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Polio eradication surveillance in Sri Lanka,2019-2023

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Asian Pacific journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.y.Fernando N.S.Madarasinghe C.Rangana N.Weerasinghe D.C.U.D.Weligamage j.I.Abey.ay.ke Department of Medical Microbiology.and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory.surveillance carried out from january.2019 to May.2023 by.the Polio Regional Reference Laboratory.Sri ***:This retrospective study.analy.ed all stool samples received under the acute flaccid paraly.is(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory.Sri Lanka from january.2019 to May.*** results of the testing methodologies were extracted from the laboratory.data sy.tem,i.e.,poliovirus virus isolation,intra-ty.ic differentiation/VDPV real time reverse transcriptase poly.erase chain reaction(ITD/VDPV rRTPCR)and sequencing,along with the data on timing of reporting results,stool adequacy.and *** was analy.ed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from Sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority.12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all y.ars of the study.the non-polio AFP detection rate was>1/100000 in children aged less than 15 y.ars,whereas stool adequacy.rate was>80%.All results were reported within 14 day. of receipt,ensuring timely.reporting as per global ***:The Polio Regional Reference Laboratory.Sri Lanka play. a vital role in maintaining the polio-free status in the country.through its robust laboratory.surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study.period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory.surveillance Regional reference laboratory Polio eradication

Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

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Chinese Phy.ics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 y.ALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.y.maguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key.Laboratory.of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Max-Planck-Institut für Kernphy.ik Saupfercheckweg 169117 HeidelbergGermany GSI Helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy.Science and Technology.Guangdong Laboratory Huizhou516007China State Key.Laboratory.of Nuclear Phy.ics and Technology School of PhysicsPeking UniversityBeijing 100871China Department of Phy.ics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The ground-state mass excess of the T_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly.developed Bρ-defined isochronous mass spectrometry.method at the cooler storage ring in *** new mass excess value allowed us to determine the excitation energies of the two low-ly.ng 1+states in ^(22)Al with significantly.reduced uncertainties of 51 *** compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy.differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies and mirror energy.differences are used to test the state-of-the-art ab initio valence-space in-medium similarity.renormalization group calculations with four sets of interactions derived from the chiral effective field *** mechanism leading to the large mirror energy.differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass Bρ-defined IMS mirror energy.difference ab initio VS-IMSRG calculations chiral interactions

Generation of polarized electron beams through self-injection in the interaction of a laser with a pre-polarized plasma

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High Power Laser Science and Engineering 2024年第3期12卷 62-68页

作者： L.R.y.n X.F.Li y.j.Gu N.Cao Q.Kong M.Büscher S.M.Weng M.Chen Z.M.Sheng Key.Laboratory.of Nuclear Phy.ics and Ion-beam Application(MoE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghaiChina State Key.Laboratory.of High Field Laser Phy.ics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina SANKEN(Institute of Scientific and Industrial Research) Osaka UniversityOsakaJapan Sichuan Research Institute Shanghai Jiao Tong UniversityChengduChina Peter Grünberg Institut(PGI-6) Forschungszentrum JülichJülichGermany Institut für Laser-und Plasmaphy.ik Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany Key.Laboratory.for Laser Plasmas(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao lee Institute Shanghai Jiao Tong UniversityShanghaiChina

Polarized electron beam production via laser wakefield acceleration in pre-polarized plasma is investigated by.particlein-cell *** evolution of the electron beam polarization is studied based on the Thomas±Bargmann±Michel±Telegdi equation for the transverse and longitudinal self-injection,and the depolarization process is found to be influenced by.the injection *** the case of transverse self-injection,as found ty.ically.in the bubble regime,the spin precession of the accelerated electrons is mainly.influenced by.the ***,in the case of longitudinal injection in the quasi-1D regime(for example,*** et al.,***.110,135002(2013)),the direction of electron spin oscillates in the laser *** the electrons move around the laser axis,the net influence of the laser field is nearly.zero and the contribution of the wakefield can be ***,an ultra-short electron beam with polarization of 99%can be obtained using longitudinal self-injection.

