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Towards full-spectrum photocatalysis： Achieving a Z-scheme between Ag2S and TiO2 by engineering energy band alignment with interfacial Ag

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Nano Research 2015年第11期8卷 3621-3629页

作者： Yanrui Li leilei Li Yunqi gong Song Bai Huanxin Ju Chengming Wang Qian Xu Junfa Zhu Jun Jiang Yujie Xiong Hefei National Laboratory for Physical Sciences at the Microscale iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) School of Chemistry and Materials Science and National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026 China

A Z-scheme is a promising approach to achieve broad-spectrum photocatalysis. Integration of TiO2 with another semiconductor with a band gap of -1.0 eV would be ideal to harvest both ultraviolet and visible-near infrared light for photocatalysis; however, most narrow-bandgap semiconductors have straddling band structure alignments with TiO2, constituting an obstacle to forming the Z-scheme for photocatalytic hydrogen production. In this communication, we demonstrate Ag2S as a model system where the energy band upshift of the narrow-bandgap semiconductor that shares an interface with a metal can overcome this limitation. To fabricate the design, we developed a unique approach to synthesize Ag2S-Ag-TiO2 hybrid structures. The obtained ternary hybrid structures exhibited dramatically enhanced performance in photocatalytic hydrogen pro- duction under full-spectrum light illumination. The activities were significantly higher than the sum of those of Ag2S-Ag-TiO2 structures under λ〈 400 nm and λ 〉 400 nm irradiation as well as those of their counterparts under any light illumination conditions.

关键词： photocatalysis Z-scheme semiconductor band structure water splitting

miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3

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Neuroscience Bulletin 2021年第4期37卷 569-574页

作者： Lili Zhao leilei gong Ping Li Jing Qin Lingchi Xu Qiyao Wei Huimin Xie Susu Mao Bin Yu Xiaosong Gu Songlin Zhou Model Animal Research Center and Ministry of Education Key Laboratory of Animal Models of Disease Nanjing UniversityNanjing210000China Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantong226001China Pathological Anatomy Department Medical CollegeNantong UniversityNantong226001China School of Life Sciences East China Normal UniversityShanghai200241China Medical College Nantong UniversityNantong226001China

Dear Editor,The peripheral nervous system(PNS)regenerates more easily after injury than the central nervous system(CNS)[1].Sensory neurons in the L4–L6 dorsal root ganglia(DRGs)extend axons to form the sciatic nerve ... 详细信息

关键词： Regeneration exceptional injury

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The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury

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Neural Regeneration Research 2014年第24期9卷 2151-2158页

作者： leilei gong Yun Zhu Xi Xu Huaiqin Li Weimin Guo Qin Zhao Dengbing Yao Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of Neuroregeneration Key Laboratory of People’s Liberation Army Institute of Orthopedics Chinese PLA General Hospital School of Life Sciences Nantong University

Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration （0-4 days） in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt anal ERK1/2 patl^ways, l^urther studies reve^ed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration.

关键词： nerve regeneration peripheral nerve injury Wallerian degeneration sciatic nerve injury Claudin 14 rat Schwann cell Signal pathways c-Jun Akt ERK1/2 NSFC grant neural regeneration

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Spatiotemporal Dynamics of the Molecular Expression Pattern

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Neuroscience Bulletin 2023年第2期39卷 213-244页

作者： leilei gong Yun Gu Xiaoxiao Han Chengcheng Luan Chang Liu Xinghui Wang Yufeng Sun Mengru Zheng Mengya Fang Shuhai Yang Lai Xu Hualin Sun Bin Yu Xiaosong Gu Songlin Zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantong 226001China

Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits or promotes *** technological advances in spatial transcriptomics(ST)provide a unique opportunity to decipher most genes systematically throughout scar formation,which remains poorly ***,we frst constructed the tissue-wide gene expression patterns of mouse spinal cords over the course of scar formation using ST after spinal cord injury from 32 ***,we profled gene expression gradients from the leading edge to the core of the scar areas to further understand the scar microenvironment,such as neurotransmitter disorders,activation of the pro-infammatory response,neurotoxic saturated lipids,angiogenesis,obstructed axon extension,and extracellular structure *** addition,we described 21 cell transcriptional states during scar formation and delineated the origins,functional diversity,and possible trajectories of subpopulations of fbroblasts,glia,and immune ***,we found some regulators in special cell types,such as Thbs1 and Col1a2 in macrophages,CD36 and Postn in fbroblasts,Plxnb2 and Nxpe3 in microglia,Clu in astrocytes,and CD74 in ***,salvianolic acid B,a blood–brain barrier permeation and CD36 inhibitor,was administered after surgery and found to remedy ***,we described the extent of the scar boundary and profled the bidirectional ligand-receptor interactions at the neighboring cluster boundary,contributing to maintain scar architecture during gliosis and fbrosis,and found that GPR37L1_PSAP,and GPR37_PSAP were the most signifcant gene-pairs among microglia,fbroblasts,and ***,we quantifed the fraction of scar-resident cells and proposed four possible phases of scar formation:macrophage infltration,proliferation and diferentiation of scar-resident cells,scar emergence

关键词： Spinal cord injury Glial scar Spatial transcriptomics Microenvironment Therapeutic strategy Salvianolic acid

Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord

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Engineering 2021年第11期7卷 1592-1602页

