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Enabling the transfer matrix method to model serial-parallel compliant mechanisms including curved flexure beams

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International Journal of Mechanical System Dynamics 2024年第1期4卷 48-62页

作者： Mingxiang Ling lei yuan Tingjun Zeng Xianmin Zhang Robotics and Microsystems Center Soochow UniversitySoochowChina Guangdong Key Laboratory of Precision Equipment and Manufacturing Technology School of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhouChina

Compliant mechanisms with curved flexure hinges/beams have potential advantages of small spaces,low stress levels,and flexible design parameters,which have attracted considerable attention in precision engineering,metamaterials,robotics,and so ***,serial-parallel configurations with curved flexure hinges/beams often lead to a complicated parametric ***,the transfer matrix method is enabled for analysis of both the kinetostatics and dynamics of general serial-parallel compliant mechanisms without deriving laborious formulas or combining other modeling ***,serial-parallel compliant mechanisms with curved flexure hinges/beams can be modeled in a straightforward manner based on a single transfer matrix of Timoshenko straight beams using a step-by-step *** and numerical validations on two customized XY nanopositioners comprised of straight and corrugated flexure units confirm the concise modeling process and high prediction accuracy of the presented *** conclusion,the present study provides an enhanced transfer matrix modeling approach to streamline the kinetostatic and dynamic analyses of general serial-parallel compliant mechanisms and beam structures,including curved flexure hinges and irregular-shaped rigid bodies.

关键词： compliant mechanisms curved flexure beams transfer matrix method nanopositioner rigid-body dynamics

Precipitating thermally reinforcement phase in aluminum alloys for enhanced strength at 400℃

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Journal of Materials Science & Technology 2024年第5期172卷 71-82页

作者： Xiang Su yuan lei Yang Chen Hongjie Qu Zhixiang Qi Gong Zheng Xu Liu Henggao Xiang Guang Chen National Key Laboratory of Advanced Casting Technologies MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials TechnologyEngineering Research Center of Materials Behavior and DesignMinistry of EducationNanjing University of Science and TechnologyNanjing 210094China School of Aviation and Mechanical Engineering Changzhou Institute of TechnologyChangzhou 213032China

Heat-resistant aluminum alloys are widely used in aerospace and automotive fields for manufacturing hot components due to their advantages in lightweight design and energy ***,the high-temperature strength of existing cast aluminum alloys is always limited to about 100 MPa at 350℃due to coarsening and transformation of strengthening ***,we reveal that the yield strength and ultimate tensile strength of the T6 state Al-8.4Cu-2.3Ce-1.0Mn-0.5Ni-0.2Zr alloy at 400◦C increase by 34%and 44%after re-aging at 300℃for 100 h,and its thermal strength exhibits distinguished ad-vantage over traditional heat-resistant aluminum *** enhanced elevated-temperature strength is attributed to the reprecipitation of the Ni-bearing T-Al_(20)Cu_(2)Mn_(3)phase,whose number density increases over one *** significant segregation of Ni,Ce,and Zr elements at the interfaces helps improve the thermal stability of the T *** thermostable T phase effectively strengthens the matrix by in-hibiting dislocation ***,a highly interconnected 3D intermetallic network along the grain boundaries can still remain after long-term re-aging at 300℃,which is conducive to imposing a drag on the grain boundaries at high *** finding offers a viable route for enhancing the elevated-temperature strength of heat-resistant aluminum alloys,which could provide expanded opportunities for higher-temperature applications.

关键词： Aluminum alloys Precipitation Thermally reinforcement phase Re-aging treatment High-temperature strength

A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo Qin yuan lei Luo Bao You-Jia Zhang Ke-Yin Liu Yu-Hong Chen Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China Key Laboratory of Myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China State Key Laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(P<0.01).Additionally,ONOO-levels were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,P<0.01 for AH;OR=1.004,95%CI:1.002-1.006,P<0.001 for plasma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,P<0.01 for AH;R=0.45,P<0.001 for plasma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,P<0.001).However,administering MnTMPyP to mouse eyes reversed the elevated IOP caused by SIN-1(P<0.05).CONCLUSION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG ***,ONOO-is a potential biomarker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

Multi-agent policy transfer via task relationship modeling

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Science China(Information Sciences) 2024年第8期67卷 102-114页

