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中国城镇失能老年人口规模及养老服务需求预测

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北京社会科学 2024年第3期 114-128页

作者：程明梅杨华磊中南财经政法大学财政税务学院中南财经政法大学公共管理学院

以全国第六次和第七次人口普查数据为基准数据,结合CLHLS微观数据库,对2050年以前城镇失能老年人口养老服务需求进行了预测。结果显示:随着年龄的增加,中国城镇老年人的失能率不断提高,其中在65岁以上、80岁以上及100岁以上的老年人群体... 详细信息

以全国第六次和第七次人口普查数据为基准数据,结合CLHLS微观数据库,对2050年以前城镇失能老年人口养老服务需求进行了预测。结果显示:随着年龄的增加,中国城镇老年人的失能率不断提高,其中在65岁以上、80岁以上及100岁以上的老年人群体中,其平均失能率分别为28.98%、42.12%和76.04%;未来城镇重度失能老年人口规模将不断扩大,2050年以前其所占比例会超过城镇总失能老年人口的25%,而且男性重度失能人口规模始终低于女性重度失能人口规模;未来城镇重度失能老年人养老服务人员需求数量处于上升状态,预计2050年以前其每年需求的平均规模会超过500万人;随着城镇化的推进,未来城镇失能人口将高于农村失能人口。因此,应尽快建立覆盖城镇居民的长期照护机制;针对不同的城镇失能人群构建差异化的长期护理模式;加快建设针对城镇失能老年人的专业照护人员队伍;完善失能老年人养老服务规制。

关键词：失能老年人养老服务需求人口预测长期护理

Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming lei Zhong-Yuan Chen Yi guo Ya-Jie guo Bing-Qian guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-hua Jiang Zeng-Nan Mo Center for genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAgMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone genome-wide association studies Disease model

Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONg Jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao gUO Wei-jian DINg Hong-hua.gUO Yuan-biao LIU Li-kun SONg Jin-jie WU Ji-ping CHENg Yue-lei ZENg Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AgC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AgC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AgC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(PgC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

Chinese pangolins (Manis pentadactyla) are not functionally extinct in China

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 79-81页

作者： Zhi-Cheng Liu Peng Cen Jian-Kun Sun Fu-hua Zhang Amna Mahmood Chen lei Shi-Bao Wu School of Life Sciences South China Normal UniversityGuangzhouGuangdong 510631China

DEAR EDITOR,The key features of functional extinction include continuous reproductive failure,lack of new recruitment,and persistent population decline(Jarićet al.,2016;Roberts et al.,2017).However,the conclusion of functional extinction for the Chinese pangolin(Manis pentadactyla)by the China Biodiversity Conservation and green Development Foundation(CBC-gDF)based on preliminary field information is unconvincing as they did not assess reproductive function or new individual recruitment of Chinese pangolin populations(Supplementary Materials).

关键词： extinction Roberts Manis

The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes:findings from a prospective,nationwide,and multicenter registry

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Journal of geriatric Cardiology 2024年第5期21卷 523-533页

作者： Rui FU Ying-Xuan ZHU Kong-Yong CUI Jin-gang YANg Hai-Yan XU Dong YIN Wei-hua SONg Hong-Jian WANg Cheng-gang ZHU lei FENg Wei WU Kai-HongCHEN Yan-Yan ZHAO Ye LU Ke-Fei DOU Yue-Jin YANg on behalf of the CAMI Registry Investigators Cardiometabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangzhou Traditional Chinese Medical College First Affiliated HospitalGuangdong ProvinceChina Department of Cardiology Longyan Hospital First HospitalFujian ProvinceChina 不详

OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPg)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism *** We selected 5,308 participants with AMI from the prospective,nationwide,multicenter CAMI registry,of which 2,081 were diabetic and 3,227 were *** were divided into high FPg and low FPg groups according to the optim-al cutoff values of FPg to predict in-hospital mortality for diabetic and nondiabetic cohorts,*** primary endpoint was in-hospital *** Overall,94 diabetic patients(4.5%)and 131 nondiabetic patients(4.1%)died during hospitalization,and the optimal FPg thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,*** with individuals who had low FPg,those with high FPg were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1%vs.2.8%;odds ratio[OR]=3.862,95%confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4%vs.1.7%;HR=4.542,95%CI:3.041-6.782).After adjusting the potential confounders,this significant association was not ***-more,FPg as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic *** FPg to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic *** This large-scale registry indicated that there is a strong positive association between FPg and in-hospital mor-tality in AMI patients with and without *** might be useful to stratify patients with AMI.

关键词： patients fasting infarction

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动态障碍物状态空间重构的无人车路径规划

机械设计与制造 2024年第3期 243-248页

作者：雷芳华袁小芳湖南大学电气与信息工程学院湖南长沙410082 郴州职业技术学院现代装备制造学院湖南郴州423000

为了保证无人驾驶汽车在动态障碍物的环境下,实现安全的避障路径规划,提出了一种基于动态障碍物状态空间重构的避障路径规划方法。该避障路径规划方法,以前轮偏角为控制量,运用模型预测控制(MPC)方法,忽略车身尺寸信息建立点质量模型,... 详细信息

