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中国绵阳研究堆高压中子衍射谱仪在材料研究中的应用

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高压物理学报 2024年第3期38卷 111-120页

作者：孙嘉程陈喜平谢雷房雷鸣中国工程物理研究院核物理与化学研究所四川绵阳621999

中国绵阳研究堆(CMRR)的高压中子衍射谱仪(凤凰,HPND)由中子聚焦系统、探测器系统、高压加载与集成系统等部分组成,可进行常压高低温、高压环境下的中子衍射实验,其中子衍射实验的原位室温高压加载最高可达30 GPa,高温高压加载最高可达2... 详细信息

中国绵阳研究堆(CMRR)的高压中子衍射谱仪(凤凰,HPND)由中子聚焦系统、探测器系统、高压加载与集成系统等部分组成,可进行常压高低温、高压环境下的中子衍射实验,其中子衍射实验的原位室温高压加载最高可达30 GPa,高温高压加载最高可达2000 K、10 GPa。目前,凤凰谱仪已被广泛应用于材料研究领域,如过渡金属氮化物、锂离子材料、磁性材料、含能材料、铁电陶瓷等。利用常规中子衍射、高低温中子衍射以及高压中子衍射技术,获得材料的原子精确占位、磁结构、晶体结构以及相变等信息。

关键词：高压中子衍射原子占位结构相变

Mitochondrion-processed TERC regulates senescence without affecting telomerase activities

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Protein & Cell 2019年第9期10卷 631-648页

作者： Qian Zheng Peipei Liu Ge Gao Jiapei Yuan Pengfeng Wang Jinliang Huang leiming xie Xinping Lu Fan Di Tanjun Tong Jun Chen Zhi Lu Jisong Guan Geng Wang MOE Key laboratory of Bioinformatics Cell Biology and Development CenterSchool of Life SciencesTsinghua University Beijing 100084China Peking University Research Center on Aging Beijing 100191China Department of Biochemistry and Molecular Biology Peking University Health Science CenterBeijing 100191China

Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc^-/- cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals.

关键词： mitochondria retrograde signal nucleus transcription regulation non-coding RNA telomerase

Altitude shape genetic and phenotypic variations in growth curve parameters of Larix kaempferi

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Journal of Forestry Research 2023年第2期34卷 507-517页

作者： Yalin Zhang leiming Dong Yunhui xie Dongsheng Chen Xiaomei Sun Research Institute of Forestry Chinese Academy of ForestryBeijing 100091People’s Republic of China State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry and Grassland AdministrationBeijing 100091People’s Republic of China Beijing Floriculture Engineering Technology Research Centre Beijing Botanical GardensBeijing 100084People’s Republic of China

To study the effects of geoclimatic variables of provenances on growth phenotypes and selected plus provenances,over 3000 trees of 22-year-old Larix kaempferi were evaluated from trials established in two climate zones for provenance selection and to explore the influence of climate variables on provenance performance.The material was replicated plantings of 84 open pollinated families from six provenances distributed in the mountains of central Japan.Provenance variation was observed in most age groups and the heritability of growth traits showed large differences.The phenotypic maximum value of height and diameter were significantly positive with altitude,and mean annual precipitation being important factors.Diameter at breast height growth was significantly negative with altitude and spring rainfall.The Ina provenance of relatively high altitudes,was well adapted to a variety of climates.Altitude might be the driving force for phenotypic and genetic variations and local adaptation.

