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Carrimycin in the treatment of acute promyelocytic leukemia combined with pulmonary tuberculosis: A case report

World Journal of Clinical Cases 2024年第3期12卷 623-629页

作者： Fu-Yu Yang lei shao Jie Su Zhen-Meng Zhang Department of Infectious Diseases The Affiliated Central Hospital of Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Pulmonary tuberculosis(PTB)is prevalent in immunocompromised populations,including patients with hematologic malignancies,human immunodeficiency virus infections,and chronic diseases.Effective treatment for acute promyelocytic leukemia(APL)combined with PTB is lacking.These patients show an extremely poor prognosis.Therefore,studies should establish efficient treatment options to improve patient survival and prognosis.CASE SUMMARY A 60-year-old male with pain in the right side of his chest and a fever for 4 d visited the outpatient department of our hospital.Peripheral blood smear revealed 54%blasts.Following bone marrow examinations,variant APL with TNRC18-RARA fusion gene was diagnosed.Chest computed tomography scan showed bilateral pneumonitis with bilateral pleural effusions,partial atelectasis in the lower lobes of both lungs,and the bronchoalveolar lavage fluid gene X-Pert test was positive,indicative of PTB.Carrimycin,ethambutol(EMB),and isoniazid(INH)were administered since he could not receive chemotherapy as the WBC count decreased continuously.After one week of treatment with carrimycin,the patient recovered from fever and received chemotherapy.Chemotherapy was very effective and his white blood cells counts got back to normal.After being given five months with rifampin,EMB and INH and chemotherapy,the patient showed complete remission from pneumonia and APL.CONCLUSION We report a case of PTB treated successfully with carrimycin with APL that requires chemotherapy.

关键词： Carrimycin Hematologic disease Acute myeloid leukemia Acute promyelocytic leukemia Pulmonary tuberculosis Case report

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Paleogene transgression process and environmental evolution in the deepwater area of the Baiyun Depression in the northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 15-24页

作者： Peijun Qiao Yuchi Cui Qiong Ma Qiang Yu lei shao State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China CNOOC Energy Technology&Services-Drilling&Production Co. CNOOC Central Laboratory Shenzhen BranchGuangdong 516000China

Multiple borehole samples are collected from the Baiyun Depression in deep-water area of the northern South China Sea(SCS)in an effort to reconstruct transgression processes during the Paleogene based on palynalgal analysis.This study indicates that the Baiyun Depression generated a large group of palynopore assemblages and fluvial/lacustrine-related algae during the early and middle Eocene when the Wenchang Formation was deposited.The entire depression was dominated by fluvial and lacustrine facies before transgression.Its eastern and southeastern sags transitioned to shallow marine environment by generating a large abundance of marine dinoflagellates during the Enping deposition of the late Eocene.Meanwhile,the southern uplift zone simply yielded fluvial/lacustrine-related palynopores and algae,and was dominated by the fluvial and lacustrine environment during the early stage of the Enping Formation,prior to shifting into transitional setting in the later period.Northwestern sags remained extensive fluvial and delta facies without existence of marine dinoflagellates.It was until the depositional stage of the Zhuhai Formation(Oligocene)that the overall depression was strongly impacted from transgression process.Both eastern and southeastern sags were mainly under deep marine setting on a continental slope while northwestern and southern areas developed transitional facies.Although distribution and accumulation patterns varied greatly among sub-sags,the overall Baiyun Depression was characterized by widespread development of marine dinoflagellates.It should be noted that the northwestern sag also partly generated large-scale river delta deposits.Due to the eustatic rise and change of SCS spreading axis,the overall Baiyun Depression was mostly influenced by the deep marine environment on a continental slope during the early Miocene.Both northwestern sag and southern uplift zone were found plentiful marine dinoflagellates.In summary,transgression initiated from the eastern and southeastern Baiyun Depression before

关键词： South China Sea Paleogene transgression sedimentary environment plant ecology

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Late Eocene–early Miocene provenance evolution of the Crocker Fan in the southern South China Sea

