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Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice

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Genes & Diseases 2023年第3期10卷 1062-1074页

作者： Junjie Li Yayan Pang Yehong Du lei xia Mulan Chen Yepeng Fan Zhifang Dong Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Disrupting the balance of neuronal excitation and inhibition (E/I) is an important pathogenic mechanism of anxiety and depression. Interferon regulatory factor 3 (IRF3) plays a key role in the innate immune response, and activation of IRF3 triggers the expression of type I interferons and downstream interferon-stimulated genes, which are associated with anxiety and depression. However, whether IRF3 participates in the pathogenesis of anxiety/depression by regulating E/I balance remains poorly understood. Here, we reported that global knockout (KO) of IRF3 (IRF3^(−/−)) significantly increased anxiety/depression-like behaviors, but did not affect normal spatial learning and memory. Compared with wild type (WT) control mice, the E/I balance was disrupted, as reflected by enhanced glutamatergic transmission and decreased GABAergic transmission in the neurons of hippocampal CA1 and medial prefrontal cortex (mPFC) in IRF3-KO mice. Importantly, genetic rescue of IRF3 expression by adeno-associated virus (AAV) was sufficient to alleviate anxiety/depression-like behaviors and restore the neuronal E/I balance in IRF3-KO mice. Taken together, our results indicate that IRF3 is critical in maintaining neuronal E/I balance, thereby playing an essential role in ensuring emotional stability.

关键词： Anxiety Depression Hippocampus IRF3 Medial prefr ontal cortex Synaptic transmission

Risks of incident heart failure with preserved ejection fraction in Chinese patients hospitalized for cardiovascular diseases

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Journal of Geriatric Cardiology 2019年第12期16卷 885-893页

作者： Jun-xia ZHANG Yi-xian LIU Chun-lei xia Peng CHU Xin-Liang QU Lin-Lin ZHU Shao-Liang CHEN Department of Cardiology Nanjing First Hospital Nanjing Medical University

Background Endogenous aldehyde damages DNA and potentiates an ageing phenotype. The aldehyde dehydrogenase 2(ALDH2) rs671 polymorphism has a prevalence of 30%–50% in Asian populations. In this study, we aimed to analyze risk factors contributing to the development of heart failure with preserved ejection fraction(HFpEF) along with the genetic exposure in Chinese patients hospitalized with cardiovascular diseases(CVD). Methods From July 2017 to October 2018, a total of 770 consecutive Chinese patients with normal left ventricular ejection fractions(LVEF) and established CVD(hypertension, coronary heart diseases, or diabetes) were enrolled in this prospective cross-sectional study. HFpEF was defined by the presence of at least one of symptom(dyspnoea and fatigue) or sign(rales and ankle swelling) related to heart failure;N-terminal pro-B-Type natriuretic peptide(NT pro-BNP ≥ 280 pg/mL);LVEF ≥ 50%;and at least one criterion related to elevated ventricular filling pressure or diastolic dysfunction(left atrial diameter > 40 mm, E/E’ ≥ 13, E’/A’ < 1 or concurrent atrial fibrillation). Logistic regression was performed to yield adjusted odds ratios(ORs) for HFp EF incidence associated with traditional and/or genetic exposures. Results Finally, among 770 patients with CVD, 92(11.9%) patients were classified into the HFpEF group according to the diagnostic criteria. The mean age of the participants was 67 ± 12 years, and 278(36.1%) patients were females. A total of 303(39.4%) patients were ALDH2*2 variant carriers. In the univariate analysis, eight exposures were found to be associated with HFpEF: atrial fibrillation, ALDH2*2 variants, hypertension, age, anaemia, smoking, alcohol consumption and sex. Multivariable logistic regression showed that 4 ‘A’ variables(atrial fibrillation, ALDH2*2 variants, age and anaemia) were significantly associated with an increased risk of HFpEF. Atrial fibrillation was associated with a 3.8-fold increased HFpEF risk(95% CI: 2.21–6.61, P < 0.0

关键词： Aldehyde dehydrogenase 2 Cardiovascular diseases Diastolic dysfunction Heart failure with preserved ejection fraction Riskfactor

Effects of Prior Corrosion with and Without Stress on the Mechanical Properties of 7475-T761 Aluminum Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 608-613页

作者： Zuo-Yan Ye Dao-Xin Liu Meng Yuan xiao-Ming Zhang Zhi Yang Ming-xia lei Corrosion and Protection Research Laboratory Northwestern Polytechnical University Aviation Industry Corporation of China the First Aircraft Institute

The effect of prior corrosion on the mechanical properties of 7475-T761 aluminum alloy was investigated by immersion test, stress corrosion test, cathode charge method and electrochemical polarization test. Results show that prior corrosion in the solution with 3 wt% NaC1 and 0.5 wt% H202 leads to mechanical properties deterioration of 7475-T761 aluminum alloy. Moreover, the elongation decreases significantly. This is mainly attributed to electrochemical corrosion and hydrogen embrittlement, in which corrosion plays a major role. Tensile stress promotes the degradation of the mechanical properties by accelerating the pitting corrosion and hydrogen embrittlement.

