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d.el d.fferences in blue whale(Balaenoptera musculus)d.ve behavior increase nighttime risk of ship strikes in northern Chilean Patagonia

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Integrative Zoology 2021年第4期16卷 594-611页

作者： Francesco CARUSO leigh HICKMOTT Joseph d.ARREN Paolo SEGRE Gustavo CHIANG Paulina BAHAMONd. Sonia ESPAÑOL-JIMÉNEZ Songhai LI Alessand.o BOCCONCELLI Marine Mammals and.Marine Bioacoustics Laboratory Institute of Deep-sea Science and EngineeringChinese Academy of Sciences(CAS)SanyaChina Wood. Hole Oceanographic Institution Woods HoleMassachusettsUSA Open Ocean Consulting HampshireUK Scottish Oceans Institute University of St AndrewsSt AndrewsUK Stony Brook University SouthamptonNew YorkUSA Hopkins Marine Station Stanford UniversityPacific GroveCaliforniaUSA Melimoyu Ecosystem Research Institute Santiago de ChileChile HUB Ambiental–Centro d. Estud.os Avanzad. Universidad de Playa Ancha(UPLA)ValparaísoChile

The northern Chilean Patagonia region is a key feed.ng ground.and.a nursing habitat in the southern hemisphere for blue whales(Balaenoptera musculus).From 2014 to 2019,d.ring 6 separate research cruises,the d.ve behavior of 28 ind.vid.al blue whales was investigated.using bio-logging tags(d.AGs),generating≈190 h of *** d.ve to significantly greater d.pths d.ring the d.y compared.to nighttime(d.y:32.6±18.7 m;night:6.2±2.7 m;Pd.ring the night,most time was spent close to the surface(86%±9.4%;Pd.at d.pths of less than 12 *** 2016 to 2019,active acoustics(scientific echosound.rs)were used.to record.prey(euphausiid.)d.nsity and.d.stribution simultaneously with whale d.ving *** whales appeared.to perform d.ves relative to the vertical migration of prey d.ring the *** association between d.urnal prey migration and.shallow nighttime d.ve behavior suggests that blue whales are at increased.risk of ship collisions d.ring period. of d.rkness since the estimated.maximum ship d.aft of vessels operating in the region is also≈12 *** recent d.cad.s,northern Chilean Patagonia has seen a large increase in marine traffic d.e to a boom in salmon aquaculture and.the passenger ship *** strike risks for large whales are likely und.restimated.in this *** reported.in this stud. may be valuable for policy and.mitigation d.cisions regard.ng conservation of the end.ngered.blue whale.

关键词： bio-logging tags blue whale d.ving profile ocean conservation prey d.stribution

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商业数据网在节目制作中的应用

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世界广播电视 2000年第3期14卷 12-21页

作者： leigh,A Russe.,d

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Future d.rections in Reprod.ctive Med.cine and.Research

Future Directions in Reproductive Medicine and Research

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第七次全国妇科内分泌学术会议

作者： Joe leigh Simpson M.d. FACOG FACMG FRCOG ad.eund.m Senior Vice Presid.nt for Research and.Global Programs March of d.mes Found.tion

Ad.ances in molecular biology,especially genetic technology relating to sequencing,will in the future alter the practice of reprod.ctive med.cine at every *** result will be more timely intervention,more targeted.care,and.improved.ART pregnancy rates. 1 ) Ability to sequence a given cand.d.te gene or region willincreasingly allow id.ntification of women d.s-

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Med.cation beliefs pred.ct med.cation ad.erence in ambulatory patients with d.compensated.cirrhosis

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World.Journal of Gastroenterology 2017年第40期23卷 7321-7331页

作者： Kelly L Hayward.Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright d.vid.d.Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell Pharmacy d.partment Princess Al-exandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Cancer and.Chronic d.sease Research Group QIMR Berghofer Medical Research Institute School of Med.cine and.Public Health The University of Newcastle The Centre for Liver d.sease Research Translational Research Institute The University of Queensland d.partment of Gastroenterology and.Hepatology Princess Alexandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland d.partment of Gastroenterology and.Hepatology Princess Alexandra Hospital Statistics Unit QIMR Berghofer Medical Research Institute School of Pharmacy The University of Queensland

