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Seabuckthorn Berries Extract Attenuates Pulmonary Vascular Hyperpermeability in Lipopolysaccharide-Induced Acute Lung Injury in Mice

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Chinese Journal of Integrative Medicine 2022年第12期28卷 1081-1087页

作者： DU lei-lei LIU Ying wan Li CHEN Chu FAN Gang School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Basic Medicine Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Sichuan Provincial Key Laboratory of Qualityand Innovation Research of Chinese Materia Medica Sichuan Academy of Chinese Medicine SciencesChengdu 610041China

Objective:To investigate the effect of seabuckthorn berries extract(SBE)on pulmonary vascular hyperpermeability in the mice model of acute lung injury(ALI)induced by lipopolysaccharide(LPS).Methods:Sixty Kunming mice were allocated into 6 groups by a random number table,including control,LPS,dexamethasone(Dex,1 mg/kg),and 120,240 and 480 mg/kg SBE groups,10 mice in each group.Except the control group,mice were pre-treated with Dex and SBE,respectively,for 7 days before LPS was intraperitoneally injected to induce ALl.Pulmonary vascular hyperpermeabilitywas evaluated by histopathologic observation and transvascular leakagedetermination.Tumor necrosis factor alpha(TNF-α)and interleukin-6(IL-6)levels in serum were measured using enzyme-linked immunosorbent assay.The expression of nuclear factor-kappa B(NF-k B)p65 in lung cells was determined by immunofluorescence analysis.The contents of cytoplasmic inhibitorof nuclear factor-kBkinase(IKK)and nuclearp65,as wellasdownstreamproteins of E-selectin(CD62E)and intercellular adhesion molecule-1(ICAM-1),were determined using Western blot analysis.Results:Histopathological observation confirmed SBEtreatment alleviatedmorphological lesion induced by LPS.Compared with the LPS group,480 mg/kg SBE significantly decreased the water content of lung,Evans blue accumulation in lung tissue,and protein concentration and neutrophils count in bronchoalveolar lavage fluid(P

关键词： seabuckthorn berries extract pulmonary vascular hyperpermeability acute lung injury nuclear factor-kappa B neutrophil

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Semantic Consistency and Correctness Verification of Digital Traffic Rules

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Engineering 2024年第2期33卷 47-62页

作者： Lei Wan Changjun wang Daxin Luo Hang Liu Sha Ma Weichao Hu Policy Standardand Patent DepartmentIntelligent Automotive Solution BUHuawei Technologies Co.Ltd.Beijing 100094China Research Institute for Road Safety of the Ministry of Public Security Beijing 100062China

The consensus of the automotive industry and traffic management authorities is that autonomous vehicles must follow the same traffic laws as human drivers.Using formal or digital methods,natural language traffic rules can be translated into machine language and used by autonomous vehicles.In this paper,a translation flow is designed.Beyond the translation,a deeper examination is required,because the semantics of natural languages are rich and complex,and frequently contain hidden assumptions.The issue of how to ensure that digital rules are accurate and consistent with the original intent of the traffic rules they represent is both significant and unresolved.In response,we propose a method of formal verification that combines equivalence verification with model checking.Reasonable and reassuring digital traffic rules can be obtained by utilizing the proposed traffic rule digitization flow and verification method.In addition,we offer a number of simulation applications that employ digital traffic rules to assess vehicle violations.The experimental findings indicate that our digital rules utilizing metric temporal logic(MTL)can be easily incorporated into simulation platforms and autonomous driving systems(ADS).

关键词： Autonomous driving Traffic rules Digitization Formalization Verification

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High χ polystyrene-b-polycarbonate for next generation lithography

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Science China Chemistry 2017年第6期60卷 679-680页

作者： Lei Wan HGST A Western Digital Company San Jose CA 95119 United States

Over the past half century,the semiconductor chips have deeply influenced our everyday life through increasingly sophisticated electronic products.The central driving force underlying the remarkable evolution in semiconductor industry is Moore’s Law,nowadays referring to a doubling of transistor counts per chip every 18 months.Sustaining Moore’s Law is economically beneficial;while the manufacturing cost per chip has been held constant,integrating smaller and denser transistors reduces the cost per

关键词：下一代光刻半导体芯片半导体行业晶体管数量电子产品制造成本驱动力

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Research on sentiment terms extraction and visualization of character sentimental interactions in A Dream of Red Mansions

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The Journal of China Universities of Posts and Telecommunications 2022年第2期29卷 24-32页

