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Recent advances in the identification and the study of composition and activities of medicinal plants

Journal of Coastal Life Medicine 2016年第12期4卷 983-999页

作者： Fatiha Brahmi Sabiha Achat Naima Guendouze-Bouchefa leila benazzouz-smail Mahmoud Fahmi Elsebai Khodir Madani 3BS Laboratory Faculty of Natural Sciences and LifeUniversity of BejaiaBejaia 06000Algeria Department of Pharmacognosy Faculty of PharmacyMansoura UniversityMansouraEgypt

Medicinal and aromatic plants are the foremost source of life economy drugs for the majority of the world’s *** plant metabolites are essential for life as drugs,fragrances,pigments and food *** study of plants is an inevitable step in the ethnopharmacological approach and it is the reference system since it allows sitting scientifically research that follows from of these new ***,the purpose of many scientists is to advance a new approach useful for identifying plants within a folk pharmacopoeia which deserve the increased research attention of phytochemists and *** the objective to study medicinal plants,usually we start by extraction of the bioactive compounds,which is an essential ***,new important extraction processes were elaborated to recover bioactive constituants from herbal plants by augmenting the yield at inferior *** approachs and methods used in isolation and characterization of active compounds from herbal preparations are also given according to their important ***,in the present work,an update on some biological activities properties of medicinal plants is reviewed.

关键词： Medicinal plants Botanical identification Extraction Analysis methods Biological activities

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Impact of glucotoxicity induced in vivoand in vitroin Psammomys obesus

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Journal of Diabetes Mellitus 2012年第1期2卷 59-71页

作者： Berdja Sihem smail leila Othmani Kheira Neggazi Samia Hamlat Nadjiba Boumaza Saliha Sahraoui Abdelhamid Kacimi Ghouti Haffaf El Mahdi Benazzoug Yasmina Aouichat Bouguerra Souhila Laboratory of Cellular and Molécular Physiopathology Institute of Natural Sciences University of Technological Sciences Houari Boumediene Algiers Algeria

Objective: Chronic hyperglycemia characteristic of type diabetes 2 is responsible for the accelerated atherosclerosis with increased cardiovascular risk. In this study, we will propose to analyze the effect of a long-term of glucotoxicity in vivo in Psammomys obesus by addition of sucrose to 30% for 11 months and in vitro study of adventitial fibroblasts in the presence of D-glucose 0.6% for 7 days. Materials and methods: Evaluation of plasma biochemical parameters was carried out at the initial time and at the end of experiment. At autopsy, a morphological study of the aorta was performed after fixation in aqueous Bouin and staining with Masson’s trichrome. The experimental glucotoxicity is induced by incubation of fibroblasts in DMEM enriched with D-glucose at 0.6% for 7 days. The impact of glucotoxicity is assessed in the intracellular compartments through dosage of total nitrite and malondialdehyde, a product of lipid peroxidation, and thanks to a morphological assay after fixation of cells with aqueous bouin and blood staining with May Grünwald Giemsa. The evaluation of cell proliferation is accomplished by cell counting. Collagens I and III of the extracellular compartment are characterized by SDS-PAGE. Results: Animals subjected to sucrose showed hyperglycemia associated with hyperinsulinemia, dyslipidemia, hyperproteinemia, increased CPK and VLDL-LDL and decreased HDL. Histology of aortas revealed endothelial cells hypertrophy, severe disorganization of intima and media. In the presence of glucose, the proliferation of fibroblasts increases very significantly (P = 2.34 × 10-5), the rate of malonaldehyde, nitrite and total density of chains α2 (I) and α1 (I + III) extra-cellular collagens I and III increased significantly. After staining, the cells showed hypertrophy, vacuolation of cytoplasm and chromatin condensation with nuclear fragmentation, indicative of apoptosis. Conclusion: The glucotoxicity induced in vivo and in vitro is responsible for major struc

关键词： Psammomys Obesus Aorta Adventitial Fibroblasts in Culture DT2 Glucotoxicity Extracellular Matrix Oxidative Stress

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