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Chemical Mechanical Polishing of Glass Substrate with α-Alumina-g-Polystyrene Sulfonic Acid Composite Abrasive

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Chinese Journal of Mechanical Engineering 2010年第3期23卷 276-281页

作者： lei Hong bu Naijing ZHANG Zefang CHEN Ruling Research Center of Nano-science and Nano-technology Shanghai University Shanghai 200444 China

Abrasive is the one of key influencing factors during chemical mechanical polishing（CMP） process. Currently, α-Alumina （α-Al2O3） particle, as a kind of abrasive, has been widely used in CMP slurries, but their high hardness and poor dispersion stability often lead to more surface defects. After being polished with composite particles, the surface defects of work pieces decrease obviously. So the composite particles as abrasives in slurry have been paid more attention. In order to reduce defect caused by pure α-Al2O3 abrasive, α-alumina-g-polystyrene sulfonic acid （α-Al2O3-g-PSS） composite abrasive was prepared by surface graft polymerization. The composition, structure and morphology of the product were characterized by Fourier transform infrared spectroscopy（FTIR）, X-ray photoelectron spectroscopy（XPS）, time-of-flight secondary ion mass spectroscopy（TOF-SIMS）, and scanning electron microscopy（SEM）, respectively. The results show that polystyrene sulfonic acid grafts onto α-Al2O3, and has well dispersibility. Then, the chemical mechanical polishing performances of the composite abrasive on glass substrate were investigated with a SPEEDFAM-16B-4M CMP machine. Atomic force microscopy（AFM） images indicate that the average roughness of the polished glass substrate surface can be decreased from 0.835 nm for pure α-Al2O3 abrasive to 0.583 nm for prepared α-Al2O3-g-PSS core-shell abrasive. The research provides a new and effect way to improve the surface qualities during CMP.

关键词： chemical mechanical polishing glass substrate α-alumina graft polymerization composite abrasive

安胃汤含药血清调控NLRP3-Caspase-1-IL-1β信号轴促进MC细胞焦亡机制研究

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中华中医药学刊 2024年第9期42卷 59-64,I0007页

作者：韦维陈丽谭程匀蒋婳影卜磊甘秀凤刘熙荣广西中医药大学广西南宁530200 广西中医药大学第一附属医院广西南宁530228

目的探究安胃汤含药血清对MC(MNNG诱导GES-1恶性转化)细胞NLRP3-Caspase-1-IL-1β信号通路相关因子及细胞焦亡的影响,揭示安胃汤抗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)作用机制。方法将MC细胞分为空白组、安胃汤组、安胃汤+... 详细信息

目的探究安胃汤含药血清对MC(MNNG诱导GES-1恶性转化)细胞NLRP3-Caspase-1-IL-1β信号通路相关因子及细胞焦亡的影响,揭示安胃汤抗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)作用机制。方法将MC细胞分为空白组、安胃汤组、安胃汤+Z-YVVD-FMK(阻断剂)组、Z-YVVD-FMK(阻断剂)组4组;CCK8分别检测12 h、24 h、48 h时间点细胞增殖情况,确定最佳检测时间点及含药血清比例;检测各组细胞上清液乳酸脱氢酶(LDH)活性;AO-EB染色法检测细胞膜的完整性及胞核形态;ELISA检测血清白介素-18(interleukin-18,IL-18)、白介素-1β(interleukin-1β,IL-1β)水平;Real-time PCR检测核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体(NACHT-LRR-PYD-containing proteins 3 inflammasome,NLRP3)、半胱氨酸天冬氨酸蛋白水解酶-1(cysteine-requiring aspartate protease-1,Caspase-1)、消皮素D(gasdermin D,GSDMD)、IL-18、IL-1β基因的表达;Western-blot检测NLRP3、Caspase-1、GSDMD蛋白的表达。结果选用48 h时间点、10%含药血清比例加入后续实验;与其余3组比较,安胃汤组LDH活性增高(P<0.01);给药组AO-EB染色均可见胞膜肿胀变形以及细胞核形态改变;ELISA结果提示:与空白组比较,安胃汤组IL-18、IL-1β均见升高(P<0.01),Z-YVVD-FMK组IL-18、IL-1β均见下降(P<0.01),差异具有统计学意义;Real-time PCR检测提示:与空白组比较,安胃汤组NLRP3 mRNA、Caspase-1 mRNA、GSDMD mRNA、IL-18 mRNA、IL-1βmRNA表达水平均见升高(P<0.01,P<0.05),Z-YVVD-FMK组GSDMD mRNA、IL-18 mRNA、IL-1βmRNA表达水平均见降低(P<0.01),差异具有统计学意义;Western-blot结果提示:与空白组比较,安胃汤组NLRP3/Actin、GSDMD/Actin表达上升(P<0.01),Z-YVVD-FMK组Caspase-1/Actin表达量减少(P<0.01)。结论安胃汤抗CAG可能与其通过调控NLRP3-Caspase-1-IL-1β信号转导通路诱导胃黏膜细胞焦亡逆转CAG病理状态有关。

