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Primary Synovial Sarcoma of the Kidney: A Case Report

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Journal of Cancer Therapy 2021年第10期12卷 579-584页

作者： Nouha Ammar Imene Chabchoub Rihab ben Jaafar Hiba Sboui Makram Hochlef Faten Ezzaairi Sami Sfar Imtinane Belaid leila ben fatma Manel Njim Nadia Bouzid Mohsen Belguith Rzig Ahmed Zakhama Abdelfateh Slim ben Ahmed Medical Onocology Department University Hospital Farhat Hached Sousse Tunisia Pediatric Surgery Department University Hospital Fatouma Bourguiba Monastir Tunisia Anathomopathology Department University Hospital Fatouma Bourguiba Monastir Tunisia Radiotherapy Department University Hospital Farhat Hached Sousse Tunisia Radiology Department University Hospital Fatouma Bourguiba Monastir Tunisia

Synovial sarcoma originating from the kidney is extremely rare. A 13-year-old girl presented with a mild left flank pain of one-week duration, with no associated history of hematuria or any other systemic symptoms. Computed tomography (CT) demonstrated a 6 × 13 × 9 cm mass in the left kidney. No soft tissue or extrarenal masses were identified. The patient received a combined of treatment with doxorubicin and ifosfamide. A radical nephrectomy was performed in the left kidney with no complications. Postoperative pathology revealed post-chemotherapy residue of monophasic spindle cell synovialosarcoma of the left kidney. She received a combined treatment with doxorubicin and ifosfamide in concomittance with external radiation therapy. The patient was re-examined 4 months after surgery. An abdominal and pulmonary CT found no recurrence or metastasis.

关键词： Synovial Sarcoma Kidney

Epidemiological and histopathological characteristics of thyroid carcinoma in a Tunisian health care center

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 37-42页

作者： Maissa ben Thayer fatma Khanchel Imen Helal Dorra Chiboub Hedhli Raoueh Ehsen ben Brahim Raja Jouini Aschraf Chadli-Debbiche Faculty of Medicine of Tunis Tunis El Manar UniversityTunisTunisia Depatment of Pathology Habib Thameur's HospitalTunisTunisia Department of Otorhinolaryngology-Head and Neck surgery Habib Thameur's HospitalTunisTunisia

Background:Thyroid carcinoma(TC)accounts for almost 0.5%–1%of total *** incidence is increasing rapidly *** studies have drawn up the epidemiological profile of TC and its clinical and pathological ***,to date,no similar studies have been conducted in ***:To establish an epidemiological profile of TC in a Tunisian health care institute and to analyze its clinical and histopathological characteristics in our *** and Methods:We present a retrospective study reviewing the cases of TC diagnosed in our institution in a 4-year ***:We collected a sample of 192 cases of *** consisted of 31 males and 161 females(83.8%)with a sex-ratio M/F of *** mean age was 46.4 *** thyroid carcinoma was the most frequent histological *** multifocality rate was 33.8%.The mean size of TC was 2.2±1.9 cm.60.9%of TC were staged pT1 and 20.3%had nodal *** thyroid microcarcinomas were noted in 37.5%of ***:Our results were consistent with those of the literature.A high proportion of pT1 and pN0 tumors were noted in our series,suggesting that TC's diagnosis and management was performed at an early stage of the disease in our *** addition,our study enabled us to notice the impact of the Coronavirus disease 19 crisis on the management of TC in our *** studies are needed to establish the epidemiological profile of TC in Tunisia and to assess its clinical and pathological features.

