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Therapeutic prospects of mesenchymal stem/stromal cells in COVID-19 associated pulmonary diseases:From bench to bedside

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World Journal of Stem Cells 2021年第8期13卷 1058-1071页

作者： lei-sheng zhang Yi Yu Hao Yu Zhong-Chao Han Qianfoshan Hospital&The First Affiliated Hospital Shandong First Medical UniversityJinan 250014Shandong ProvinceChina State Key Laboratory of Experimental Hematology&National Clinical Research Center for Blood Disease Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China School of Medicine Nankai UniversityTianjin 300071China Precision Medicine Division Health-Biotech(Tianjin)Stem Cell Research Institute Co.Ltd.Tianjin 301700China The First Affiliated Hospital Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Cell Products of National Engineering Center&National Stem Cell Engineering Research Center Tianjin IMCELL Stem Cell and Gene Technology Co.Ltd.Tianjin 300457China

The ongoing outbreak of coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2 has become a sudden public emergency of international concern and seriously threatens millions of people’s life *** current studies have indicated a favorable role for mesenchymal stem/stromal cells(MSCs)in clinical remission of COVID-19 associated pulmonary diseases,yet the systematical elaboration of the therapeutics and underlying mechanism is far from *** the present review,we summarize the therapeutic potential of MSCs in COVID-19 associated pulmonary diseases such as pneumonia induced acute lung injury,acute respiratory distress syndrome,and pulmonary ***,we review the underlying mechanism of MSCs including direct-and trans-differentiation,autocrine and paracrine anti-inflammatory effects,homing,and neovascularization,as well as constitutive ***,we discuss the prospects and supervision of MSC-based cytotherapy for COVID-19 management before large-scale application in clinical ***,this review supplies overwhelming new references for understanding the landscapes of MSCs in the remission of COVID-19 associated pulmonary diseases.

关键词： Mesenchymal stem/stromal cells COVID-19 Acute lung injury Acute respiratory distress syndrome Pulmonary fibrosis Molecular mechanism

Prevalence of Chronic Kidney Disease-Mineral Bone Disorder in Hemodialysis Patients in Hebei,China

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Chinese Medical Journal 2018年第22期131卷 2749-2751页

作者： Jing-Jing Jin sheng-lei zhang Jin-sheng Xu Li-Wen Cui Hui-Ran zhang Ya-Ling Bai Department of Nephrology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050011China

To the Editor:Chronic kidney disease-mineral bone disorder (CKD-MBD)has been found universally in hemodialysis (HD) *** increases the risk of cardiovascular morbidity and mortality,particularly vascular calcification.[1]Consequently, it is crucial to effectively control the biochemical indicators' abnormalities of ***,al guidelines have provided measures for CKD-MBD,but relevant research from developing countries is limited,especially in China.[2]

关键词： Prevalence Hemodialysis Patients

Therapeutic challenge for immunotherapy targeting cold colorectal cancer: A narrative review

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World Journal of Clinical Oncology 2023年第2期14卷 81-88页

作者： Shi-Xun Ma Li Li Hui Cai Tian-Kang Guo lei-sheng zhang Department of General Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Scientific Research Division Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Radiation Technology and Biophysics Hefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031Anhui ProvinceChina

Cold colorectal tumors are not likely to trigger a robust immune response and tend to suppress the immune *** may be three ***,the complex tumor microenvironment of cold colorectal cancer(CRC)leads to tolerance and clearance of ***,the modification and concealment of tumor-specific targets in cold CRC cause immune escape and immune response ***,the difference in number and function of immune cell subsets in patients with cold CRC makes them respond poorly to ***,we can only overcome the challenges in immunotherapy of cold CRC through in-depth research and understanding the changes and mechanisms in the above three aspects of cold CRC.

关键词： Cold colorectal cancer Immunotherapy Tumor microenvironment Immune targets Immune cells

红黏土地层静压闭口管桩残余应力模型试验分析

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岩土力学 2017年第7期38卷 1878-1886页

作者：王家全刘垒雷朱庆盛张昊广西科技大学土木建筑工程学院广西柳州545006 哈尔滨工业大学深圳研究生院广东深圳518055

在典型的上硬、下软红黏土地层中静压管桩滞留的残余应力对基桩承载特性有较大影响。通过自行设计模型试验设备进行红黏土地层单、群桩静压闭口管桩室内试验,分析3种桩径下静压单、群桩残余应力的变化规律及时间效应。结果表明,静压管... 详细信息

在典型的上硬、下软红黏土地层中静压管桩滞留的残余应力对基桩承载特性有较大影响。通过自行设计模型试验设备进行红黏土地层单、群桩静压闭口管桩室内试验,分析3种桩径下静压单、群桩残余应力的变化规律及时间效应。结果表明,静压管桩桩身残余应力沿桩身从上到下先增大后变小,呈折线型分布;对于典型的红黏土上硬、下软地层,桩端持力层位于硬塑层和可塑层时,桩身和桩端残余应力均较小;当管桩压入到基岩持力层后桩端受约束增强,桩身和桩端残余应力明显增大;静压单桩完成后静置初期桩身残余应力时间效应比较明显,减小幅度较大,复压后而后随着休止时间的延长,桩身残余应力呈指数型衰减至一较低稳定值;静载试验时忽略残余应力就将认为整个桩身所受压力偏小,偏大计算中性面以上侧摩阻力7.97%,偏小计算中性面以下侧摩阻力8.33%和桩端阻力2.29%。

关键词：红黏土地层:静压管桩残余应力群桩时间效应

Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao zhang Zhanyu Li Yijia lei Baozeng Sun Xiaoyu Yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： lei Xue Tong Shi Chenhui Han Heng zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi zhang Dong Liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin zhang Guangyu Yang lei Xiao Zhiyong Kan Jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms