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journal of Integrative Agriculture 2021年第1期20卷 159-167页

作者： leidy j.valencia-hernandez Karina LÓOPEZ-LÓPEZ Eyder D.GÓMEZ-LÓPEZ Liliana SERNACOCK Cristobal N.AGUILAR Universidad Nacional de Colombia Palmira CampusValle 763533Colombia Food Research Department School of ChemistryAutonomous University of CoahuilaSaltillo CampusCoahuila 25280Mexico

The fungistatic activity of a lactic acid bacterium, which had been isolated from yellow pitahaya cultures, against fungi associated with basal rot(Fusarium oxysporum and Fusarium fujikuroi) was measured in the present study. Its activity was assessed in three fractions: fermented(S1), metabolic products(S2), and biomass(S3), using two fermentation substrates: Man Rogosa Sharpe agar(MRS) and potato dextrose agar(PDA). The bacterium was molecularly identified as Lactobacillus plantarum. S3 reduced F. fujikuroi growth by 100% over 48 h of fermentation, which occurred during the stationary phase of bacterial growth. The three fractions' fungistatic activity against F. fujikuroi depended on the substrate employed. The fermentation kinetic parameters for L. plantarum indicated that its specific growth rate was 0.46 h^–1, with 93.63% substrate consumption, 0.045 kg kg^–1 cell yield, and 0.54 kg kg^–1 product yield. The kinetic parameters calculated will allow for bacteria production scaling. These in-vitro trials reveal L. plantarum's possible application as a biocontrol agent for diseases associated with Fusarium. However, further ex-vivo and in-vivo researches are required to demonstrate its behavior in crops.

关键词： lactic acid bacteria Fusarium fungistatic activity biomass yellow pitahaya

Engineering T cells for immunotherapy of primary human hepatocellular carcinoma

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journal of Genetics and Genomics 2020年第1期47卷 1-15页

作者： leidy DCaraballo Galva Lun Cai Yanxia Shao Yukai He Georgia Cancer Center.Medical College of Georgia Augusta University.AugustaGA.30912USA Department of Medicine.Medical College of Georgia Augusta UniversityAugustaGA30912USA

Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects.

关键词： Immunotherapy Hepatocellular carcinoma T cell receptor Chimeric antigen receptor T cell engineering Gene transfer

Use of fly and bottom ashes from a thermoelectrical plant in the synthesis of geopolymers:Evaluation of reaction efficiency

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Energy Geoscience 2021年第2期2卷 167-173页

作者： leidy j.jaramillo Nieves Fabio Elyseu Silviany Goulart Mariana de Souza Pereira Erick Zabot Valvassori Adriano Michael Bernardin Ceramic Materials Group Universidade do Extremo Sul CatarinenseAv.Universitaria 110588806-000CriciumaSanta CatarinaBrazil

The use of by-products as raw materials in the manufacturing of industrial products has risen in the last years because of environmental *** example is the use of coal ashes from thermalelectrical plants in the production of geopolymer–a green cement made by mixing aluminosilicate with alkaline *** this study,fly and bottom ashes from a thermal-electrical unit were used as sources of aluminosilicate in the synthesis of geopolymers.A mixture of sodium hydroxide(10 mol/L)and sodium silicate(SiO_(2)/Na_(2)O ratio of 2.2)was used as the alkaline *** type(fly or bottom ash)and content of the ash were the variables in the *** ashes were characterized by X-ray fluorescence(XRF),X-ray diffraction(DRX),particle size distribution(PSD),specific surface area(BET),and thermal analysis(DTA/TGA).The ash-based geopolymer samples were measured to obtain their compressive strength after *** evolution of the geopolymerization process was also assessed based on final alkali concentration *** results show that it is possible to obtain geopolymers using coal ashes as raw materials with high solid *** compressive strength for the bottom ash geopolymer after 90 days of curing is 35 *** low concentration of unreacted alkalis after curing(1.5×10^(-3)e 3.5×10^(-3)M)corresponds to high efficiency of the geopolymerization reaction.