关键词： Prior corrosion Corrosion with stress 7475 aluminum alloy Mechanical properties Hydrogen embrittlement

Excellent Glass Forming Ability and Refrigeration Capacity of a Gd_(55)Al_(2)0Ni_(12)Co_(10)Mn_(3)Bulk Metallic Glass

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Chinese Physics Letters 2013年第9期30卷 105-108页

作者： DING Ding WANG Peng GUAN Quan TANG Mei-Bo xia lei Laboratory for Microstructure Shanghai UniversityShanghai 200072 Key Laboratory of Transparent and Opto-functional Inorganic Materials Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050

We investigate an excellent refrigeration capacity𝑆Rc𝑑of Gd_(55)Al_(20)Ni_(12)Co_(10)Mn_(3)bulk metallic glass(BMG).The Gd_(55)Al_(20)Ni_(12)Co_(10)Mn_(3)glassy rod is subjected to Cu mold suction-casting to prepare bulky metallic glasses,with a diameter of *** glass forming ability as well as the magnetic properties of the BMG is *** BMG exhibits a rather high glass formation ability with critical diameter of about *** peak value of magnetic entropy change of about 8J·kg^(−1)K^(−1)is obtained in this *** BMG alloy also exhibits excellent magnetic refrigerant capacity of about 880J·kg^(−1)under the field of 5T and 35%larger than that of other alloys reported previously,supposed to be closely related to the high effective moment(∼7.3μB)of the Gd 55 Al_(20)Ni_(12)Co_(10)Mn_(3)BMG.

关键词： alloy casting alloys

Temperature/electric field induced photoluminescence-modulation effect in dysprosium-doped barium titanate ferroelectric ceramics

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Journal of Materiomics 2024年第5期10卷 1117-1125页

作者： lei xia xiao Liu Zhan Mao Yanbin Cai Jing Zhu Jiyang Xie Wanbiao Hu Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming650091China Electron Microscopy Center Yunnan UniversityKunming650091China University of Science and Technology of China Hefei230026China

Lanthanide(Ln^(3+))based ferroelectric phosphors,with an integration of PL emission and ferroelectric effect,are unveiling an exciting realm of possibilities for multifunctional ferroelectric-optic ***,how the ferroelectric host enables the tuning on the PL emissions through modulating the local structure(e.g.,lattice site,symmetry,strains etc.)of the Ln^(3+)activator is not established *** this work,a luminescent-ferroelectric material,***^(3+)doped BaTiO_(3) ceramic(Ba_(1–x)Dy_(x)TiO_(3)(x=0–0.07),abbr:BTO:Dy^(3+)),was explored to address the aforementioned *** BTO:Dy^(3+)ceramics were synthesized by a solid-state reaction *** crystal structure,photoluminescence(PL)and electric properties(dielectric constant,ferroelectric hysteresis and piezoelectric hysteresis loop)were systematically *** BTO:Dy^(3+)ceramics show two predominant emission peaks,corresponding to the blue magnetic dipole transition(477 nm,^(4)F_(7/2)→^(6)H_(15/2))and yellow electric dipole transition(573 nm,^(4)F_(7/2)→^(6)H_(13/2)),the intensity ration of which can be modulated by the ferroelectric polarization that causes the slight lattice *** a polarization-emission modulation combining with the Dy^(3+) doping could accelerate the color change,from yellow to blue,which is characterized to detect the phase transition,with a method and mechanism were proposed,that is,the phase change is reflected by the PL characteristic peak intensity ***,the current results offer a convenient photoluminescence method for detecting the ferroelectric phase transition and a feasible approach to study the interaction between the photoluminescence and polarization in ferroelectric materials,for providing new insights for the development of multifunctional materials.

关键词： Photoluminescence Barium titanate Modulation Ferroelectric ceramics

Study on Surface Adsorption and Inhibition Behavior of Corrosion Inhibitors Contained in Copper Foil Rolling Oil

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China Petroleum Processing & Petrochemical Technology 2015年第1期17卷 96-107页

作者： Xiong Sang Sun Jianlin Jiang Wei Xu Yang Zeng Yingfeng xia lei School of Materials Science and Engineering University of Science and Technology Beijing Research Institute of Petroleum Processing Sinopec Corp.

