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APPLICATION OF Ct-PARAMETER FOR CREEP-FATIGUE CRACK GROWTh WITh SLOW LOAD RISING CONDITION

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Acta Metallurgica Sinica(English Letters) 1999年第1期12卷 22-30页

作者： lee, j.h. Yoon, K.B. Kim, Y.j. Back, U.B. Korea Inst of Nuclear Safety Taejon South Korea

Most of the assessment equations for Ct which is a wellknown fracture parameter characterizing high temperature crack growth rates, have limited applicability to constant load conditions after sudden loading. however, crack growth due to creep can also occur under load varying conditions when load rising time is so long that accumulated creep deformation near the crack tip is not *** this paper, the estimation equation of the Ctparameter which can be applied to the case of slow load rising, i.e., (Ct)r, is explained. And the correlation between (Ct)r at the end of the load increasing period and Ct at the beginning of the succeeding load hold period is discussed. Finite element analyses of several cases with various loading conditions were performed and results were presented to show the effectiveness of the proposed Ct estimation scheme. The general applicability of the equation is also discussed.

关键词： creep fatigue crack time dependent fracture mechanics Ctparameter,C*integral

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现生产柴油机二级平衡机构的研制

柴油机设计与制造 1989年第1期 12-18页

作者： lee,j.h. 徐仲良

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毕II式胃切除术后胰腺超声内镜检查

世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 22-23页

作者： lee j.h. Topazian M. 樊菁 Div. of Gas-troenterology/hepatology Mayo Clinic 200 First Street S.W. Rochester MN 55905 United StatesDr.

Background and Study Aims: Prior Billroth II gastrectomy is considered a relative contraindication to endoscopic ultrasonography (EUS) of the pancreatic head. This study reviews experience with pancreatic EUS in such patients. Patients and Methods: Eleven patients were identified who had previous Billroth II gastrectomy and underwent attempted pancreatic EUS. Results: Examination of the pancreatic head was technically feasible in 10 of the patients. The inferior pancreatic head, ampulla, and periampullary ducts were seen in all; the superior pancreatic head and porta hepatis were visualized in 50%of cases with radial echo endoscopes and 100% with a lineararray echo endoscope. The pancreatic neck was fully imaged in 25% of cases with radial echo endoscopes and in 60% with a linear-array echo endoscope. One known pancreatic neck mass was not visualized. Conclusions: Pancreatic EUS is technically feasible in most patients with a prior Billroth II gastrectomy. Linear-array echo endoscopes provide a more complete examination than radial echo endoscopes. The pancreatic neck may be difficult to visualize.

关键词：超声内镜检查胃切除术 II 胰颈壶腹周围肝门辐射状壶腹部

单侧延髓梗死患者的吞咽困难:外侧病变和中间病变的比较

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世界核心医学期刊文摘(神经病学分册) 2006年第1期 39-40页

作者： Kwon M. lee j.h. Kim j.S. 周永 Department of Neurology Asan Medical Center Song-Pa PO Box 145 Seoul 138-600 South Korea Dr.

Objective:To study dysphagia in pure,unilateral medullary infarction using video fluoroscopic swallowing (VFS) tests and to compare the results between lateral medullary infarction (LMI)-and medial medullary infarction (MMI). Methods: We studied 46 patients with medullary infarction (37 LMI, 9 MMI). Based on the MRI findings, each LMI was classified rostrocaudally as either a rostral or caudal lesion, and horizontally as either a superficial (lateral +dorsal) or nonsuperficial lesion. Each MMI was assigned to either a deep (lesion extending to the dorsal surface) or superficial lesion group. VFS examination was conducted and an 8-point scale was used for assessing the severity of dysphagia. Based on these results, dysphagia was classified as: 1) problems on timing of hyolaryngeal excursion (PT), and 2) problems on range of hyolaryngeal excursion (PR). Results: Dysphagia was more frequent (p han in LMI patients (35%). Among the LMI patients, dysphagia was more frequent (p he rostral than in the cadual group and in the nonsuperficial than in the superficial group. In the MMI group, there was no difference in the frequency of dysphagia between the deep and superficial groups. Regarding the characteristics of dysphagia, seven (54%) of the LMI patients had PR, five (38%) had PT, and one (8%) had both. For the MMI patients, PT was frequent (86%) but PR was present in only one patient (14%). Five MMI patients (71%) showed no responses to penetration or aspiration, and silent dysphagia was observed in only four LMI patients (31%). Conclusions: Dysphagia is as frequent and severe in medial medullary infarction (MMI) as in lateral medullary infarction (LMI) patients. The types and characteristics of dysphagia are different between the LMI and MMI patients, implicating the rationale for a different treatment strategy.

关键词：吞咽困难延髓梗死患者病变单侧

影响大脑中动脉梗死溶栓后脑血管再通和早期临床改善的因素

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 19-20页

作者： Kwon j.-h. Kwon S.U. lee j.h. j.S. Kim 王英鹏 Department of Neurology Asan Medical Center Song Pa PO Box 1 45 Seoul 138-600 South Korea Dr.

