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Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway

Neural Regeneration Research 2024年第2期19卷 434-439页

作者： Chenxi Zhao Tiangang Zhou Ming Li Jie Liu Xiaoqing Zhao Yilin Pang xinjie Liu Jiawei Zhang lei Ma Wenxiang Li Xue Yao Shiqing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General HospitalTianjinChina Orthopedic Research Center of Shandong University Cheeloo College of MedicineDepartment of OrthopedicsQilu Hospital of Shandong UniversityJinanShandong ProvinceChina

Argatroban is a synthetic thrombin inhibitor approved by *** and Drug Administration for the treatment of ***,whether it plays a role in the repair of spinal cord injury is *** this study,we established a rat model of T10 moderate spinal cord injury using an NYU Impactor ModerⅢand performed intraperitoneal injection of argatroban for 3 consecutive *** results showed that argatroban effectively promoted neurological function recovery after spinal cord injury and decreased thrombin expression and activity in the local injured spinal *** sequencing transcriptomic analysis revealed that the differentially expressed genes in the argatroban-treated group were enriched in the JAK2/STAT3 pathway,which is involved in astrogliosis and glial scar *** blotting and immunofluorescence results showed that argatroban downregulated the expression of the thrombin receptor PAR1 in the injured spinal cord and the JAK2/STAT3 signal *** also inhibited the activation and proliferation of astrocytes and reduced glial scar formation in the spinal *** together,these findings suggest that argatroban may inhibit astrogliosis by inhibiting the thrombin-mediated PAR1/JAK2/STAT3 signal pathway,thereby promoting the recovery of neurological function after spinal cord injury.

关键词： argatroban astrogliosis JAK/STAT signaling pathway protease-activated receptor-1 spinal cord injury thrombin vimentin

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A temperature-insensitive silver nanostructures@graphene foam for high accuracy and full range human health monitoring

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Rare Metals 2024年第11期 5953-5963页

作者： Min-Xuan Xu Chun Dou Teng-Yue Song xin Li Qi Zhang Center for Advanced Optoelectronic Materials College of Materials and Environmental EngineeringHangzhou Dianzi University Key Laboratory of Novel Materials for Sensor of Zhejiang Province Hangzhou Dianzi University School of Mechanical Engineering Zhejiang University Department of Mechanical Engineering University of Tokyo

Recently,application-oriented strain sensor has been intensively investigated in the fields of human motion detection,personalized health management and portable medical *** significant efforts in improving its sensitivity and linear sensing range,developing the wearable strain sensor with stable signal remains a ***,we proposed an ideal hybrid material with nearly zero temperature coefficient resistance（TCR）for temperature-insensitive strain sensing:the silver nanostructures（AgNTs） were introduced to coat the graphene foam（GrF） conformably by hydrothermal *** nanoscaled metal additives（TCR> 0） not only endow GrF（TCR 3000 cycles）.Moreover,our strain sensor can be easily mounted on human skin as an epidermal device for reliable detection of electrophysiological stimuli,thus showing a great promising in practical wearable applications.

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多排螺旋CT增强扫描结直肠黏液腺癌患者肠壁及肠腔的特征

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肿瘤研究与临床 2014年第11期26卷 737-740页

作者：杨继虎杨晓棠王艳艳辛磊宋晓婕山西省肿瘤医院核磁/CT室太原030013

目的探讨多排螺旋CT三期增强扫描在结直肠黏液腺癌患者的肠壁及肠腔特征性分析中的应用.方法采用GE Discovery CT 750HD扫描仪行平扫、动脉期、门静脉期和延时期的扫描.观察5 1例结直肠黏液腺癌病例平扫及增强后病变肠壁、肠腔及近端... 详细信息

