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Modern phenomics to empower holistic crop science, agronomy, and breeding research

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Journal of Genetics and Genomics 2024年第8期51卷 790-800页

作者： Ni jiang Xin-Guang Zhu institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China center of Excellence for molecular Plant sciences Chinese Academy of SciencesShanghai 200032China

Crop phenomics enables the collection of diverse plant traits for a large number of samples along different time scales,representing a greater data collection throughput compared with traditional *** modern crop phenomics use different sensors to collect reflective,emitted,and fluorescence signals,etc.,from plant organs at different spatial and temporal *** multi-modal,high-dimensional data not only accelerates basic research on crop physiology,genetics,and whole plant systems modeling,but also supports the optimization of field agronomic practices,internal environments of plant factories,and ultimately crop *** challenges and opportunities facing the current crop phenomics research community include developing community consensus or standards for data collection,management,sharing,and processing,developing capabilities to measure physiological parameters,and enabling farmers and breeders to effectively use phenomics in the field to directly support agricultural production.

关键词： Crop phenomics High-throughput phenotyping Traits Crop designer breeding Agronomy

Avian lower beak is always overlooked:its coordinate role in shaping species-specific beak should not be underestimated

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Integrative Zoology 2024年第2期19卷 339-342页

作者： Yalin CHENG Fumin lei College of Life Science/Hebei Basic Science center for Biotic Interactions Institute of Life Science and Green DevelopmentHebei UniversityBaodingChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina University of chinese academy of sciences BeijingChina center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingChina

The beak is a key evolutionary innovation in the avian tree of *** diversity in morphology shows birds’successful colonization of various ecological niches on the Earth(Pigot et al.2020),and its morphological plasticity can also enable birds to rapidly respond to changes in environments(Grant&Grant 2006).These natures helped birds survive multiple extinction events(Larson et al.2016).Therefore,investigating the morphological evolution of avian beaks and the underlying developmental and molecular mechanisms will help to decipher the evolution of birds and boost the development of the theory of evolutionary biology.

关键词： coordinate extinction enable

Fluorinated [2]rotaxanes as sensitive ^(19)F MRI agents: Threading for higher sensitivity

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chinese Chemical Letters 2024年第10期35卷 379-382页

作者： Lan Yang Yu Li Mou jiang Rui Zhou Hengjiang Cong Minghui Yang lei Zhang Shenhui Li Yunhuang Yang Maili Liu Xin Zhou Zhong-Xing Jjiang Shizhen Chen State Key Laboratory of Magnetic Resonance and Atomic and molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory forOptoelectronicsWuhan430071China University of chinese academy of sciences Beijing 100049China School of Pharmaceutical sciences&College of chemistry and molecular sciences Wuhan UniversityWuhan 430071China Optics Valley Laboratory Wuhan 430074China

As a promising imaging technology,the low sensitivity of fluorine-19 magnetic resonance imaging(^(19)F MRI)severely hinders its biomedical ***,we have developed an unprecedented rotaxanebased strategy to improve the sensitivity of^(19)F MRI *** threading the fluorinated macrocycle into2-blade pinwheel[2]rotaxanes,the^(19)F longitudinal relaxation rate R1was dramatically increased,resulting in a significant^(19)F MRI signal intensity enhancement of up to 79%.Through comparative molecular dynamics studies using a series of solution and solid-state^(1)H/^(19)F nuclear magnetic resonance(^(1)H/^(19)F NMR)and molecular dynamics simulations,it was found that the formation of mechanical bonds dramatically restricts the motion of the wheel fluorines and thus increasing the R1for higher^(19)F MRI *** a novel strategy for improving^(19)F MRI sensitivity,this study has established^(19)F NMR/MRI as a valuable technology for monitoring the molecular dynamics of rotaxanes,which may shed new light on high-performance^(19)F MRI agents and molecular devices.

关键词： Rotaxane ^(19)FMRI Imaging agent Mechanical bond Relaxation rate

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： Jinghui lei Xiaoyu jiang Daoyuan Huang Ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi Zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu Advanced Innovation center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of chinese academy of sciences Beijing 100049China institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China beijing institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China china National center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological ***,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely ***,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response *** comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular *** found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic ***,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

Advances in the Application of molecular Diagnostic Techniques to Brucellosis

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Biomedical and Environmental sciences 2024年第7期37卷 790-794页

作者： Haiwen Liu Hai jiang School of Public Health Baotou Medical CollegeBaotou 014040Inner Mongolia AutonomousChina National Key Laboratory of Intelligent Tracing and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Brucellosis is a zoonotic infectious and allergic disease caused by Brucella *** occurs worldwide and has had a huge economic impact on the livestock industry in many countries and *** has become a major public health *** is an endoparasitic,non-motile Gram-negative bacterium capable of surviving within a diverse range of domestic animal hosts.