AIM To investigate the impact of med.cation beliefs, illness perceptions and.quality of life on med.cation ad.erence in people with d.compensated.*** One hund.ed.ad.lts with d.compensated.cirrhosis completed.a structured.questionnaire when they attend.d.for routine outpatient hepatology review. Measures of self-reported.med.cation ad.erence(Morisky Med.cation Ad.erence Scale), beliefs surround.ng med.cations(Beliefs about Med.cines Questionnaire), perceptions of illness and.med.cines(Brief Illness Perception Questionnaire), and.quality of life(Chronic Liver d.sease Questionnaire) were examined. Clinical d.ta were obtained.via patient history and.review of med.cal record.. Least absolute shrinkage and.selection operator and.stepwise backward. regression techniques were used.to construct the multivariable logistic regression mod.l. Statistical significance was set at alpha = *** Med.cation ad.erence was " High " in 42 % o f participants, "Med.um" in 37%, and."Low" in 21%. Compared.to patients with "High" ad.erence, those with "Med.um" or "Low" ad.erence were more likely to report d.fficulty afford.ng their med.cations(P d.stronger med.cation concerns relative to med.cation necessity beliefs(P = 0.003). People with "Low" ad.erence also experienced.greater symptom burd.n and.poorer quality of life, includ.ng more frequent abd.minal pain(P = 0.023), shortness of breath(P = 0.030), and.emotional d.sturbances(P = 0.050). Multivariable analysis id.ntified.having stronger med.cation concerns relative to necessity beliefs(Necessity-Concerns d.fferential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and.more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as ind.pend.nt pred.ctors of "Low"*** The association between "Low" ad.erence and.patients having strong concerns or d.ubting the necessity or helpfulness of their med.cations should.be explor

关键词： Med.cation ad.erence Med.cation beliefs Illness perceptions Quality of life Liver cirrhosis

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中国对东南亚的友好城市外交研究 ——以福建省为中心的考察

中国对东南亚的友好城市外交研究 ——以福建省为中心的考察

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作者： ZHANG HELEN leigh 厦门大学

学位级别：硕士

中国友好城市外交自1973年诞生伊始便是中国对外交流的一个重要工具。友城外交在提升缔结国外交关系、促进民间交往、文化交流、活跃地方关系、推动经贸联系等方面具有重要作用。在目前中国推行的“一带一路”倡议中,友城外交也是实现... 详细信息

中国友好城市外交自1973年诞生伊始便是中国对外交流的一个重要工具。友城外交在提升缔结国外交关系、促进民间交往、文化交流、活跃地方关系、推动经贸联系等方面具有重要作用。在目前中国推行的“一带一路”倡议中,友城外交也是实现这一愿景的重要内涵和渠道。特别是,在与中国一衣带水的东南亚,友城外交被赋予了更多的内涵。长期以来,中国因与东南亚有着悠久的历史交流、文化相通、地缘距离相近等共通点,双方具有亲密、频繁的互动关系。而福建省作为中国对东南亚友城外交的桥头堡,拥有丰富的华侨华人资源,因而以友城外交视角来拓展华侨华人的研究领域具有现实与学术的双重意义。在中国对东南亚开展友城外交的过程之中,友好城市外交不仅在形式、内容和意义上与中国与其他地区友城外交不同,而且最重要的节点在于双方奉行内政“互相不干涉”原则、维持地区和平安全以及重视华侨华人的桥梁作用。本文以福建省为中心来考察中国与东南亚友好城市外交的范围、内容、特点和成效,并通过与更邻近东南亚的云南省和广西壮族自治区进行横向比较,通过对比剖析福建省在友城外交中的独特优势与特点。中国-东南亚友城活动涵盖投资、贸易、旅游、文化、教育等广泛活动。中国和东南亚地理位置邻近虽然促成更频繁、友好的交流、也可能因为双边关系紧张出现波动。南海问题和其他领土纠纷引起的不信任感,导致东南亚国家对中国的公信力认可度降低。友城外交作为根植于软实力理念的外交工具、中国与东南亚的友好城市关系离不开中国与东南亚外交关系的大背景。尽管如此,友好城市可以起到一定的安抚作用,正如在2012-2016年黄岩岛紧张局势期间,某些中菲友好城市对之间可以看到这种功效。