作者： Jian Yang Lili Zhao Sheng Yi Fei Ding Yumin Yang Yan Liu Yongjun Wang Mei Liu Chengbin Xue Lian Xu leilei gong Xinghui Wang Yu Zhang Bin Yu Guo-li Ming Xiaosong Gu Department of Human Anatomy and Histology and Embryology Medical CollegeSoochow UniversitySuzhou 215123China Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and the Ministry of EducationCo-Innovation Center of NeuroregenerationNantong UniversityNantong 226001China Department of Neuroscience Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals,especially in terms of their relationships with vital biological processes such as ***,using a large-scale temporal transcriptomic analysis of rat spinal cord from the embryonic stage to adulthood,we show that fluctuating RNA expression levels reflect highly active transcriptional regulation,which may initiate spinal cord *** also demonstrate that microRNAs(miRNAs)and transcriptional factors exhibit a mosaic profile based on their expression patterns,while differential alternative splicing events reveal that alternative splicing may be a driving force for the development of the node of *** study also supports the existence of a negative correlation between innate immunity and intrinsic growth *** modifications appear to perform their respective regulatory functions at different stages of development,while guanine nucleotidebinding protein(G protein)-coupled receptors(including olfactory receptors(ORs))may perform pleiotropic roles in axonal *** study provides a valuable resource for investigating spinal cord development and complements the increasing number of single-cell *** findings also provide a genetic basis for the development of novel tissue engineering strategies.

关键词： Development Gene expression pattern Innate immunity Spinal cord Transcriptome

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Achyranthes bidentata polypeptide k attenuates neuroinflammation by inhibiting PI3K/Akt pathway and promoting Nrf2 translocation in BV-2 microglia

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Achyranthes bidentata polypeptide k attenuates neuroinflamma...

Regulation of mitochondrial biogenesis by pyrroloquinoline quinone in Parkinson’s disease models

中国解剖学会2021年年会

作者： Cheng Qiong Ge Xiangyu Wang Yitong Zhao Yahong gong leilei Ding Fei Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong University

Activated microglia play a critical role in regulating neuroinflammatory responses in central nervous *** studies have shown that Achyranthes bidentata pelypeptide k’s (ABPPk’s) neuroprotective effects are partly du...

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Regulation of mitochondrial biogenesis by pyrroloquinoline q...

Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect

中国解剖学会2019年年会

作者： Qi Zhang leilei gong Jinli Lu Juan Chen Hui Guo Fei Ding Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education

＜正＞A mouse model of Parkinson’s disease （PD） was established by intraperitoneal injection of rotenone to study the protective effect of pyrroloquinoline quinone （PQQ） and the regulation of mitochondrial biogenesis in *** was injected into ICR mice for 21 days consecutively by intraperitoneal injection to induce the PD *** mice were divided

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Bioactive Materials 2024年第3期33卷 572-590页

作者： Chengbin Xue Hui Zhu Hongkui Wang Yaxian Wang Xi Xu Songlin Zhou Dong Liu Yahong Zhao Tianmei Qian Qi Guo Jin He Kairong Zhang Yun Gu leilei gong Jian Yang Sheng Yi Bin Yu Yongjun Wang Yan Liu Yumin Yang Fei Ding Xiaosong Gu Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Research Center of Clinical MedicineAffiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNantong UniversityNantongJS226001PR China Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJS226001PR China Department of Hand Surgery China-Japan Union HospitalJilin UniversityChangchunPR China Medical School of Nantong University NantongJS226001PR China

A central question in neural tissue engineering is how the tissue-engineered nerve(TEN)translates detailed transcriptional signals associated with peripheral nerve regeneration into meaningful biological ***,we report a skin-derived precursor-induced Schwann cell(SKP-SC)-mediated chitosan/silk fibroin-fabricated tissue-engineered nerve graft(SKP-SCs-TEN)that can promote sciatic nerve regeneration and functional restoration nearly to the levels achieved by autologous nerve grafts according to behavioral,histological,and electrophysiological *** achieving better effect of neuroregeneration,this is the first time to jointly apply a dynamic perfusion bioreactor and the ascorbic acid to stimulate the SKP-SCs secretion of extracellular matrix(ECM).To overcome the limitation of traditional tissue-engineered nerve grafts,jointly utilizing SKP-SCs and their ECM components were motivated by the thought of prolongating the effect of support cells and their bioactive cues that promote peripheral nerve *** further explore the regulatory model of gene expression and the related molecular mechanisms involved in tissue engineering-aided peripheral nerve regeneration,we performed a cDNA microarray analysis of gene expression profiling,a comprehensive bioinformatics analysis and a validation study on the grafted segments and dorsal root ganglia tissues.A wealth of transcriptomic and bioinformatics data has revealed complex molecular networks and orchestrated functional regulation that may be responsible for the effects of SKP-SCs-TEN on promoting peripheral nerve *** work provides new insights into transcriptomic features and patterns of molecular regulation in nerve functional recovery aided by SKP-SCs-TEN that sheds light on the broader possibilities for novel repair strategies of peripheral nerve injury.

关键词： SKP-SCs-TEN Transcriptomic feature Reconstruction of regenerative microenvironment Molecular regulation Molecular regenerative-medicine

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浅析扬·凡·艾克油画色彩及技法研究

流行色 2021年第9期 92-93页

作者：宫磊磊南京师范大学泰州学院

色彩是油画最重要的表现形式之一,色彩的运用也是使油画发扬光大的因素之一。尼德兰画家扬·凡·艾克对于油画有着重要的贡献,其使用了干性油作为绘画媒介,促使了油画的发展,本文将详细阐述扬·凡·艾克油画技法的产生及探究色彩在油画... 详细信息

色彩是油画最重要的表现形式之一,色彩的运用也是使油画发扬光大的因素之一。尼德兰画家扬·凡·艾克对于油画有着重要的贡献,其使用了干性油作为绘画媒介,促使了油画的发展,本文将详细阐述扬·凡·艾克油画技法的产生及探究色彩在油画中的运用。

关键词：色彩油画技法