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Cellular & Molecular Immunology 2010年第2期7卷 157-162页

作者： Shudao xiong lei Zhang Yiwei Chu Department of Immunology Shanghai Medical College Institute for Immunobiology Key Laboratory of Molecular Medicine of Ministry of Education Fudan University ShanghaiChina

Low-dose total body irradiation （LTBI） is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4^＋CD25^＋Foxp3^＋ regulatory T cells are markedly decreased in naive mice following treatment with LTBI. On the contrary, the CD4^＋CD44^＋/CD8^＋CD44^＋ effector-memory T cells are greatly increased. Importantly, naive mice treated with dendritic cell-gp100 tumor vaccines under LTBI induced an enhancement of antigen-specific proliferation and cytotoxicity as well as interferon-γ, （IFN-γ） secretion against FIO melanoma tumor challenge, compared to treatment with either the tumor vaccine or LTBI alone. Consequently, the treatment resulted in a reduced tumor burden and prolonged mouse survival. Our data demonstrate that LTBI＇s enhancement of antitumor immunity was mainly associated with selectively decreasing the proportion and number of T regulatory cells, implying the potential application of the combination of LTBI and a tumor vaccine in antitumor therapy.

关键词： CD4^+CD25^+Foxp3^+ T cells CD4^+CD44^+/CD8^+CD44^+ effector-memory T cells low-dose total body irradiation LTBI tumor vaccine

Sequential Filtering for Surface Wind Speed Estimation from Ambient Noise Measurement

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China Ocean Engineering 2017年第1期31卷 74-78页

作者： XIAO Peng YANG Kun-de lei Zhi-xiong School of Marine Science and Technology Northwestern Polytechnical University Xi'an 710072 China

Many research results show that ocean ambient noise and wind speed are highly relevant, and the surface wind speed can be effectively inverted using ocean noise data. In most deep-sea cases, the ambient noise of medium frequency is mainly determined by the surface wind, and there is a conventional relationship between them. This paper gives an equation which shows this relationship firstly, and then a surface-wind inversion method is proposed. An efficient particle filter is used to estimate the speed distribution, and the results exhibit more focused close to the actual wind speed. The method is verified by the measured noise data, and analysis results showed that this approach can accurately give the trend of sea surface wind speed.

关键词： particle filtering wind speed noise spectrum level inversion

A Query Expansion Method Based on Evolving Source Code

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Wuhan University Journal of Natural Sciences 2019年第5期24卷 391-399页

作者： JIN Huan xiong lei College of Information Engineering Jiangxi University of Technology Nanchang 330000 Jiangxi China Center of Collaboration and Innovation Jiangxi University of Technology Nanchang 330000 Jiangxi China

The existing query expansion(QE) methods cannot find the most users-requested source code version at times due to the over-expansion resulting from noises. To solve this problem, we propose a QE method based on evolving contexts(EC) that are added/deleted terms and their dependent terms during code evolution. On expanding a query, we appended the added terms as relevant terms, and excluded the deleted terms as noisy terms. We also developed a QE-integrating framework based on the Support Vector Machine(SVM) Ranking, called QESR, to simultaneously integrate multiple QE methods. Our experiment shows that QESR outperforms the state-of-the-art QE methods CodeHow and Query Expansion based on Crowd Knowledge(QECK) by 13%-16% in terms of precision when the first query result is inspected.

关键词： code search query expansion crowd knowledge evolving context

Micro structure and corrosion behavior of ALD AI2O3 film on AZ31 magnesium alloy with different surface roughness

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Journal of Magnesium and Alloys 2020年第2期8卷 480-492页

作者： Fumin Xu Lan Luo lei xiong Yong Liu Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province Nanchang UniversityNanchang 330031China School of Materials Science and Engineering Nanchang UniversityNanchang 330001China

There remains growing interest in magnesium(Mg)and its alloys,as they are the lightest structural metallic materials and potential metallic *** spite of the greatest historical Mg usage at present,the wider use of Mg alloys remains restricted by the poor corrosion resistance.A nano amorphous film,as the composition of Al2O3,had now been deposited on the AZ31 Mg alloy substrate by atomic layer deposition(ALD).Grazing incidence X-ray diffraction(GIXRD),X-ray reflectivity(XRR),X-ray photoelectron spectroscopy(XPS),atomic force microscope(AFM)and scanning electron microscopy(SEM)had been employed to identify the chemical compositions,microstructure and Al2O3/Mg interface of specimens *** corrosion behavior had been evaluated by neutral salt spray test and electrochemical *** results showed that nano amorphous film made a homogeneous cover on Mg *** film could improve the corrosion resistance of Mg alloy greatly,not only with a positive shift in Ecorr and a decrease in icorr,but also with a more uniform corroded ***,the roughness was found to be an important factor for corrosion resistant,in the way that rougher surface was corroded worse,and greater improvement would be in corrosion resistant after nano amorphous film deposition.

