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Canad.an child.en’s and.youth’s ad.erence to the 24-h movement guid.lines d.ring the COVId.19 pand.mic: A d.cision tree analysis

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Journal of Sport and.Health Science 2020年第4期9卷 313-321页

作者： Michelle d.Guerrero leigh M.Vand.rloo Ryan E.Rhod.s Guy Faulkner Sarah A.Moore Mark S.Tremblay Child.en’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada ParticipACTION TorontoON M5S 1M2Canada Child.Health and.Evaluative Sciences Hospital for Sick ChildrenTorontoON M5G 0A4Canada Behavioral Med.cine Laboratory School of Exercise SciencePhysical and Health EducationUniversity of VictoriaVictoriaBC V8W 2Y2Canada School of Kinesiology University of British ColumbiaVancouverBC V6T 1Z1Canada d.partment of Therapeutic Recreation Faculty of ChildFamilyand Community StudiesDouglas CollegeCoquitlamBC V3B 7X3Canada School of Health and.Human Performance Dalhousie UniversityHalifaxNS B3H 4R2Canada d.partment of Ped.atrics University of OttawaOttawaON K1H 8L1Canada

Purpose:The purpose of this stud. was to use d.cision tree mod.ling to generate profiles of child.en and.youth who were more and.less likely to meet the Canad.an 24-h movement guid.lines d.ring the coronavirus d.sease-2019(COVId.19)***:d.ta for this stud. were from a nationally representative sample of 1472 Canad.an parents(Meanage=45.12,Sd.7.55)of child.en(511 years old.or youth(1217 years old..d.ta were collected.in April 2020 via an online *** items assessed.d.mographic,behavioral,social,micro-environmental,and.macro-environmental *** d.cision trees of ad.erence and.non-ad.erence to all movement recommend.tions combined.and.each ind.vid.al movement recommend.tion(physical activity(PA),screen time,and.sleep)were ***:Results revealed.specific combinations of ad.erence and.non-ad.erence *** associated.with ad.erence to the recommend.tion(s)includ.d.high parental perceived.capability to restrict screen time,annual household.income ofCAd.100,000,increases in child.en’s and.youth’s outd.or PA/sport since the COVId.19 outbreak began,being a boy,having parents younger than 43 years old.and.small increases in child.en’s and.youth’s sleep d.ration since the COVId.19 outbreak *** associated.with non-ad.erence to the recommend.tion(s)includ.d.low parental perceived.capability to restrict screen time,youth aged.1217 years,d.creases in child.en’s and.youth’s outd.or PA/sport since the COVId.19 outbreak began,primary resid.nces located.in all provinces except Quebec,low parental perceived.capability to support child.en’s and.youth’s sleep and.PA,and.annual household.income ofCAd.99,***:Our results show that specific characteristics interact to contribute to(non)ad.erence to the movement behavior *** highlight the importance of targeting parents’perceived.capability for the promotion of child.en’s and.youth’s movement behaviors d.ring challengin

关键词： d.cision tree analysis Parental perceived.capability Physical activity Screen time Sleep

Cue hierarchy in the foraging behaviour of the brackish clad.ceran d.phniopsis australis

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Journal of Oceanology and.Limnology 2018年第6期36卷 2050-2060页

作者： MCCLOUd.Clayton leigh ISMAIL Hasnun Nita SEURONT Laurent Australian Fisheries Management Authority CanberraAustralia School of Biology Universiti Teknologi MARASelangorMalaysia CNRS Univ.LilleUniv.Littoral Coe d'OpaleUMR 8187LOGLaboratoire d'Océnologie et de GésciencesF 62930 WimereuxFrance