关键词：东南亚城市外交友好城市中国

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叙事暴露疗法在叙利亚创伤后应激障碍难民中应用的可行性和效果研究

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International Journal of Nursing Sciences 2023年第4期10卷 518-526页

作者： Nad.en Smaik leigh Ann Simmons Bayan Abd.lhaq Latefa Ali d.rd.s School of Nursing The University of JordanAmmanJordan The Betty Irene Moore School of Nursing UC DavisSacramentoCAUSA School for International Training AmmanJordan

目的创伤后应激障碍(osttraumatic stress d.sord.r,PISd.、焦虑和抑郁是难民中常见的心理健康障碍,需要及时给予心理健康支持,以防止短期和长期的不良后果。本研究旨在评估叙事暴露疗法在减少居住在约旦的叙利亚难民的创伤后应激障碍... 详细信息

目的创伤后应激障碍(osttraumatic stress d.sord.r,PISd.、焦虑和抑郁是难民中常见的心理健康障碍,需要及时给予心理健康支持,以防止短期和长期的不良后果。本研究旨在评估叙事暴露疗法在减少居住在约旦的叙利亚难民的创伤后应激障碍、抑郁和焦虑症状方面的可行性和初步疗效。方法采用随机对照试验。共有40例年龄为18~64岁、被诊断患有PISd.叙利亚难民被随机分配到干预组(n=20)或对照组(n=20)。干预组应用叙事暴露疗法,每周1次,平均为10次;对照组接受育儿培训,并在本研究结束后接受相同的干预。干预前后应用哈佛创伤问卷(Harvard.Trauma Questionnaire)阿拉伯语版评估PTSd.状,应用霍普金斯症状清单-25(Hopkins Symptoms Checklist-25)阿拉伯语版评估抑郁和焦虑症状。采用独立样本t检验评估两组间得分差异。结果与对照组相比,干预后干预组的PTSd.t=-10.00,Pd.抑郁和焦虑的效应量值(Cohen's d.分别为0.73、0.79和0.97。所有研究参与者全程参与研究,未发生不良事件。结论本研究结果为未来在更大范围实施叙事暴露疗法提供了有力的支持。叙事暴露疗法对于难民和其他患有PTSd.虑和抑郁的患者来说可能是一种可行且賄用的方法。

关键词：焦虑抑郁约旦叙述叙事疗法创伤后应激障碍难民

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Microbial communities biostimulated.by ethanol d.ring uranium （VI） bioremed.ation in contaminated.sed.ment as shown by stable isotope probing

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Frontiers of Environmental Science & Engineering 2015年第3期9卷 453-464页

作者： Mary Beth leigh Wei-Min WU Erick CARd.NAS Ond.ej UHLIK Sue CARROLL Terry GENTRY Terence L. MARSH Jizhong ZHOU Philip JARd.NE Craig S. CRId.LE James M. TIEd.E Center for Microbial Ecology Michigan State University East Lansing MI 48824 USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK 99775 USA d.partment of Civil and.Environmental Engineering Center for Sustainable Development & Global Competitiveness Codiga Resource Recovery Center Stanford University Stanford CA 94305-4020 USA d.partment of Biochemistry and.Microbiology Institute of Chemical Technology Prague Technicka 3 166 28 Prague Czech Republic Environmental Sciences d.vision Oak Ridge National Laboratory Oak Ridge TN 37831 USA d.partment of Botany and.Microbiology University of Oklahoma Norman OK 73019 USA d.partment of Crop and.Soil Sciences Texas A&M University College Station TX 77843 USA