关键词： Mg alloys Nano amorphous film Corrosion resistance Surface roughness Electrochemical measurement

A method to determine Young's modulus of soft gels for cell adhesion

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Acta Mechanica Sinica 2009年第4期25卷 565-570页

作者： Xiaoling Peng Jianyong Huang lei Qin Chunyang xiong Jing Fang Laboratory of Cell Mechanics Department of Biomedical Engineering Peking University 100871 Beijing China

A convenient technique is reported in this note for measuring elastic modulus of extremely soft material for cellular adhesion. Specimens of bending cylinder under gravity are used to avoid contact problem between testing device and sample, and a beam model is presented for evaluating the curvatures of gel beams with large elastic deformation. A self-adaptive algorithm is also proposed to search for the best estimation of gels＇ elastic moduli by comparing the experimental bending curvatures with those computed from the beam model with preestimated moduli. Application to the measurement of the property of polyacrylamide gels indi- cates that the material compliance varies with the concentrations of bis-acrylamide, and the gels become softer after being immersed in a culture medium for a period of time, no matter to what extent they are polymerized.

关键词： Young's modulus Bending measurement Cell adhesion Polyacrylamide gel

Hyperaccretion after the Blandford-Znajek Process:A New Model for GRBs with X-Ray Flares Observed in Early Afterglows

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Chinese Journal of Astronomy and Astrophysics 2008年第4期8卷 404-410页

作者： Wei-Hua lei Ding-xiong Wang Yuan-Chuan Zou lei Zhang Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We propose a three-stage model with Blandford-Znajek （BZ） and hyperaccretion process to interpret the recent observations of early afterglows of Gamma-Ray Bursts （GRBs）. In the first stage, the prompt GRB is powered by a rotating black hole （BH） invoking the BZ process. The second stage is a quiet stage, in which the BZ process is shut off, and the accretion onto the BH is depressed by the torque exerted by the magnetic coupling （MC） process. Part of the rotational energy transported by the MC process from the BH is stored in the disk as magnetic energy. In the third stage, the MC process is shut off when the magnetic energy in the disk accumulates and triggers magnetic instability. At this moment, the hyperaccretion process may set in, and the jet launched in this restarted central engine generates the observed X-ray flares. This model can account for the energies and timescales of GRBs with X-ray flares observed in early afterglows.

关键词： accretion, accretion disks - black hole physics - magnetic fields - gammarays bursts

Generating Kerr nonlinearity with an engineered non-Markovian environment

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Chinese Physics B 2020年第4期29卷 146-153页

作者： Fei-lei xiong Wan-Li Yang Mang Feng State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China Department of Physics Zhejiang Normal UniversityJinhua 321004China School of Physics and Engineering Zhengzhou UniversityZhengzhou 450001China

Kerr nonlinearity is an important resource for creating squeezing and entanglement in quantum *** we propose a scheme for generating Kerr nonlinearity originated from an engineered non-Markovian environment,which is different from the previous efforts using nonlinear media or quantum systems with special energy *** the present work,the generation of Kerr nonlinearity depends on the system-environment interaction time,the energy spectrum of the environment,and the system-environment coupling strength,regardless of the environmental initial *** scheme can be realized in systems originally containing no Kerr interaction,such as superconducting circuit systems,optomechanical systems,and cavity arrays connected by transmission lines.

关键词： Kerr nonlinearity quantum non-Markovianity engineered environment

LMWH inhibits anterior chamber inflammation after extra capsular lens extraction through down regulation of bFGF content in aqueous humor

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 430-433页

作者： Jian-Ming Wang lei xiong Quan-Chen xiong and Ya-Zhi Fan Department of Ophthalmology the Second Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China

