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Lewis base catalyzed ring-expansion of isatin with 2,2,2-trifluorodiazoethane(CF3CHN2):An efficient route to3-hydroxy-4-(trifluoromethyl)quinolinones

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Chinese Chemical Letters 2020年第6期31卷 1568-1571页

作者： Shuaipeng Lv Yunfang Sun Yue Xu shihai Yang lei wang Department of Traditional Chinese Medicine Jilin Agricultural UniversityChangchun 130118China Institute of Medicinal Plant Development Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100193China

A Lewis base catalyzed ring expansion of isatin with 2,2,2-trifluorodiazoethane(CF3 CHN2)is *** is characterized that the merge of tetramethylethylenediamine and CF3 CHN2 generates reactive triazene intermediates,which construct substituted 3-hydroxy-4-(trifluoromethyl)quinolinones with high *** application of the procedure is broadened by 3-trifluormethylpyrazole fused3-hydroxy-4-(trifluoromethyl)quinolinone synthesis.

关键词： Ring-expansion Lewis base Heterocycle Quinolinones Triazene

3D bioprinting of integral ADSCs-NO hydrogel scaffolds to promote severe burn wound healing

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Regenerative Biomaterials 2021年第3期8卷 1-10页

作者： Yu Wu Tangzhao Liang Ying Hu shihai Jiang Yuansen Luo Chang Liu Guo wang Jing Zhang Tao Xu lei Zhu Department of Plastic and Aesthetic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityNo.600 Tianhe RoadTianhe DistrictGuangzhou 510630China East China Institute of Digital Medical Engineering Shangrao 334000China Department of Joint and Trauma Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Institute of Laboratory Medicine Clinical Chemistry and Molecular DiagnosticsUniversity Hospital LeipzigLeipzig 04103Germany Department of The Second Plastic Surgery The First People’s Hospital of FoshanFoshan 528000China Department of Mechanical Engineering Tsinghua UniversityNo.30 Shuangqing RoadHaidian DistrictBeijing 100084China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China

Severe burns are challenging to heal and result in significant death throughout the *** mesenchymal stem cells(ADSCs)have emerged as a promising treatment for fullthickness burn healing but are impeded by their low viability and efficiency after grafting in *** oxide(NO)is beneficial in promoting stem cell bioactivity,but whether it can function effectively in vivo is still largely *** this study,we bioprinted an efficient biological scaffold loaded with ADSCs and NO(3D-ADSCs/NO)to evaluate its biological efficacy in promoting severe burn wound *** integral 3D-ADSCs/NO hydrogel scaffolds were constructed via 3D *** results shown that 3D-ADSCs/NO can enhance the migration and angiogenesis of Human Umbilical Vein Endothelial Cells(HUVECs).Burn wound healing experiments in mice revealed that 3D-ADSCs/NO accelerated the wound healing by promoting faster epithelialization and collagen ***,immunohistochemistry of CD31 suggested an increase in neovascularization,supported by the upregulation of vascular endothelial growth factor(VEGF)mRNA in ADSCs in the 3D *** findings indicated that 3D-ADSC/NO hydrogel scaffold can promote severe burn wound healing through increased neovascularization via the VEGF signalling *** scaffold may be considered a promising strategy for healing severe burns.

关键词： 3D bioprinting ADSCs nitric oxide angiogenesis severe burn wound healing

Comparisons on Mineralogy and Lithology between Paleozoic Marine and Lacustrine Dolostones, Northern China

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Acta Geologica Sinica(English Edition) 2017年第S1期91卷 281-282页

作者： LI Hong LIU Yiqun NIU Yuanzhe FENG shihai lei Yun LIU Yongjie State Key Laboratory of Continental Dynamics(Northwest University) Xi’an710069

1 Introduction Dolomite[Ca Mg(CO3)2],a common mineral in carbonate rocks,can be found in various geological settings from Precambrian to modern age,and is widely reported in almost all sedimentary and digenetic

关键词： Comparisons on Mineralogy and Lithology between Paleozoic Marine and Lacustrine Dolostones Northern China

Hsa_circ_0002137 stabled by LIN28B promotes osteosarcoma cell growth through the hsa-miR-1246/BCL2 axis

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BIOCELL 2022年第3期46卷 699-709页

作者： FEI ZHANG JIANZHONG LAI RONGHAN HE YI SHI KUN XU shihai JIANG TANGZHAO LIANG WANYU ZHAO WEIDA REN lei ZHU SONG JIN KUN wang Department of Joint and Trauma Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Department of Othopaedic Surgery The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen518033China Department of Othopaedic Surgery Dongguan Dongcheng HospitalDongguan523007China Department of Orthopedic The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Key Laboratory for Regenerative Medicine Ministry of EducationCollege of Life Science and TechnologyJinan UniversityGuangzhou510632China Department of Plastic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China