关键词： coronavirus disease 19 epidemiology papillary thyroid carcinoma papillary thyroid microcarcinoma pathology thyroid carcinoma

Sperm quality improvement after date seed oil in Vitro supplementation in spontaneous and induced oxidative stress

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Asian Journal of Andrology 2009年第3期11卷 393-398页

作者： ben A. fatma Chakroun F. Nozha Dammak Ines Attia Hamadi Hentati Basma Ammar K. leila Human Pathologies and Oxidative Stress Unit Superior Institute of Biotechnology of Sfax Sfax 3028 Tunisia Laboratory of Histology Embryology and Reproductive Biology Medicine Faculty of Sfax Sfax 3028 Tunisia

In vitro supplementation with date seed oil （DSO） can protect spermatozoa against hydrogen peroxide （HiO2）- mediated damage and can improve sperm function, possibly owing to antioxidant properties. We tested the antioxidant effects of DSO on human sperm motility, sperm viability, reacted acrosome and lipid peroxidation assessed in vitro after H202-mediated oxidative damage in spermatozoa. Sixteen patients （mean age： 35 years; range： 25-45 years） referred to the Histology-Embryology Laboratory of the Medicine Faculty of Sfax for semen analysis after 12-24 months of sexual intercourse without conception were selected. After spermiogram, sperm selection by twointerface discontinuous Sill Select gradient was performed, and selected spermatozoa were used in four experimental assays： control; incubation with 100um H2O2; incubation with 0.1% DSO; and co-incubation with 0.1% DSO and 100 um H2O2. Motility and viability were determined using World Health Organization criteria. Acrosome reaction and lipid peroxidation were assessed by staining with fluorescein isothiocyanate-Pisum sativum and spectrophotometric measurement of malondialdehyde, respectively. Results showed that incubation with H2O2 alone led to a significant increase in lipid peroxidation （57.83%, P 〈 0.05） associated with a significant decrease in sperm motility, sperm viability （after 30 min and 24 h） and percentage of reacted acrosome （P 〈 0.05）. Date seed oil im- proved sperm motility after 24 h of incubation （P 〈 0.05） and protected spermatozoa against the deleterious effects of H2O2 on motility, viability, acrosome reaction and lipid peroxidation. We conclude that supplementation with DSO may have a function in antioxidant protection against male infertility.

关键词： acrosome reaction date seed oil in vitro lipid peroxidation sperm motility sperm viability

Interactions of zinc and cadmium toxicity in their effects on growth and in antioxidative systems in tomato plants (Solanum lycopersicum)

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Journal of Environmental Sciences 2011年第5期23卷 837-844页

作者： Jaouhra Cherif Chamseddine Mediouni Wided ben Ammar fatma Jemal Unit of Research "Nitrogenized Nutrition and Metabolism and Stress Proteins" UR 99/09-20 Department of BiologyFaculty of Science University of Tunis Tunis 2092 Tunisia Unit of Research "Nitrogenized Nutrition and Metabolism and Stress Proteins" UR 99/09-20 Department of BiologyFaculty of ScienceUniversity of Tunis Tunis 2092 Tunisia

The interaction between zinc and cadmium was investigated in tomato plants （Solanum lycopersicum）. Ten-day-old seedlings were treated with 10 μmol/L CdC12 associated to different concentrations of ZnC12 （10, 50, 100, and 150 μmol/L）. Zn supply clearly reduced Cd accumulation in leaves and simultaneously increased Zn concentration. Cd induced oxidative stress in leaves as indicated by an increase in thiobarbituric acid-reactive substances （TBARS） level and chlorophyll breakdown. Furthermore, compared with control, Cd- treated plants had significantly higher activities of superoxide dismutase （SOD, EC 1.***.1.1）, whereas, catalase （CAT, EC 1.***.1.6）, ascorbate peroxidase （APX, EC 1.***.1.11）, and glutathione reductase （GR, EC 1.***.4.2） activities were significantly suppressed by Cd addition. Zn supplementation, at low level, restored and enhanced the functional activity of these enzymes （SOD, CAT, APX and GR） as compared to Cd-alone-treated plants. The beneficial effect of adequate Zn level on Cd toxicity was confirmed by a significant decrease in TBARS level and restoration of chlorophyll content. However, when Zn was added at high level in combination with Cd there was an accumulation of oxidative stress, which was higher than that for Cd or excess Zn alone treatments. These results suggested that higher Zn concentrations and Cd are synergistic in their effect on plant growth parameters and oxidative stress.