关键词：安胃汤 MC细胞 NLRP3-Caspase-1-IL-1β 细胞焦亡

Sponge as Scaffolds in Bone and Cartilage Tissue Engineering

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Chemical Research in Chinese Universities 2024年第5期40卷 786-797页

作者： LUO lei GONG Yining YAN Liang bu Yazhong Yan’an University Yan’an716000P.R.China Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an710054P.R.China Institute of Medical Engineering Department of BiophysicsSchool of Basic Medical SciencesHealth Science CenterXi’an Jiaotong UniversityXi’an710061P.R.China

In recent years,tissue scaffolds have emerged as a new therapeutic method for bone and cartilage regeneration,with sponge scaffolds gaining increasing *** scaffolds possess several favorable characteristics,including appropriate biodegradability,excellent biocompatibility,good processability,powerful osteogenic ability,a unique porous structure,and adjustable pore size and *** attributes make sponge scaffolds a promising option for bone and cartilage ***,to date,there is a lack of comprehensive reviews summarizing the use of sponge scaffolds in this *** this review,our objective is to provide a comprehensive overview of the research progress and development trends of sponge ***,we introduce the various materials used for sponge ***,we summarize the different preparation methods employed for creating sponge ***,we discuss the functional additives that can be incorporated into the ***,we present some special structures that can be achieved in sponge *** aim is for this review to offer valuable insights and serve as a comprehensive resource for the design of sponge scaffolds in cartilage and bone regeneration.

关键词： Bone Sponge Scaffold Tissue regeneration

安胃汤抑制CAG大鼠PD-1/PD-L1信号轴免疫逃逸机制研究

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世界华人消化杂志 2024年第2期32卷 148-157页

作者：陈丽宋泓燕谭程匀蒋婳影甘秀凤卜磊韦维林寿宁广西中医药大学广西壮族自治区南宁市530200 广西中医药大学瑞康医院消化内科广西壮族自治区南宁市530011

背景众多证据表明免疫逃逸在肿瘤形成过程中扮演重要角色,慢性萎缩性胃炎(chronic atrophic gastritis,CAG)是胃癌的癌前疾病.安胃汤被发现可改善CAG临床症状及病理表现,实现CAG的逆转,该作用是否与免疫逃逸机制相关有待进一步研究.目... 详细信息