关键词： Larix kaempferi Breeding Altitude Genetic parameters

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基于局域网的智能访客管理系统的研究

绿色建造与智能建筑 2024年第3期 92-95页

作者：谢吉通张岚周俊波周雷鸣战略支援部队航天系统部后勤部工程代建管理办公室北京102499

本文主要解决部分企事业单位因网络安全问题,仍在采用传统访客管理方式时存在的登记效率低、信息存储难、访客去向难掌握、滞留访客人数不清、数据可追溯性差、访客体验差等问题。本文提出了基于局域网系统,依托数字安防系统的智能访客... 详细信息

本文主要解决部分企事业单位因网络安全问题,仍在采用传统访客管理方式时存在的登记效率低、信息存储难、访客去向难掌握、滞留访客人数不清、数据可追溯性差、访客体验差等问题。本文提出了基于局域网系统,依托数字安防系统的智能访客管理系统,按照分层架构设计,并针对性地设置预约访问模式和临时访问模式,有效解决传统访客管理模式的痛点问题。

关键词：预约访客临时访客访客管理系统

丙型病毒性肝炎抗体检测与HCV高敏核酸检测对病毒性丙型肝炎的筛查价值研究

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标记免疫分析与临床 2024年第3期31卷 456-459,467页

作者：谢骊蔡雷鸣冯颖段玉萍厉倩复旦大学附属中山医院吴淞医院检验科上海200940

目的通过对本院2019年1月至2022年9月需进行手术、输血或其他侵入性医疗服务的住院患者的HCV血清学抗体及高敏HCV RNA筛查结果进行回顾性分析,探讨丙型病毒性肝炎抗体检测与HCV高敏核酸检测对病毒性丙型肝炎的筛查检测价值。方法对本院... 详细信息

目的通过对本院2019年1月至2022年9月需进行手术、输血或其他侵入性医疗服务的住院患者的HCV血清学抗体及高敏HCV RNA筛查结果进行回顾性分析,探讨丙型病毒性肝炎抗体检测与HCV高敏核酸检测对病毒性丙型肝炎的筛查检测价值。方法对本院相关住院患者进行Elecsys Anti-HCV II或(和)高敏HCV RNA检测,统计分析其检测结果。结果HCV血清学抗体检测22443人次,阳性率为0.68%,阳性COI中位数为38.4(1.0~165)。高敏HCV RNA检测34628人次,阳性率0.30%,阳性病毒载量中位数为1.00×10^(6)IU/mL(3.50×10^(1)~4.00×10^(7)IU/mL)。两种方法学均显示45~59岁人群阳性率显著高于其他人群(P100的HCV RNA阳性率低。结论HCV抗体检测和高敏HCV RNA均为有效的丙型肝炎筛查手段,需进一步加强对重点人群的丙型肝炎感染管理。

关键词：丙型肝炎丙型肝炎病毒抗体丙型肝炎病毒RNA 发光免疫标记核酸检测

Anaerobic oxidation of arsenite by bioreduced nontronite

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Journal of Environmental Sciences 2021年第12期33卷 21-27页

作者： Ziwang Zhao Ying Meng Yahua Wang leiming Lin Fuyu xie Fubo Luan Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The redox state of arsenic controls its toxicity and mobility in the subsurface environment. Understanding the redox reactions of arsenic is particularly important for addressing its environmental behavior. Clay minerals are commonly found in soils and sediments, which are an important host for arsenic. However, limited information is known about the redox reactions between arsenic and structural Fe in clay minerals. In this study, the redox reactions between As(Ⅲ)/As(Ⅴ) and structural Fe in nontronite NAu-2 were investigated in anaerobic batch experiments. No oxidation of As(Ⅲ) was observed by the native Fe(Ⅲ)-NAu-2. Interestingly, anaerobic oxidation of As(Ⅲ) to As(Ⅴ) occurred after Fe(Ⅲ)-NAu-2 was bioreduced. Furthermore, anaerobic oxidization of As(Ⅲ) by bioreduced NAu-2 was significantly promoted by increasing Fe(Ⅲ)-NAu-2 reduction extent and initial As(Ⅲ) concentrations. Bioreduction of Fe(Ⅲ)-NAu-2 generated reactive Fe(Ⅲ)-O-Fe(Ⅱ) moieties at clay mineral edge sites. Anaerobic oxidation of As(Ⅲ) was attributed to the strong oxidation activity of the structural Fe(Ⅲ) within the Fe(Ⅲ)-O-Fe(Ⅱ) moieties. Our results provide a potential explanation for the presence of As(Ⅴ) in the anaerobic subsurface environment. Our findings also highlight that clay minerals can play an important role in controlling the redox state of arsenic in the natural environment.