为了保证无人驾驶汽车在动态障碍物的环境下,实现安全的避障路径规划,提出了一种基于动态障碍物状态空间重构的避障路径规划方法。该避障路径规划方法,以前轮偏角为控制量,运用模型预测控制(MPC)方法,忽略车身尺寸信息建立点质量模型,主要在规划层中利用车载传感器的采集信息,对动态障碍物状态空间信息进行重构,研究不同重构构型对避障效果以及“穿越”现象的影响问题。在特定行驶工况中,采用CarSim和Simulink进行联合仿真,以低中高三种速度进行动态障碍物避障稳定性分析,仿真结果表明,所提出的避障路径规划方法对于存在动态障碍物环境下是有效的,避免了由于忽略车身尺寸所导致的“穿越”现象,通过与传统人工势场法比较,验证了本方法规划的路径更短,避障曲率更优。基于动态障碍物状态空间重构的避障路径规划具有安全性和稳定性。

关键词：无人车动态障碍物状态空间重构路径规划

杏芎氯化钠注射液联合阿加曲班治疗急性脑梗死的临床研究

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现代药物与临床 2024年第6期39卷 1468-1472页

作者：王飒雷蕾华锋宋波姬利延安大学咸阳医院神经内科陕西咸阳712000 延安大学咸阳医院神经外科陕西咸阳712000

目的探讨杏芎氯化钠注射液联合阿加曲班治疗急性脑梗死的临床疗效。方法选取2022年6月—2023年7月延安大学咸阳医院收治的急性脑梗死患者108例,按照随机数字表法分为对照组(54例)和治疗组(54例)。对照组患者静脉泵注阿加曲班注射液,起始... 详细信息

目的探讨杏芎氯化钠注射液联合阿加曲班治疗急性脑梗死的临床疗效。方法选取2022年6月—2023年7月延安大学咸阳医院收治的急性脑梗死患者108例,按照随机数字表法分为对照组(54例)和治疗组(54例)。对照组患者静脉泵注阿加曲班注射液,起始2 d剂量为2.5 mg/h,24 h持续,之后剂量为10 mg/次,在3 h左右完成静脉滴注,2次/d,此剂量连续使用5 d。治疗组患者在对照组基础上静脉滴注杏芎氯化钠注射液,100 mL/次,1次/d。两组患者治疗7 d。观察两组患者临床疗效,比较治疗前后两组患者可溶性血管细胞黏附因子-1(s VCAM-1)、白细胞介素-1β(IL-1β)、D-二聚体和纤维蛋白原水平,及美国国立卫生研究院卒中量表(NIHSS)评分和90 d预后情况。结果治疗后,治疗组总有效率为94.44%,比对照组的81.48%明显升高(P<0.05)。治疗后,两组s VCAM-1、IL-1β、D-二聚体、纤维蛋白原水平和NIHSS评分明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗组90 d预后良好率为88.89%,对照组为74.07%,两组比较差异具有统计学意义(P<0.05)。结论杏芎氯化钠注射液联合阿加曲班对急性脑梗死的治疗效果以及安全性均较为理想,可改善体内炎症反应、血液高凝状态以及神经功能。

关键词：杏芎氯化钠注射液阿加曲班注射液急性脑梗死可溶性血管细胞黏附因子-1 D-二聚体纤维蛋白原

Health promotion and education proposal among Chinese female college students:eliminating cervical cancer is no longer a dream

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Infectious Diseases Research 2024年第3期5卷 32-41页

作者： Kui-Mei Zhang Nan Jiang Shu-Ling Zhang Mei-hua Wu Xiao-lei Song Ji-Xuan Liu Wen-Ming Cao gynecology Department Shandong Changle People’s HospitalWeifang 262400China gynecology Department Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen 518104China gynecology Department Pingshan District Central HospitalShenzhen 518122China

Cervical cancer is a serious threat to women’s *** high-risk human papillomavirus(HPV)infection is a necessary factor for cervical cancer development and has become a serious public health threat to *** present,young women have become a high-risk group for potential HPV *** vaccination is an effective method to prevent HPV infection and related diseases and is a primary preventive measure for HPV infection-related *** study explores the influencing factors of female college students’willingness to receive HPV vaccination,their ability to understand college students’HPV awareness,their motivation for HPV vaccination,their behavioral skills related to HPV vaccination,their willingness to receive HPV vaccination and their vaccination *** aim of this study was to increase the HPV vaccination rate of Chinese female college students through health education programs and thus reduce the incidence of cervical cancer.

关键词： cervical cancer human papillomavirus HPV vaccination female college students

广义阈值表示的机加工自动线能量需求跨层模型

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机械设计与制造 2024年第8期402卷 140-147页

作者：王丽平雷蕾宋宪华郑州铁路职业技术学院河南郑州450002 西安航空学院陕西西安710077

为了实现多层次分析的最优设置,提出了一种基于双机广义阈值表示的机加工自动线能量需求跨层模型。首先通过在优化阶段建立机器和系统组织层之间的交互消除了所描述的次优决策。并且将传统的序贯优化方法转化为递归优化方法。另外分析... 详细信息

为了实现多层次分析的最优设置,提出了一种基于双机广义阈值表示的机加工自动线能量需求跨层模型。首先通过在优化阶段建立机器和系统组织层之间的交互消除了所描述的次优决策。并且将传统的序贯优化方法转化为递归优化方法。另外分析利用了最小能量时间函数,将具有可变功率和处理速率的机器级高分辨率模型与系统级状态模型联系起来。进一步利用一个马尔可夫广义阈值模型,通过指数分布的向下状态来模拟机器的随机行为,并在互操作缓冲区的实际水平上实现控制策略。最后通过一个工业案例验证了提出的方法能够有效降低成本,提升效率。

关键词：多层次分析马尔可夫广义阈值模型最小能量时间函数

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