numerical modelling with a new correlation of nusselt number Author links open overlay panel

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Particuology 2024年第8期91卷 168-175页

作者： lele Feng Jie Liu Haihui Xin Liangliang Jiang Yuxin Wu Saeideh Babaee Jiangsu Key Laboratory of Coal-based Greenhouse Gas Control and Utilization China University of Mining and TechnologyXuzhou221008China School of Safety Engineering China University of Mining and TechnologyXuzhou221116China Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials Wuhan University of Science and TechnologyWuhan430000China Department of Chemical and Petroleum Engineering University of CalgaryCalgaryAlbertaCanada Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China Department of Chemical and Metallurgical Engineering University of the WitwatersrandJohannesburgSouth Africa

Understanding the influencing mechanism of turbulent fluctuation on the ignition characteristics of millimeter coal particles is *** this work,to study the effect of turbulent fluctuation on ignition time,millimeter coal particles are subjected to a specific flow field,generated in a furnace with symmetric fans.A one-dimensional model with the new proposed correlation and the Ranz-Marshall(R-M)correlation for Nu(Nusselt number)is established to simulate the coal ignition *** addition,the effects of fan speed,temperature,particle diameter,particle distance and coal type on the ignition time are *** is found that an increase in fan speed from 0 to 3000 rpm leads to a particle Reynolds number Re_(p)increase from 0 to 22.5,and a turbulent particle Reynolds number Re_(t)*increase from 0 to *** a consideration of the fluctuation effect,the new correlation of Nu gives a better prediction of ignition time compared to the R-M ***,the ignition time is revealed to decrease with an increasing fan speed and an elevating *** the ignition time shows merely an initial boost with enlarging particle distance,it exhibits a linearity with the term of particle diameter dp1.3-1.7 and Reynolds numbers(Nu*/Nu)-0.6(Nu*is turbulent Nusselt number).Based on this relationship,the difference of predicted ignition time is calculated at different Re_(p)and Re_(t)*.It is shown that at low Re_(p)or high Re_(t)*values,the new correlation should substitute for the R-M correlation.

关键词： Turbulent fluctuation Particle heat transfer Empirical correlation Coal ignition

低温等离子放电与催化剂结合方式对生物油提质的影响

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农业机械学报 2019年第4期50卷 290-297页

作者：樊永胜王佳伟朱雷樊乐乐赵卫东纪玮盐城工学院汽车工程学院盐城224051 盐城工学院江苏省新型环保重点实验室盐城224051 江苏大学汽车与交通工程学院镇江212013

为提高生物油的提质效率,在HZSM-5及Ti/HZSM-5催化的基础上引入低温等离子体技术,分析等离子体协同催化(PSC)和等离子体增强催化(PEC)等不同结合方式对精制生物油产率、理化特性、化学组成及催化剂稳定性的影响。结果表明,Ti改性和等离... 详细信息

为提高生物油的提质效率,在HZSM-5及Ti/HZSM-5催化的基础上引入低温等离子体技术,分析等离子体协同催化(PSC)和等离子体增强催化(PEC)等不同结合方式对精制生物油产率、理化特性、化学组成及催化剂稳定性的影响。结果表明,Ti改性和等离子体放电使精制生物油产率逐渐降低,Ti/HZSM-5(PEC)催化所得精制生物油产率较低,生物油质量分数为13. 84%,但烃类物质的分布得到明显改善;而Ti/HZSM-5(PSC)催化所得精制生物油中烃类总含量略低,但高氢碳比产物相对含量达68. 89%,理化特性较优,高位热值达到36. 52 MJ/kg; PSC方法等离子体对催化剂表面的冲击作用较强,使催化剂结焦量相对较低,Ti/HZSM-5(PSC)的结焦量较低,积分面积仅为5. 24%,催化稳定性较高。综合而言,基于Ti/HZSM-5的催化作用,PSC方法优于PEC方法。

关键词：生物油催化提质 Ti/HZSM-5 结合方式

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重庆市南岸区地名景观分析

科教文汇 2013年第8期 204-205页

作者：范乐乐重庆工商大学马克思主义学院重庆400067

每个地名都蕴含着地域自身的特点。本文以重庆市南岸区地名景观为研究对象,对命名类型、特点以及出现的主要问题等进行简要分析。结果显示:重庆市南岸区地名充分展示出重庆的地形地貌,以及山水之城的特色。而且,大部分都带有很强烈的乡... 详细信息

每个地名都蕴含着地域自身的特点。本文以重庆市南岸区地名景观为研究对象,对命名类型、特点以及出现的主要问题等进行简要分析。结果显示:重庆市南岸区地名充分展示出重庆的地形地貌,以及山水之城的特色。而且,大部分都带有很强烈的乡村气息,成为地名景观的一大特点。

关键词：地名景观环境特征