目的探讨多排螺旋CT三期增强扫描在结直肠黏液腺癌患者的肠壁及肠腔特征性分析中的应用.方法采用GE Discovery CT 750HD扫描仪行平扫、动脉期、门静脉期和延时期的扫描.观察5 1例结直肠黏液腺癌病例平扫及增强后病变肠壁、肠腔及近端正常肠腔的表现,进行必要的数值测量和CT值测量.结果结直肠黏液腺癌患者肠壁呈环形不均匀增厚,半球形增厚.增厚肠壁见内缘有分叶,外缘有分叶或无分叶.增强后见三层结构和两层结构的分层征及类囊肿征.转移淋巴结体积较大时、肝转移、卵巢转移可表现为类囊肿征.肠腔狭窄根据形态分为自然流线型狭窄、不规则同定型狭窄、不规则缩窄型狭窄.病变近端正常肠管表现为闭合、轻度扩张或重度扩张.结论结直肠黏液腺癌患者肠壁呈不均匀环形增厚或半球形增厚.肠壁内可有钙化.增强后表现为分层征和类囊肿征.病变肠壁僵硬程度下降近端肠管发生梗阻者减少.依靠这些特征,CT检查可以做出结直肠黏液腺癌的诊断.

关键词：结直肠黏液腺癌 X线计算机体层摄影术

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合肥旅游目的地形象感知——基于网络游记多维话语的探讨

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安庆师范学院学报（社会科学版） 2016年第2期35卷 105-111页

作者：雷若欣朱定秀吴萍巢湖学院旅游管理学院安徽巢湖238000

近年来,合肥利用环巢湖丰富的旅游资源树立了"览百里巢湖,游千年合肥"的旅游目的地形象和"大湖名城、创新高地"的城市形象定位。百度旅游、搜狗旅游、马蜂窝、travelpod四大旅游传播网站的相关网络游记内容,从文化、宜居和生态、现代化... 详细信息

近年来,合肥利用环巢湖丰富的旅游资源树立了"览百里巢湖,游千年合肥"的旅游目的地形象和"大湖名城、创新高地"的城市形象定位。百度旅游、搜狗旅游、马蜂窝、travelpod四大旅游传播网站的相关网络游记内容,从文化、宜居和生态、现代化都市、社会和谐、经济发展等维度直观反映了合肥旅游目的地的形象。要真正打造合肥"大湖名城"的城市名片,就要积极创新旅游开发思路,做好"水文化"文章;提高旅游接待能力,形成国际化发展态势;提高旅游地和谐度,创建文明旅游城。

关键词：合肥旅游目的地形象网络游记

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Germylene-Fe complexes caused by heterometallic coupling and investigation into the 3d-4p bonding

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Chinese Chemical Letters 2024年第3期35卷 304-307页

作者： Yingying Qin Yongmei Kang lei Zhang Jianping Sun Zhijing Zhang Jialei Xu Fanlong Zeng Anyang Li Wenyuan Wang Weiqun Shi Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710127China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Shaanxi Coal and Chemical Industry Xi'an 710054China

The interpretation of heterometallic bonding nature is a basic work of inorganic *** means of intermetallic substitution of germylene anions with iron halide complexes CpFe(CO)_(2)I andβ-diketiminato Fe^Ⅱchloride,the ferrogermylene complexes 3a,3b and 4a were synthesized and structurally *** structural and IR characterizations show the presence of the Ge←Feπbackbonding in molecules 3a,3b and *** computational works on frontier molecular orbitals and their comparison of energy states confirmed thatσdonation andπbackbonding are both weak in these molecules,despite three complexes have longer Ge-Fe bonds,whose strength decreases slightly with the degressive electron density around Fe environment in a sequence from 3a,3b to 4a.

关键词： Metallic bonding Germylene Iron Crystal structure σbond πbackbond

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Analysis of Solutions of the Holling-Tanner Model

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ying-chao HAO Kun-lun HUANG xin-tian JIA Cui-Ping LI School of Mathematical Sciences Beihang University

In this paper we consider a kind of predator-prey model named Holling-Tanner model. Firstly, we prove all solutions of this model to be bounded from above. Secondly, we find a positive invariant set of the model, and prove the existence of stable limit cycle in this invariant set by Poincar′e-Bendixson theorem for the unstable equilibrium. Thirdly, we get the region of parameters in which the corresponding stable equilibrium are also globally asymptotically stable. Lastly, we give a bifurcation diagram and illustration with two limit cycles for special parameters through numerical simulation. By our knowledge, the invariant set constructed in this paper is better than that in the book written by Murray.