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Acta Oceanologica Sinica 2023年第3期42卷 215-226页

作者： Yuchi Cui lei shao Wu Tang Peijun Qiao Goh Thian Lai Yongjian Yao State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Earth Dynamics Research Group The Institute for Geoscience Research(TIGeR)School of Earth and Planetary SciencesCurtin UniversityGPO Box U1987Australia China National Offshore Oil Corporation(CNOOC)Research Institute Co. Ltd.Beijing 100028China Department of Earth Sciences and Environment Faculty of Science and TechnologyUniversity Kebangsaan MalaysiaBangi 43600SelangorMalaysia Guangzhou Marine Geological Survey Ministry of Natural ResourcesGuangzhou 510075China

There are many large-scale Cenozoic sedimentary basins with plentiful river deltas,deep-water fans and carbonate platforms in the southern South China Sea.The Crocker Fan was deposited as a typical submarine fan during the late Eocene–early Miocene,and stretches extensively across the entire Sarawak–Sabah of the northern Borneo area.However,systematic analyses are still lacking regarding its sediment composition and potential source suppliers.No consensus has been reached yet on the provenance evolution and sedimentary infilling processes,which seriously impeded the oil-and-gas exploration undertakings.By combining with sedimentaryfacies identification,heavy mineral assemblages,elemental geochemistry and detrital zircon U-Pb dating,this paper aims to generalize an integrated analysis on the potential provenance terranes and restore source-to-sink pathways of the Crocker Fan.In general,the Crocker Fan was initially formed over the Cretaceous–lower/middle Eocene Rajang Group by an angular Rajang unconformity.The continual southward subduction of the protoSouth China Sea resulted in magmatic activities and subsequent regional deformation and thrusting along the Lupar Line in the northern Borneo.The lowermost Crocker sequence is featured by a thick conglomerate layer sourced from in-situ or adjacent paleo-uplifts.From the late Eocene to the early Miocene,the Crocker Fan was constantly delivered with voluminous detritus from the Malay Peninsula of the western Sundaland.The Zengmu Basin was widely deposited with delta plain and neritic facies sediments,while the Brunei-Sabah Basin,to the farther east,was ubiquitously characterized by turbiditic sequences.The Crocker Fan successions are overall thick layers of modest-grained sandstones,which formed high-quality reservoirs in the southern South China Sea region.

关键词： source-to-sink analysis zircon U-Pb age submarine fan Malay Peninsula southern South China Sea

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生成式人工智能对社交机器人的影响与治理对策

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情报杂志 2024年第7期43卷 154-163页

作者：邵雷石峰四川警察学院泸州646000

[研究目的]生成式人工智能使作为社交媒体舆情传播核心的社交机器人具有更加强大的舆论操纵能力,且随着生成式人工智能的快速发展,社交机器人与人类在社交媒体中的活动更加难以区分,隐匿性更强,危害性更大,需要提早研究社交机器人的治... 详细信息

[研究目的]生成式人工智能使作为社交媒体舆情传播核心的社交机器人具有更加强大的舆论操纵能力,且随着生成式人工智能的快速发展,社交机器人与人类在社交媒体中的活动更加难以区分,隐匿性更强,危害性更大,需要提早研究社交机器人的治理策略,以维护网络舆情安全和国家安全。[研究方法]结合生成式人工智能的特点,剖析了其对社交机器人操纵舆情能力的影响,采取“技术管控技术”的理念,提出基于生成式人工智能的社交机器人情报分析建模思路,在模型中增加向量数据库和本体推理,增强了模型的相似性检索、语义理解、多模态数据分析、动态数据更新以及少样本学习能力。[研究结论]通过将“大语言模型”和“知识图谱”进行深度融合,利用知识图谱中的知识减少大语言模型的“幻觉问题”。同时,利用大语言模型完善和补全知识图谱,增强了对社交媒体情报信息的检索和应用能力。在社交迷雾演化全生命周期提高了对社交媒体舆情,特别是社交机器人的监测识别、感知预警、追踪溯源和研判管控能力。