AIM: To observe the changes of basic fibroblast growth factor (bFGF) content in anterior chamber before and after extra capsular lens extraction for investigating the mechanism of low molecular weight heparin (LMWH) inhibiting anterior chamber inflammation. METHODS: Eighty-four rabbits were randomly divided into control and experimental group, 42 rabbits in each group. Extra capsular lens extraction was done on unilateral eye in each rabbit. LMWH was perfused into anterior chamber by the concentration of 50U/mL at the end of operation in experimental group. The degrees of corneal edema, aqueous flare and fibrin were evaluated with slit lamp microscope in postoperative day 1, 3, 6, 15, 30, 45 and 60, respectively. Six eyes of each group were at each time point. Contents of bFGF in aqueous humor were determined by ELISA after animals were killed. Another six eyes were used for determining the base line level of bFGF in aqueous humor. RESULTS: The degrees of corneal edema, aqueous flare and fibrin in experimental group were significantly lighter than those in control group (p<0.01) on postoperative day 1, 3 and 6, respectively. No difference was showed between the two groups at other point time. Contents of bFGF in aqueous humor increased at the same time. bFGF content was reached peal on postoperative day 1 in experimental group, while on postoperative day 6 in control group. Contents of bFGF in the two groups declined slowly after reaching peak. The bFGF content in control group were significantly higher than that in experimental group 1-30 days after surgery (p<0.05). No significant differences were shown between the two groups on postoperative day 45 and 60, respectively. CONCLUSION: Perfusion with LMWH by the concentration of 50U/mL can significantly reduce anterior chamber inflammation after extra capsular lens extraction in rabbits, which may be related to down regulation of bFGF content in aqueous humor.

关键词： low molecular weight heparin inflammation aqueous humor basic fibroblast growth factor extracapsular lens extraction

Insulin promotes sinusoidal endothelial cell proliferation mediated by upregulation of vascular endothelial growth factor in regenerating rat liver after partial hepatectomy

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World Journal of Gastroenterology 2005年第38期11卷 5978-5983页

作者： Jian-Guo Qiao Long Wu Dao-xiong lei Lu Wang Department of General Surgery Zhongnan Hospital Affiliated to Wuhan University Wuhan 430071 Hubei Province China

AIM： To determine whether insulin could promote sinusoidal endothelial cell （SEC） proliferation mediated by upregulation of vascular endothelial growth factor （VEGF） in regenerating rat liver after partial hepatectomy （PHx）. METHODS： Adult male Sprague-Dawley rats undergoing 70% PHx were injected with insulin （300 MU/kg） or saline via the tail veins every 8 h after surgery for 7 d and killed at 0, 24, 48, 72, 96, 120, 144, and 168 h after surgery. Proliferation of both hepatocytes and SECs was monitored by evaluating the proliferating cell nuclear antigen （PCNA） labeling index （LI）. The expression of VEGF protein was evaluated by immunohistochemistJv. The mRNA expressions of VEGF and its receptors FIt-1 and FIk-1 were evaluated by semi-quantitative reverse transcription-PCR. RESULTS： Insulin markedly increased the expression of VEGF mRNA between 24 and 120 h after hepatectomy compared to controls. Similarly, insulin significantly increased the expression of Fit-1 between 24 and 96 h. However, insulin had no significant effect on FIk-1. Furthermore, the immunohistochemical staining revealed that expression of VEGF protein increased in the insulin groups. Insulin significantly increased the PCNA LI of hepatocytes and SECs compared to controls. CONCLUSION： Exogenous insulin may promote SEC proliferation with an enhanced expression of VEGF and its receptor Fit-1 in regenerating rat liver after PHx.

关键词： Insulin Sinusoidal endothelial cell VEGF

A secure and high-performance multi-controller architecture for software-defined networking

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Frontiers of Information Technology & Electronic Engineering 2016年第7期17卷 634-646页

作者： Huan-zhao WANG Peng ZHANG lei xiong Xin LIU Cheng-chen HU Department of Computer Science and Technology Xi'an Jiaotong UniversityXi'an 710059China Science and Technology on Information Transmission and Dissemination in Communication Networks Laboratory Shijiazhuang 050081China MOE Key Laboratory for Intelligent Networks and Network Security Xi'an Jiaotong UniversityXi'an 710049China

Controllers play a critical role in software-defined networking(SDN).However,existing singlecontroller SDN architectures are vulnerable to single-point failures,where a controller's capacity can be saturated by flooded flow *** addition,due to the complicated interactions between applications and controllers,the flow setup latency is relatively *** address the above security and performance issues of current SDN controllers,we propose distributed rule store(DRS),a new multi-controller architecture for *** DRS,the controller caches the flow rules calculated by applications,and distributes these rules to multiple controller *** controller instance holds only a subset of all rules,and periodically checks the consistency of flow rules with each *** from switches are distributed among multiple controllers,in order to mitigate controller capacity saturation *** the same time,when rules at one controller are maliciously modified,they can be detected and recovered in *** implement DRS based on Floodlight and evaluate it with extensive *** results show that DRS can effectively maintain a consistently distributed rule store,and at the same time can achieve a shorter flow setup time and a higher processing throughput,compared with ONOS and Floodlight.

关键词： Software-defined networking(SDN) Security Multi-controller Distributed rule store