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Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第36期28卷 5250-5264页

作者： Aswathy r Devan Keechilat Pavithran Bhagyalakshmi Nair Maneesha Murali lekshmi r nath Department of Pharmacognosy Amrita School of PharmacyAmrita Vishwa VidyapeethamAIMS Health Science CampusKochi 682041KeralaIndia Department of Medical Oncology and Hematology Amrita Institute of Medical Sciences and Research CentreAmrita Vishwa VidyapeethamKochi 682041KeralaIndia

Transforming growth factor-beta(TGF-β)is a multifunctional cytokine that performs a dual role as a tumor suppressor and tumor promoter during cancer *** different ligands of the TGF-βfamily,TGF-β1 modulates most of its biological *** the abundant expression of TGF-β1 in the liver,steatosis to hepatocellular carcinoma(HCC)progression triggers elevated TGF-β1 levels,contributing to poor prognosis and ***,elevated TGF-β1 levels in the tumor microenvironment create an immunosuppressive stage via various ***-β1 has a prime role as a diagnostic and prognostic biomarker in ***,TGF-β1 is widely studied as a therapeutic target either as monotherapy or combined with immune checkpoint *** review provides clinical relevance and up-to-date information regarding the potential of TGF-β1 in diagnosis,prognosis,and therapy against HCC.

关键词： Transforming growth factor-beta 1 Inflammation Immunosuppression Fibrogenesis Hepatocellular carcinoma Biomarker Immunotherapy

Fractional order prey-predator model incorporating immigration on prey:Complexity analysis and its control

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International Journal of Biomathematics 2024年第5期17卷 285-317页

作者： Md.Jasim Uddin Chandra nath Podder Departmentof Mathematics University of Dhaka Dhaka-1000Bangladesh

In this paper,the Caputo fractional derivative is assumed to be the prey-predator *** order to create Caputo fractional differential equations for the prey-predator model,a discretization process is first *** fixed points of the model are categorized *** identify requirements for the fixed points of the suggested prey-predator model's local asymptotic *** demonstrate analytically that,under specific parametric conditions,a fractional order prey-predator model supports both a Neimark-Sacker(NS)bifurcation and a Flip *** present evidence for NS and Flip bifurcations using central manifold and bifurcation *** parameter values and the initial conditions have been found to have a profound impact on the dynamical behavior of the fractional order prey-predator *** the bifurcation parameter is increased,the system displays chaotic *** simulations are shown to demonstrate chaotic behaviors like bifurcations,phase portraits,invariant closed cycles,and attractive chaotic sets in addition to validating analytical *** suggested prey-predator dynamical system's chaotic behavior will be controlled by the OGY and hybrid control methodology,which will also visualize the chaotic state for various biological parameters.

关键词： Prey-predator model Caputo fractional derivative Flip and Neimark-Sacker(NS)bifurcations immigration chaos control numerical simulation

random Amplification Polymorphic DNA and Agro-Morphological Traits-Based Fingerprinting for Detection of Genetic Divergence in Indian Black rice

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rice science 2024年第4期31卷 366-370,I0004-I0014页

作者： Manisha SHArMA Dhananjay rATUrI Vijay rani rAJPAL Manju CHAUDHArY Soom nath rAINA Apekshita SINGH Amity Institute of Biotechnology Amity University Uttar PradeshSector-125UP 201313India Department of Botany Hansraj CollegeUniversity of DelhiDelhi 110007India

In this study, 32 black rice genotypes spanning diverse geographies in India were evaluated at both phenotypic and DNA sequence levels to gain insights into their genetic makeup. Significant variations were observed f... 详细信息

关键词： Indian Morphological Traits

Dengue hemorrhagic fever with rectus sheath hematoma:A case report

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 136-138页

作者： Boudhayan Bhattacharjee Hardik Patel rucha Karad Vasireddy Teja Agnibho Mondal Soumendra nath Haldar Bibhuti Saha Department of Infectious Diseases and Advanced Microbiology School of Tropical MedicineKolkataIndia

rationale:Acute pain is a medical emergency that requires prompt abdominal evaluation and ***,a mosquito-borne arboviral infection,can lead to complications such as acute abdominal *** concerns:A 72-year-old hypertensive female presented with high-grade intermittent fever with chills and rigors for four *** was diagnosed with dengue fever(NS1Ag-reactive)the day before admission.A contrast-enhanced computed tomography of the abdomen showed a hematoma along the rectus sheath which was managed conservatively as per surgical ***:Dengue hemorrhagic fever with rectus sheath ***:Blood transfusion and fluid ***:Ten days after discharge,the patient reproted no pain in the right iliac fossa and the size of the hematoma was significantly ***:Although it is rarely seen as a cause of acute abdomen,complaints of adnominal pain should never be ignored in critical or convalescent phase of dengue *** investigations should be promptly conducted as hematoma is often difficult to be diagnosed *** in diagnosis of rectus sheath hematoma can be fatal.