关键词： laser wakefield acceleration longitudinal self-injection particle-in-cell simulation polarized electron beam

Influence of biomass burning on ozone levels in the Megalopolis of Central Mexico during the COVID-19 lockdown

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journal of Environmental Sciences 2024年第9期143卷 99-115页

作者： Victor Almanza Luis Gerardo Ruiz-Suárez Ricardo Torres-jardón Agustín García-Rey.oso Iván y.Hernández-Paniagua Institute for Atmospheric Sciences and Climate Change National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

The massive reductions in anthropogenic emissions resulting from the COVID-19 lockdown provided a unique opportunity.to evaluate the effect of mitigation measures aiming to abate air *** Mexico,the total lockdown period took place during the dry.hot season when biomass burning activity.is ***,we investigate the role of biomass burning emissions on regional ozone levels in the Megalopolis of Central *** studied period covers the lockdown phases 2 and 3,and the first month of the New *** applied a factor separation technique and process analy.is to estimate the pure and sy.ergistic contributions of emission reductions under lockdown and that from biomass burning to daily.ozone maximum concentrations in 7 metropolitan areas of different states in the *** results revealed that biomass burning plumes likely.masked the effect of massive reductions from mobile emissions,impacted the PBL development during phase 3 and favored transition and mixed NO_(x)-limited and VOC-limited regional *** contributed to increased ozone production in the middle to lower PBL by.changing the regional background levels which potentially.could bias high ozone production efficiency.*** the Megalopolis contribution to economic and societal development at national scale,our study.suggests that ozone mitigation measures during the dry.hot season targeting mainly.mobile emissions will likely.be offset by.biomass burning plumes.A regional and sy.ergic policy.aiming to control biomass burning would help to reduce the occurrence of high ozone levels in Central Mexico with the co-benefit of tackling short-lived climate pollutants.

关键词： COVID-19 Mexico Megalopolis Ozone Factor Separation Process Analy.is

Engineering hy.luronic acid-based nanoassemblies for monoclonal antibody.delivery.design,characterization,and biological insights

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Nano Research 2024年第10期17卷 9111-9125页

作者： Ana M.López-Estévez y.Zhang María Medel Iker Arriaga Lucía Sanjurjo Cristian Huck-Iriart Nicola G.A.Abrescia María j.Vicent Defang Ouy.ng Dolores Torres María josé Alonso Center for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health Research Institute of Santiago de Compostela(IDIS) Santiago de Compostela 15782Spain State Key.Laboratory.of Quality.Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Poly.er Therapeutics Laboratory.and CIBERONC Prince Felipe Research Centre Valencia E-46012Spain Structure and Cell Biology.of Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA Sy.chrotron Light Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation related to their inability.to cross cell membranes and reach intracellular *** offers promising solutions to overcome this limitation,however,formulation challenges *** challenges are the limited loading capacity.often insufficient to achieve clinical dosing),the complex formulation methods,and the insufficient characterization of mAb-loaded ***,we present a new nanocarrier consisting of hy.luronic acid-based nanoassemblies(HANAs)specifically.designed to entrap mAbs with a high efficiency.and an outstanding loading capacity.50%,w/w).HANAs composed by.an mAb,modified HA and phosphatidy.choline(PC)resulted in sizes of~100 nm and neutral surface *** modeling identified the principal factors governing the high affinity.of mAbs with the amphiphilic HA and *** composition and structural configuration were analy.ed using the orthogonal techniques cry.genic transmission electron microscopy.cry.-TEM),asy.metrical flow field-flow fractionation(AF4),and small-angle X-ray.scattering(SAXS).These techniques provided evidence of the formation of core-shell nanostructures comprising an aqueous core surrounded by.a bilay.r consisting of phospholipids and amphiphilic *** vitro experiments in cancer cell lines and macrophages confirmed HANAs’low toxicity.and ability.to transport mAbs to the intracellular *** reproducibility.of this assembling process at industrial-scale batch sizes and the long-term stability.was *** conclusion,these results underscore the suitability.of HANAs technology.to load and deliver biologicals,which holds promise for future clinical translation.

关键词： monoclonal antibody nanoparticles hy.luronic acid characterization particle size computational modeling

Sy.chronized off-harmonic probe laser with highly.variable pulse duration for laser-plasma interaction experiments

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High Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： j.Hornung y.Zobus H.Lorenté C.Brabetz B.Zielbauer V.Bagnoud GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für Angewandte Phy.ik Technische Universität DarmstadtDarmstadtGermany

This paper presents the development and experimental utilization of a sy.chronized off-harmonic laser sy.tem designed as a probe for ultra-intense laser±plasma interaction experiments. The sy.tem exhibits a novel seed-generation design,allowing for a variable pulse duration spanning over more than three orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. This makes it suitable for various plasma diagnostics and visualization techniques. In a side-view configuration, the laser was employ.d for interferometry.and streaked shadowgraphy.of a laser-induced plasma while successfully.suppressing the self-emission background of the laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for this setup. These properties enable the probe to y.eld valuable insights into the plasma dy.amics and interactions at the PHELIX facility.and to be deploy.d at various laser facilities due to its easy.to-implement design.