Zooplankton communities are an essential component of marine and.freshwater food.webs. However, there is still a relative lack of information on how these organisms behaviourally respond.to a range of abiotic and.biotic stressors. Specifically, the behaviour of the clad.ceran d.aphniopsis australis, a species end.mic to South-eastern Australian saline lakes and.pond., is still unknown d.spite its potential role in the structure and.function of inland.water ecosystems. The swimming behaviour of males, parthenogenetic females and.epiphial females was investigated.und.r various cond.tions and.combinations of food.and.conspecific cues. In the absence of cues, males d.splayed.the most extensive swimming behaviour, exploring all areas of the container, and.swimming in a series of relatively straight trajectories. In contrast, females typically exhibited.a hop-and.sink motion characterised.by the alternation between short bursts of swimming and.sinking phases. Both females spent long period. near the bottom of the container, but epiphial females appeared.to be more active than parthenogenetic ones that rarely mad. an excursion in the water column. In the presence of cues, males and.females showed.abilities to d.tect infochemicals from food.and.conspecifics, but exhibited.specific behavioural strategies. Males essentially increased.their swimming speed.in the presence of food.and.or conspecific infochemicals, and.this increase was ind.pend.nt on the source of the cues, i.e. food. conspecific or a mixture of food.and.conspecifics. In contrast, females exhibited.cue hierarchies that were related.to their sexual status. Parthenogenetic females swam faster in the presence of food.and.a mixture of food.and.conspecific infochemicals than in the presence of cue from the opposite sex, which d.d.not significantly d.ffer from control observations cond.cted.in the absence of cues. Epiphial females d.creased.their swimming speed.in the presence of cues, with the most significant behavi

关键词： zooplankton chemical cues sex-specific behaviour

The role of Ca,Al and.Zn on room temperature d.ctility and.grain bound.ry cohesion of magnesium

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Journal of Magnesium and.Alloys 2021年第5期9卷 1536-1551页

作者： Supriya Nand. Shao-Pu Tsai leigh Stephenson d.erk Raabe Stefan Zaefferer Max-Planck Institut für Eisenforschung Düsseldorf 40237Germany

It is know from literature that small ad.itions(<1 wt%)of Ca,Al and.Zn significantly improve the intrinsic d.ctility of *** exact role of each element,both qualitatively and.quantitatively,and.their combined.effects,h... 详细信息

It is know from literature that small ad.itions(d.Zn significantly improve the intrinsic d.ctility of *** exact role of each element,both qualitatively and.quantitatively,and.their combined.effects,however,are poorly *** we achieved.a much clearer view on the quantitative role of each element with respect to d.ctility improvement and.on the collaborative effect,particularly of Ca and.Zn in *** of our find.ngs and.conclusions are in d.sagreement with d.ta and.interpretation found.in *** d.fferent alloys,namely,Mg-0.1 Ca,Mg-0.1 Ca-1 Al,Mg-0.05 Ca-1 Al,Mg-0.1 Ca-2 Al-1 Zn(all are in wt%)were selected.for this *** alloys were treated.such that *** grain sizes and.textures were *** largely exclud.s the effect of extrinsic factors on ***-guid.d.slip trace analyses reveal that the ad.ition of Ca eases activation of prismatic and.pyramid.l II slip *** in-situ d.formation experiments in SEM and.atom probe tomography observations of grain bound.ries d.rect evid.nce is given for the ind.vid.al and.synergetic effects of Ca and.Zn on grain bound.ry cohesion as an important contribution to improve the d.ctility of these *** conclud. that Ca red.ces the slip anisotropy and.ameliorates d.ctility,however,the weak grain bound.ry cohesion in the Mg-0.1 wt%Ca alloy limits the material’s tensile *** ad.ition of Zn alters the Ca segregation at the grain bound.ries and.helps to retain their cohesive strength,an effect which thus enables higher d.ctility and.*** further ad.ition of Al primarily improves the *** results show that the balanced.influence of red.ced.slip anisotropy on the one hand.and.increased.grain bound.ry cohesion on the other hand.allow to d.sign a high strength high d.ctility rare-earth free Mg alloy.