关键词： Dengue fever rectus sheath hematoma Surgical emergency Acute appendicitis

Optimizing Biodiesel Production from Karanja and Algae Oil with Nano Catalyst:rSMand ANN Approach

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Energy Engineering 2024年第9期121卷 2363-2388页

作者： Sujeet Kesharvani Sakhi Katre Suyasha Pandey Gaurav Dwivedi Tikendra nath Verma Prashant Baredar Energy Centre Maulana Azad National Institute of TechnologyBhopal462003India Department of Mechanical Engineering Maulana Azad National Institute of TechnologyBhopal462003India

This study delves into biodiesel synthesis from non-edible oils and algae oil sources using response Surface Methodology(rSM)and an Artificial Neural Network(ANN)model to optimize biodiesel *** of *** and Karanja oils is utilized,aiming to reduce free fatty acid content to 1%through single-step *** reveals peak biodiesel yield conditions:1%catalyst quantity,91.47 min reaction time,56.86℃reaction temperature,and 8.46:1 methanol to oil molar *** ANN model outperforms rSM in yield prediction *** impact assessment yields an E-factor of 0.0251 at maximum yield,indicating responsible production with minimal *** analysis reveals significant cost savings:30%-50%reduction in raw material costs by using non-edible oils,10%-15%increase in production efficiency,20%reduction in catalyst costs,and 15%-20%savings in energy *** optimized process reduces waste disposal costs by 10%-15%,enhancing overall economic ***,the widespread adoption of biodiesel offers economic,environmental,and social benefits to a diverse range of stakeholders,including farmers,producers,consumers,governments,environmental organizations,and the transportation *** among these stakeholders is essential for realizing the full potential of biodiesel as a sustainable energy solution.

关键词： Non-edible oil algae rSM ANN optimization environmental factor

Modeling measles transmission in adults and children:Implications to vaccination for eradication

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Infectious Disease Modelling 2024年第4期9卷 1007-1026页

作者： Anjana Pokharel Khagendra Adhikari ramesh Gautam Kedar nath Uprety Naveen K.Vaidya Padma Kanya Multiple Campus Tribhuvan UniversityKathmanduNepal Mathematical Biology research Center KathmanduNepal Amrit Campus Tribhuvan UniversityKathmanduNepal ratna rajya Laxmi Campus Tribhuvan UniversityKathmanduNepal Central Department of Mathematics Tribhuvan UniversityKathmanduNepal Department of Mathematics and Statistics San Diego State UniversitySan DiegoCAUSA Computational Science research Center San Diego State UniversitySan DiegoCAUSA Viral Information Institute San Diego State UniversitySan DiegoCAUSA

Despite the availability of successful vaccines,measles outbreaks have occurred frequently in recent years,presumably due to the lack of proper vaccination ***,measles cases in adult groups,albeit small in number,indicate that the previously neglected adult group may need to be brought into vaccine coverage to achieve WHO's goal of measles eradication from the *** this study,we develop a novel transmission dynamics model to describe measles cases in adults and children to evaluate the role of adult infection in persistent measles cases and vaccination programs for *** of our model,validated by measles cases from outbreaks in Nepal,provides the vaccination reproduction number(conditions for measles eradication or persistence)and the role of contact network *** results highlight that while children are primary targets for measles outbreaks,a small number of infections in adults may act as a reservoir for measles,causing obstacles to ***,our model analysis shows that while impactful controls can be achieved by children-focused vaccines,a combined adult-child vaccination program may help assert eradication of the disease.