关键词： Solanum lycopersicum cadmium zinc oxidative stress antagonism synergism.

Investigation of Extracts from Tunisian Ethnomedicinal Plants as Antioxidants,Cytotoxins,and Antimicrobials

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Biomedical and Environmental Sciences 2017年第11期30卷 811-824页

作者： Guesmi fatma ben Hadj Ahmed Sami Landoulsi Ahmed Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of BizerteUniversity of CarthageZarzouna 7021Tunisia Laboratory of Protein Engineering and Bioactive Molecules(LIP-MB) National Institute of Applied Sciences and Technology(INSA T)BP 6761080 Tunis CedexTunisia

Objective To determine the medicinal potential of various plants and their parts extracted with different solvents. Methods The total phenolic content of acetonitrile/water（60%-40%）（ACN/W） and aqueous（W） extract fractions was determined by high-performance liquid chromatography（HPLC）, and terpenic compounds were detected by gas chromatography/mass spectrometry（GC/MS）. Antioxidant activity of the samples was evaluated using 2,2-diphenyl-1-picrylhydrazyl（DPPH） assay and β-carotene bleaching method. Cell viability was investigated by thiazolyl blue tetrazolium bromide [3-（4,5-dimethylthiazol）-2-yl 2,5-diphenyltetrazolium bromide]（MTT） assay. The mechanisms involved in cytotoxic activity were investigated in a murine macrophage cell line（RAW 264.7） and cancer lines. Results Our findings show that 11 plant species exhibited biological activity. In addition, moderate antibacterial activity was reported against one or more of the tested bacterial strains at two concentrations： 300 μg and 3 mg/disc. Furthermore, our data reveal that among all plants investigated, some extract and hydrophobic fractions were potent scavengers of the DPPH radical（6.78 μg/m L 〈 EC50 〈 8.55 μg/mL）. Taken together, our results show that Nerium oleander（NOACN/W） and Pituranthos tortuosus（PTACN/W） were highly cytotoxic against RAW 264.7 cells with IC80 values of 0.36, and 1.55 μg/mL, respectively. In contrast, murine macrophage cell lines had low growth and were significantly sensitive to water extracts of Thymus hirtus sp. algeriensis（THW）, Lavandula multifida（LMW）, and ACN/W extract of Erica multiflora（EMACN/W） at doses 〉 400, 47.20, and 116.74 μg/m L, respectively. The current work demonstrates that RAW 264.7 cell proliferation was inhibited by samples in a dose-dependent manner. Conclusion Our findings, validated through free radical scavenging activity, agar diffusion assay, and cytotoxicity of essential oils towards cancer cells, show that ethnomedicinal plants used in this work have a novel

关键词： Phenolic compounds Cytotoxicity Antioxidant Antibacterial

Efficacy of Essential Trace Elements Supplementation on Mineral Composition,Sperm Characteristics,Antioxidant Status,and Genotoxicity in Testis of Tebuconazole-treated Rats

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Biomedical and Environmental Sciences 2020年第10期33卷 760-770页

作者： Hajer ben SAAD fatma ben ABDALLAH Intidhar BKHAIRIA Ons BOUDAWARA Moncef NASRI Ahmed HAKIM Ibtissem ben AMARA Laboratory of Enzyme engineering and Microbiology National Engineering School in SfaxUniversity of SfaxB.P.11733038 SfaxTunisia Laboratory of Human Molecular Genetics Faculty of Medicine ofSfaxUniversity of SfaxTunisia Laboratory of Anatomopathology CHU Habib BourguibaUniversity of Sfax3029 SfaxTunisia Laboratory of Pharmacology Faculty of Medicine3029 SfaxUniversity of SfaxTunisia