作者： Rongjun QIN Feng CHEN Tonghan WANG lei yuan Xiaoran WU Yipeng KANG Zongzhang ZHANG Chongjie ZHANG Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies School of Engineering and Applied Sciences Harvard University Department of Computer Science and Technology Tsinghua University Institute for Interdisciplinary Information Sciences Tsinghua University

Team adaptation to new cooperative tasks is a hallmark of human intelligence, which has yet to be fully realized in learning agents. Previous studies on multi-agent transfer learning have accommodated teams of different sizes but heavily relied on the generalization ability of neural networks for adapting to unseen tasks. We posit that the relationship among tasks provides key information for policy *** utilize this relationship for efficient transfer by attempting to discover and exploit the knowledge among tasks from different teams, proposing to learn an effect-based task representation as a common latent space among tasks, and using it to build an alternatively fixed training scheme. Herein, we demonstrate that task representation can capture the relationship among teams and generalize to unseen tasks. Thus, the proposed method helps transfer the learned cooperation knowledge to new tasks after training on a few source ***, the learned transferred policies help solve tasks that are difficult to learn from scratch.

关键词： multi-agent reinforcement learning cooperative transfer learning task relationship modeling multi-agent policy reuse multi-agent multi-task learning

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Advance in reversible Zn anodes promoted by 2D materials

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Rare Metals 2024年第4期43卷 1350-1369页

作者： Shu-yuan lei Jin-Xiu Feng Yu-Chao Chen Dong Zheng Wen-Xian Liu Wen-Hui Shi Fang-Fang Wu Xie-Hong Cao School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou310014China Center for Membrane Separation and Water Science and Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

With the growing energy demand associated with high safety and low-cost requirement,aqueous zinc-ion batteries(AZIBs)have been considered as one of the most promising next-generation ***,some key issues,such as uncontrollable dendrites growth,severe corrosion,hydrogen evolution and side reactions of Zn anodes during charge/discharge process,have hindered its pragmatic ***-dimensional(2D)materials hold advantages of unique physical and chemical properties,large surface areas and abundant active sites,which have been successfully used to overcome the above shortcomings of Zn anodes in recent *** this review,the issues and challenges of Zn anodes are ***,the state-of-the-art progress on Zn anodes modification based on 2D materials such as graphene,2D metal carbides and nitrides(MXenes),2D metal-organic frameworks(MOFs),2D covalent organic frameworks(COFs),2D transition metal compounds and other 2D materials is discussed in ***,the perspectives of employing 2D materials in highly reversible Zn anodes are summarized and discussed.

关键词： 2D materials Aqueous zinc-ion battery Zn anodes Dendrites growth

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Exploring non-curative endoscopic submucosal dissection:Current treatment optimization and future indication expansion

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World Journal of Gastroenterology 2024年第9期30卷 1257-1260页

作者： Yi-Nong Zhu Xiang-lei yuan Wei Liu Yu-Hang Zhang Yi Mou Bing Hu Lian-Song Ye Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

The increasing popularity of endoscopic submucosal dissection(ESD)as a treatment for early gastric cancer has highlighted the importance of quality assessment in achieving curative *** article emphasizes the significance of evaluating ESD quality,not only for curative cases but also for non-curative *** assessment relies on the endoscopic curability(eCura)classification,but management strategies for eCuraC-1 tumour with a positive horizontal margin are *** research primarily focuses on comparing additional surgical procedures in high-risk patients,while studies specifically targeting eCuraC-1 patients are *** management strategies and follow-up outcomes for such cases could provide valuable ***,the application of molecular imaging using near-infrared fluorescent tracers holds promise for precise tumour diagnosis and navigation,potentially impacting the management of early-stage gastric cancer *** research in these areas is essential for improving the overall efficacy of endoscopic techniques and refining treatment indications.