关键词： Bioreduction Nontronite NAu-2 Arsenic Redox reactions Clay mineral

基于门脉高压症血流动力学特征的Hassab手术疗效研究

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腹部外科 2024年第1期37卷 44-50页

作者：叶德强曹涌高华毛卫谢能文邢毅焦磊明黄义华袁航杜小军南昌市第九医院普外科江西南昌330002

目的探讨脾切除和贲门周围血管离断术(Hassab手术)是否可以有效提高失代偿期肝硬化病人肝动脉灌注并改善肝功能。方法回顾性收集2020年1月至2022年12月在南昌市第九医院普外科接受Hassab手术的97例乙型肝炎肝硬化门脉高压症并脾功能亢... 详细信息

目的探讨脾切除和贲门周围血管离断术(Hassab手术)是否可以有效提高失代偿期肝硬化病人肝动脉灌注并改善肝功能。方法回顾性收集2020年1月至2022年12月在南昌市第九医院普外科接受Hassab手术的97例乙型肝炎肝硬化门脉高压症并脾功能亢进病人的临床资料,依据脾动脉盗血综合征(splenic artery steal syndrome,SASS)诊断标准分为SASS组(40例)和非SASS组(对照组,57例)。比较两组术前、术中、术后各项指标之间的差异。结果SASS组与对照组间术前和术中各项指标差异均无统计学意义(均P>0.05),两组术后第3天终末期肝病模型评分(model for end-stage liver disease,MELD)差异无统计学意义(P>0.05)。两组术后第7天的MELD评分均明显优于术前(均P<0.05);SASS组术后第7天的MELD评分为3.17±2.96,明显优于对照组的4.68±2.31(P<0.05);SASS组术后第14天的肝固有动脉直径[(4.13±0.33)mm]和肝固有动脉流速[(50.83±3.85)cm/s]均明显优于对照组[(3.85±0.34)mm、(47.55±3.05)cm/s](均P<0.05)。结论Hassab手术可以有效提高失代偿期肝硬化病人肝动脉灌注并改善肝功能,将“肝硬化性SASS”的概念引入临床可以使更多肝硬化门脉高压症和脾功能亢进病人受益。

关键词： Hassab手术肝硬化门脉高压症脾动脉盗血综合征肝动脉

In-situ ultrasonic calibrations of pressure and temperature in a hinge-type double-stage cubic large volume press

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Chinese Physics B 2022年第6期31卷 272-277页

作者：李青泽陈喜平谢雷韩铁鑫孙嘉程房雷鸣 Key Laboratory for Neutron Physics Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyang 621900China

Here,simultaneous in-situ calibration of pressures and temperatures was performed in a hinge-type second-stage cubic large volume press(LVP)up to 15 GPa and 1400 K by an acoustic travel-time approach.Based on the recently reported P-tSand P-T-tP-tSequations for Al2O3buffer rod,the cell pressures and temperatures in the chamber of LVP were insitu determined,in comparison with those by conventional off-line(or fixed-points)pressure calibration method and direct thermocouple measurement,respectively.It is found that the cell pressures of the LVP chamber are significantly reduced after annealing at simultaneous high pressures and high temperatures,owing to the stress relaxation as accumulate in the LVP chamber.This acoustic travel-time method is verified to be a good way for precise determination of thermal(cell)pressures at high temperature conditions,and is of great importance and necessity to conduct in-situ physical property measurements under extreme high P-T conditions,especially when the precious synchrotron x-ray/neutron diffraction beams are not available.

关键词： cubic press simultaneous in-situ calibration of pressures and temperatures acoustic travel-time high pressure and high temperature

ADCP1 interacts with high mobility group protein HMGA to maintain heterochromatic chromocenter in plants

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ADCP1 interacts with high mobility group protein HMGA to mai...