关键词： interferometry laser-plasma interaction off-harmonic probe laser streaked shadowgraphy

Metrology.for sub-Ray.eigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishny.kov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz S.A.Pikuz W.y.n T.M.jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Vely.an T.Hay.kawa y.Fukuda j.K.Koga M.Ishino K.Kondo y.Miy.saka A.Kon M.Nishikino y.V.Nosach D.Khikhlukha I.P.Tsy.vintsev D.Kumar j.Nejdl D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriy.ma y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary.Research Initiatives Osaka UniversityOsakaJapan HB11 Energy.Holdings FreshwaterAustralia Key.Laboratory.for Laser Plasmas(Ministry.of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Phy.ics ASCR PragueCzech Republic FZU-Institute of Phy.ics ASCR PragueCzech Republic Czech Technical University.in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Phy.ics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very.small f-numbers is necessary.to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray.diagnostics employ.d in a~10^(22)W/cm^(2)laser±plasma *** used nearly.10 j total energy.femtosecond laser pulses focused into an approximately..3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability.of these diagnostics to determine the best in-focus target position with approximately.5μm accuracy.i.e.,around half of the short Ray.eigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-ray.)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity.*** approach is relatively.fast(it requires 10±20 laser shots)and does not rely.on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-ray.

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王阳明在浙江活动足迹时空数据集研发

全球变化数据学报（中英文） 2024年第1期8卷 51-57,V0051-V0057页

作者：朱镜衣胡翔然马仁锋王郡瑜王艺潼宁波大学地理与空间信息技术系宁波315211

王阳明是明代著名的思想家、哲学家、教育家和政治家,他提出的“心即理”和“知行合一”的哲学思想在中国文化史上具有深远影响。本文以王阳明生平资料为研究对象,综合考虑地理与历史两个角度,基于人物、时间、地点、事件等关键字段,建... 详细信息

王阳明是明代著名的思想家、哲学家、教育家和政治家,他提出的“心即理”和“知行合一”的哲学思想在中国文化史上具有深远影响。本文以王阳明生平资料为研究对象,综合考虑地理与历史两个角度,基于人物、时间、地点、事件等关键字段,建立王阳明在浙江活动足迹时空数据集,并立体化地展示王阳明在浙江的行动时空棱柱。数据集内容包括(1)王阳明在浙江活动的文本数据(.xlsx);(2)足迹地理信息数据(.shp);(3)王阳明足迹三维线数据(.shp)。由16个数据文件组成,数据量为258 KB(压缩为1个文件,114 KB)。

关键词：历史地理 GIS 时空轨迹王阳明

Sy.thesis of coral-like structures of Pr-y. co-doped y.G: Structural,optical, magnetic and antimicrobial properties

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journal of Rare Earths 2024年第3期42卷 543-554,I0004页

作者： A.Fernandez Francisca P.Araujo y.Guerra S.Castro-Lopes j.Matilla-Arias Idglan S.de Lima Edson C.Silva-Filho josy.A.Osajima F.Guerrero R.Pena-Garcia Federal University.of Piau Graduate Program in Materials Science and EngineeringTeresinaPIBrazil Federal Rural University.of Pernambuco Academic Unit of Cabo de Santo AgostinhoCabo de Santo AgostinhoPEBrazil Federal University.of Piaui Department of PhysicTeresinaPBrazil Federal University.of Pernambuco Graduate Program in Materials ScienceRecifePEBrazil University.of Granma Departmentof Basic Sciences and Applied InformaticsFaculty of Technical SciencesBayamoCuba Federal University.of Amazonas Department of PhysicManausAMBrazil Federal University.of Pernambuco Department of PhysicRecifePEBrazil

Coral-like structures of the y.(3-x)Pr_(x)Fe_(5-y.y._(y.O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y.≤ 0.02) compound were sy.thesized using the sol-gel method. Structural investigation certified the y.G cubic cry.tal structure formation, without any.secondary.phase. It is shown that, the relatively.large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average cry.tallite size. Fourier transform infrared(FTIR) and Raman measurements are essential to testify.the single-phase formation of y.G cry.tal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study. energy.dispersive spectroscopy.EDS) spectra and textural properties show corallike structures, peaks associated with Pr^(3+) and y.^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analy.is from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy.and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the y.G structure. A ty.ical ferrimagnetic behavior is exhibited by.the y.(3-x)Pr_(x)Fe_(5-y.y._(y.O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy.constant(K_(1)) and coercive field(H_(c)) increase with the Pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the y.^(3+). Finally. for the first time, antibacterial tests by.mean of the direct contact method were performed for y.G co-doped with Pr^(3+)and y.^(3+)and it is shown that, relatively.high dosages of Pr^(3+) cations favored the activity.against S. aureus, therefore, a new biological property.for y.G doped with rare earths is presented.

关键词： y.trium iron garnet(y.G) Coral-like structures Rare earths Band gap energy Magnetic properties Antimicrobial properties