关键词：生成式人工智能社交机器人信息迷雾向量数据库社交媒体知识图谱

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A novel route for the synthesis of androgen receptor antagonist enzalutamide

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Chinese Chemical Letters 2023年第6期34卷 449-453页

作者： Xiangguo Meng Siju Bi Shixin Jin Kai Wu Shanchao Wu lei shao Pierre-Antoine Bonnet Chunquan Sheng College of Pharmacy Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Medicinal Chemistry School of PharmacySecond Military Medical UniversityShanghai 200433China State Key Lab of Anti-Infectives Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China IBMM Faculty of PharmacyMontpellier UniversityCNRSENSCM34093 Montpellier Cedex 5France

A novel route of enzalutamide was developed in five steps.Starting from 4-amino-2-(trifluoromethyl)benzonitrile(7)and Boc-2-aminoisobutyric acid(16),condensation,deprotection,Ullmann coupling,cyclization and amination provided enzalutamide in 41.0%total yield.This route avoids the using of toxic chemical,unstable intermediate and high-risk reaction.It is a potential efficient and economical procedure for industrialization.

关键词： Enzalutamide Condensation Deprotection Ullmann coupling Cyclization Amination

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基于自适应横程走廊的再入滑翔飞行器改进预测校正算法

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系统工程与电子技术 2024年第2期46卷 692-702页

作者：贺杨超李炯邵雷周池军雷虎民空军工程大学研究生院陕西西安710051 空军工程大学防空反导学院陕西西安710051

针对再入滑翔飞行器(reentry gliding vehicle,RGV)预测校正制导算法中规避逻辑和制导逻辑相分离的问题,提出了一种基于自适应横程走廊的融合算法。首先,通过飞行器侧向运动轨迹与禁飞区的相交关系,动态引入规避逻辑;同时,提出禁飞区有... 详细信息

针对再入滑翔飞行器(reentry gliding vehicle,RGV)预测校正制导算法中规避逻辑和制导逻辑相分离的问题,提出了一种基于自适应横程走廊的融合算法。首先,通过飞行器侧向运动轨迹与禁飞区的相交关系,动态引入规避逻辑;同时,提出禁飞区有效映射横程来量化影响飞行轨迹的禁飞区区域;最后,设计自适应横程走廊,动态调整走廊边界,控制倾侧角的翻转,实现规避逻辑和侧向制导逻辑的融合。仿真结果表明,在本文方法下,飞行器可以针对不同情况的禁飞区实现有效制导,对再入扰动具有一定的鲁棒性,并与制导逻辑和规避逻辑分离设计的算法相比,在保证制导精度的同时,具备更少的倾侧角翻转次数。

关键词：预测校正算法自适应横程走廊禁飞区有效映射横程

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New interpretation on the provenance changes of the upper Pinghu–lower Huagang Formation within Xihu Depression,East China Sea Shelf Basin

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Acta Oceanologica Sinica 2023年第3期42卷 89-100页

作者： Jinshui Liu Shuai Li Kaifei Liao Yuchi Cui lei shao Peijun Qiao Yi Lu Yuanli Hou Thian Lai Goh Yongjian Yao Shanghai Branch of China National Offshore Oil Corporation(CNOOC)Co. Ltd.Shanghai 200030China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Earth Dynamics Research Group The Institute for Geoscience Research(TIGeR)School of Earth and Planetary SciencesCurtin UniversityGPO Box U1987Australia Department of Earth Sciences and Environment Faculty of Science and TechnologyUniversity Kebangsaan Malaysia43600 BangiSelangorMalaysia Guangzhou Marine Geological Survey Ministry of Natural ResourcesGuangzhou 510075China

