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Study of retinal vessel oxygen saturation in ischemic and non-ischemic branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 99-107页

作者： lei-lei lin Yan-Min Dong Yao Zong Qi-Shan Zheng Yue Fu Yong-Guang Yuan Xia Huang Garrett Qian Qian-Ying Gao Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat-sen University School of Optometry and Vision Science The University of New South Wales

AIM：To explore how oxygen saturation in retinal blood vessels is altered in ischemic and non-ischemic branch retinal vein occlusion（BRVO）.·METHODS：Fifty BRVO eyes were divided into ischemic（=26）and non-ischemic（=24）groups,based on fundus fluorescein *** individuals（=52 and=48,respectively）were also recruited as controls for the two *** mean oxygen saturations of the occluded vessels and central vessels were measured by oximetry in the BRVO and control groups.·R ESULTS：In the ischemic BRVO group,the occluded arterioles oxygen saturation（Sa O2-A,106.0%±14.3%）,instead of the occluded venule oxygen saturation（Sa O2-V,60.8%±9.4%）,showed increases when compared with those in the same quadrant vessels（Sa O2-A,86.1%±16.5%）in the contralateral eyes（〈0.05）.The oxygen saturations of the central vessels showed similar trends with those of the occluded *** the non-ischemic BRVO group,the occluded and central Sa O2-V and Sa O2-A showed no significant *** both the ischemic and non-ischemic BRVOs,the central Sa O2-A was significantly increased when compared to healthy individuals.·CONCLUSION：Obvious changes in the occluded and central Sa O2-A were found in the ischemic BRVO group,indicating that disorders of oxygen metabolism in the arterioles may participate in the pathogenesis of ischemic BRVO.

关键词： hypoxia ischemia oximetry oxygensaturation branch retinal vein occlusion

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-lin Jiang Bao-Xia Dong Yun-lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

刀具柱面二维条码识读发光二极管照明均匀度仿真分析

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上海交通大学学报 2011年第7期45卷 945-948,953页

作者：王红霄何卫平雷蕾林清松西北工业大学现代设计与集成制造重点实验室西安710072

为了预测刀具柱面条码图像的光源设计能否达到照明均匀度要求,通过计算机辅助光学照明软件,在实际发光二极管(LED)光源实体模型、发光特性、光强分布分析的基础上建立仿真光源模型,根据实际应用要求进行拓展模型设计.分析了3种关键因素... 详细信息

为了预测刀具柱面条码图像的光源设计能否达到照明均匀度要求,通过计算机辅助光学照明软件,在实际发光二极管(LED)光源实体模型、发光特性、光强分布分析的基础上建立仿真光源模型,根据实际应用要求进行拓展模型设计.分析了3种关键因素对LED照明均匀度的影响规律,对仿真和实验结果通过拟合曲线进行对比分析,验证了仿真模拟的正确性和指导性.研究结果对刀具柱面二维条码识读时的光学系统设计具有指导意义.

关键词：二维条码光学系统照明均匀度

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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磁性纳米材料与磁场效应加速骨损伤修复

中国组织工程研究 2025年第4期29卷 827-838页

作者：肖放黄雷王琳华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心湖北省武汉市430022 华中科技大学同济医学院附属协和医院检验科湖北省武汉市430022

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进... 详细信息

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进展。方法:在PubMed和Web of Science数据库中进行相关文献检索,检索词为“magnetic nanomaterials,magnetic field,bone repair,bone tissue engineering,stem cell,osteoblast,osteoclast”。检索文献时限为2003-2023年,将其进行筛选和分析,最终纳入98篇文献进行分析。结果与结论:①磁性纳米材料具有促成骨细胞分化、抑制破骨细胞形成和调节免疫微环境等生物效应;此外,磁性纳米材料可调节组织工程支架的机械性能和表面形貌等理化性质,并赋予其磁性,有利于调控干细胞的黏附、增殖与成骨分化。②磁场具有调控细胞内多条信号通路发挥促成骨细胞分化、抑制破骨细胞形成和刺激血管生成等生物学效应,从而加速损伤的骨组织愈合。③磁性纳米材料与磁场的联合应用,通过激活机械转导、增加细胞内磁性纳米粒子含量、增强微磁场效应等加速骨损伤修复,为骨组织工程的研究提供了新的思路。④磁场在临床骨折、骨质疏松症和骨关节炎疾病的治疗中展现出确切疗效,促进骨组织生长、减轻骨质流失和缓解疼痛,改善患者的生活质量。⑤磁性纳米材料与磁场在骨损伤修复与再生中应用潜力大,但磁性纳米材料、磁场和细胞之间的相互作用机制尚未完全阐明,而且磁场调控细胞内分子事件的关键参数,包括磁场类型、强度、频率、作用时间和作用方式等,以及特定磁场对骨细胞的精确生物效应和潜在机制仍有待明确。⑥未来需要进一步关注其对损伤组织微环境中的破骨细胞、神经、血管和免疫细胞的影响,而关于磁性材料用于人体安全性问题,有待系统性研究其分布、代谢以及急性和慢性毒性等。

关键词：磁性纳米材料磁场骨修复骨组织工程干细胞成骨细胞破骨细胞

两株铁皮石斛内生真菌对组培苗和原球茎生长的影响

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植物病理学报 2017年第4期47卷 541-550页

作者：喻静蒋海侠张保钱金磊磊徐德林张本厚陈集双南京工业大学生物与制药工程学院南京211816 遵义医学院基础医学院遵义563000 南京工业大学大丰海洋产业研究院盐城224100