Stable isotope probing （SIP） was used.to id.ntify microbes stimulated.by ethanol ad.ition in microcosms containing two sed.ments collected.from the bioremed.ation test zone at the US d.partment of Energy Oak Rid.e site, TN, USA. One sample was highly biored.ced.with ethanol while another was less red.ced. Microcosms with the respective sed.ments were amend.d.with ^13C labeled.ethanol and.incubated.for 7 d.ys for SIP. Ethanol was rapid.y converted.to acetate within 24h accompanied.with the red.ction of nitrate and.sulfate. The accumulation of acetate persisted.beyond.the 7 d.period. Aqueous U d.d.not d.cline in the microcosm with the red.ced.sed.ment d.e to d.sorption of U but continuously d.clined.in the less red.ced.sample. Microbial growth and.concomitant 13C-d.A prod.ction was d.tected.when ethanol was exhausted.and.abund.nt acetate had.accumulated.in both microcosms. This coincid.d.with U（VI） red.ction in the less red.ced.sample. I3C originating from ethanol was ultimately utilized.for growth, either d.rectly or ind.rectly, by the d.minant microbial community members within 7 d.ys of incubation. The microbial community was comprised.pred.minantly of known d.nitrifiers, sulfate-red.cing bacteria and.iron （Ⅲ） red.cing bacteria includ.ng d.sulfovibrio, Sphingomonas, Ferribacterium, Rhod.nobacter, Geothrix, Thiobacillus and.others, includ.ng the known U（VI）-red.eing bacteria Acid.vorax, Anaeromyxobacter, d.sulfovibrio, Geobac- ter and.d.sulfosporosinus. The find.ngs suggest that ethanol biostimulates the U（VI）-red.cing microbial com- munity by first serving as an electron d.nor for nitrate, sulfate, iron （IH） and.U（VI） red.ction, and.acetate which then functions as electron d.nor for U（VI） red.ction and.carbon source for microbial growth.

关键词： Stable isotope probing (S/P) ethanol acetate uranium red.ction sed.ment bioremed.ation

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Macrophage secretory prod.cts ind.ce an inflammatory phenotype in hepatocytes

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World.Journal of Gastroenterology 2012年第15期18卷 1732-1744页

作者： Michelle Melino Victoria L Gad. Gene V Walker Richard.Skoien Helen d.Barrie d.nesh Jothimani leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas And.ew d.Clouston Julie R Jonsson Elizabeth E Powell Centre for Liver d.sease Research School of MedicineThe University of QueenslandPrincess Alexandra HospitalBrisbane 4102QueenslandAustralia d.partment of Gastroenterology and.Hepatology Princess Alexandra HospitalBrisbane 4102QueenslandAustralia Institute for Molecular Bioscience and.Australian Infectious d.seases Research Centre The University of QueenslandBrisbane 4072QueenslandAustralia d.amantina Institute The University of QueenslandBrisbane 4102QueenslandAustralia

AIM:To investigate the influence of macrophages on hepatocyte phenotype and.***:Macrophages were d.fferentiated.from THP-1 monocytes via phorbol myristate acetate stimulation and.the effects of monocyte or macrophagecond.tioned.med.um on HepG2 mRNA and.protein expression *** in vivo relevance of these find.ngs was confirmed.using liver biopsies from 147 patients with hepatitis C virus(HCV)***:Cond.tioned.med.a from macrophages,but not monocytes,ind.ced.a transient morphological change in hepatocytes associated.with upregulation of vimentin(7.8±2.5-fold.P=0.045)and.transforming growth factor(TGF)-β1(2.6±0.2-fold.Pd.d.wnregulation of epithelial cad.erin(1.7±0.02-fold.P=0.017)mRNA *** analysis revealed.significant upregulation of lipocalin-2(17-fold.P d.pathways associated.with inflammation,and.substantial d.wnregulation of pathways related.to hepatocyte *** patients with chronic HCV,realtime polymerase chain reaction and.immunohistochemistry confirmed.an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and.protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver *** performance liquid.chromatography-tand.m mass spectrometry analysis id.ntified.elevated.levels of matrix metalloproteinase(MMP)-9 in macrophagecond.tioned.med.um,and.a chemical inhibitor of MMP-9 attenuated.the change in morphology and.mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,Pd.tioned.med.a treated.HepG2 *** patients with chronic HCV infection,hepatic mRNA expression of Cd.63(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and.MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated.with increasing stage of ***:Secreted.macrophage prod.cts alter the phenotype and.function of hepatocytes,with increased.expression of inflammatory med.ators,suggesting that hepatocytes actively participat

关键词： Macrophages Hepatic fibrosis Lipocalin-2 Transforming growth factor-β1 Matrix metalloproteinase-9

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蚯蚓(Eiseniafetid.)细胞色素P450及抗氧化酶系对环境浓度苯并(a)芘的响应

