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中国临床医学 2019年第3期26卷 340-359页

作者： lee d.cranmer Edward Y.Kim 华盛顿大学肿瘤内科美国华盛顿州西雅图98109 华盛顿大学肿瘤放疗科美国华盛顿州西雅图98109

虽然手术是肢体和躯干原发软组织肉瘤的根治性治疗手段,但对于高危患者单纯手术常难以获得疾病的长期控制。治疗失败的主要原因为远处转移,其次为局部复发。一些局部进展期的患者可能面临无法手术切除,或仅边缘可切除,因此预后很差。围... 详细信息

虽然手术是肢体和躯干原发软组织肉瘤的根治性治疗手段,但对于高危患者单纯手术常难以获得疾病的长期控制。治疗失败的主要原因为远处转移,其次为局部复发。一些局部进展期的患者可能面临无法手术切除,或仅边缘可切除,因此预后很差。围手术期的系统治疗和放疗可提高手术疗效。如何确立围手术期系统治疗的价值颇具挑战。系统治疗可以缩小肿瘤。但要证明其对局部控制的价值从而促进实施更为保守的外科手术的证据仍不充分。对于那些原发肿瘤被认定为难以或不可能切除的患者,新辅助化疗可能为疾病的局部控制提供一种选择。围手术期的系统治疗也可以避免远处转移的发生。近期的研究表明,以蒽环类药物/异环磷酰胺为基础的辅助治疗能够使患者获益,虽然证据来自于对一项大型研究的再次分析。一项新辅助化疗的随机研究提示,对某些经过选择的肉瘤组织学亚型,以蒽环类药物/异环磷酰胺为基础的系统化疗可能改善患者无病生存和总生存期。其疗效的获得主要是通过改善远处无转移生存而不是局控率的提高。这两项研究所采用的方法均存在一定的局限性,因此需要进一步探索。尽管如此,我们相信这些结果支持在局部进展期、肢体和躯干原发的软组织肉瘤患者中进行新辅助化疗。放疗与手术结合在软组织肉瘤的治疗中有确切的疗效。虽然预后并不因放疗和手术的先后顺序而异,但不良反应却存在差异。辅助放疗较新辅助放疗有更低的围手术期伤口并发症,但相对于新辅助放疗而言,辅助放疗需要更高的放射剂量,对长期功能的预后差于新辅助放疗。因此,我们相信围手术期放疗与化疗一样,在可能的情况下,应尽可能在术前进行。

关键词：软组织肉瘤躯干肢体化疗放疗

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov d. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames d. Amidei S.P. Amor dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.d. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos d. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos d. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio d. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron d.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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食物特异性IgG4抗体指导的限制性饮食可改善肠易激综合征症状和直肠顺应性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 51-52页

作者： Zar S. Mincher L. Benson M.J. Kumar d. 郝筱倩 department of Gastrointestinal Surgery St. George' s Hospital Medical SchoolCranmer Terrace London SW17 0QT United Kingdom Dr.

Objective. dietary modification improves symptoms in irritable bowel syndrome (IBS). Identification of offending foods by dietary elimination/re- challenge is cumbersome. IgG4 antibodies to common food antigens are elevated in IBS. The aim of this article was to evaluate the effect of exclusion diet based on IgG4 titres on IBS symptoms and rectal sensitivity and compliance. Material and methods. The study comprised 25 patients with IBS (3M, 22 F,mean age 43 years,Rome II criteria). IgG4 titres to 16 foods (milk, eggs, cheese, wheat, rice, potatoes, chicken, beef, pork, lamb, soya bean, fish, shrimps, yeast, tomatoes and peanuts) were measured. Foods with titres >250 μ g/l were excluded for 6 months. Symptom severity was assessed with a previously validated questionnaire at baseline, at 3 months and at 6 months. Rectal compliance and sensitivity were measured in 12 patients at baseline and at 6 months. Results. IgG4 antibodies to milk, eggs, wheat, beef, pork and lamb were commonly elevated. Significant improvement was reported in pain severity (p d effect of IBS on life in general (p = 0.008) at 3 months. Symptom improvement was maintained at 6 months. Rectal compliance was significantly increased (p = 0.011) at 6 months but the thresholds for urge to defecate/discomfort were unchanged. Conclusions. Food- specific IgG4 antibody- guided exclusion diet improves symptoms in IBS and is associated with an improvement in rectal compliance.

关键词：肠易激综合征 IgG 抗体滴度特异性顺应性罗马Ⅱ标准证实有效食物构成评价根据排便习惯

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常规免疫的时间选择及其后的花粉病的发病危险

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 14-15页

作者： Bremner S.A. Carey I.M. de Wilde S. d.G. Cook 郭战宏 department of Epi demiology St George's Hospital Medical School Cranmer Terrace London SW17 0R E United Kingdom Prof.

Background: Suggestions that immunisation influences allergic disease risk, ei ther positively (pertussis) or negatively (BCG)-are of concern for vaccination policy. Aims: To determine whether dTP, MMR, and BCG vaccination in infancy infl uenced hay fever risk. Methods: Case-control study of 7098 hay fever cases and controls, within two primary care databases. One control per case was matched fo r practice, age, and sex. Odds ratios (OR)were derived using conditional logisti c regression. Results: Compared to those completing in month 5 (base group) (39. 3%), dTP unvaccinated children (4.3%) had a similar risk of hay fever (OR = 0. 94, 95%Cl 0.73 to 1.23). However, those completing after 12months (4.2%) had a reduced risk (OR = 0.60, 95%Cl 0.45 to 0.76) compared to the base group. Compa red to those vaccinated in month 14 (base group) (29.5%), MMR unvaccinated chil dren (2.3%) had an OR of 0.79 (95%Cl 0.58 to 1.08). Completion of MMR after tw o years was associated with reduced hay fever risk (OR = 0.62, 95%Cl 0.48 to 0. 80) compared to the base group. The effects of late immunisation with dTP and MM R were independent. Those vaccinated with BCG by age 2 (2.4%) had an odds ratio of 1.28 (95%Cl 0.96 to 1.70). Adjustment for consulting behaviour, social fact ors, or sibship size did not alter these associations. Conclusions: Immunisation against dTP or MMR does not increase the risk of hay fever. The lower confidenc e limit for BCG vaccination contradicts the hypothesised protective effect. The reduced risk of hay fever among children immunised late may be explained by a th ird factor causing both postponement and reduced risk such as intercurrent febri le illnesses.

关键词：常规免疫时间选择花粉病免疫接种接种者过敏性疾病病例对照研究发热性疾病社会因素比值比

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