关键词： Coal ash Geopolymer Industrial by-product Geopolymerization reaction

Acid-Functionalized Nanoparticles for Pretreatment of Wheat Straw

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journal of Biomaterials and Nanobiotechnology 2012年第3期3卷 342-352页

作者： leidy Pena Myles Ikenberry Keith L.Hohn Donghai Wang Department of Biological and Agricultural Engineering Kansas State UniversityManhattanUSA Department of Chemical Engi-neering Kansas State UniversityManhattanUSA

Perfluoroalkylsufonic (PFS) and alkylsufonic (AS) acid-functionalized magnetic nanoparticles were synthesized and characterized, then evaluated for their ability to hydrolyze hemicelluloses. The magnetic core was made of cobalt spinel ferrite and was coated with silica to protect it from oxidation. The silanol groups allowed surface chemical modification of the nanoparticles with the PFS and AS acid functionalities. Thermogravimetric analysis gave a total organic load of 12.6% and 32.5% (w/w) for AS and PFS nanoparticles, respectively. The surface sulfur content was calculated from XPS analysis as 1.37% and 1.93% for PFS and AS nanoparticles, respectively. Wheat straw samples were treated with the acid-functionalized nanoparticles at two different conditions: 80℃ for 24 h and 160℃ for 2 h. These experiments aimed to hydrolyze wheat straw hemicelluloses to soluble oligosaccharides. PFS nanoparticles solubilized significantly higher amounts of hemicelluloses (24.0% ± 1.1%) than their alkyl-sulfonic counterparts (9.1% ± 1.7%) at 80℃, whereas the hydrothermolysis control solubilized 7.7% ± 0.8% of the original hemicelluloses in the sample. At 160℃, PFS and AS nanoparticles gave significantly higher amounts of oligosaccharides (46.3% ± 0.4% and 45 ± 1.2%, respectively) than the control (35.0% ± 1.8%). The hemicelluloses conversion at 160?C reached 66.3% ± 0.9% using PFS nanoparticles and 61.0% ± 1.2% using AS nanoparticles compared with the control experiment, which solubilized 50.9% ± 1.7% of hemicelluloses in the biomass.

关键词： Acid-Functionalized Magnetic Nanoparticles Biomass Hemicelluloses Hydrolysis

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漆器审美:蒙古治下的汉族传统

美成在久 2017年第2期 38-47页

作者： Denise Patry leidy 高菲池

在建立元朝之前,蒙古人很可能就已知悉并重视汉族的漆器传统。文字史料和图像证据都显示,在十至十三世纪的中国北方,人们已熟知以南方为基地的漆器制造业。例如,在一段描述北宋东京(今河南开封)的文字记载中,就提及了一家贩售温州漆器... 详细信息

在建立元朝之前,蒙古人很可能就已知悉并重视汉族的漆器传统。文字史料和图像证据都显示,在十至十三世纪的中国北方,人们已熟知以南方为基地的漆器制造业。例如,在一段描述北宋东京(今河南开封)的文字记载中,就提及了一家贩售温州漆器的商铺[一]。

关键词：大都会艺术博物馆八思巴文家族墓地

Assembly of jAZ–jAZ and jAZ–NINjA complexes in jasmonate signaling

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Plant Communications 2023年第6期4卷 296-312页

作者： X.Edward Zhou Yaguang Zhang jian Yao jie Zheng Yuxin Zhou Qing He javier Moreno Vinh QLam Xiaoman Cao Koichi Sugimoto leidy Vanegas-Cano Leena Kariapper Kelly Suino-Powell Yuanye Zhu Scott Novick Patrick R.Griffin Feng Zhang Gregg A.Howe Karsten Melcher Department of Structural Biology Van Andel InstituteGrand RapidsMI 49503USA Key Laboratory of Pesticide College of Plant ProtectionNanjing Agricultural UniversityNanjingChina MSU-DOE Plant Research Laboratory Michigan State UniversityEast LansingMI 48824USA Department of Molecular Medicine UF Scripps Biomedical ResearchJupiterFL 33458USA Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA Present address:Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014China Present address:Tsukuba-Plant Innovation Research Center University of TsukubaTsukubaIbaraki 305-8572Japan

jasmonates(jAs)are plant hormones with crucial roles in development and stress *** activate MYC transcription factors by mediating the proteolysis of MYC inhibitors called jAZ *** the absence of jA,jAZ proteins bind and inhibit MYC through the assembly of MYC–jAZ–Novel Interactor of jAZ(NINjA)–TPL repressor ***,jAZ and NINjA are predicted to be largely intrinsically unstructured,which has precluded their experimental structure *** a combination of biochemical,mutational,and biophysical analyses and AlphaFold-derived ColabFold modeling,we characterized jAZ–jAZ and jAZ–NINjA interactions and generated models with detailed,high-confidence domain *** demonstrate that jAZ,NINjA,and MYC interface domains are dynamic in isolation and become stabilized in a stepwise order upon complex *** contrast,most jAZ and NINjA regions outside of the interfaces remain highly dynamic and cannot be modeled in a single *** data indicate that the small jAZ Zinc finger expressed in Inflorescence Meristem(ZIM)motif mediates jAZ–jAZ and jAZ–NINjA interactions through separate surfaces,and our data further suggest that NINjA modulates jAZ *** study advances our understanding of jA signaling by providing insights into the dynamics,interactions,and structure of the jAZ–NINjA core of the jA repressor complex.