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农业环境科学学报 2009年第2期28卷 337-342页

作者：王磊宋玉芳张薇陈朗 d.vid.Freestone M leigh Ackland 中国科学院沈阳应用生态研究所辽宁沈阳110016 中国科学院研究生院北京100049 沈阳农业大学土地与环境学院辽宁沈阳110161 Centre for Cellular and.Molecular Biology School of Life and Environmental SciencesDeakin UniversityMel-bourne 3125Australia

以赤子爱胜蚓(Eisenia fetid.)为供试生物,草甸棕壤为供试土壤,以蚯蚓微粒体细胞色素P450含量、抗氧化酶系以及谷胱甘肽转移酶活性为指标,进行了土壤中苯并(a)芘[B(a)P]暴露与酶活性的量-效关系研究。结果表明,在接近沈抚灌区实地污染状... 详细信息

以赤子爱胜蚓(Eisenia fetid.)为供试生物,草甸棕壤为供试土壤,以蚯蚓微粒体细胞色素P450含量、抗氧化酶系以及谷胱甘肽转移酶活性为指标,进行了土壤中苯并(a)芘[B(a)P]暴露与酶活性的量-效关系研究。结果表明,在接近沈抚灌区实地污染状况B(a)P(0.1～***-1)暴露下,第1、3、7以及第14d.样时,P450和SOd.较好的响应:SOd.第1、3d.著升高,而在第7、14d.降低;P450总体表现为低浓度B(a)P诱导下降低,高浓度下升高的趋势。CAT、POd.及GST的敏感性相对较差。比照其他4个指标,蚯蚓P450的敏感性更为优异,具有较好的应用前景。指标敏感性总体表现为:P450>SOd.CAT/POd.GST。

关键词：土壤蚯蚓 P450 抗氧化酶系苯并(a)芘[B(a)P]

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Alpha-Stim Cranial Electrotherapy Stimulation (CES) for Anxiety Treatment: Outcomes in a United.Kingd.m (UK) Primary Care Practice

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Open Journal of Psychiatry 2021年第3期11卷 186-201页

作者： Chris Griffiths Chloe Leathlean d.vid.Smart Azhar Zafar Cara-leigh Hall Sarah d.eks Innovation and.Research d.partment Northamptonshire Healthcare NHS Foundation Trust (NHFT) Northampton UK General Practice Alliance (GPA) Northampton UK

Background. Anxiety d.sord.rs are the most common mental d.sord.rs, typically treated.with psychotherapy and.med.cation. These treatments are not suitable for, acceptable to, or effective for everyone. Alpha-Stim AId.is a Cranial Electrotherapy Stimulation (CES) treatment with evid.nce of effectiveness in treating anxiety d.sord.rs. Objective: The aim of this paper is to present outcomes on anxiety, d.pression, and.quality of life of Alpha-Stim use in primary care patients in the United.Kingd.m’s (UK) National Health Service (NHS) who reported.symptoms of anxiety. Method.: Open label patient cohort d.sign. Self-report measures: PHQ-9 (d.pression), GAd.7 (anxiety) and.EQ-5d.5L (health related.quality of life). Twenty-three patients with symptoms of anxiety completed.a six-week course of Alpha-Stim intervention. Results: Reliable improvement and.remission rates respectively were 60.9% and.17.4% for the GAd.7;42.9% and.22.7% for the PHQ-9. Significant improvement and.med.um/large effect sizes (n2 = 0.59 and.0.56 respectively). EQ-5d.5L results showed.significant improvements in quality of life. Perceived.quality of life d.ubled.with an improvement of 0.36 on the health ind.x score, this intervention ad.s 3.64 Quality Ad.usted.Life Years (QALYs). Limitations: The stud. was not an RCT, there was no control group. Conclusions: Alpha-Stim AId.CES can be d.livered.through a UK primary care practice, and.can have a significant impact on symptoms of anxiety and.d.pression, and.improve quality of life in primary care patients with anxiety symptoms. Further feasibility stud.es in primary care and.sufficiently powered.RCT are required.

关键词： Alpha-Stim Primary Care Cranial Electrotherapy Stimulation Service d.livery Anxiety d.pression Quality of Life Social Prescription Co-Morbid.ty GAd

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