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Adipose-derived mesenchymal stem cell-incorporated PLLA porous microspheres for cartilage regeneration

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Animal Models and Experimental Medicine 2024年第05期 685-695页

作者： Chang Gao Wenlong Yuan Dongcheng Wang xin Zhang Tong Zhang Zhimin Zhou Biomedical Barriers Research Center Institute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin Key Laboratory of Biomedical Materials Clinical Laboratory Tianjin Hospital

Background: In facial plastic surgery, patients with nasal deformity are often treated by rib cartilage transplantation. In recent years, cartilage tissue engineering has developed as an alternative to complex surgery for patients with minor nasal defects via injection of nasal filler material. In this study, we prepared an injectable nasal filler material containing poly-L-l actic acid(PLLA) porous microspheres(PMs), hyaluronic acid(HA) and adipose-derived mesenchymal stem cells(ADMSCs).Methods: We seeded ADMSCs into as-prepared PLLA PMs using our newly invented centrifugation perfusion technique. Then, HA was mixed with ADMSC-i ncorporated PLLA PMs to form a hydrophilic and injectable cell delivery system(ADMSCincorporated PMH).Results: We evaluated the biocompatibility of PMH in vitro and in vivo. PMH has good injectability and provides a favorable environment for the proliferation and chondrogenic differentiation of ADMSCs. In vivo experiments, we observed that PMH has good biocompatibility and cartilage regeneration ***: In this study, a injectable cell delivery system was successfully *** believe that PMH has potential application in cartilage tissue engineering,especially in nasal cartilage regeneration.

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Priority Encoder Based on DNA Strand Displacement

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Chinese Journal of Electronics 2024年

作者： Fang WANG xinjian ZHANG xin CHEN Shuying Lü Congzhou CHEN Xiaolong SHI Institution of Computing Science and Technology Guangzhou University Beijing University of Technology School of Computer Science Peking University

The slow development of traditional computing has prompted a search for new materials to replace silicon-based computers. Bio-computers, which use molecules as the basis of computation, are highly parallel and information capable, attracting a lot of attention. In this study, we designed a NAND logic gate based on the DNA strand displacement mechanism. We assembled a molecular calculation model, a 4-wire-2-wire priority encoder logic circuit, by cascading the proposed NAND gates. Different concentrations of input DNA chains were added into the system, resulting in corresponding output, through DNA hybridization and strand displacement. Therefore, it achieved the function of a priority encoder. Simulation results verify the effectiveness and accuracy of the molecular NAND logic gate and the priority coding system presented in this study. The unique point of this proposed circuit is that we cascaded only one kind of logic gate, which provides a beneficial exploration for the subsequent development of complex DNA cascade circuits and the realization of the logical coding function of information.

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跨界生态链产品的用户接受行为影响因素研究——基于UTAUT模型

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哈尔滨商业大学学报（社会科学版） 2021年第2期 54-68页

作者：叶笛陈欣蕾刘震宇华侨大学工商管理学院福建泉州362021 华侨大学东方企业管理中心福建泉州362021 厦门大学管理学院福建厦门361005

跨界作为一种具有创新意义的商业模式,已成为企业转型发展和获取竞争优势的重要路径。研究基于整合技术接受理论(UTAUT),分析影响用户接受跨界产品的主要因素,同时加入感知风险、价格感知、品牌忠诚度等新增变量,构建跨界产品用户接受... 详细信息

跨界作为一种具有创新意义的商业模式,已成为企业转型发展和获取竞争优势的重要路径。研究基于整合技术接受理论(UTAUT),分析影响用户接受跨界产品的主要因素,同时加入感知风险、价格感知、品牌忠诚度等新增变量,构建跨界产品用户接受行为影响因素模型。数据分析结果显示,绩效期望、努力期望、品牌忠诚度、社群影响对用户使用意愿存在显著正向影响,价格感知会负向影响用户的使用行为;感知风险不会对用户使用意愿产生显著负向影响;促进因素和使用意愿会正向影响用户的使用行为;使用经验在绩效期望与用户接受意愿的关系中起显著正向调节影响。研究结果可为正在或试图进行跨界生产的企业组织提出考量跨界产品相关性等参考意见,为跨界产品研发推广、推动企业更好更快地实现产业转型与优化提供一定思路。