关键词： problem diverse capable

Radio Observations of Sgr B2

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chinese Journal of Astronomy and Astrophysics 2001年第5期1卷 406-410页

作者： XinJieMao jiang－TaoSu chineseacademyofScience－PekingUniversityJointbeijingAstrophysicscenter Beijing100087 DepartmentofAstr

The 13C0 (J 1 - 0) map of the molecular cloud Sgr B2 reveals that the mass center of the molecular cloud nucleus does not coincide with that of compact HII regions which are likely to be the outcome of a shock on the ... 详细信息

关键词： ISM: clouds - evolution - ISM: lines and bands

FAST Observations of Four Comets to Search for the molecular Line Emissions between 1.0 and 1.5 GHz Frequencies

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Research in Astronomy and Astrophysics 2024年第10期24卷 130-140页

作者： Long-Fei Chen Chao-Wei Tsai Jian-Yang Li Bin Yang Di Li Yan Duan Chih-Hao Hsia Zhichen Pan lei Qian Donghui Quan Xue-Jian jiang Xiaohu Li Ruining Zhao Pei Zuo School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guiyang 550025China Research center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China School of Atmospheric sciences Sun Yat-sen UniversityZhuhai 519082China Núcleo de Astronomía Facultad de Ingenieríay CienciasUniversidad Diego PortalesChile Department of Astronomy College of Physics and Electronic EngineeringQilu Normal UniversityJinan 250200China Department of Electronic and Optical Engineering Space Engineering UniversityBeijing 101416China Laboratory for Space Research Faculty of ScienceThe University of Hong KongHong Kong(SAR)China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space sciences University of Chinese Academy of SciencesBeijing 100049China

We used the Five-hundred-meter Aperture Spherical radio Telescope(FAST)to search for the molecular emissions in the L-band between 1.0 and 1.5 GHz toward four comets,C/2020 F3(NEOWISE),C/2020 R4(ATLAS),C/2021 A1(Leonard),and 67P/Churyumov-Gerasimenko during or after their perihelion *** of molecular transition lines fall in this low-frequency range,many attributed to complex organic or prebiotic *** conducted a blind search for the possible molecular lines in this frequency range in those comets and could not identify clear signals of molecular emissions in the *** several molecules have been detected at high frequencies of greater than100 GHz in comets,our results confirm that it is challenging to detect molecular transitions in the L-band frequency *** non-detection of L-band molecular lines in the cometary environment could rule out the possibility of unusually strong lines,which could be caused by the masers or non-LTE *** the line strengths are predicted to be weak,for FAST,using the ultra-wide bandwidth receiver and improving the radio frequency interference environments would enhance the detectability of those molecular transitions at low frequencies in the future.

关键词： astrochemistry ISM:molecules comets:general line:identification

Dangling Ligand Enables an Iron Hexa-Coordinated molecular Catalyst for Water Oxidation by Photocatalysis

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CCS chemistry 2024年第3期6卷 623-630页

作者： Bing Yang Qi Liu Xiang-Zhu Wei Tao lei Qing-Qing Yang Xu-Zhe Wang Jing-Xin Jian Xin jiang Chen-Ho Tung Li-Zhu Wu Key Laboratory of Photochemical Conversion and Optoelectronic Materials New Cornerstone Science LaboratoryTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049

Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal *** this regard,ironbased water oxidation catalysts are prone to hydrolysis and/or dissociate the ligands to form nanoparticles under a real catalytic ***,we describe a unique hexa-coordinated catalyst 1[Fe^(II)(Py_(3)tacn)Cl_(2)]and its reference 2[Fe^(II)(PhPy_(2)tacn)Cl_(2)]with a dangling pyridyl ligand and a phenyl group,*** anticipated that the dynamically open and close coordination behaviors of the pyridyl ligand enabled balance of the reactivity and stability of catalyst *** our delight,the“open form”of catalyst 1 provided a free coordination site,and the“close form”guaranteed its molecular integrity,resulting in a water oxidation reaction with high efficiency and *** turnover number and turnover frequency values of 2332 and 60 s^(−1)are the highest known to date among iron-based homogeneous water oxidation systems under visible light irradiation.

关键词： water oxidation photocatalysis homogeneous catalysis iron complexes dangling ligand intermediates characterization

Gut microbial-host-isozymes are new targets for diseases

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Science china(Life sciences) 2024年第7期67卷 1525-1527页

作者： Zhiwei Zhang Kai Wang Changtao jiang Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Female Fertility PromotionCenter for Reproductive MedicinePeking UniversityBeijing 100191China center for Obesity and Metabolic Disease Research School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China

Gut microbiota can interact with the host through lots of media including small molecular metabolites and proteins(Cani,2019;Fan and Pedersen,2021;Krautkramer et al.,2021).Recently,a new interaction pattern was identified,i.e.,gut microbiota can mimic the function of the host by producing a variety of enzymes with functions homologous to host enzymes.

关键词： diseases pattern