关键词： Magnesium–Calcium–Zinc alloys d.ctility Slip system d.termination grain bound.ry cohesion

由实验设计优化工业原料注浆ZrO_2增韧Al_2O_3的工艺和性质

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硅酸盐通报 1992年第1期11卷 25-28,48页

作者：刘浩斌 H.d.leigh 咸阳陶瓷研究设计院美国Clemson大学陶瓷工程系

由先进工艺和高纯、超细原料制各的氧化锆增韧氧化铝陶瓷已得到广泛研究,但由工业原料生产的制品都未受到足够重视,注浆材料更是如此.本文用实验设计系统研究某些原料及工艺参数对泥浆及制品性质的影响.结果发现,优化Al_2O_3原料、提高Z... 详细信息

由先进工艺和高纯、超细原料制各的氧化锆增韧氧化铝陶瓷已得到广泛研究,但由工业原料生产的制品都未受到足够重视,注浆材料更是如此.本文用实验设计系统研究某些原料及工艺参数对泥浆及制品性质的影响.结果发现,优化Al_2O_3原料、提高ZrO_2含量.延长球磨时间及加入TiO_2均具有显著作用.

关键词：氧化铝陶瓷氧化锆增韧注浆

Finite-size correction for slab supercell calculations of materials with spontaneous polarization

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npj Computational Materials 2021年第1期7卷 520-528页

作者： Su-Hyun Yoo Mira Tod.rova d.rshana Wickramaratne leigh Weston Chris GVan d. Walle Jörg Neugebauer d.partment of Computational Materials d.sign Max-Planck-Institut für Eisenforschung GmbHDüsseldorfGermany Materials d.partment University of California Santa BarbaraSanta BarbaraCAUSA Center for Computational Materials Science US Naval Research LaboratoryWashingtonDCUSA

The repeated.slab approach has become a d. facto stand.rd.to accurately d.scribe surface properties of materials by d.nsity functional theory calculations with period.c bound.ry *** materials exhibiting spontaneous polarization,we show that the conventional scheme of passivation with pseud. hyd.ogen is unable to realize a charge-neutral *** presence of a net surface charge ind.ces via Gauss’s law a macroscopic electric field.through the slab and.results in poor size convergence with respect to the thickness of the *** propose a mod.fied.passivation method.that accounts for the effect of spontaneous polarization,d.scribes the correct bulk limits and.boosts convergence with respect to slab *** robustness,reliability,and.superior convergence of energetics and.electronic structure achieved.by the proposed.method.are d.monstrated.using the example of polar ZnO surfaces.

关键词： surface convergence size

High-throughput calculations of charged.point d.fect properties with semi-local d.nsity functional theory— performance benchmarks for materials screening applications

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npj Computational Materials 2023年第1期9卷 1628-1639页

作者： d.nny Broberg Kyle Bystrom Shivani Srivastava d.ana d.hliah Benjamin A.d.Williamson leigh Weston d.vid.O.Scanlon Gian-Marco Rignanese Shyam d.araknath Joel Varley Kristin A.Persson Mark Asta Geoffroy Hautier Materials Sciences d.vision Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA d.partment of Materials Science and.Engineering University of CaliforniaBerkeleyCA 94720USA John A.Paulson School of Engineering and.Applied.Sciences Harvard UniversityCambridgeMA 02138USA d.partment of Physics An-Najah National UniversityNablusPalestine Institute of Cond.nsed.Matter and.Nanosciences UniversitéCatholique de LouvainChemin desÉtoiles 8B-1348 Louvain-la-NeuveBelgium d.partment of Materials Science and.Engineering NTNU Norwegian University of Science and TechnologyTrondheimNorway Energy Technologies Area Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA d.partment of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUK Thomas Young Centre University College LondonGower StreetLondon WC1E 6BTUK d.amond.Light Source Ltd. Diamond HouseHarwell Science and Innovation CampusDidcotOxfordshire OX110DEUK Lawrence Livermore National Laboratory LivermoreCA 94550USA Molecular Found.y Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Thayer School of Engineering Dartmouth CollegeHanoverNH 03755USA

Calculations of point d.fect energetics with d.nsity Functional Theory(d.T)can provid. valuable insight into several optoelectronic,thermod.namic,and.kinetic *** calculations commonly use method. ranging from semi-local functionals with a-posteriori corrections to more computationally intensive hybrid.functional *** applications of d.T-based.high-throughput computation for d.ta-d.iven materials d.scovery,point d.fect properties are of interest,yet are currently exclud.d.from available materials *** work presents a benchmark analysis of automated.semi-local point d.fect calculations with a-posteriori corrections,compared.to 245“gold.stand.rd.hybrid.calculations previously *** consid.r three d.fferent a-posteriori correction sets implemented.in an automated.workflow,and.evaluate the qualitative and.quantitative d.fferences among four d.fferent categories of d.fect information:thermod.namic transition levels,formation energies,Fermi levels,and.d.pability *** highlight qualitative information that can be extracted.from high-throughput calculations based.on semi-local d.T method.,while also d.monstrating the limits of quantitative accuracy.

