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High-quality Development of Public Health in Guizhou Province, China

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Journal of Resources and Ecology 2024年第4期15卷 925-936页

作者： zhang Jisha LUO Jing CHEN Guolei zhang Chunyan WANG Jishu LI Lianlian School of Geography and Environmental Science Guizhou Normal UniversityGuiyang 550025China Hubei Provincial Key Laboratory for Geographical Process Analysis and Simulation&College of Urban and Environmental Sciences Central China Normal UniversityWuhan 430079China Hubei High-quality Development Research Institute Research Office of Hubei Provincial People’s Government and Central China Normal UniversityWuhan 430079China

People’s health is the basis for the progress of social civilization and an important symbol of national prosperity and national *** the entropy method,spatial autocorrelation,spatio-temporal geographic weighted regression and other methods,we conducted a comprehensive evaluation of the high-quality development level of public health in Guizhou Province from 2011 to 2020 and an evolutionary analysis of the spatio-temporal *** results revealed four key aspects of the state of public health in Guizhou Province.(1)The overall level of public health is constantly improving,but structural imbalance is prominent.(2)From the spatial dimension,the spatial differences in the level of public health have gradually moved from significant to a state of *** northeastern cities were more strongly driven by the radiation of the peripheral cities,while this effect was weaker in the southwestern *** the time dimension,the spatial pattern shows a clear gradient,with a faster vertical growth rate.(3)The overall spatial correlation of the level of public health is weak,with more cold spots than hot spots,showing a distribution pattern of“strong in the northeast and weak in the southwest”.(4)The new rural cooperative medical care participation rate,(rural)per capita health expenditure,and the electronic health record creation rate have become the most important drivers affecting the high-quality development of public health in Guizhou Province.

关键词： public health high-quality development entropy method Guizhou Province

Lipid-derived radical-trapping antioxidants suppress ferroptosis

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Life Metabolism 2024年第2期3卷 6-8页

作者： Ruoxi zhang Guido Kroemer Daolin Tang Department of Surgery UT Southwestern Medical CenterDallasTX 75390United States Centre de Recherche des Cordeliers INSERM U1138Equipe labellisée-Ligue contre le cancerUniversitéParis CitéSorbonne UniversitéInstitut Universitaire de FranceParis 75006France Metabolomics and Cell Biology Platforms Gustave Roussy Cancer CampusVillejuif 94800France Institut du Cancer Paris CARPEM Department of BiologyHôpital Européen Georges PompidouAssistance Publique-Hôpitaux de ParisParis 75015France

Ferroptosis,characterized by lipid peroxidation-mediated cell demise,is governed by a nuanced interplay of lipid species influencing its *** recent publications in Nature discovered 7-dehydrocholesterol,a cholesterol precursor,as a radical-trapping antioxidant that can suppress ferroptosis,thereby presenting a novel metabolic target to improve ferroptosis-related cancer therapy.

关键词： Lipid peroxidation cholesterol

Abdominal Pain After Cardiac Surgery Caused by Crohn Disease, Intestinal Ischemia, and Colonic Diverticulitis, Respectively: A Report of 3 Cases

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Cardiology Discovery 2024年第1期4卷 55-57页

作者： Huanan Liu Zhaoming Lin Xiaoshen zhang Department of Cardiovascular Surgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Abdominal complications following cardiac surgery are rare events,but can be fatal if not diagnosed and managed in *** treatments offer a better chance for survival in patients with risk *** case report describes the clinical presentation and details of 3 recently operated patients who suffered acute abdominal pain after cardiac *** underlying causes were Crohn disease-associated ileal perforation,intestinal necrosis,and diverticulitis-associated colonic *** presentation and management of these severe conditions are discussed.