关键词：跨界商业模式 UTAUT模型使用行为生态链产品

环状RNAs与类风湿关节炎骨破坏潜在关系的研究

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海南医学院学报 2021年第24期27卷 1916-1920页

作者：王杰刘健文建庭王馨杜新雷安徽中医药大学第一附属医院安徽合肥230031

类风湿关节炎(rheumatoid arthritis,RA)骨破坏是一直伴随RA患者病程发展的病理状态,会造成患者关节严重变形,生活质量下降。环状RNAs(circular RNAs,circRNAs)是一类具有环形结构的RNA分子,在多种生物体中广泛存在,并在多种疾病中发挥... 详细信息

类风湿关节炎(rheumatoid arthritis,RA)骨破坏是一直伴随RA患者病程发展的病理状态,会造成患者关节严重变形,生活质量下降。环状RNAs(circular RNAs,circRNAs)是一类具有环形结构的RNA分子,在多种生物体中广泛存在,并在多种疾病中发挥特殊的生物学功能。大量研究表明circRNAs可以作为miRNA海绵,在治疗RA骨破坏方面具有重要作用。本文就circRNAs在调控细胞凋亡、成骨细胞和破骨细胞分化功能和调控免疫炎症等方面来阐述其与RA骨破坏之间的潜在关系,为研究RA骨破坏的潜在机制和可能的治疗方法提供一种新的途径。

关键词：环状RNAs 类风湿关节炎骨破坏

frequency domain estimation and compensation method for system synchronization parameters of distributed-HFSWR

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Journal of Systems Engineering and Electronics 2024年第5期35卷 1084-1097页

作者： WANG Hongyong SUO Ying DENG Weibo WU Xiaochuan BAI Yang ZHANG xin School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Marine Environmental Monitoring and Information Processing Ministry of Industry and Information TechnologyHarbin 150001China

To analyze the influence of time synchronization error,phase synchronization error,frequency synchronization error,internal delay of the transceiver system,and range error and angle error between the unit radars on the target detection performance,firstly,a spatial detection model of distributed high-frequency surface wave radar(distributed-HFSWR)is established in this *** this model,a method for accurate extraction of direct wave spectrum based on curve fitting is proposed to obtain accurate system internal delay and frequency synchronization error under complex electromagnetic environment background and low signal to noise ratio(SNR),and to compensate for the shift of range and Doppler frequency caused by time-frequency synchronization *** direct wave component is extracted from the spectrum,the range estimation error and Doppler estimation error are reduced by the method of curve fitting,and the fitting accuracy of the parameters is ***,the influence of frequency synchronization error on target range and radial Doppler velocity is quantitatively *** relationship between frequency synchronization error and radial Doppler velocity shift and range shift is ***,the system synchronization parameters of the trial distributed-HFSWR are obtained by the proposed spectrum extraction method based on curve fitting,the experimental data is compensated to correct the shift of the target,and finally the correct target parameter information is *** and experimental results demonstrate the superiority and correctness of the proposed method,theoretical derivation and detection model proposed in this paper.

关键词： distributed high-frequency surface wave radar(distributed-HFSWR) direct wave synchronization error curve fitting system synchronization parameter compensation

Antibody-platinum(IV)prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma

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Journal of Pharmaceutical Analysis 2024年第3期14卷 389-400页

作者： Xiangye Yin Yingjie Zhuang Haiqin Song Yujian Xu Fan Zhang Jianxin Cui lei Zhao Yingjie Yu Qixu Zhang Jun Ye Youbai Chen Yan Han Department of Plastic and Reconstructive Surgery The First Medical CenterChinese PLA General HospitalBeijing100853China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200023China State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Plastic Surgery University of Texas MD Anderson Cancer CenterHoustonTX77030USA State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Antibody-drug conjugates(ADCs)are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells,thereby attracting considerable attention in precise oncology ***(Cet)is a typical antibody that offers the benefits of good targeting and safety for individuals with advanced and inoperable cutaneous squamous cell carcinoma(cSCC);however,its anti-tumor activity is limited to a single ***(CisPt)shows good curative effects;however,its adverse effects and non-tumor-targeting ability are major *** this study,we designed and developed a new ADC based on a new cytotoxic platinum(IV)prodrug(C8Pt(IV))and *** so-called antibody-platinum(IV)prodrugs conjugates,named Cet-C8Pt(IV),showed excellent tumor targeting in ***,it accurately delivered C8Pt(IV)into tumor cells to exert the combined anti-tumor effect of Cet and ***,metabolomic analysis showed that Cet-C8Pt(IV)promoted cellular apoptosis and increased DNA damage in cSCC cells by affecting the vitamin B6 metabolic pathway in tumor cells,thereby further enhancing the tumor-killing ability and providing a new strategy for clinical cancer treatment using antibody-platinum(IV)prodrugs conjugates.