Objective This research was performed to evaluate the effect of tebuconazole(TBZ)on reproductive organs of male rats and to assess the protective role of combined essential trace elements in alleviating the detrimental effect of TBZ on male reproductive *** For this purpose,48 rats were exposed to 100 mg/kg TBZ,TBZ supplemented with zinc(Zn),selenium(Se),copper(Cu),and iron(Fe),TBZ+(Se+Zn);TBZ+Cu;or TBZ+*** experiment was conducted for 30 consecutive *** TBZ caused a significant perturbation in mineral levels and reduction in reproductive organs weights,plasma testosterone level,and testicular antioxidant enzyme *** TBZ-treated group also showed a significant increase in sperm abnormalities(count,motility,and viability percent),plasma follicle-stimulating hormone and luteinizing hormone concentrations,lipid peroxidation,protein oxidation,and severe DNA degradation in comparison with the ***,TBZ caused testis ***,treatment with trace elements,in combination or alone,improved the reproductive organ weights,sperm characteristics,TBZ-induced toxicity,and histopathological modifications in *** TBZ exerts significant harmful effects on male reproductive *** concurrent administration of trace elements reduces testis dysfunction,fertility,and toxicity induced by TBZ.

关键词： Zinc Selenium Iron Copper Testicular toxicity

Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal ben Yahia George Akafity Manar Ezzelarab Ramadan fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis

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Biomedical and Environmental Sciences 2016年第4期29卷 275-285页

作者： fatma Guesmi Hamida Beghalem Amit K Tyagi Manel ben Ali Ramla ben Mouhoub Houda Bellamine Ahmed Landoulsi Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Cytokine Research Laboratory Department of Experimental Therapeutics The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Laboratory of Biomonitoring of the Environment (LRO1/ES14) Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Service of Anatomo-Pathology of Menzel Bourguiba Bizerte 7050 Tunisia

Objective We evaluate the effects of Thymus algeriensis （TEO） against hydrogen peroxide （H202） toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats. Methods Rats were treated with low （LD） and high dose （HD） of H202 （0.1 and 1 mmol/L） in the presence or absence of TEO （150 mg/kg）. Results The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease （P〈0.05）, sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H202 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase （P〈0.05） in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations. Conclusion H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats.

关键词： Testis Hydrogen peroxide TEO Antioxidants Infertility

Physiological, histopathological and cellular immune effects of Pergularia tomentosa extract on Locusta migratoria nymphs

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Journal of Integrative Agriculture 2019年第12期18卷 2823-2834页

作者： Meriam Miladi Khemais Abdellaoui Amel ben Hamouda Iteb Boughattas Mouna Mhafdhi fatma Acheuk Monia ben Halima-Kamel Higher Agronomic Institute of Chott Mariem Sousse UniversityChott Mariem 4042Tunisia General Directorate of Plant Health and Agricultural Inputs Control Ministry of AgricultureTunis 1002Tunisia Laboratory of Valorization and Conservation of Biological Resources Department of BiologyFaculty of SciencesUniversity of BoumerdesBoumerdes 35000Algeria

The migratory locust Locusta migratoria(Orthoptera,Acrididae)is one of the most important pests due to its extensive and severe damage to crops in large parts of Africa and *** and ecologically natural products such as bota nical insecticides are emergi ng can didates for replaceme nt of usually applied chemical *** crude methanolic extract of Pergularia tomentosa(PME)was investigated for their toxicity and physiological aspects on *** *** showed that treatment of newly emerged fourth and fifth instar nymphs resulted in significant mortality and significant repellent activity with an LC50 value of 0.18 and 0.38%,respectively,after seven days of *** PME toxicity was also dem on strated by histopathological cha nges in the alime ntary canal resulting in con siderable disorganization and severe damage of the caeca and proventriculus *** extract induced cellular immune reactions which manifested by a significant decrease in the number of the differential haemocyte counts(prohemocytes and plasmatocytes)and important cell *** of biochemical analyses showed that the PME reduced the activity of acetylcholinesterase and induced the glutathione *** neurotoxic effect was confirmed by the histological alterations in the brain structure,particularly in the neurosecretory cells showing typical signs of cell necrosis.

关键词： Locusta migratoria Pergularia tomentosa toxicity histopathology haemocytes enzymes