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A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns

Burns & Trauma 2021年第1期9卷 652-677页

作者： Morgan Carlton Joanne Voisey Tony J.Parker Chamindie Punyadeera leila cuttle Queensland University of Technology(QUT) Centre for Children’s Burn and Trauma ResearchCentre for Children’s Health ResearchSouth BrisbaneQueenslandAustralia Queensland University of Technology(QUT) Faculty of HealthSchool of Biomedical SciencesBrisbaneQueenslandAustralia Queensland University of Technology(QUT) Faculty of HealthSchool of Biomedical SciencesSaliva and Liquid Biopsy Translational LaboratoryBrisbaneQueenslandAustralia

Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric *** objective of this review is to summarize the evidence supporting the use of biomarkers in children with *** extensive review of the literature was performed using PubMed.A total of 59 biomarkers were identified relating to burn presence,specifically relating to processes involved in inflammation,wound healing,growth and *** addition,biomarkers involved in the stress response cascade following a burn trauma were also *** many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma,an understanding of burn biology is still lacking in *** propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers,examine the biological interactions of different biomarkers,utilize child-appropriate biological fluids such as urine or saliva,and include a range of different severity *** further research,the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed,for the improvement of healing outcomes in paediatric burn patients.

关键词： Paediatric burns Biomarker Inflammatory Hypothalamic-pituitary-adrenal axis Physical trauma Psychological trauma

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