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Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in china,2.11

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Biomedical and Environmental Sciences 2013年第11期26卷 877-885页

作者： YOU Yuan Hai SONG yan yan yan Xiao Mei WANG Hai Bin {3. Meng Han tao Xiao Xia Li lei lei {3. Yu Xin jianG Xi Hong {3. Bing Hua ZHOU Hao XIAO Di jin lian Mei {12. Zi jian LUO {12. Ji {3. jian Zhong Collabroative Innovation Center for Diagnosis Treatment of Infectious Disease State Key Laboratory for Infectious Disease Prevention and ControlNational Institute for Communicable Disease Control and Prevention Chaoyang District Center for Disease Control and Prevention Beijing Suzhou City Center for Disease Control and Prevention Office of Disease Control and Emergency Response Chinese Center for Disease Control and Prevention Harbin Municipal Center for Disease Control and Prevention

Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in china in 2.11. Methods Seventy-four 5treptococcol pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in china from May to August of 2.11. Emm genotyping, pulsed-field gel electrophoresis （PFGE）, superantigen （SAg） genes and antimicrobial susceptibility profiling were analyzed for these isolates. Results A total of 4 different emm types were identified. Emm12.was the most prevalent type which contained four predomina{2. PFGE patterns corresponding to four different virulence and superantigen profiles. Emm12.79.7%） and emml （14.9%） accounted for approximately 94% of all the isolates. The speA gene was all negative in emm12.isolates and positive in emml isolates. All strains were resistant to erythromycin, and 89.4% of them were resistant to erythromycin, tracycline, and clindamycin simultaneously. Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circula{2. strains, though no new emm type was found in this outbreak. The data provide a baseline for further surveillance of scarlet fever, which may contribute to the explanation of the outbreak and development of a GAS vaccine in china.

关键词： Scarlet fever Streptococcus pyogenes Molecular epidemiology

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中药虎杖中抗癌活性物质研究

中药材 2006年第7期29卷 689-691页

作者：冯磊张莲芬严婷金坚陶文沂江南大学生物工程学院生物制药实验室江苏无锡214036 江南大学工业生物技术教育部重点实验室江苏无锡214036

目的:为虎杖药用价值的开发利用提供科学据依。方法:在生物活性测定指导下,从虎杖中分离得到一种较高抗癌活性的物质,并且用液质联用、红外光谱、紫外全扫描等方法鉴定其结构。MTT法测定它对L-02.HepG2.SHZ-888、MCF-7、MCF-7/ADM等... 详细信息

目的:为虎杖药用价值的开发利用提供科学据依。方法:在生物活性测定指导下,从虎杖中分离得到一种较高抗癌活性的物质,并且用液质联用、红外光谱、紫外全扫描等方法鉴定其结构。MTT法测定它对L-02.HepG2.SHZ-888、MCF-7、MCF-7/ADM等细胞的抑制作用并用HE染色法观察其作用MCF-7/ADM细胞48 h、72.h后的肿瘤细胞形态学变化。结果:分离得到的物质为顺、反式-白藜芦醇,它能特异性抑制多种肿瘤细胞的生长,而对正常肝细胞毒性很小。同时,首次发现其对耐阿霉素的MCF-7乳腺癌细胞有直接的细胞毒性。结论:白藜芦醇是虎杖中一种活性强、低毒的抗癌物质。

关键词：虎杖白藜芦醇 MCF-7/ADM细胞 MTT法

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai {2.yong Cai Wujun Cai {3.jian Cai {3.zhou Cai Yuchen Cai Hai{3.ng Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti {3.min Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen {3.ng Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti {2. Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Zi{12.g Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xu{2. Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang De{2. Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Hai{3. Dong jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang {2. HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jinR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 3. GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at var{2.ng energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 3. MW per beam,it can achieve a luminosity of 5×10^(3.)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13.ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.3.s.

关键词： initiated exceeding precise

Timing analysis of the black hole candidate EXO 1846–03. with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-Cheng Xiao Qing-Cui Bu jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma {3. tao Wei zhang Li Chen Li-Ming Song Ti-Pei Li Yu-Peng Xu Xue-lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua jiang Wei-Chun jiang jing jin Yong-Jie jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li Xu-Fang Li yang-Guo Li Zheng-Wei Li Xiao-Hua {3.g jing-Yuan Liao Bai-Sheng Liu Guo-Qing Liu Hong-Wei Liu Xiao-jing Liu yi-Nong Liu Bo Lu Xue-feng Lu Qi Luo tao Luo Bin Meng yi Nang jian-yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-ying Song {3.g Sun ying Tan You-Li Tuo Chen Wang Guo-feng Wang Juan Wang Ling-Jun Wang weng-Shuai Wang Yu-Sa Wang Xiang-yang wen Bai-yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He Xu Jia-Wei yang Sheng yang yan-Ji yang yi-Jung yang Qi-Bin yi Qian-Qing yin Yuan You Ai-Mei zhang Cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang wen-Zhao zhang yi zhang yi-Fei zhang Yong-Jie zhang Yuan-Hang zhang Yue zhang Zhao zhang Zhi zhang Zi-{3.g zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China key laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-03. during its outburst in 2.19 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2.Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–03.

早产儿视网膜病变自然消退患儿黄斑光学相干断层扫描血管成像(OCTA)变化

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眼科新进展 2019年第5期39卷 449-452页

作者：吴桢泉赵金凤张福燕田汝银陈懿马大卉佘洁婷郑磊陈妙虹杨宇航曾宪露曾键汪建涛张国明贵州医科大学贵州省贵阳市550025 深圳市眼科医院暨南大学附属深圳眼科医院深圳眼科学重点实验室广东省深圳市518040

目的使用光学相干断层扫描血管成像(optical coherence tomographic angiography,OCTA)观察早产儿视网膜病变(retinopathy of prematurity,ROP)自然消退患儿的黄斑形态与血流的变化。方法采用横断面研究。收集自然消退的轻度ROP患儿6例... 详细信息

目的使用光学相干断层扫描血管成像(optical coherence tomographic angiography,OCTA)观察早产儿视网膜病变(retinopathy of prematurity,ROP)自然消退患儿的黄斑形态与血流的变化。方法采用横断面研究。收集自然消退的轻度ROP患儿6例(12.)为ROP自然消退组,同时收集年龄匹配的足月产健康儿童8例(16眼)为对照组。使用OCTA的3.mm×3.mm扫描模式获得两组儿童的黄斑中心凹无血管区(foveal avascular zone,FAZ)面积、FAZ形态指数、表层视网膜血管密度及表层视网膜灌注密度,利用SD-OCT测量黄斑中心凹视网膜厚度(central foveal thickness,CFT),并对比两组儿童的最佳矫正视力(best corrected visual acuity,BCVA)。采用两独立样本t检验进行统计分析。结果 ROP自然消退组与对照组的FAZ面积分别为(0.13.±0.12.)mm^2.(0.3.6±0.080)mm^2.CFT分别为(193.77±17.92.μm和(164.2.±2..2.)μm,两组相比差异均有统计学意义(均为P0.05)。结论 ROP自然消退患儿黄斑区形态结构及血流有明显改变,FAZ面积偏小,CFT增厚,但BCVA未受明显影响。

关键词：早产儿视网膜病变光学相干断层扫描血管成像黄斑中心凹无血管区黄斑中心凹视网膜厚度