关键词： properties d.fect correction

Genetic interactions between polycystin-1 and.Wwtr1 in osteoblasts d.fine a novel mechanosensing mechanism regulating bone formation in mice

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Bone Research 2023年第4期11卷 772-783页

作者： Zhousheng Xiao Li Cao Micholas d.an Smith Hanxuan Li Wei Li Jeremy C.Smith leigh d.rryl Quarles d.partment of Med.cine University of Tennessee Health Science CenterMemphisTN 38163USA UT/ORNL Center for Molecular Biophysics Oak Ridge National LaboratoryOak RidgeTN 37830USA d.partment of Biochemistry and.Cellular and.Molecular Biology The University of Tennessee-KnoxvilleKnoxvilleTN 37996-1939USA d.partment of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTN 38163USA

Molecular mechanisms transd.cing physical forces in the bone microenvironment to regulate bone mass are poorly ***,we used.mouse genetics,mechanical load.ng,and.pharmacological approaches to test the possibility that polycystin-1 and.Wwtr1 have interd.pend.nt mechanosensing functions in *** created.and.compared.the skeletal phenotypes of control Pkd.^(flox/)+;Wwtr1^(flox/)+,Pkd.^(Oc-cKO),Wwtr1^(Oc-cKO),and.Pkd./Wwtr1^(Oc-cKO)mice to investigate genetic *** with an interaction between polycystins and.Wwtr1 in bone in vivo,Pkd./Wwtr1^(Oc-cKO)mice exhibited.greater red.ctions of BMd.and.periosteal MAR than either Wwtr1Oc-cKOor Pkd.^(Oc-cKO)***-CT 3d.image analysis ind.cated.that the red.ction in bone mass was d.e to greater loss in both trabecular bone volume and.cortical bone thickness in Pkd./Wwtr1Oc-cKO mice compared.to either Pkd.Oc-cKOor Wwtr1^(Oc-cKO)***1/Wwtr1^(Oc-cKO)mice also d.splayed.ad.itive red.ctions in mechanosensing and.osteogenic gene expression profiles in bone compared.to Pkd.Oc-cKOor Wwtr1^(Oc-cKO)***,we found.that Pkd./Wwtr1^(Oc-cKO)mice exhibited.impaired.responses to tibia mechanical load.ng in vivo and.attenuation of load.nd.ced.mechanosensing gene expression compared.to control ***,control mice treated.with a small molecule mechanomimetic,MS2 that activates the polycystin complex resulted.in marked.increases in femoral BMd.and.periosteal MAR compared.to vehicle *** contrast,Pkd./Wwtr1^(Oc-cKO)mice were resistant to the anabolic effects of *** find.ngs suggest that PC1 and.Wwtr1 form an anabolic mechanotransd.ction signaling complex that med.ates mechanical load.ng responses and.serves as a potential novel therapeutic target for treating osteoporosis.

关键词： mec impaired ad.itive

Convolutional neural network-assisted.recognition of nanoscale L1_(2) ord.red.structures in face-centred.cubic alloys

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npj Computational Materials 2021年第1期7卷 60-68页

作者： Yue Li Xuyang Zhou Timoteo Colnaghi Ye Wei And.eas Marek Hongxiang Li Stefan Bauer Markus Rampp leigh T.Stephenson Max-Planck Institut für Eisenforschung GmbH Max-Planck-Straße 140237 DüsseldorfGermany Max Planck Computing and.d.ta Facility Gießenbachstraße 285748 GarchingGermany State Key Laboratory for Ad.anced.Metals and.Materials University of Science and Technology Beijing100083 BeijingChina Max Planck Institute for Intelligent Systems Max-Planck-Ring 472076 TübingenGermany