关键词： Abdominal pain Cardiac surgery Ulceration Ischemia Diverticulitis

Improving Satellite-Retrieved Cloud Base Height with Ground-Based Cloud Radar Measurements

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Advances in Atmospheric Sciences 2024年第11期41卷 2131-2140页

作者： Zhonghui TAN Ju WANG Jianping GUO Chao LIU Miao zhang Shuo MA College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjing 210044China National Satellite Meteorological Center(National Center for Space Weather) China Meteorological AdministrationBeijing 100081China

Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in passive satellite radiometer observations, few operational satellite CBH products are currently available. This study presents a new method for retrieving CBH from satellite radiometers. The method first uses the combined measurements of satellite radiometers and ground-based cloud radars to develop a lookup table(LUT) of effective cloud water content(ECWC), representing the vertically varying cloud water content. This LUT allows for the conversion of cloud water path to cloud geometric thickness(CGT), enabling the estimation of CBH as the difference between cloud top height and CGT. Detailed comparative analysis of CBH estimates from the state-of-the-art ECWC LUT are conducted against four ground-based millimeter-wave cloud radar(MMCR) measurements, and results show that the mean bias(correlation coefficient) is0.18±1.79 km(0.73), which is lower(higher) than 0.23±2.11 km(0.67) as derived from the combined measurements of satellite radiometers and satellite radar-lidar(i.e., Cloud Sat and CALIPSO). Furthermore, the percentages of the CBH biases within 250 m increase by 5% to 10%, which varies by location. This indicates that the CBH estimates from our algorithm are more consistent with ground-based MMCR measurements. Therefore, this algorithm shows great potential for further improvement of the CBH retrievals as ground-based MMCR are being increasingly included in global surface meteorological observing networks, and the improved CBH retrievals will contribute to better cloud radiative effect estimates.

关键词： cloud base height passive radiometer ground-based cloud radar remote sensing

A near-complete cucumber reference genome assembly and Cucumber-DB,a multi-omics database

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Molecular Plant 2024年第8期17卷 1178-1182页

作者： Jiantao Guan Han Miao Zhonghua zhang Shaoyun Dong Qi Zhoul Xiaoping Liu Diane M.Beckles Xingfang Gul Sanwen Huang Shengping zhang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina Engineering Laboratory of Genetic Improvement of Horticultural Crops of Shandong Province College of HorticultureQingdao Agricultural UniversityQingdao266109China Department of Plant Sciences University of CaliforniaDavisOne Shield AvenueDavisCA95616USA

Dear Editor,Cucumber(Cucumis sativus)is a key vegetable crop and an essential model for genetics and genomics research in Cucurbitaceae,especially in studies on plant sex determination and vascular *** the first sequenced genome among vegetable crops,the cucumber reference genome has been a crucial genetic resource for comparative genomics and genetic ***,the latest version of the cucumber *** Long reference genome(CLv3.0),generated using PacBio long-reads data,is *** a predicted genome size of 350-367 Mb,CLv3.0 encompasses only 226.2 Mb,leaving 72 gaps and over 120 Mb of unknown *** low assembly completeness(approximately 62%)is primarily due to the high proportion(~30%)of heterochromatic satellite and rDNA sequences in cucumber,substantially higher than that observed in many other species such as Arabidopsis,rice,maize,and watermelon,where it is less than 5%(Han et al.,2008;Huang et al.,2009;Li et al.,2019).

关键词： crops incomplete cucumber

TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

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Oncology Research 2024年第2期32卷 373-391页

作者： JIANFA WU QIANYI LIAO LI zhang SUQIN WU ZHOU LIU Department of Gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Gynecology Shanghai University of Medicine&Health SciencesShanghaiChina Department of Gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of different iron metabolism processes(DIMP)on ovarian cancer remains *** this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian *** was used to determine mutations in DIMP-associated genes in ovarian ***-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian *** analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation *** to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian ***,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was *** addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free ***,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited aft

关键词： Chemoresistance Cisplatin Iron Ovarian neoplasms TGF-β

A Noise-Resistant Superpixel Segmentation Algorithm for Hyperspectral Images

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Computers, Materials & Continua 2019年第5期59卷 509-515页

作者： Peng Fu Qianqian Xu Jieyu zhang leilei Geng School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing210094China School of Information Technologies The University of SydneySydneyNSW2006Australia School of Science China Pharmaceutical UniversityNanjing211198China Institute of Computer Science and Technology Shandong University of Finance and EconomicsJinan250014China