Circular RNAs(circRNAs)are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional *** evidence has indicated that circRNAs could serve as competing endogenous RNAs(ceRNAs)to sponge microRNAs(miRNAs)and suppress functions of targeted ***(OS)is the most common malignant primary bone ***_circ_0002137 is upregulated in ***,the role of hsa_circ_0002137 in OS remains *** miRNA pull-down assay,we showed that cir_0002137 sponged hsa-miR-1246,and BCL2 apoptosis regulator(BCL2)mRNA was a potential target of hsa-miR-1246 in human osteosarcoma(HOS)***,we found that hsa_cir_0002137 could enhance the expression of BCL2 hsa-miR-1246 and promote HOS cell growth through sponging ***,RNA binding protein immunoprecip itation(RIP)assay revealed that lin-28 homolog B(LIN28B)protein associated with hsa_circ_0002137,and LIN28B could increase hsa_circ_0002137 stability and thus accelerate OS cell *** work was the first to study the functions of hsa_circ_0002137,has-miR-1246 and LIN28B in OS,and these results may provide novel therapeutic targets for OS treatment.

关键词： Osteosarcoma hsa_circ_0002137 hsa-miR-1246 Proliferation Apoptosis

CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis

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Journal of Molecular Cell Biology 2023年第10期15卷 10-25页

作者： Haixia Cheng Lingyang Hua Hailiang Tang Zhongyuan Bao Xiupeng Xu Hongguang Zhu Shuyang wang Zeyidan Jiapaer Roma Bhatia Ian FDunn Jiaojiao Deng Daĳun wang Shuchen Sun shihai Luan Jing Ji Qing Xie Xinyu Yang Ji lei Guoping Li Xianli wang Ye Gong Department of Pathology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210000China Xinjiang Key Laboratory of Biology Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqi 830046China Beth Israel Deaconess Medical Center Harvard Medical SchoolBostonMA 02215USA Department of Neurosurgery University of Oklahoma Health Sciences CenterOklahoma CityOK 73117USA Fangshan Hospital of Beĳing University of Traditional Chinese MedicineBeĳing 102400China Center for Transplantation Science Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Cardiovascular Research Center Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China

Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive *** is hence an urgent demand to decrypt the biological and molecular landscape of malignant ***,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma ***7 restoration significantly induces cell cycle arrest and inhibits meningioma cell ***-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative *** mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell *** importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma ***,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.

关键词： CBX7 meningioma glycolysis USP44 c-MYC LDHA malignancy glucose metabolism

Experimental investigation and numerical simulation on the effect of fissure water pressure in vertical sliding surface

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Science China(Technological Sciences) 2005年第Z1期48卷 53-64页

作者： ZHANG lei1,2, LI shihai1, LIAN Zhenzhong1,2 & wang Yuannian1 1. Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China 2. Graduate School, Chinese Academy of Sciences, Beijing 100060, China Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China Graduate School Chinese Academy of Sciences Beijing 100060 China

This paper studies the effect of fissure water pressure in different fractures on the critical angle of landslide by laboratory investigation and numerical simulation in order to understand the mechanisms of fissure water pressure on landslide stability. Laboratory observations show that the effect of fissure water pressure on the critical angle of landslide is little when the distance between water-holding fracture and slope toe is three times greater than the depth of fissure water. These experimental results are also simulated by a three-dimensional face-to-face contact discrete element method. This method has included the fissure water pressure and can accurately calculate the critical angle of jointed slope when fissure water pressure in vertical sliding surface exists. Numerical results are in good agreement with experimental observations. It is revealed that the location of water-holding structural surface is important to landslide stability. The ratio of the distance between water-holding fissure and slope toe to the depth of fissure water is a key parameter to justify the effect of fissure water pressure on the critical angle of landslide.

关键词： jointed rock slope, discrete element method, fracture in vertical sliding surface, model experiment,fissure water pressure.