背景众多证据表明免疫逃逸在肿瘤形成过程中扮演重要角色,慢性萎缩性胃炎(chronic atrophic gastritis,CAG)是胃癌的癌前疾病.安胃汤被发现可改善CAG临床症状及病理表现,实现CAG的逆转,该作用是否与免疫逃逸机制相关有待进一步研究.目的从细胞免疫逃逸角度,探讨程序性死亡受体-1(programmed cell death protein 1,PD-1)/程序性死亡受体配体-1(programmed cell death ligand 1,PD-L1)信号轴与安胃汤对CAG模型大鼠疗效之间的关系.方法采用1-甲基-3-硝基-1-亚硝基胍(1-Methyl-3-nitro-1-nitrosoguanidine,MNNG)慢性萎缩性胃炎大鼠模型,应用不同剂量安胃汤及维酶素片进行干预;HE染色观察安胃汤对CAG模型大鼠胃黏膜炎症细胞浸润及组织形态改变的影响;免疫组化检测CAG模型大鼠胃黏膜组织PD-1、PD-L1蛋白表达;ELISA检测血清CD4^(+)、CD8^(+)水平变化;qPCR检测CAG模型大鼠胃黏膜PD-1mRNA、PD-L1mRNA表达;Western-blot检测CAG模型大鼠胃黏膜组织PD-1、PD-L1蛋白表达.结果免疫组化结果示:与模型组和维酶素组比较,安胃汤高、低剂量组PD-L1表达均较低(P<0.01,P<0.05).ELISA实验结果示:与模型组比较,安胃汤高剂量组CD4^(+)表达及CD4^(+)/CD8^(+)比值升高(P<0.01,P<0.05),安胃汤各组和维酶素组CD8^(+)表达降低(P<0.01);与维酶素组比较,安胃汤高剂量组CD8^(+)表达降低(P<0.05).qPCR实验结果显示:与模型组比较,安胃汤高剂量组和维酶素组PD-1mRNA表达下降(P<0.01),安胃汤高、中剂量组PD-L1mRNA表达下降(P<0.01,P<0.05).Western-blot实验结果显示:与模型组比较,安胃汤高、中剂量组PD-1/Actin,PD-L1/Actin表达下降(P<0.01,P<0.05).结论安胃汤抗CAG作用可能与抑制PD-1/PD-L1信号通路诱导的细胞免疫逃逸有关.

关键词：安胃汤慢性萎缩性胃炎 PD-1/PD-L1 免疫逃逸

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口腔楔状缺损的不同修复方式研究进展

北京口腔医学 2024年第4期32卷 301-304页

作者：卜磊青王志洁李娟谷建琦吴文慧邢台医学高等专科学校邢台054000 河北省人民医院口腔科华北理工大学

楔状缺损是牙齿硬组织常见的非龋性缺损,轻者可引起牙本质过敏,重者可引起牙髓症状。深型楔状缺损的修复分为充填、嵌体和贴面式嵌体。本文从微渗漏、抗折、粘接等方面说明了不同修复材料的优点,通过临床指标观察得出不同修复方式的优... 详细信息

楔状缺损是牙齿硬组织常见的非龋性缺损,轻者可引起牙本质过敏,重者可引起牙髓症状。深型楔状缺损的修复分为充填、嵌体和贴面式嵌体。本文从微渗漏、抗折、粘接等方面说明了不同修复材料的优点,通过临床指标观察得出不同修复方式的优势。Ⅲ度和Ⅳ度楔状缺损,用嵌体和贴面式嵌体修复缺损是一种比较好的方式,树脂基陶瓷材料结合了树脂和陶瓷的优点,具有临床使用价值。

关键词：楔状缺损嵌体树脂充填

Peritoneal cancer after bilateral mastectomy, hysterectomy, and bilateral salpingo-oophorectomy with a poor prognosis: A case report and review of the literature

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World Journal of Clinical Cases 2019年第22期7卷 3872-3880页

作者： Ya-Na Ma Hua-lei bu Cheng-Juan Jin Xia Wang You-Zhong Zhang Hui Zhang Department of Obstetrics and Gynecology Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of Obstetrics and Gynecology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 201620China

BACKGROUND Primary peritoneal cancer(PPC)patients with BRCA mutations have a good prognosis;however,for patients with BRCA mutations who are diagnosed with PPC after prophylactic salpingo-oophorectomy(PSO),the prognosis is poor,and survival information is *** SUMMARY We treated a 56-year-old woman with PPC after bilateral mastectomy,hysterectomy,and bilateral *** patient had primary drug resistance and died 12 mo after the diagnosis of *** genetic test performed on this patient indicated the presence of a germline BRCA1 *** searched the PubMed,Scopus,and Cochrane databases and extracted studies of patients with BRCA mutations who developed PPC after *** a detailed literature search,we found 30 cases,7 of which had a history of breast cancer,14 of which had no history of breast cancer,and 9 of which had an unknown *** average age of PSO patients was 48.86 years old(range,31-64 years).The average time interval between the diagnosis of PPC and preventive surgery was 61.03 mo(range,12-292 mo).The 2-year survival rate for this patient population was 78.26%(18/23),the 3-year survival rate was 50.00%(9/18),and the 5-year survival rate was 6.25%(1/16).CONCLUSION Patients with BRCA mutations who are diagnosed with PPC after preventative surgery have a poor *** measures and treatments for these patients need more attention.