Background: Factors affecting the angiographic recanalization (AR) and clinica l improvement (CI) still remain unclear in pa tients receiving thrombolytic the rapy. Objectives: To elucidate factors related to AR and early CI in patients wi th middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion. Desi gns: Retrospective study. Sotting: Department of Neurology, Asan Medical Center, Seoul, South Korea. Patients: We studied 42 patients who (1) underwent diffu sion weighted magnetic resonance (MR) imaging and MR angiography within 6 hou rs after onset, (2) had MCA territory infarction, (3) had nonvisualization of th e MCA or the ICA on initial MR angiography, (4) were treated with thrombolytics, and (5) underwent followup MR imaging and MR angiography at day 2 or 3. Results :Successful AR and CI were achieved in 31 and 16 patients,respectively. Angiogra phic recanalization was related to CI (Phealth Stroke Scale scores (Phe absence of a dominant ipsilateral posterior cerebral artery (Phy, and the sparing of the internal capsule on both initial (Ph the absence of ICA (vs MCA) flow signa ls (Phe sparing of the internal capsule (Ph th e infarct volume change (P=.06). Conclusions: In patients with MCA or ICA occlus ion, CI after thrombolysis is related to the AR and the sparing of the critical motor pathway. The presence of a dominant ipsilateral posterior cerebral artery may predict poor AR after thrombolysis.

关键词：大脑中动脉梗死早期临床血管再通队列研究神经功能状态临床改善颈内动脉梗死体积血管造影术肿瘤坏死因子α

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9例肢端雀斑样痣原位黑色素瘤的研究

世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 21-22页

作者： Kwon I.h. lee j.h. Cho K.h. 罗素菊冯义国 Department of Dermatology Seoul Natl. Univ. Coll. of Medicine 28-Yongon-dong Chongno-gu Seoul 118-744 South Korea Dr.

An acral lentiginous melanoma (ALM) is the most common type of cutaneous melanoma in Asians. however, it is unusual to encounter a patient showing only the histologic features of an ALM in situ. here we describe clinical and histologic features of nine cases of ALM in situ including immunohistochemical staining with anti-S 100 protein and hMB-45. All the patients had a long clinical history. Clinically, the lesions were characterized by a longitudinal pigmented streak in the nail plates, black pigmentation on the proximal or lateral nail fold, and an irregular border and variegated pigmentation on the sole or thumb. Total resections of the lesions were performed in all patients. All lesions, in both biopsy and excisional specimens demonstrated more melanocytes generally located in the basal layer of the epidermis. There was no dermal invasion. No recurrence of the disease had occurred in any patient after a follow-up period of between 6 months to 12 years after surgery. These results suggest that ALM can evolve slowly over many years.

关键词：黑色素瘤雀斑样痣肢端黑色素沉着表皮基底层斑驳状切除术亚洲人近端

Oddi括约肌压力测定后血清淀粉酶、胰导管支架和胰腺炎的发生

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 45-46页

作者： Sheehan S.j. lee j.h. Wells C.K. Topazian M. 陈云茹 Mayo Clinic 200 First St. SW Rochester MN 55906United StatesDr.

Background: Serum amylase levels 2 hours after ERCP predict postprocedure pancreatitis. The value of serum amylase measurements after sphincter of Oddi manometry (SOM) and the effect of pancreatic-duct stent placement on serum amylase are unknown. Methods: Records were reviewed for 88 SOM patients who had serum amylase measured 2 hours after the procedure. Post-SOM pancreatitis was defined as pain with a >3-fold elevation of serum amylase on the morning after SOM. “ Possible pancreatitis" was defined as pain with a he morning after SOM. Results: Post-SOM pancreatitis and possible pancreatitis each occurred in 13% of the study cohort. Post-SOM pancreatitis was associated with the absence of a pancreatic stent and occurred in 0% of patients without a stent who had normal 2-hour serum amylase vs. 67% with elevated 2-hour serum amylase (p ho received a stent, pancreatitis occurred in 6% , regardless of whether the 2-hour serum amylase was elevated. Possible pancreatitis occurred mainly in patients who received stents, and it also was associated with elevation of the 2-hour serum amylase. Conclusions: Elevation of the serum amylase level 2 hours after SOM predicts post-SOM pancreatitis but only in patients who do not receive a pancreatic stent. Among patients who received a stent, elevated 2-hour serum amylase levels predict subsequent findings that may be caused by attenuated pancreatitis.

关键词： Oddi括约肌血清淀粉酶管支架压力测定腹部疼痛相关记录

原发性硬化性胆管炎患者自身免疫性肝炎的迅速恶化

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 54-55页

作者： hong-Curtis j. Yeh M.M.-C. jain D. lee j.h. 赵丽娜 Anderson Cancer Center Dept. of GI Medicine and Nutrition 1515 Holcombe Boulevard Houston TX 770304009 United StatesDr.MD

“Overlap syndromes”have been reported among various autoimmune liver diseases, particularly between primary biliary cirrhosis and autoimmune hepatitis (AIh) in adults and between AIh and autoimmune cholangitis in children. The overlap syndrome of AIh and primary sclerosing cholangitis (PSC), however, has been scarcely reported. Furthermore, in most of the reported cases of AIh/PSC overlap syndrome, PSC and AIh were believed to occur simultaneously. We report a case of a 34-year-old woman who has ulcerative colitis and PSC (diagnosed by colonoscopy, histology, and cholangiogram) and 7 years later develops rapidly progressive liver failure and hemolytic anemia from AIh. Liver biopsy showed dense portal lymphoplasmacytic infiltrate with interface hepatitis and acidophil bodies confirming AIh. She responded well to immunosuppressive therapy with steroids, both with respect to her liver disease and her autoimmune hemolytic anemia. Additionally, her clinical symptoms of fatigue,jaundice, and pruritus improved markedly and quickly. Overlap or “crossover”syndrome should be considered in all patients with PSC when they present with sudden deterioration of the liver function and changes in liver enzymes. By making the diagnosis of AIh in a patient with well-established PSC, appropriate treatment can be initiated, resulting in the patients prompt recovery.

关键词：自身免疫性肝炎 AIh 重叠综合征结肠镜溃疡性结肠炎溶血性贫血肝功衰竭组织学检查浆细胞浸润肝门部

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network