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核保障用探测器的现状与发展

原子能科学技术 2024年第S2期58卷 438-451页

作者：赵永刚靳尚泰庄晓郭佳承柏磊沈彦黄声慧陈雷智宇李沛玉胡守扬周静孙鹏飞宋金兴赵明锐贾世海邓桂华吝守龙卢志永许天驹王浩祯蒋涛李笑梅中国原子能科学研究院放射化学研究所北京102413 中国原子能科学研究院核数据重点实验室北京102413

国际原子能机构(IAEA)建立了比较完整的核保障体系并不断加以完善,以确保有能力监督原子能技术的和平利用,以及保障相关核技术不被应用于军事用途。本文对IAEA核保障体系的建立和发展进行了描述。核保障技术的应用与发展依赖于探测技术... 详细信息

国际原子能机构(IAEA)建立了比较完整的核保障体系并不断加以完善,以确保有能力监督原子能技术的和平利用,以及保障相关核技术不被应用于军事用途。本文对IAEA核保障体系的建立和发展进行了描述。核保障技术的应用与发展依赖于探测技术的进步,国内在核保障技术方面做了大量的研究,基于各种探测需求开发了不同探测装置,如针对γ射线、X射线、中子的辐射探测器,针对衰变产生热量的量热计,针对不同质量数进行区分的质谱仪。对IAEA核保障设备的发展趋势进行了分析,提出了一些未来可以应用的探测器或探测技术。

关键词：核保障核材料探测器辐射测量

ArborTracking:a tree topology track pattern recognition algorithm

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Radiation Detection Technology and Methods 2020年第3期4卷 377-382页

作者： Mingrui Zhao Manqi Ruan Shouyang Hu Jing Zhou Yuliang Yan lei Chen Wendi Liu Peiyu Li shihai Jia Yunyu Zhang Xiaomei Li Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Purpose The purpose of this work is to develop a novel pattern tracking algorithm to be used on the detectors of the future electron-positron *** ArborTracking,a light-weighted tracking algorithm,has been developed based on the tree topology of track clusters and applied to the baseline detector of the circular electron-positron collider(CEPC).The algorithm collects all the hits in the tracker as a tree(forest),splits the tree branches to form the track segments,and merges the track segments to form the *** Compared with the general track following method,the algorithm has the advantages of low coding complicity and low CPU *** performances at different benchmarks are *** results are exhaustively listed showing that the method is approaching the limit of the *** tracking efficiencies on single muon sample and three-prong sample are both higher than 99%.The transverse momentum resolution reaches 0.1%level and the boson mass resolution reaches 4.7 GeV/*** The performances are similar with those of the baseline tracking algorithm of CEPC,and the physics requirement of CEPC is *** new tree pattern recognition algorithm is a necessary part in the CEPC *** it is also a competitive algorithm on the market,which can be chosen by the future experiments.

关键词： Tracking Arbor Future collider Circular electron-position collider

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时间投影室原理及其应用

原子能科学技术 2024年第S2期58卷 452-463页

作者：李笑梅李沛玉张昀昱孙鹏飞宋金兴庄晓靳尚泰陈雷胡守扬智宇周静赵明锐贾世海邓桂华吝守龙卢志永郭佳承许天驹王浩祯蒋涛中国原子能科学研究院核数据重点实验室北京102413 国家国防科技工业局核技术支持中心北京100070 中国原子能科学研究院放射化学研究所北京102413

时间投影室是一种广泛应用于大型物理实验的粒子鉴别探测器,它通过粒子径迹产生电离电子的漂移时间和漂移方向的投影位置确定径迹三维坐标,具备较好的能量分辨和很高的位置分辨能力。自时间投影室被发明以来,已广泛应用于国外的大科学... 详细信息

时间投影室是一种广泛应用于大型物理实验的粒子鉴别探测器,它通过粒子径迹产生电离电子的漂移时间和漂移方向的投影位置确定径迹三维坐标,具备较好的能量分辨和很高的位置分辨能力。自时间投影室被发明以来,已广泛应用于国外的大科学实验装置上,在对撞机和固定靶实验等方面均发挥了很大的作用。虽然国内的科研机构在早期对时间投影室进行过一些初步研究,但由于技术的限制并没有展开过很多应用。近十年间,伴随着锦屏地下实验室的PandaX-Ⅲ实验的开展、东莞中国散裂中子源等一批科研装置的落地、环形正负电子对撞机的概念设计完成,时间投影室作为主径迹探测器在这些实验中承担了很大一部分工作,并已进行了更多的研发和使用。现阶段有必要对时间投影室在国内外的具体应用与发展进行梳理,本文先梳理出时间投影室的发展历史、工作原理和现状以及时间投影室上核心读出探测器的发展,然后介绍时间投影室在国外大科学实验装置上的应用和最新进展,最后给出时间投影室在国内科研项目上的应用。以此为时间投影室下一步的研发与应用奠定基础。

关键词：时间投影室微结构探测器大科学装置