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Efficacy of topical chamomile on the incidence of phlebitis due to an amiodarone infusion in coronary care patients:a double-blind,randomized controlled trial

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Journal of Integrative Medicine 2017年第5期15卷 373-378页

作者： Maryam Sharifi-Ardani leili yekefallah Saeed Asefzadeh Marjan Nassiri-Asl School of Nursing and Midwifery Qazvin University of Medical SciencesQazvin 341197-5981Iran Social Determinants of Health Research Center Qazvin University of Medical SciencesQazvin 341197-5981Iran Cellular and Molecular Research Center Department of PharmacologyQazvin University of Medical SciencesQazvin 341197-5981Iran

BACKGROUND：Amiodarone is a useful antiarrhythmic ***,caused by intravenous amiodarone,is common in patients in coronary care units（CCUs）.OBJECTIVE：The aim of this study was to evaluate the effect of topical chamomile on the incidence of phlebitis due to the administration of an amiodarone infusion into the peripheral ***,SETTING,PARTICIPANTS AND INTERVENTIONS：This was a randomized,double-blind clinical trial,conducted on 40 patients（n=20 per group）in two groups—an intervention group（chamomile ointment）and a control group（lanoline,as a placebo）,hospitalized in the CCUs and undergoing an amiodarone infusion into the peripheral vein over 24 *** the cannulation and commencement of the infusion,placebo or chamomile ointment was rubbed in,up to 10 cm superior to the catheter and repeated every eight hours for three *** cannula site was then assessed based on the phlebitis *** OUTCOME MEASURES：The incidence and time of occurrence of phlebitis,relative risk,severity of phlebitis were the main outcome ***：Nineteen patients（19/20）in the control group had phlebitis on the first day of the study and one patient（20/20）on the second *** the intervention group,phlebitis occurred in 13 cases（13/20）on the first day and another two（2/7）was found on the second *** incidence of phlebitis was significantly different between two groups（P=0.023）.The cumulative incidence of phlebitis in the intervention group（15/20）is significantly later and lower than that in the control group（20/20）during two days（P=0.008）.Two patients in the intervention group did not develop phlebitis at all during the 3-day ***,the relative risk of phlebitis in the two groups was 0.68（P=0.008 5）.A significant difference was not observed with regard to phlebitis severity in both ***：It seems that phlebitis occurred to a lesser extent and at a later time frame in the intervention group compared to control *** chamomile may be e

关键词： phlebitis amiodarone prevention chamomile clinical trial plants, medicinal

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