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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie Jia-Lin Li Ling Gong xiang-Li Zhong hong-Jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

自适应交互式多模型AUV组合导航算法（英文）

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中国惯性技术学报 2016年第4期24卷 511-516,523页

作者：王磊程向红李双喜高海涛安徽科技学院电气与电子工程学院蚌埠233100 东南大学仪器科学与工程学院南京210016

提出了一种基于期望模式修正(EMA)的改进交互式多模型(IMM)算法。该算法主要解决自主水下航行器(AUV)复杂工作环境下量测噪声统计特性未知或易发生变化时的状态估计问题,其核心思想是将期望模式修正机制和交互式多模型滤波算法相结合,... 详细信息

提出了一种基于期望模式修正(EMA)的改进交互式多模型(IMM)算法。该算法主要解决自主水下航行器(AUV)复杂工作环境下量测噪声统计特性未知或易发生变化时的状态估计问题,其核心思想是将期望模式修正机制和交互式多模型滤波算法相结合,利用状态估计过程中的获取的模型概率进行决策,得到更加接近与系统真实模式的期望模型集合,再通过期望模型集合滤波结果对固定模型集合滤波结果进行修正。与传统的交互式多模型算法相比,提出的基于期望模式修正的交互式多模型算法可以捕捉到系统模式更细微的变化。仿真结果表明,该算法可以大幅提高AUV组合导航系统的估计精度和稳定性。

关键词：自主水下航行器组合导航交互式多模型期望模式修正

Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang lei Qian Xiaofei Hu Ting Zhang Chaoyu xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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基于有限元的尼龙板热膨胀性能分析

舰船科学技术 2016年第1期38卷 99-102页

作者：雷向红王建军中国船舶重工集团公司第七一三研究所河南郑州450015

尼龙材料由于其良好的机械性能及热性能而被广泛应用于各种生产领域,了解掌握尼龙板材在不同温度环境下的热膨胀变形对于设备的维护和保养十分重要。本文从材料的热膨胀理论出发,以有限元的理论为基础,详细讨论尼龙板材在不同温度下发... 详细信息

尼龙材料由于其良好的机械性能及热性能而被广泛应用于各种生产领域,了解掌握尼龙板材在不同温度环境下的热膨胀变形对于设备的维护和保养十分重要。本文从材料的热膨胀理论出发,以有限元的理论为基础,详细讨论尼龙板材在不同温度下发生的热膨胀变形,通过有限元仿真分析尼龙板材在不同温度下的热膨胀性能,得出尼龙板在一定温度范围内的热膨胀变化规律。

关键词：尼龙热膨胀有限元

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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新型封隔器胶筒防突装置的设计及分析

工程设计学报 2017年第3期24卷 359-364页

作者：黎伟宋伟雷鸿翔黎宗琪李斌西南石油大学机电工程学院四川成都610500 西南石油大学石油天然气装备教育部重点实验室四川成都610500 中国石油集团川庆钻探工程有限公司井下作业公司四川成都610051

为了防止封隔器胶筒在大间隙和高压差工况下肩部突出,提高封隔器的封隔能力,针对传统防突装置的不足设计了一种伞式完全防突装置。首先,使用有限元软件对无防突装置、安装部分防突装置和使用完全防突装置的胶筒在封隔大间隙工况下的密... 详细信息

为了防止封隔器胶筒在大间隙和高压差工况下肩部突出,提高封隔器的封隔能力,针对传统防突装置的不足设计了一种伞式完全防突装置。首先,使用有限元软件对无防突装置、安装部分防突装置和使用完全防突装置的胶筒在封隔大间隙工况下的密封性能进行了对比分析,发现使用完全防突装置时胶筒的最大Von Mises应力最小、封隔能力最强。其次,介绍了伞式防突装置的结构和工作原理,对其机构进行了分析。同时设计了一款适用于Y111-150型封隔器胶筒的伞式防突装置,验证了机构不会发生自锁,各零部件之间也无干涉发生。当防突装置翼板展开防突时,连杆两端处的销钉受力最大,此处易发生失效;当防突装置用于大间隙、高压差封隔时可适当增加这2处销钉的直径和连杆的厚度。研究结果对封隔器防突装置的设计具有一定参考意义。

关键词：封隔器胶筒完全防突伞式翼板

AsyCo: an asymmetric dual-task co-training model for partial-label learning

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Science China(Information Sciences) 2025年

作者： Beibei LI Yiyuan ZHENG Beihong JIN Tao xiang Haobo WANG lei FENG College of Computer Science Chongqing University State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences University of Chinese Academy of Sciences School of Software Technology Zhejiang University School of Computer Science and Engineering Nanyang Technological University

Partial-label learning (PLL) is a typical problem of weakly supervised learning, where each training instance is annotated with a set of candidate labels. Self-training PLL models achieve state-of-the-art performance but suffer from error accumulation problems caused by mistakenly disambiguated instances. Although co-training can alleviate this issue by training two networks simultaneously and allowing them to interact with each other, most existing co-training methods train two structurally identical networks with the same task, i.e., are symmetric, rendering it insufficient for them to correct each other due to their similar limitations. Therefore, in this paper, we propose an asymmetric dual-task co-training PLL model called AsyCo,which forces its two networks, i.e., a disambiguation network and an auxiliary network, to learn from different views explicitly by optimizing distinct tasks. Specifically, the disambiguation network is trained with a self-training PLL task to learn label confidence, while the auxiliary network is trained in a supervised learning paradigm to learn from the noisy pairwise similarity labels that are constructed according to the learned label confidence. Finally, the error accumulation problem is mitigated via information distillation and confidence refinement. Extensive experiments on both uniform and instance-dependent partially labeled datasets demonstrate the effectiveness of AsyCo.

关键词：

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井下防喷器的设计及实验研究

工程设计学报 2016年第4期23卷 371-377页

作者：黎伟雷鸿翔杨博黎宗琪李斌西南石油大学机电工程学院四川成都610500 西南石油大学石油天然气装备教育部重点实验室四川成都610500 中国石油川庆钻探工程有限公司井下作业公司四川成都610051

为了提高钻井作业的安全性,保证井底发生溢流后能迅速可靠封隔环空、方便后续压井作业,设计了一种安装在近钻头端的井下防喷器,对其结构和工作原理进行了详细介绍.通过建立井下防喷器中推块机构的受力模型,分析了推块对管柱的反作用力... 详细信息

为了提高钻井作业的安全性,保证井底发生溢流后能迅速可靠封隔环空、方便后续压井作业,设计了一种安装在近钻头端的井下防喷器,对其结构和工作原理进行了详细介绍.通过建立井下防喷器中推块机构的受力模型,分析了推块对管柱的反作用力与推块锥面角和碟簧变形量之间的关系.对花键进行了强度校核,使用有限元软件对不同厚度和硬度的胶筒的封隔能力进行了分析,同时进行了井下防喷器的室内实验.研究结果表明:当单个碟簧的变形量为0.2mm、推块的锥面角度为45°时,单个推块可对钻柱产生2.2kN的反作用力,设计值和实验数据接近;当钻柱扭矩达到45 000N·m,花键的挤压应力仍在许用应力范围内;在压缩量和封隔间隙相同的情况下,胶筒的宽度越宽、硬度越大,封隔能力越强,且胶筒硬度越大,需要的下压力也越大.研究结果对井下防喷器的设计具有一定指导作用.

关键词：井下防喷器推块胶筒封隔能力