The superpixel segmentation has been widely applied in many computer vision and image process *** recent years,amount of superpixel segmentation algorithms have been ***,most of the current algorithms are designed for natural images with little noise *** order to apply the superpixel algorithms to hyperspectral images which are always seriously polluted by noise,we propose a noiseresistant superpixel segmentation(NRSS)algorithm in this *** the proposed NRSS,the spectral signatures are first transformed into frequency domain to enhance the noise robustness;then the two widely spectral similarity measures-spectral angle mapper(SAM)and spectral information divergence(SID)are combined to enhance the discriminability of the spectral similarity;finally,the superpixels are generated with the proposed frequency-based spectral *** qualitative and quantitative experimental results demonstrate the effectiveness of the proposed superpixel segmentation algorithm when dealing with hyperspectral images with various noise ***,the proposed NRSS is compared with the most widely used superpixel segmentation algorithm-simple linear iterative clustering(SLIC),where the comparison results prove the superiority of the proposed superpixel segmentation algorithm.

关键词： Superpixel segmentation hyperspectral images fourier transformation spectral similarity random noise

Automated and miniaturized screening of antibiotic combinations via robotic-printed combinatorial droplet platform

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1801-1813页

作者： Fangchi Shao Hui Li Kuangwen Hsieh Pengfei zhang Sixuan Li Tza-Huei Wang Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Department of Mechanical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA

Antimicrobial resistance(AMR)has become a global health crisis in need of novel *** this end,antibiotic combination therapies,which combine multiple antibiotics for treatment,have at-tracted significant attention as a potential approach for combating *** facilitate advances in anti-biotic combination therapies,most notably in investigating antibiotic interactions and identifying synergistic antibiotic combinations however,there remains a need for automated high-throughput plat-forms that can create and examine antibiotic combinations on-demand,at scale,and with minimal reagent *** address these challenges,we have developed a Robotic-Printed Combinatorial Droplet(RoboDrop)platform by integrating a programmable droplet microfuidic device that generates antibiotic combinations in nanoliter droplets in automation,a robotic arm that arranges the droplets in an array,and a camera that images the array of thousands of droplets in *** further implement a resazurin-based bacterial viability assay to accelerate our antibiotic combination *** a demonstration,we use RoboDrop to corroborate two pairs of antibiotics with known interactions and subsequently identify a new synergistic combination of cefsulodin,penicillin,and oxacillin against a model *** *** therefore envision RoboDrop becoming a useful tool to efficiently identify new synergistic antibiotic combinations toward combating AMR.

关键词： Droplet microfluidics Antimicrobial resistance Antibiotic combinatorial screening Contact printing Robotics Pharmaceutical analysis High-throughput Antibiotic interactions

Deletion of heterogeneous nuclear ribonucleoprotein K in satellite cells leads to inhibited skeletal muscle regeneration in mice

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Genes & Diseases 2024年第4期11卷 102-105页

作者： Yongjie Xu Haixia Xu Xiaofang Cheng Nuo Chen Yaling Wang Yueru Huang Jiahua Guo Yueqian Zheng Mengjia zhang Chuunyu Du Cunzhen Zhao Cencen Li Pengpeng zhang College of Life Science Xinyang Normal UniversityXinyangHenan 464000China Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain Xinyang Normal UniversityXinyangHenan 464000China

Heterogeneous nuclear ribonucleoprotein K(hnRNPK)is a predominantly nuclear RNA-binding protein that can bind to DNA or RNA through three KH domains and interact with multiple proteins by interactive *** binding activities enable hnRNPK to link the function in a wide array of diverse cellular processes,such as chromatin remodeling,gene transcription,RNA metabolism,protein translation,DNA repair,and cell signal transduction,thereby playing crucial roles in many biological processes,including development,axonal regeneration,spermatogenesis,cell cycle,apoptosis,differentiation,and carcinogenesis.

关键词： inhibited metabolism carcinogenesis