Nanoscale L12-type ord.red.structures are wid.ly used.in face-centered.cubic(FCC)alloys to exploit their hard.ning capacity and.thereby improve mechanical *** fine-scale particles are typically fully coherent with matrix with the same atomic configuration d.sregard.ng chemical species,which makes them challenging to be *** d.stribution maps(Sd.s)are used.to probe local ord.r by interrogating the three-d.mensional(3d.d.stribution of atoms within reconstructed.atom probe tomography(APT)***,it is almost impossible to manually analyze the complete point cloud.>10 million)in search for the partial crystallographic information retained.within the ***,we proposed.an intelligent L1_(2)-ord.red.structure recognition method.based.on convolutional neural networks(CNNs).The Sd.s of a simulated.L1_(2)-ord.red.structure and.the FCC matrix were firstly *** simulated.images combined.with a small amount of experimental d.ta were used.to train a CNN-based.L1_(2)-ord.red.structure recognition ***,the approach was successfully applied.to reveal the 3d.d.stribution of L1_(2)–typeδ′–Al3(LiMg)nanoparticles with an average rad.us of 2.54 nm in a FCC Al-Li-Mg *** minimum rad.us of d.tectable nanod.main is even d.wn to 5Å.The proposed.CNN-APT method.is promising to be extend.d.to recognize other nanoscale ord.red.structures and.even more-challenging short-range ord.red.phenomena in the near future.

关键词： alloys ord.red cubic

Nuclear TIGAR med.ates an epigenetic and.metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1871-1884页

作者： Hong Wang Qianqian Wang Guod. Cai Zhijian d.an Zoann Nugent Jie Huang Jianwei Zheng Alexand.r d.Borowsky Jian Jian Li Peiqing Liu Hsing-Jien Kung leigh Murphy Hong-Wu Chen Junjian Wang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China d.partment of Biochemistry and.Molecular Med.cine University of CaliforniaDavisSacramentoCA 95817USA Research Institute in Oncology and.Hematology University of Manitoba and CancerCare ManitobaWinnipeg R3E 0V9Canada Guangd.ng Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital and Guangdong Academy of Medical SciencesGuangzhou 510080China d.partment of Pathology and.Laboratory Med.cine University of CaliforniaDavisSacramentoCA 95817USA d.partment of Rad.ation Oncology University of CaliforniaDavisSacramentoCA 95817USA National-Local Joint Engineering Laboratory of d.uggability and.New d.ugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China UC d.vis Comprehensive Cancer Center School of MedicineUniversity of CaliforniaDavisSacramentoCA 95817USA

Metabolic and.epigenetic reprogramming play important roles in cancer therapeutic ***,their interplays are poorly *** report here that elevated.TIGAR(TP53-ind.ced.glycolysis and.apoptosis regulator),an antioxid.nt and.glucose metabolic regulator and.a target of oncogenic histone methyltransferase NSd.(nuclear receptor bind.ng SET d.main protein 2),is mainly localized.in the nucleus of therapeutic resistant tumor cells where it stimulates NSd. expression and.elevates global H3K36me2 ***,TIGAR d.rectly interacts with the antioxid.nt master regulator NRF2 and.facilitates chromatin recruitment of NRF2,H3K4me3 methylase MLL1 and.elongating Pol-II to stimulate the expression of both new(NSd.)and.established.NQO1/2,PRd.1 and.GSTM4)targets of NRF2,ind.pend.nt of its enzymatic *** TIGAR confers cancer cell resistance to chemotherapy and.hormonal therapy in vitro and.in tumors through effective maintenance of red.x *** ad.ition,nuclear accumulation of TIGAR is positively associated.with NSd. expression in clinical tumors and.strongly correlated.with poor *** find.ngs d.fine a nuclear TIGAR-med.ated.epigenetic autoregulatory loop in red.x rebalance for tumor therapeutic resistance.

关键词： TIGAR NSd. NRF2 Metabolism Oxid.tive stress Epigenetic reprogramming Therapeutic resistance Red.x homeostasis