作者： Huang Pei Zhang Meng wan Liu lei Xuanzheng School of Digital Media and Design Arts Beijing University of Posts and TelecommunicationsBeijing 100876China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Network System and Network Culture Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

In the context of interdisciplinary research,using computer technology to further mine keywords in cultural texts and carry out semantic analysis can deepen the understanding of texts,and provide quantitative support and evidence for humanistic studies.Based on the novel A Dream of Red Mansions,the automatic extraction and classification of those sentiment terms in it were realized,and detailed analysis of large-scale sentiment terms was carried out.Bidirectional encoder representation from transformers(BERT) pretraining and fine-tuning model was used to construct the sentiment classifier of A Dream of Red Mansions.Sentiment terms of A Dream of Red Mansions are divided into eight sentimental categories,and the relevant people in sentences are extracted according to specific rules.It also tries to visually display the sentimental interactions between Twelve Girls of Jinling and Jia Baoyu along with the development of the episode.The overall F_(1) score of BERT-based sentiment classifier reached 84.89%.The best single sentiment score reached 91.15%.Experimental results show that the classifier can satisfactorily classify the text of A Dream of Red Mansions,and the text classification and interactional analysis results can be mutually verified with the text interpretation of A dream of Red Mansions by literature experts.

关键词： A Dream of Red Mansions sentiment term extraction character sentiment interaction bidirectional encoder representation from transformers(BERT) data visualization

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QMCR:A Q-Learning-Based Multi-Hop Cooperative Routing Protocol for Underwater Acoustic Sensor Networks

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China Communications 2021年第8期18卷 224-236页

作者： Yougan Chen Kaitong Zheng Xing Fang Lei Wan Xiaomei Xu Key Laboratory of Underwater Acoustic Communication and Marine Information Technology(Xiamen University) Ministry of EducationXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China Dongshan Swire Marine Station College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China School of Information Technology Illinois State UniversityNormalIL 61790USA School of Informatics Xiamen UniversityXiamen 361005China

Routing plays a critical role in data transmission for underwater acoustic sensor networks(UWSNs)in the internet of underwater things(IoUT).Traditional routing methods suffer from high end-toend delay,limited bandwidth,and high energy consumption.With the development of artificial intelligence and machine learning algorithms,many researchers apply these new methods to improve the quality of routing.In this paper,we propose a Qlearning-based multi-hop cooperative routing protocol(QMCR)for UWSNs.Our protocol can automatically choose nodes with the maximum Q-value as forwarders based on distance information.Moreover,we combine cooperative communications with Q-learning algorithm to reduce network energy consumption and improve communication efficiency.Experimental results show that the running time of the QMCR is less than one-tenth of that of the artificial fish-swarm algorithm(AFSA),while the routing energy consumption is kept at the same level.Due to the extremely fast speed of the algorithm,the QMCR is a promising method of routing design for UWSNs,especially for the case that it suffers from the extreme dynamic underwater acoustic channels in the real ocean environment.

关键词： Q-learning algorithm routing internet of underwater things underwater acoustic communication multi-hop cooperative communication

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Effect of nutrient level on phytoplankton community structure in different water bodies

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Journal of Environmental Sciences 2010年第1期22卷 32-39页

作者： Wei Zhu Lei Wan Lianfang Zhao College of Environmental Science and Engineering Hohai University Nanjing 210098 China College of Environmental Engineering Xuzhou Institute of Technology Xuzhou 221008 China

Increasing levels of pollution within water bodies can cause eutrophication and an associated rapid growth in and reproduction of phytoplankton. Although most frequently occurring in bodies of water such as lakes and dams, in recent years an increasing number of river systems in China have suffered serious algal blooms. The community structure of phytoplankton may differ, however, dependent on the hydrodynamic conditions and nutrient levels within the water body. The field investigation results obtained from a stagnant river in Suzhou City and Taihu Lake, China, showed that in water with higher concentrations of nitrogen and phosphorus, Chlorophyta became the predominant species and in water with lower concentrations of nitrogen and phosphorus, Cyanobacteria became the predominant species. Growth experiments with competitive species, Microcystis aeruginosa Kutz and Scenedesmus quadricauda （Turp.）, were conducted at three different nutrient levels. The biomass of algae in pure and mixed cultures was measured under conditions of different N/P ratios at oligotrophic, eutrophic and hypertrophic nutrient levels. The results indicated that the most suitable state for the growth and reproduction of M. aeruginosa and S. quadricauda were eutrophic conditions in both pure and mixed cultures. Under competition, however, the lower medium nutrient levels favoured M. aeruginosa, while the higher medium nutrient levels better suited S. quadricauda. Under similar hydrodynamic conditions, the community structure of phytoplankton in the water body was determined by the dominant species in competition for nutrients.