关键词： Antibody drug conjugate Cutaneous squamous cell carcinoma DNA damage Platinum drug Targeted therapy

The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types

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Neural Regeneration Research 2024年第9期19卷 1947-1953页

作者： Hongye Xu He Li Ping Zhang Yuan Gao Hongyu Ma Tianxiang Gao Hanchen Liu Weilong Hua lei Zhang Xiaoxi Zhang Pengfei Yang Jianmin Liu Neurovascular Center Changhai HospitalNaval Medical UniversityShanghaiChina Department of Emergency Naval Hospital of Eastern TheaterZhoushanZhejiang ProvinceChina

Astrocytes are the most abundant glial cells in the central nervous system;they participate in crucial biological processes,maintain brain structure,and regulate nervous system *** are cell-derived extracellular vesicles containing various bioactive molecules including proteins,peptides,nucleotides,and lipids secreted from their cellular *** evidence shows that exosomes participate in a communication network in the nervous system,in which astrocyte-derived exosomes play important *** this review,we have summarized the effects of exosomes targeting astrocytes and the astrocyte-derived exosomes targeting other cell types in the central nervous *** also discuss the potential research directions of the exosome-based communication network in the nervous *** exosome-based intercellular communication focused on astrocytes is of great significance to the biological and/or pathological processes in different conditions in the *** strategies may be developed for the diagnosis and treatment of neurological disorders by focusing on astrocytes as the central cells and utilizing exosomes as communication mediators.

关键词： astrocytes communication exosomes neurological disorders targeting mechanism

Chronic social defeat stress‑induced depression reduces BCG efficacy by promoting regulatory T‑cell levels in mice

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Animal Diseases 2024年第2期4卷 115-126页

作者： Rohit Tyagi Xi Chen Atika Dhar Bing Yang Wei Zhou Aikebaier Reheman Yingying lei Gang Cao National Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China National Institute of Immunology New Delhi 110067India College of Animal Science and Technology Tarim UniversityAlar 843300China Bio‑Medical Center Huazhong Agricultural UniversityWuhan 430070China

Despite the initial successes of the Bacillus Calmette-Guerin(BCG)vaccine in children,its efficacy against tuberculosis is highly *** is a lack of understanding about how mental conditions influence BCG ***,we used the chronic social defeat stress(CSDS)model to explore the effects of depression on BCG vaccination *** observed higher lung and spleen bacterial loads and a lower organ index in depressed compared to BCG ***,a relatively lower T cell protective efficacy was observed in both compared to control and BCG mice via a mycobacterium growth inhibition assay(MGIA).Cytokine expression of IL-12p40,IL-1β,IL-17,TNF-αand IFN-γwas reduced,whereas the expression of IL-10 and IL-5 was increased in the spleen of both compared to BCG ***,the proportions of CD4^(+)IFN-γ^(+),CD8^(+)IFN-γ^(+)T lymphocytes and CD4^(+)effector/central memory T cells were reduced in the splenocytes of the depressed BCG *** promotes CD4^(+)regulatory T cells(Treg)and myeloid-derived suppressor cell(MDSC)generation in depressed mice,contributing to the reduced pro-inflammatory immune response upon BCG *** study provides insight into the decreased protective immunity by BCG vaccination attributable to depression in mice.

关键词： BCG Vaccine efficacy Treg Immune suppression Depression

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几种新型热喷涂技术

机械工程与自动化 2012年第3期 206-208页

作者：万春锋代新雷陕西国防工业职业技术学院陕西西安710302 陕西交通职业技术学院陕西西安710018

论述了几种新型热喷涂的原理,以及热喷涂材料的新进展和热喷涂层质量监控的一些新方法,在此基础上介绍了热喷涂技术的最新应用。

关键词：热喷涂涂层材料