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国外医学（输血及血液学分册） 2003年第1期26卷 90-91页

作者： legler tj Maas JH Kohler Met al 廖耘节成都市血液中心

RHD基因序列分析可以明确区分弱D和不完全D的基因异质性。当血清学方法的检测结果出现矛盾或不确定时,应引入分子生物学方法。确定和区分DⅥ型和不完全型D的基因分型方法已经建立,新近又有弱D基因型的研究报道。最近两年公布的RHD等位... 详细信息

RHD基因序列分析可以明确区分弱D和不完全D的基因异质性。当血清学方法的检测结果出现矛盾或不确定时,应引入分子生物学方法。确定和区分DⅥ型和不完全型D的基因分型方法已经建立,新近又有弱D基因型的研究报道。最近两年公布的RHD等位基因数目在不断增加,大约60个RHD等位基因得到描述。由此可预测RHD基因内部存在更多的突变。

关键词： RHD序列分析预防输血疗法 RhD抗原检测

Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms

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Journal of Environmental Sciences 2017年第12期29卷 133-137页

作者： Renate Kopp Irene Ozáez Martínez Jessica Legradi Juliette legler Institute for Environmental Studies(IVM) VU University Amsterdam1081HVThe Netherlands. Biology and Environmental Toxicology Group Faculty of SciencesNational Distance Education University28015 MadridSpain Institute for Environment Health and SocietiesCollege of Health and Life SciencesBrunel University LondonUxbridgeUB8 3PHUnited Kingdom

A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds（EDCs）, including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease.

关键词： zebrafish adiposity tributyltin flame retardants clock genes

Integration of production and use information into an exposure-based screening approach to rank chemicals of emerging Arctic concern for potential to be planetary boundary threats

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Emerging Contaminants 2021年第1期7卷 213-218页

作者： Marta Plaza-Hernandez Juliette legler Matthew MacLeod Brunel University London Department of Life SciencesUK Utrecht University Institute for Risk Assessment SciencesNetherlands Stockholm University Department of Environmental ScienceSweden

Planetary boundaries delimit a‘safe operating space for humanity’that should not be overstepped to maintain stable Holocene-like conditions on *** chemical pollutants have the potential to pose a planetary boundary threat to the functioning of vital Earth system processes as so-called‘novel entities’.Recently,an exposure-based prioritization scheme was developed that uses model-estimated data on persistence and degree of mobility in air and water to identify and prioritise chemical substances that may be planetary boundary *** a case study,chemicals of emerging Arctic concern identified by the Arctic Monitoring and Assessment Programme(AMAP)were used to develop the *** exposure-based prioritization scheme cannot address all scenarios for a chemical to pose an unknown planetary boundary threat,but it does allow for prioritization of chemicals according to environmental fate and exposure profiles.A key limitation of the scheme is that the quantity of chemical potentially released to the environment was not considered in the ***,we use data on chemical production and use reported under the European chemicals regulation REACH,and an emission scoring system developed by the European Food Safety Authority(EFSA)to attempt to add information about estimated emissions to the exposure-based prioritization *** REACH data and the EFSA scoring system,we ranked the AMAP substances according to their potential for environmental release and combined that information with the previously reported exposure-based prioritization that considers persistence and long-range transport *** method successfully assigned‘high priority’to known ozone-depleting substances(methyl chloride and dichloromethane)and identified chemicals of concern recently under consideration for nomination as persistent organic pollutants under the Stockholm Convention(octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane).The EFSA scoring system offers a

关键词： Arctic contaminants AMAP Environmental release Planetary boundary threats Exposure-based hazard profiles REACH

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RhD放散型相关的等位基因的鉴定

中国免疫学杂志 2003年第9期19卷 631-632,640页

作者：邵超鹏 Tobias J.legler 深圳市输血医学研究所 Department of Transfusion Medicine University of Goettingen Goettingen 37075 Germany

目的 :为了探讨D放散型 (Del)表型的分子基础。方法 :采用序列分析方法分析 2 6名Del表型个体RHD基因全长编码区和一名个体的RHD基因第 7内含子部分序列 ;同时使用血清学方法检测全部个体的RhCcEe表型。结果 :全部样品的第 9外显子均存... 详细信息

目的 :为了探讨D放散型 (Del)表型的分子基础。方法 :采用序列分析方法分析 2 6名Del表型个体RHD基因全长编码区和一名个体的RHD基因第 7内含子部分序列 ;同时使用血清学方法检测全部个体的RhCcEe表型。结果 :全部样品的第 9外显子均存在RHD 12 2 7G >A碱基突变 ,其余序列则与正常RHD基因一致 ,一名个体的第 7内含子观察到一处碱基突变RHDIVS7+15 2c >a ;血清学结果显示所有Del表型个体均为RhC抗原阳性个体。结论 :由于 12 2 7A位于RHD基因第 9外显子与第 9内含子交界处 ,可能影响前RNA转录后mRNA的正常拼接 ,形成Del表型。

关键词： RhD放散型相关等位基因鉴定序列分析方法遗传免疫学

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RhD表型阴性分子机制的研究

中华医学杂志 2003年第10期83卷 879-880页

作者：邵超鹏 Tobias J. legler 深圳市输血医学研究所 151803 Department of Transfusion Medicine

我们对76名中国汉族RhD阴性个体的RHD基因全长编码区进行序列分析，初步探讨中国人D阴性的分子背景。

关键词： RhD表型阴性分子机制 RHD基因全长编码区序列分析中国汉族

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日常临床中的抗生素治疗

国外药学(抗生素分册) 1983年第3期 224-228页

作者： T.legler 陈金和

本文旨在以评价的观点对日常临床合理选用抗生素予以介绍。其中主要是讨论抗生素,但也涉及狭义的化学治疗药,如增效磺胺甲基异(口恶)唑。在得到病原体证实和药敏试验报告之前所采取的初期治疗,即所谓“推测”治疗,是抗生素治疗中最困难... 详细信息

本文旨在以评价的观点对日常临床合理选用抗生素予以介绍。其中主要是讨论抗生素,但也涉及狭义的化学治疗药,如增效磺胺甲基异(口恶)唑。在得到病原体证实和药敏试验报告之前所采取的初期治疗,即所谓“推测”治疗,是抗生素治疗中最困难的一步。这必须以当时病情中病原体出现的增殖、耐药情况以及机

关键词：氨基青霉素病原体灭滴灵抗菌治疗病原物甲硝羟乙唑氯林肯霉素抗生素治疗肠杆菌科变形杆菌属变形菌属药敏试验头抱菌素耐药状况假单胞菌属感染氨基糖碳水化合物

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Sulzer织机织造独特的产业用织物

国外纺织技术（纺织针织服装化纤染整） 2002年第5期 11-14页

作者： F.legler 翁鸣

对质量(尤其是产业和工业用纺织品)和对低成本生产的需求决定了织机改进和发展的趋势.所选的样品将展示Sulzer Textil织造系统在从织物到市场的定位等各种用途上的质量优势.快速可靠地配置不同的经纱和纬纱、绝对地再现织物风格以及织... 详细信息

对质量(尤其是产业和工业用纺织品)和对低成本生产的需求决定了织机改进和发展的趋势.所选的样品将展示Sulzer Textil织造系统在从织物到市场的定位等各种用途上的质量优势.快速可靠地配置不同的经纱和纬纱、绝对地再现织物风格以及织机上具有快速变换织物品种的装置都是在产业和工业用纺织品中取得成功所必不可少的.

关键词： Sulzer织机织造产业用织物