Both Pinghu and Huagang formations are important hydrocarbon reservoirs of the Xihu Depression in the East China Sea Shelf Basin.Clarifying the source suppliers and restoring source-to-sink transport routes are of great significance to the future petroleum and gas undertakings.Previous researchers were largely confined by either limitation of geological records,highly dependence on a singular method or low-precision dating techniques.Our study integrated heavy mineral assemblages,geochemical analyses and detrital zircon U-Pb dating to reconstruct multiple source-to-sink pathways,and to provide a better understanding on the provenance evolution for the upper Pinghu–lower Huagang depositions of the Xihu Depression.At least three major provenances have been confirmed and systematically investigated for their separate compositional features.The Hupijiao Uplift(or even farther northern area)was dominated by a major Paleoproterozoic population peaked at ca.1830 Ma along with minor Mesozoic clusters.The Haijiao Uplift to the west and the Yushan Low Uplift to the southwest,on the other hand,generate opposite U-Pb age spectra with apparently larger peaks of Indosinian and Yanshanian-aged zircons.To be noted,both Indosinian and Paleoproterozoic peaks are almost identical in proportion for the Haijiao Uplift.The overall sedimentary pattern of late Eocene-early Oligocene was featured by both spatial and temporal distinction.The Hupijiao Uplift was likely to cast limited impact during the late Eocene,whereas the broad southern Xihu Depression was transported by a large abundance of materials from the nearby Haijiao and Yushan Low Uplifts.The northern source substantially extended its influence to the farther south during the early Oligocene by delivering plentiful sediments of higher-degree metamorphic parent rocks.Combined with the proximal western and southwestern suppliers,the overall Xihu Depression was under control from both distant and local provenances.

关键词： Xihu Depression East China Sea Shelf Basin detrital zircon U-Pb ages Pinghu–Huagang Formation provenance

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耳穴综合疗法治疗月经性偏头痛患者临床疗效及对血清前列腺素的影响

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针刺研究 2024年第2期49卷 177-184页

作者：邵国梁黄绍磊李瑞杨佃会王萌萌山东中医药大学针灸推拿学院济南250014 山东中医药大学附属医院针灸科济南250011

目的:观察耳穴综合疗法治疗月经性偏头痛(MM)的临床疗效及对血清前列腺素F2α(PGF_(2α))、前列腺素E_(2)(PGE_(2))含量、比值的影响,探讨其可能的作用机制。方法:将66例肝火旺盛型MM患者随机分为观察组(33例,脱落2例)和对照组(33例,脱... 详细信息

目的:观察耳穴综合疗法治疗月经性偏头痛(MM)的临床疗效及对血清前列腺素F2α(PGF_(2α))、前列腺素E_(2)(PGE_(2))含量、比值的影响,探讨其可能的作用机制。方法:将66例肝火旺盛型MM患者随机分为观察组(33例,脱落2例)和对照组(33例,脱落2例),并纳入20例健康女性作为正常组。对照组口服盐酸氟桂利嗪胶囊,每天2次,连续治疗3周;观察组予以耳穴综合疗法治疗,从月经来潮前2~5 d开始,1周治疗1次,共治疗3次。观察组与对照组分别于治疗前后及治疗后随访2个月经周期时以视觉模拟量尺(VAS)和偏头痛积分评价患者头痛程度,观察组、对照组和正常组分别于治疗前后测定月经期血清PGF_(2α)、PGE_(2)含量并计算PGF_(2α)/PGE_(2)比值,评定两组MM患者的临床疗效。结果:与治疗前比较,观察组与对照组患者治疗后及随访时VAS评分均明显降低(P<0.05),且观察组低于对照组(P<0.05)。与治疗前比较,观察组与对照组患者治疗后及随访时偏头痛积分中头痛发作次数、每次发作持续时间、头痛程度及伴随症状评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前观察组与对照组患者PGF_(2α)含量高于正常组(P<0.05),PGE_(2)含量低于正常组(P<0.05),PGF_(2α)/PGE_(2)比值高于正常组(P<0.05);与治疗前比较,观察组与对照组患者治疗后血清PGF_(2α)含量明显降低(P<0.05),且观察组低于对照组(P<0.05);与治疗前比较,观察组与对照组患者治疗后血清PGE_(2)含量明显升高(P<0.05),且观察组高于对照组(P<0.05);与治疗前比较,观察组与对照组患者治疗后血清PGF_(2α)/PGE_(2)比值均明显降低(P<0.05),且对照组较正常组明显升高(P<0.05),观察组较对照组明显降低(P<0.05)。观察组的临床有效率为93.5%(29/31),对照组的临床有效率为77.4%(24/31),观察组高于对照组(P<0.05)。结论:耳穴综合疗法治疗肝火旺盛型MM疗效明显优于口服盐酸氟桂利嗪胶囊,在缓解头痛程度、减少头痛发作次数、发作时间以及伴随症状等方面疗效更好,其作用机制可能与调节患者异常PGF_(2α)和PGE_(2)含量,降低PGF_(2α)/PGE_(2)比值有关。