Adsorption and inhibition behavior of 2,5-bis(ethyldisulfanyl)-1,3,4-thiadiazole(DMTDA) and N-((6-methyl-1H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-octyloctan-1-amine(EAMBA) as corrosion inhibitors contained in copper foil rolling oil have been investigated using gravimetric and electrochemical techniques. Meanwhile, scanning electron microscopy(SEM) and energy dispersive spectrometer(EDS) have been employed to observe the surface topography and analyze the components on copper foil. The results show that the rolling oil containing DMTDA and EAMBA can significantly decrease the dissolution rate and increase the inhibition efficiency of samples, especially in the case of best compounded rolling oil system. The SEM and EDS investigations also confirmed that the protection of the copper foil surface is achieved by strong adsorption of the molecules which can prevent copper from being corroded easily. Reactivity descriptors of the corrosion inhibitors have been calculated by the density functional theory(DFT) and the reactivity has been analyzed through the molecular orbital and Fukui indices. Active sites of inhibitor are mainly concentrated on the ring and the polar functional groups, and in the meanwhile, the distribution is helpful to form coordination and backbonding among molecules and then to form stable adsorption on the metal surface. And this work provides theoretical evidence for the selection of corrosion inhibitors contained in copper foil rolling oil.

关键词： copper foil surface corrosion inhibitor electrochemistry DFT reactivity adsorption

Antenna calibration using channel prediction for time-varying channels

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Journal of Modern Transportation 2012年第4期20卷 213-219页

作者： Yamin SONG xia lei Zhaofu KONG Binhong DONG National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China

Traditional antenna calibration methods for time division duplex （TDD） systems asSume that the flee-space channel remains the same during calibration, which is unreasonable under the high-speed rail and other time-varying channel scenarios, and will cause calibration error due to time variability. This paper proposes an antenna calibration method for time-varying channels. In the proposed method, the transceiver first sequentially sends a pilot signal to ob- tain equivalent do^vnlink and uplink channel responses. Then, by predicting the downlink （uplink） channel response fed back from the receiver using the channel prediction algorithm, the transmitter obtains the channel response correspond- ing to the channel response on uplink （downlink）. Finally, the transmitter calculates the transmission calibration factor through the prediction value. Compared with the traditional antenna calibration method, this method can improve the accuracy of the calibration factor. Simulation results show that the performance degradation of antenna calibration can be caused by time-varying channels and the proposed method can well compensate for the performance loss and sig- nificantly improve the antenna calibration performance for time-varying channels.

关键词： TDD channel reciprocity time-varying channel channel prediction antenna calibration

Optimal relay allocation strategy based on maximum rate in two-user multi-relay system

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Journal of Modern Transportation 2013年第1期21卷 66-71页

作者： Ji Liu xia lei Haibo Cao Maozhu Jin National Key Laboratory of Communications University of Electronic Science and Technology of China Business School of Sichuan University

Cooperative communication can enhance the performance of wireless networks via relays, and so how to allocate the relay to obtain the optimal performance of system is a key issue. In this article, we consider a cooperative system where two users communicate with the destination via relays, and these relays connect with the destination by cable. Through the theoretical derivation and analysis, we obtain the optimal relay allocation strat- egy based on the maximum rate under the condition of relays setting forwarding thresholds. The result shows that the system has the maximum transmission rate when the relays are allocated equivalently between users. Moreover, compared with the single-user system, the results prove that diversity gain has a decisive effect on the performance in low SNR. However, with the SNR increasing, the impact of diversity gain on system rate will be reduced. In high SNR, spatial freedom degree of the channel of multiple users is brought to enhance the performance instead of diversity gain. Numerical results demonstrate the validity of the allocation strategy and conclusion arrived in this study, but we do not find the similar arguments in the literature so far, for comparison with the conclusion of this study.

关键词： Cooperative communication Relay allocation Total rate

Signal detection through circular convolution reconstruction for OFDM system in fast varying channel

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Journal of Modern Transportation 2012年第4期20卷 234-242页

作者： Hai ZUO xia lei Rongzhen LE Maozhu JIN National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China Business School Sichuan University

A signal detection algorithm is proposed for the orthogonal frequency division multiplexing （OFDM） sys- tem in the presence of fast time-varying channel. The channel is represented by a piece-wise linear variant model with normalized Doppler frequency of less than 0.2. The channel parameters are extracted through ISI/ICI （inter-symbol in- terference/inter-carrier interference） cancellation and circular convolution reconstruction. Meanwhile, an improved OFDM symbol detection algorithm is also proposed based on circular convolution reconstruction. The channel state in- formation in the OFDM symbol duration can be obtained accurately from the adjacent two block pilots in a linear model. The simulation results show that the proposed method can not only track the channel variation, but also promise better performance gain in the OFDM symbol detection. Furthermore, the bit error ratio （BER） is close to the perform- ance with the perfect channel state information.

关键词： OFDM inter-symbol interference inter-carrier interference circular convolution reconstruction