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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng lei ma.yu zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Towards few-shot mixed-type dialogue generation

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Science China(Information Sciences) 2025年第2期68卷 120-133页

作者： Zeming LIU Haifeng WANG Zeyang lei zheng-yu NIU Hua WU Wanxiang CHE Research Center for Social Computing and Information Retrieval Baidu Inc.

Building an agent capable of conducting both open-domain and task-oriented dialogues, known as mixed-type dialogues, has been an enduring challenge for the AI community. Previous approaches have focused on constructing largescale human-annotated datasets for training models. However, annotating these datasets is expensive and hinders the practical application of these models. This paper identifies a novel challenge, few-shot mixed-type dialogue generation. To address this challenge, we first present a pre-trained dialogue generation framework with modular-based architecture and prompttuning component. Additionally, we collect a mixed-type dialogue dataset that combines persona-chat with conversational recommendation or task-oriented dialogues within a single dialogue session. Specifically, the modular-based architecture allows us to easily incorporate more supervised signals and human-annotated information, thereby facilitating the learning of sessionlevel dialogue logic. We pre-train this dialogue generation framework using multiple external datasets and then fine-tune it on the mixed-type dialogue dataset we collected. Experimental results demonstrate that the three key designs — modular-based architecture, prompt-tuning component, and model pre-training — significantly enhance the performance of this framework compared to state-of-the-art baselines.

关键词： mixed-type dialogue dialogue generation PLATO-prompt Mixed-FS few-shot

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin zheng Zi-yu Ye Jun-Ji ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 258-260页

作者： Meng zheng lei Zhang Wei Liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

关键词： Networked control systems

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Attention Eraser and Quantitative Measures for Automated Bone Age Assessment

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Computers, materials & Continua 2025年第1期82卷 627-644页

作者： Liuqiang Shu lei yu College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological *** predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for *** this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained ***,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent *** is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial *** model achieves a mean absolute error(maE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE *** to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(pmaE by 0.2±0.02 years across different racial ***,t-tests on the features also confirm the statistical significance of our approach(p<0.05).

关键词： Bone age assessment attention eraser quantitative feature metacarpal bones

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Characterization of size-resolved aerosol hygroscopicity and liquid water content in Nanjing of the Yangtze River Delta

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Journal of Environmental Sciences 2025年第5期151卷 26-41页

作者： Youling Jiang Yan ma Jun zheng Nan Ye Cheng yuan School of Environmental Science and Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science&TechnologyNanjing 210044China School of Emergency management Nanjing University of Information Science&TechnologyNanjing 210044China

Aerosol hygroscopicity and liquid water content(ALWC)have important influences on the environmental and climate effect of *** this study,we measured the hygroscopic growth factors(GF)of particles with dry diameters of 40,80,150,and 200 nm during the wintertime in *** the GF-derived hygroscopicity parameter(κ_(gf))and ALWC increased with particle size,but displayed differing diurnal variations,withκ_(gf)peaking around the midday,while ALWC peaking in the early ***,ammonium and oxygenated organic aerosols(OOA)were found as the chemical components mostly strongly correlated with ALWC.A closure study suggests that during midday photo-oxidation and nighttime high ALWC periods,theκof organic aerosols(κ_(org))was underestimated when using previous ***,we re-constructed parameterizations forκ_(org)and the oxidation level of organics for these periods,which indicates a higher hygroscopicity of photochemically formed OOA than the aqueous OOA,yet both being much higher than the generally assumed OOA ***,in a typical high ALWC episode,concurrently increased ALWC,nitrate,OOA as well as aerosol surface area and mass concentrations were observed under elevated ambient *** strongly indicates a coupled effect that the hygroscopic secondary aerosols,in particular nitratewith strong hygroscopicity,led to large increase in ALWC,which in turn synergistically boosted nitrate and OOA formation by heterogeneous/aqueous *** interaction may represent an important mechanism contributing to enhanced formation of secondary aerosols and rapid growth of fine particulate matter under relatively high RH conditions.

关键词： Aerosol hygroscopicity Aerosol liquid water content Photo-oxidation Aqueous/heterogeneous reactions

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Control upconversion decay dynamics from perspective of collective response

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Journal of Rare Earths 2025年第1期43卷 57-63,I0003页

作者： Yingdong Han yutong Pan Tong Wei yu ma Xingxing Zhang lei Jiang Kai Chen Liwei Wu Jiao Cui Chao Gao College of Science Civil Aviation University of ChinaTianjin300300China School of Inspection and Testing Certification Changzhou Vocational Institute of EngineeringChangzhou213164China School of Chemical and Physical Sciences Victoria University of WellingtonWellington6012New Zealand Robinson Research Institute Faculty of EngineeringVictoria University of WellingtonWellington6012New Zealand

Very recently,upconversion luminescence(UCL)lifetime,as a powerful optical dimension,has attracted tremendous research interest due to its advantages of high information capacity and high photophysical *** the implementation and emergence of endlessly fascinating UCL features,it is particularly meaningful to understand the photophysical mechanisms inside UCL materials to enable rational subdivision-level structure design,which is however currently far from *** this work,we take an ordinary upconversion nanoparticle as an example to prove that the UCL decay curves and corresponding lifetimes are indeed a collective response of the entire UCL system to excitations,that exhibits correlated,yet quite different properties from individual ions.A specially developed theoretical random walk model combined with an experimental lifetime control for Yb^(3+)/Er^(3+)UCL demonstrates that ene rgy diffusion principally alters the decay ***,the different extent of the influence of energy diffusion on the emissions of ^(2)H_(11/2)/^(4)S_(3/2)(green)and ^(4)F_(9/2)(red)leads to an extremely uncommon crossover comparison of decay *** work provides new ideas for understanding decay dynamics and practical UCL lifetime manipulation methods.

关键词： Upconversion Lifetime Collective response Decaycurves Random walk model Rare earths

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NOTES ON THE LOG-MINKOWSKI INEQUALITY OF CURVATURE ENTROPY

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Acta mathematica Scientia 2025年第1期45卷 16-26页

作者： Deyi LI lei ma Chunna ZENG School of Science Wuhan University of Science and TechnologyWuhan430081China School of Sciences Guangdong Preschool Normal College in MaomingMaoming525200China School of mathematical Sciences Chongqing Normal UniversityChongqing401331China

An upper estimate of the new curvature entropy is provided,via the integral inequality of a concave *** two origin-symmetric convex bodies in R^(n),this bound is sharper than the log-Minkowski inequality of curvature ... 详细信息

关键词： convex bodies the log-Minkowski inequality curvature entropy the log-Minkowski inequality of curvature entropy

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I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou Li-Sheng Wang Shuang-Gui lei Bo-Cheng Tang Zhi-Cheng yu Xing Li Yan-Dong Wu Kai-Lu zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

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Soft Resource Slicing for Industrial Mixed Traffic in 5G Networks

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 463-465页

作者： Jingfang Ding Meng zheng Haibin yu the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Chinese Academy of Sciences the Institutes for Robotics and Intelligent manufacturing Chinese Academy of Sciences the University of Chinese Academy of Sciences IEEE

Dear Editor,This letter proposes a dynamic switching soft slicing strategy for industrial mixed traffic in 5G networks. Considering two types of traffic, periodic delay-sensitive (PDS) traffic and sporadic delay-tolerant (SDT) traffic, we design a dynamic switching strategy based on a traffic-Qo S-aware soft slicing (TQASS) scheme and a resource-efficiency-aware soft slicing (REASS) scheme.

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