关键词：耳穴综合疗法月经性偏头痛前列腺素F2α 前列腺素E2

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Optimal midcourse trajectory cluster generation and trajectory modification for hypersonic interceptions

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Journal of Systems Engineering and Electronics 2017年第6期28卷 1162-1173页

作者： Humin lei Jin Zhou Dailiang Zhai lei shao Dayuan Zhang Air and Missile Defense College Air Force Engineering University Xi’an 710051 China Unit 95948 of the PLA Jiuquan 732750 China

The hypersonic interception in near space is a great challenge because of the target’s unpredictable trajectory, which demands the interceptors of trajectory cluster coverage of the predicted area and optimal trajectory modification capability aiming at the consistently updating predicted impact point(PIP) in the midcourse phase. A novel midcourse optimal trajectory cluster generation and trajectory modification algorithm is proposed based on the neighboring optimal control theory. Firstly, the midcourse trajectory optimization problem is introduced; the necessary conditions for the optimal control and the transversality constraints are given.Secondly, with the description of the neighboring optimal trajectory existence theory(NOTET), the neighboring optimal control(NOC)algorithm is derived by taking the second order partial derivations with the necessary conditions and transversality conditions. The revised terminal constraints are reversely integrated to the initial time and the perturbations of the co-states are further expressed with the states deviations and terminal constraints modifications.Thirdly, the simulations of two different scenarios are carried out and the results prove the effectiveness and optimality of the proposed method.

关键词： neighboring optimal control(NOC) midcourse guidance trajectory cluster generation optimal trajectory modification

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重视病理性近视眼牵拉性黄斑病变玻璃体手术时机及术式选择

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中华眼科杂志 2024年第3期60卷 211-214页

作者：魏文斌邵蕾周文达首都医科大学附属北京同仁医院北京同仁眼科中心、北京市眼科研究所、北京市眼科学与视觉科学重点实验室北京100730

黄斑病变是导致病理性近视眼患者不可逆视力损伤的主要原因,其中牵拉性黄斑病变常需要玻璃体手术治疗。牵拉性黄斑病变包括黄斑前膜、黄斑劈裂、黄斑裂孔及黄斑裂孔性视网膜脱离等。建议对Ⅱ型黄斑前膜行玻璃体切除联合内界膜剥离术,对... 详细信息

黄斑病变是导致病理性近视眼患者不可逆视力损伤的主要原因,其中牵拉性黄斑病变常需要玻璃体手术治疗。牵拉性黄斑病变包括黄斑前膜、黄斑劈裂、黄斑裂孔及黄斑裂孔性视网膜脱离等。建议对Ⅱ型黄斑前膜行玻璃体切除联合内界膜剥离术,对黄斑劈裂行保留黄斑中心凹的内界膜剥离术,对黄斑裂孔行内界膜瓣填充术,对难治性黄斑裂孔性视网膜脱离行玻璃体切除联合黄斑兜带术治疗。病理性近视眼牵拉性黄斑病变是一种慢性发展性疾病,术者要准确把握手术时机,选择合适的术式使患者得到的收益最大化。

关键词：近视,退行性黄斑变性玻璃体切除术内界膜剥离术手术时间

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