关键词： jAZ protein NINjA AlphaFold ColabFold MYC hydrogen-deuterium exchange

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肿瘤多学科团队实施现状及影响因素研究

中国医疗管理科学 2017年第3期7卷 28-33页

作者： leidy Stefany Delgado 陶红兵蔡苗 Ashleigh Chinelo Oguagha 华中科技大学同济医学院医药卫生管理学院武汉430030

目的了解医务工作者对于肿瘤多学科团队的态度,以及识别促进和阻碍其实施的因素。方法对武汉两家公立医院的各类肿瘤相关医务人员展开问卷调查,并运用描述性统计分析和卡方检验进行数据分析。结果 99%的受访者认为肿瘤多学科团队对病人... 详细信息

目的了解医务工作者对于肿瘤多学科团队的态度,以及识别促进和阻碍其实施的因素。方法对武汉两家公立医院的各类肿瘤相关医务人员展开问卷调查,并运用描述性统计分析和卡方检验进行数据分析。结果 99%的受访者认为肿瘤多学科团队对病人有帮助,并且可促进医务工作者的工作。在中国的医院中实施和执行肿瘤多学科团队存在的主要阻碍因素为缺少时间(71.0%)、缺乏动机和激励因素(59.9%)和财政支持不足(57.0%);促进其实施的因素为工作人员之间的协调及沟通(68.6%)、领导能力和团队精神(63.8%)、医疗卫生工作者之间的关系(58.5%)。不同医务工作者对于影响因素的态度存在显著性差异。结论肿瘤专科医生对组建多学科团队的必要性高度认可,但有效实施需要针对缺少时间、缺乏动机、缺少财政支持、行政管理因素以及组织政策等方面的问题提出相应的对策,以促进我国肿瘤多学科团队的建设。

关键词：肿瘤护理多学科团队医务人员癌症研究

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慢性阻塞性肺疾病急性加重的标准化测量

中华结核和呼吸杂志 2011年第9期34卷 678-678页

作者： leidy NK Wilcox TK jones PW 白澎孙永昌不详首都医科大学附属北京同仁医院呼吸内科 100730

背景和目的：COPD急性加重（AECOPD）反复发生是COPD病情进展的重要原因之一，减少AECOPD发生频率也是对COPD进行干预的主要目标之一。但是到目前为止，评估AECOPD的发生频率、严重程度和持续时间尚无有效的、标准化的监测工具。

关键词：标准化测量慢性阻塞性肺疾病急性加重 AECOPD 发生频率病情进展持续时间

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday

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Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando Coca leidy Yasmín Vargas-Mendoza André Aptroot Laura juliana Arias Betty Besal Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.S.Cáceres josé Luis Chaves Sionara Eliasaro Martha Cecilia Gutiérrez jesús E.Hernández Marin María de los Ángeles Herrera-Campos María E.Holgado-Rojas Harald jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins joel A.Mercado-Díaz jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-Corredor jean-Marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi james D.Lawrey Botanical Garden and Botanical Museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de Caldas(FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis Avenue LexingtonVA 24450USA Charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany jardı´n Bota´nico de Bogota´jose´Celestino Mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 *** on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been *** of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is *** new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking ***.,*** Moncada,Soto-Medina&Lücking ***.,*** Moncada,Dal Forno&Lücking ***.,*** Dal Forno,Chaves&Lücking ***.,*** Moncada,***ı´guez&Lücking ***.,*** Lücking,Moncada&*** ***.,*** Moncada,Ya´nez-Ayabaca&Lücking ***.,*** Moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas Plata&Perlmutter ***.,*** Dal Forno,Eliasaro&Spielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,Martins&Lucheta ***.,*** Moncada,R.-***´rez&Lücking ***.,*** Moncada,***.&Lücking ***.,*** Moncada,CabreraAmaya&Lücking ***.,*** Moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** Moncada,***´rez-Corredor&Lücking ***.,*** Moncada,***&Lücking ***.,***

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