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Influence of extraction voltage on electron and ion behavior characteristics

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Chinese Physics B 2024年第4期33卷 553-559页

作者：徐翱甘娉娉石元杰陈磊 Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621999China

The characteristics of the extracted ion current have a significant impact on the design and testing of ion source *** this paper,a 2D in space and 3D in velocity space particle in cell(2D3V PIC)method is utilized to simulate plasma motion and ion extraction characteristics under various initial plasma velocity distributions and extraction voltages in a Cartesian coordinate *** plasma density is of the order of 10^(15)m^(-3)-10^(16)m^(-3)and the extraction voltage is of the order of 100 V-1000 *** study investigates the impact of various extraction voltages on the velocity and density distributions of electrons and positive ions,and analyzes the influence of different initial plasma velocity distributions on the extraction *** simulation results reveal that the main reason for the variation of extraction current is the spacecharge force formed by the relative aggregation of positive and negative net *** lays the foundation for a deeper understanding of extraction beam characteristics.

关键词： extraction voltage plasma ion beam ion current

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黑液气化气脱硫的主要技术参考和设计方案

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中华纸业 2010年第20期31卷 16-20页

作者：农光再牟晋建张鑫磊王双飞广西大学轻工与食品工程学院南宁530004

根据制浆厂的结构和碱液回收工艺,以及黑液气化气中含有CO2、甲硫醇和硫化氢等酸性气体的特性,本文设计一种以普通填料吸收塔为设备,以回收碱液为吸收剂的黑液气化气脱硫新方法。从理论分析,该方法不需要催化剂,不需要进行富液解吸处理... 详细信息

根据制浆厂的结构和碱液回收工艺,以及黑液气化气中含有CO2、甲硫醇和硫化氢等酸性气体的特性,本文设计一种以普通填料吸收塔为设备,以回收碱液为吸收剂的黑液气化气脱硫新方法。从理论分析,该方法不需要催化剂,不需要进行富液解吸处理,不存在盐存积问题;而且该法采用的吸收剂是现场回收碱液,脱硫效率高,净化气体能够满足燃气涡轮机的燃烧要求,所以该方法将是一种较为理想的黑液气化气脱硫方法。

关键词：黑液气化气体脱硫

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Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

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World Journal of Psychiatry 2024年第3期14卷 421-433页

作者： Juan Liu Lin Liu Yi-xin Hu Jian-Hua Li Xiao Zou Hao-Yun Zhang Li Fan Department of Cardiology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Pulmonary and Critical Care Medicine The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China The Fourth Department of Geriatric Health Care The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Anesthesiology First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited *** To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)*** Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and *** this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger ***,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on *** served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger *** In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger ***-Egger regression revealed pleiotropy in the impact of worrier/anxious

关键词： Mendelian randomization analysis Feelings Cognition Intelligence

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Analysis of Plant Diversity Characteristics in Jiangxia Wetland

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Agricultural Biotechnology 2024年第4期13卷 82-86,91页

作者： Junhui WANG Jingjie WANG lei ZHANG Hetian Normal College Academy of ScienceHetian 848000China School of Resources and Environment Tibet Agriculture and Animal Husbandry UniversityLinzhi 860000China

[Objectives]This study was conducted to explore the characteristics of plant diversity of Jiangxia Wetland in Lhasa River basin.[Methods]Based on the survey data of 37 plant community in three types of sample plots of Jiangxia Wetland in the Lhasa River basin,this study analyzed the diversity of plant community in different habitats of Jiangxia Wetland from Pielou evenness,Margalef richness,Simpson and Shannon Wiener diversity indexes of different types and levels.[Results]The Pielou index,Shannon-Wiener index and Simpson diversity index of dry land was higher than those of other plots,while the Margalef species richness index of the ecotone of seasonally flooded and dry land was higher than that of other *** Pielou index,Shannon-Wiener index,Simpson diversity index and Margalef species richness index of composite plants were higher than those of other herbaceous *** Shannon-Wiener index,Simpson diversity index and Margalef species richness index of hygrophytes were higher than those of other plants,while the Pielou index evenness index of aquatic plants was higher than that of other *** or perennial herbaceous plants occupied the primary position in the study area,and shrub plants occupied a secondary position,and floating plants took the lowest position.[Conclusions]The results of this study can provide theoretical support or reference basis for the scientific management of comprehensive wetland systems such as wetland ecosystem restoration and plant diversity protection in Jiangxia Wetland.

关键词： Diversity index Aquatic plant Hygrophyte Drought-tolerant plant

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