关键词： Prophylactic salpingo-oophorectomy BRCA Primary peritoneal cancer Prognosis Case report

Generative deep-learning-embedded asynchronous structured light for three-dimensional imaging

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Advanced Photonics 2024年第4期6卷 45-58页

作者： lei Lu Chenhao bu Zhilong Su Banglei Guan Qifeng Yu Wei Pan Qinghui Zhang Henan University of Technology College of Information Science and EngineeringZhengzhouChina Shanghai University Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai Key Laboratory of Mechanics in Energy EngineeringShanghaiChina Shaoxing Research Institute of Shanghai University ShaoxingChina National University of Defense Technology College of Aerospace Science and EngineeringChangshaChina OPT Machine Vision Tech Co. Ltd.Department of Research and DevelopmentDongguanChina

Three-dimensional(3D)imaging with structured light is crucial in diverse scenarios,ranging from intelligent manufacturing and medicine to ***,current structured light methods rely on projector-camera synchronization,limiting the use of affordable imaging devices and their consumer *** this work,we introduce an asynchronous structured light imaging approach based on generative deep neural networks to relax the synchronization constraint,accomplishing the challenges of fringe pattern aliasing,without relying on any a priori constraint of the projection *** overcome this need,we propose a generative deep neural network with U-Net-like encoder-decoder architecture to learn the underlying fringe features directly by exploring the intrinsic prior principles in the fringe pattern *** train within an adversarial learning framework and supervise the network training via a statisticsinformed loss *** demonstrate that by evaluating the performance on fields of intensity,phase,and 3D *** is shown that the trained network can separate aliased fringe patterns for producing comparable results with the synchronous one:the absolute error is no greater than 8μm,and the standard deviation does not exceed 3μ*** results on multiple objects and pattern types show it could be generalized for any asynchronous structured light scene.

关键词： structured light fringe pattern projection asynchrony deep learning generative neural networks three-dimensional imaging

Loop reduction techniques for reachability analysis of linear hybrid automata

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Science China(Information Sciences) 2012年第12期55卷 2663-2674页

作者： PAN MinXue,LI You,bu lei & LI XuanDong State Key Laboratory for Novel Software Technology,Department of Computer Science and Technology,Nanjing University,Nanjing 210093,China State Key Laboratory for Novel Software Technology Department of Computer Science and Technology Nanjing University Nanjing China

The problem of reachability analysis of linear hybrid automata(LHA) is very *** paper considers to improve the efficiency of the reachability analysis by optimizing the structures of *** identify two types of loops called the flexible loops and the zero loops,and present the techniques to replace the repetitions of those loops in the behavior of LHA with finite sequences of locations and in the meantime simplify the associated *** techniques work not only for the polyhedral computing based algorithms but also for the bounded model checkers.

关键词： real-time and hybrid systems linear hybrid automata reachability analysis

社会法的功能嬗变、代际更替和中国社会法的定位与建构

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现代法学 2012年第3期34卷 97-109页

作者：陈步雷西南政法大学重庆401120

社会法的发生机理在于对市场化运动及其负面后果进行"反向运动"和矫治,其早期功能是社会保护。它是资本主义市场经济制度调整的主要内容,是现代市场经济和混合资本主义的构成性要素。社会法可分为三代,具有明显的代际更替和功能扩展、... 详细信息

社会法的发生机理在于对市场化运动及其负面后果进行"反向运动"和矫治,其早期功能是社会保护。它是资本主义市场经济制度调整的主要内容,是现代市场经济和混合资本主义的构成性要素。社会法可分为三代,具有明显的代际更替和功能扩展、嬗变轨迹:从第一代社会法的社会保护单一功能模式,到第二代社会法的社会保护为主、社会促进为辅的主次功能模式,再到第三代社会法的社会保护与社会促进并重的功能模式。功能嬗变与代际更替的机理主要在于资本与社会的矛盾运动、公平(社会保护)与效率(社会促进)的复杂关系。中国应厘清自己的问题之"代"和制度需求,以全球正在探索的第三代社会法为参照系,定位、创新和建构中国社会法并推进社会改革。

关键词：社会法社会保护社会促进问题代沟制度供求