关键词： Measles eradication Measles reservoir Adult-child vaccination Adults and children groups Nepal

Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： Swapnil Gavhane Chandrakant Gawli Sachin Kumar Biswajit Das Gayatri Marathe Vishal S.Patil Harun M.Patel Basavaraj Bommanahalli Chanakya nath Kundu Chandragouda r.Patil r.C.Patel Institute of Pharmaceutical Education and research Karwand NakaShirpurMaharashtra 425405India Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India School of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Gadag Institute of Medical Sciences GadagKarnataka 582103India

Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network ***:IPF was induced in C57BL/6 mice by a single intratracheal instillation of bleomycin(5 mg/kg).Trigonelline was administered at doses of 25,50,and 100 mg/kg/day orally from the 2nd day post-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltration in bronchoalveolar lavage fluid,and oxidative stress were *** alterations in lung tissues were also ***,network pharmacology approach was conducted to reveal molecular interactions of bleomycin and trigonelline with targets of ***:Trigonelline treatment reduced bleomycin-induced oxidative stress and immune cell infiltration,and mitigated physiological changes in the lung tissues of ***,trigonelline alleviated bleomycin-induced histological alterations in lung *** pharmacology analysis showed that bleomycin and trigonelline interacted with IPF targets,such as NFKB1,HDAC2,HIF1A,and ***:The interaction of trigonelline with key IPF targets and its ameliorative effects on lung damage and oxidative stress highlight its potential in treating *** may be considered an antifibrotic agent for further clinical development.

关键词： Trigonelline Idiopathic pulmonary fibrosis Antifibrotic Bleomycin Network pharmacology

Strengthening Active Aging through Older People’s Association and Economic Activity of the Older People in Nepal

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Advances in Aging research 2024年第2期13卷 15-24页

作者： Hom nath Chalise James Brightman Central Department of Population Studies Tribhuvan University Kathmandu Nepal University of Central Florida Orlando Florida USA

Aging is a natural lifelong process ending in death. Many older people are living in poverty. Older people are generally considered dependent on others as they grow older. The purpose of this article is to explore the entrepreneurship activities of Nepalese older adults. Data for this study were collected from the project Help Age International (HAI) implemented in Nepal. Qualitative data observations and interviews were used to collect data. The findings of this study show the formation of the Older People’s Association (OPA) has supported many older people to participate outside the home in various social activities. Moreover, regular deposits through OPAs offer little help. OPAs support older people in their need of financial support to implement minor entrepreneurship. Older people who received support were pleased and were actively involved in their activities and also regularly deposited money in them. Subsequently, older people’s participation in social activities has increased and also helped to lower elderly abuse, loneliness, and depression. Local governments should promote such activities which will help with healthy aging.

关键词： Aging in Nepal Active Aging Older People’s Association Older People Healthy Aging

Gas Chromatographic Method for Identification and Quantification of Commonly Used residual Solvents in Pharmaceuticals Products

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American Journal of Analytical Chemistry 2024年第8期15卷 241-252页

作者： Sreekanta nath Dalal Pranab Kumar Das Department of Applied Chemistry & Chemical Engineering Faculty of Engineering & Technology University of Dhaka Dhaka Bangladesh Department of Applied Chemistry & Chemical Engineering Faculty of Engineering University of Rajshahi Rajshahi Bangladesh

Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three different types of impurities are generally available in the pharmaceutical’s product specification: organic impurities, inorganic impurities, and residual solvents. residual solvents are organic volatile chemicals used or generated during the manufacturing of drug substances or drug products. Purpose: The aim of this study is to develop a cost-effective gas chromatographic method for the identification and quantification of some commonly used solvents—methanol, acetone, isopropyl alcohol (IPA), methylene chloride, ethyl acetate, tetrahydrofuran (THF), benzene, toluene, and pyridine—in pharmaceutical product manufacturing. This method will be able to identify and quantify the multiple solvents within a single gas chromatographic procedure. Method: A gas chromatography (GC) equipped with a headspace sampler and a flame ionization detector, and a column DB 624, 30-meter-long × 0.32-millimeter internal diameter, 1,8 μm-thick, Brand-Agilent was used to develop this method. The initial GC oven temperature was 40°C and held for 5 minutes. It was then increase to 80˚C at a rate of 2˚C per minute, followed by a further increase to 225˚C at a rate of 30˚C per minute, with a final hold at 225˚C for 10 minutes. Nitrogen was used as a carrier gas at a flow rate of 1.20 mL per minute. Dimethyl sulfoxide (DMSO) was selected as sample solvent. results: The developed method is precise and specific. The percent rSD for the areas of six replicate injections of this gas chromatographic method was within 10.0 and the recovery result found within 80.0% to 120.0%.

关键词： Method Development Gas Chromatography Compendial Method GDP Specificity recovery