在铁皮石斛内生真菌的研究中,获得了对组培苗的生长呈现不同影响的两株内生真菌DCN-1和DCN-3,为探究其对组培苗和原球茎生长的影响,首先对已分离纯化的菌株DCN-1和菌株DCN-3进行菌株形态和ITS1-5.8S-ITS2区段序列鉴定;采用孢子悬浮液注... 详细信息

在铁皮石斛内生真菌的研究中,获得了对组培苗的生长呈现不同影响的两株内生真菌DCN-1和DCN-3,为探究其对组培苗和原球茎生长的影响,首先对已分离纯化的菌株DCN-1和菌株DCN-3进行菌株形态和ITS1-5.8S-ITS2区段序列鉴定;采用孢子悬浮液注射和菌丝体附着伤口的方法对铁皮石斛组培苗和原球茎进行接种,观察组培苗的生长情况;参照柯赫氏法则对菌株进行重新分离,并结合切片观察结果验证侵染情况。结果显示:菌株DCN-1和菌株DCN-3分别与Myceliophthora verrucosa、G ibberella moniliformis的相似度最高,其中菌株DCN-1对组培阶段和移栽后的组培苗和原球茎的生长无明显影响,菌株DCN-3会导致组培阶段的植株苗枯萎甚至死亡而对移栽后的组培苗影响不大,但抑制原球茎的生长。徒手组织切片观察及二次分离结果分析显示:两株内生真菌均成功侵染植株体内,并确定相应植株的生长状况与该两株内生真菌的侵染相关。两株内生真菌在在营养较丰富的组织培养条件下对铁皮石斛组培苗和原球茎造成不同的影响,为探究其与铁皮石斛的相互作用和促进铁皮石斛植株生长及有效活性物质产生的复合型菌制剂提供了依据。

关键词：铁皮石斛内生真菌鉴定生长影响柯赫氏法则

汽车电子工程创新型人才培养模式改革的探索——以成都大学为例

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科教文汇 2018年第22期 80-81页

作者：雷舒雅赵永鑫雷霖钟道应成都大学旅游与经济管理学院四川成都610106 成都大学信息科学与工程学院四川成都610106 舒城县五显中学安徽六安231300

汽车电子产品对整车性能和技术作用巨大,汽车电子的工程人才需求,但是汽车电子工程创新型人才却十分匮乏。本文结合成都市政府大力发展汽车工业的契机,立足成都大学实际,提出了一种针对地方本科院校汽车电子工程创新性人才培养的新模式... 详细信息

汽车电子产品对整车性能和技术作用巨大,汽车电子的工程人才需求,但是汽车电子工程创新型人才却十分匮乏。本文结合成都市政府大力发展汽车工业的契机,立足成都大学实际,提出了一种针对地方本科院校汽车电子工程创新性人才培养的新模式,并分析了该模式在创新性人才培方面的优势和特点。结果说明该模式在汽车电子工程创新性人才培养方面具有先进性。

关键词：汽车电子工程创新人才培养

Deep-ultraviolet nonlinear optical crystals: concept development and materials discovery

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Light(Science & Applications) 2022年第8期11卷 1718-1729页

作者： lei Kang Zheshuai lin Functional Crystals Lab Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China

Deep-ultraviolet (DUV, wavelength λ < 200 nm) nonlinear optical (NLO) crystal is the core component of frequency conversion to generate DUV laser, which plays an important role in cutting-edge laser technology and fu... 详细信息

Deep-ultraviolet (DUV, wavelength λ linear optical (NLO) crystal is the core component of frequency conversion to generate DUV laser, which plays an important role in cutting-edge laser technology and fundamental science. Significant progress has been made in both experimental exploration and theoretical design in the field of DUV NLO crystals over the past three decades. In-depth insight into “structure-property correlations”, in particular, allows for rigorous and precise identification of DUV NLO crystals. In this article, we reviewed the current experimental and theoretical research progress while elucidating the core concepts and stringent criteria of qualified DUV phase-matched second-harmonic generation crystals. We also discussed the development of the DUV NLO “structure-property correlations” from first principles and how it has sparked interest in related materials, as well as future directions for obtaining potential DUV NLO crystals.

关键词： optical ultraviolet Deep

Optical Modeling of Sea Salt Aerosols Using in situ Measured Size Distributions and the Impact of Larger Size Particles

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Advances in Atmospheric Sciences 2024年第10期41卷 1917-1935页

作者： Wushao lin lei BI Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhou 310058China

Sea salt aerosols play a critical role in regulating the global climate through their interactions with solar *** size distribution of these particles is crucial in determining their bulk optical *** this study,we analyzed in situ measured size distributions of sea salt aerosols from four field campaigns and used multi-mode lognormal size distributions to fit the *** employed super-spheroids and coated super-spheroids to account for the particles’non-sphericity,inhomogeneity,and hysteresis effect during the deliquescence and crystallization *** compute the singlescattering properties of sea salt aerosols,we used the state-of-the-art invariant imbedding T-matrix method,which allows us to obtain accurate optical properties for sea salt aerosols with a maximum volume-equivalent diameter of 12μm at a wavelength of 532 *** results demonstrated that the particle models developed in this study were successful in replicating both the measured depolarization and lidar ratios at various relative humidity(RH)***,we observed that large-size particles with diameters larger than 4μm had a substantial impact on the optical properties of sea salt aerosols,which has not been accounted for in previous ***,excluding particles with diameters larger than 4μm led to underestimating the scattering and backscattering coefficients by 27%−38%and 43%−60%,respectively,for the ACE-Asia field ***,the depolarization ratios were underestimated by 0.15 within the 50%−70%RH *** findings emphasize the necessity of considering large particle sizes for optical modeling of sea salt aerosols.

关键词： sea salt aerosol particle size distribution lidar optical property