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Novel Solid State Nitric Oxide Sensor Using Siloxane-Poly(Oxypropylene)(PPO)

Materials Sciences and Applications 2013年第11期4卷 683-688页

作者： Rondinelli D.Herculano Carlos A.Brunello Jair P.Melo Jr Mayler Martins Felipe ABorges leila a.chiavacci Carlos F.O.Graeff Departamento de Ciências Biológicas Faculdade de Ciencias e Letras de AssisUniversidade Estadual Paulista“Júlio de Mesquita Filho”AssisBrazil Departamento de Física Faculdade de FilosofiaCiências e Letras de Ribeirao PretoUniversidade de Sao PauloRibeirão PretoBrazil Departamento de Física Faculdade de CiênciasUniversidade Estadual Paulista“Júlio de Mesquita Filho”BauruBrazil Departamento de Fármacos e Medicamentos Faculdade de Ciências FarmacêuticasUniversidade Estadual Paulista“Júlio de Mesquita Filho”AraraquaraBrazil

In this paper, a novel solid state Nitric Oxide (NO) sensor made of a spin trap (iron(II)-diethyldithiocarbamate complex, FeDETC) encapsulated in a siloxane-poly(oxypropylene) (PPO) matrix was developed. Nitric oxide (NO), a free radical molecule, has numerous roles in various physiological functions, such as the regulation of blood pressure, immune response to bacterial infection, and nervous systems. Siloxane-polyether hybrid materials, for example siloxane-poly(oxypropylene) (PPO), are easy to prepare, transparent and flexible. The combination of all these characteristics in a unique material allows it to be used in several scientific and technological areas, including human health. NO radical is trapped in FeDETC, which allows its detection by electron paramagnetic resonance (EPR). FeDETC was added while PPO was a sol, which was then left in air for gelation. The novel sensor was dived directly into a solution of NO, when the NO-FeDETC complex was formed. Our results show that the novel sensor responds to NO, with similar sensitivity as previously published sensors. PPO sensors present a strong EPR signal and a high stability, keeping its signal for 45 days. We have studied ways to accelerate the NO release from the sensor, in order to study its potential as a drug delivery system. We observed an acceleration in NO release by using a modulated magnetic field of 40 G at 100 kHz;as well as by UV irradiation. Thermal induced NO release was also tested by heating NO-FeDETC PPO up to 50°C, with good results.

关键词： Biomaterials Nitric Oxide PPO Drug Delivery System

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