关键词： phytoplankton community structure nutrients level N/P ratio

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Hierarchical Optimal Power Flow Control for Loss Minimization in Hybrid Multi-terminal HVDC Transmission System

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CSEE Journal of Power and Energy Systems 2016年第1期2卷 40-46页

作者： Minxiao Han Dong Xu Lei Wan North China Electric Power University Beijing 102206China Electric Power Research Institute Beijing 102206China

A hierarchical control scheme is proposed for optimal power flow control to minimize loss in a hybrid multiterminal HVDC(hybrid-MTDC)transmission system.In this scheme,the lower level is the droop control,which enables fast response to power fluctuation and ensures a stable DC voltage,and the upper level is power flow optimization control,which minimizes the losses during the operation of hybrid-MTDC and solves the contradiction between minimizing losses and preventing commutation failure.A 6-terminal hybrid-MTDC is also designed and simulated in PSCAD according to the potential demand of power transmission and wind farms integration in China to verify the proposed control strategy.First,the steady state analysis is conducted and then compared with simulation results.The analysis shows that the proposed control scheme achieves the desired minimum losses while at the same time satisfying system constraints.The proposed control scheme also guarantees that the hybrid-MTDC not only has a good dynamic response,but also remains stable during communication failure.

关键词： Droop control hierarchical control hybrid multi-terminal HVDC loss minimization optimal power flow

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Review on remediation technologies for arseniccontaminated soil

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Frontiers of Environmental Science & Engineering 2020年第2期14卷 41-54页

作者： Xiaoming wan Mei lei Tongbin Chen Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As)is a top human carcinogen widely distributed in the environment.As-contaminated soil exists worldwide and poses a threat on human health through water/food consumption,inhalation,or skin contact.More than 200 million people are exposed to excessive As concentration through direct or indirect exposure to contaminated soil.Therefore,affordable and efficient technologies that control risks caused by excess As in soil must be developed.The presently available methods can be classified as chemical,physical,and biological.Combined utilization of multiple technologies is also common to improve remediation efficiency.This review presents the research progress on different remediation technologies for As-contaminated soil.For chemical methods,common soil washing or immobilization agents were summarized.Physical technologies were mainly discussed from the field scale.Phytoextraction,the most widely used technology for As-contaminated soil in China,was the main focus for bioremediation.Method development for evaluating soil remediation efficiency was also summarized.Further research directions were proposed based on literature analysis.

关键词： Arsenic,field-scale Immobilization Phytoextraction Soil washing

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Full electromagnetic transient simulation for large power systems

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Global Energy Interconnection 2019年第1期2卷 29-36页

作者： Yong Tang Lei Wan Junxian Hou China Electric Power Research Institute Global Energy Interconnection Development and Cooperation Organization

For building Global Energy Interconnection(GEI), it is necessary to implement new breakthroughs on largepower system simulation. Key routes for implementing full electromagnetic transient simulation of large-power systems are described in this paper, and a top framework is designed. A combination of the new large time step algorithm and the traditional small-time step algorithm is proposed where both parts A and B are calculated independently. The method for integrating the Norton equivalence of the power electronic system to the entire power grid is proposed. A two-level gird division structure is proposed, which executes a multi-rate parallel calculation among subsystems and element parallel calculation in each subsystem. The initialization method of combining load flow derivation and automatic trial-and-error launching is introduced. The feasibility of the method is demonstrated through a practical power grid example, which lays a foundation for further research.

关键词： Global Energy Intercorinection Power system Electromagnetic transient Equivalence Machine-network in terface Parallel calculati on Power electro nics Initialization Technology framework CLC

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Targeting senescent dermal fibroblasts responsible for hyperactive melanocytes in melasma

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Chinese Medical Journal 2023年第13期136卷 1563-1565页

作者： Jing wan Zhikai Liao Bingqi Dong Shan Jiang Tiechi lei Department of Dermatology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China

Melasma(chloasma)is a highly prevalent and cosmetically disfiguring pigmented skin disease that mainly manifests as bilateral irregular brown macules on sun-exposed areas of the face.[1]Although melasma causes no physical discomfort,it poses a significant psychological burden on patients due to distressing cosmetic concerns.The sustained epidermal hypermelanization is a prominent pathological feature of melasma,which is usually considered to result from melanin overproduction by hyperactive melanocytes.[2]However,existing therapeutic interventions that suppress melanocytes and tyrosinase.

关键词： cytes sustained melan

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