关键词： Early gastric cancer Endoscopic submucosal dissection Quality control Noncurative endoscopic submucosal dissection Near-infrared fluorescent tracer

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平台企业数据安全治理研究

世界社会科学 2024年第1期 103-118+244-245页

作者：原磊中国社会科学院经济研究所

平台企业以数据资源为核心推动商业模式创新，带来了生产方式和生活方式的根本性变革，但也造成了隐私泄露、数据滥用、行业损害等方面的安全问题，甚至会危害到国家安全。这些问题的产生具有一定的必然性，是由数据的脆弱性、资本的逐... 详细信息

平台企业以数据资源为核心推动商业模式创新，带来了生产方式和生活方式的根本性变革，但也造成了隐私泄露、数据滥用、行业损害等方面的安全问题，甚至会危害到国家安全。这些问题的产生具有一定的必然性，是由数据的脆弱性、资本的逐利性、技术的非对称性和规则的不完备性决定的。为加强平台企业数据安全治理，必须处理好静态安全和动态安全、绝对安全和相对安全、局部安全和整体安全、维护安全和塑造安全的关系；要平衡不同利益相关方诉求，实现多重目标协同推进；要形成政府治理、社会组织治理、公众治理、平台企业自治、全球治理协同配合的良好机制；要针对数据价值链各个环节，对平台企业数据活动进行全过程监管。

关键词：平台企业数据安全治理体系数据价值链

Developing a diagnostic model for predicting prostate cancer: a retrospective study based on Chinese multicenter clinical data

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Asian Journal of Andrology 2024年第1期26卷 34-40页

作者： Chang-Ming Wang lei yuan Xue-Han Liu Shu-Qiu Chen Hai-Feng Wang Qi-Fei Dong Bin Zhang Ming-Shuo Huang Zhi-Yong Zhang Jun Xiao Tao Tao Department of Urology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Core Facility Center for Medical Sciences The First Affiliated Hospital of USTcDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Urology Affiliated Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Urology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200000China Department of Urology Affiliated Anhui Provincial Hospital of Anhui Medical UniversityHefei 230001China

The overdiagnosis of prostate cancer(PCa)caused by nonspecific elevation serum prostate-specific antigen(PSA)and the overtreatment of indolent PCa have become a global problem that needs to be solved *** aimed to construct a prediction model and provide a risk stratification system to reduce unnecessary *** this retrospective study,clinical data of 1807 patients from three Chinese hospitals were *** final model was built using stepwise logistic regression *** apparent performance of the model was assessed by receiver operating characteristic curves,calibration plots,and decision curve ***,a risk stratification system of clinically significant prostate cancer(csPCa)was created,and diagnosis-free survival analyses were *** multivariable screening and evaluation of the diagnostic performances,a final diagnostic model comprised of the PSA density and Prostate Imaging-Reporting and Data System(PI-RADS)score was *** validation in the development cohort and two external cohorts showed excellent discrimination and ***,we created a risk stratification system using risk thresholds of 0.05 and 0.60 as the cut-off *** follow-up results indicated that the diagnosis-free survival rate for csPCa at 12 months and 24 months postoperatively was 99.7%and 99.4%,respectively,for patients with a risk threshold below O.05 after the initial negative prostate biopsy,which was significantly better than patients with higher *** diagnostic model and risk stratification system can achieve a personalized risk calculation of *** provides a standardized tool for Chinese patients and physicians when considering thenecessity of prostatebiopsy.

关键词： nomogram prostate biopsy prostate cancer Prostate Imaging-Reporting and Data System prostate-specific antigen density

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实施有利于共同富裕的新型产业政策

当代经济研究 2024年第2期342卷 14-17页

作者：原磊中国社会科学院经济研究所中国社会科学院全国中国特色社会主义政治经济学研究中心

2023年中央经济工作会议提出:“要增强宏观政策取向一致性。加强财政、货币、就业、产业、区域、科技、环保等政策协调配合,把非经济性政策纳入宏观政策取向一致性评估,强化政策统筹,确保同向发力、形成合力。”这一表述有着深刻的政策... 详细信息

2023年中央经济工作会议提出:“要增强宏观政策取向一致性。加强财政、货币、就业、产业、区域、科技、环保等政策协调配合,把非经济性政策纳入宏观政策取向一致性评估,强化政策统筹,确保同向发力、形成合力。”这一表述有着深刻的政策含义,体现了中央在宏观经济治理中更加注重将不同类型政策纳入统一框架当中,强调不同政策之间的协调性和配合性,从而在多目标中把握好综合平衡。产业政策是我国宏观政策的重要组成部分,对推动我国经济社会发展发挥了重要作用.

关键词：非经济性配合性一致性评估宏观政策产业政策统一框架宏观经济共同富裕

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