检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

人类乳腺癌细胞雌激素受体(ER)

国外医学.计划生育妇产科学分册 1981年第2期 86-88页

作者： lee sh 葛振华

实验室已反复证明某些人的乳癌出现ER,从瘤组织匀浆的细胞溶质泡液组分中能检出雌激素结合的蛋白质。此法虽可证明肿瘤细胞溶质泡液内每单位重量蛋白质类固醇结合的能力,但不能证明受体细胞的来源或被检出蛋白质的来源。近来,荧光类固... 详细信息

实验室已反复证明某些人的乳癌出现ER,从瘤组织匀浆的细胞溶质泡液组分中能检出雌激素结合的蛋白质。此法虽可证明肿瘤细胞溶质泡液内每单位重量蛋白质类固醇结合的能力,但不能证明受体细胞的来源或被检出蛋白质的来源。近来,荧光类固醇组织化学技术用17β-雌二醇-6CMO-BSA-FITC作为受体的示踪物,研究冰冻切片内单个瘤细胞ER的活性,发现大部乳癌病人ER阴性时含有异源性的瘤细胞群。为了更好的比较用激素治疗的结果,乳癌细胞应按照ER~+细胞在癌细胞内的百分率进行分类;本研究目的是把ER~+癌细胞百分率作为ER水平和聚丙烯凝胶过

关键词： ER 病人激素治疗乳癌细胞乳腺癌乳腺肿瘤

全内关节镜下距腓骨前韧带修复后附加下伸肌支持带增强术对慢性踝关节不稳的治疗是没有必要的

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志 2021年第41期101卷 3416-3416页

作者：唐尧(编译) 唐康来(编译) lee sh Cho HG Yang JH 陆军军医大学第一附属医院运动医学中心不详

近年来,随着关节镜器械和技术的不断发展,镜下踝关节韧带修复受到广泛关注。该技术可分为关节镜辅助下伸肌支持带(IER)增强术和关节镜下距腓前韧带(ATFL)修复术。采用关节镜技术治疗慢性踝关节不稳(CAI),ATFL解剖修复被认为是关键步骤然... 详细信息

近年来,随着关节镜器械和技术的不断发展,镜下踝关节韧带修复受到广泛关注。该技术可分为关节镜辅助下伸肌支持带(IER)增强术和关节镜下距腓前韧带(ATFL)修复术。采用关节镜技术治疗慢性踝关节不稳(CAI),ATFL解剖修复被认为是关键步骤然时,是否需要附加IER增强术目前存在争议。有研究报道关节镜下ATFL修复联合IER增强术后的良好结果,代价是显著增加了手术时间和难度。此外,由于IER的解剖起点位于跟腓骨韧带前方10 mm处,1ER增强术并非严格意义上的解剖修复,可能会增加术后关节活动受限的风险。

关键词：慢性踝关节不稳伸肌支持带关节镜下距腓前韧带关节镜技术腓骨韧带修复修复术

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol lee Won-Hee Park Su-hwan Yun Tae-Soon Kwon Duckhee lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the shinbundang Line of the Incheon Transportation Corporation,and the Ui-shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

文献快报(11):性早熟女童类固醇代谢的改变可能与尿双酚A的含量无关

在线全文

学校读者我要写书评

暂无评论

中国学校卫生 2014年第5期 4-4页

作者： lee sh KANG SM CHOI MH 胡国云苏普玉安徽医科大学公共卫生学院儿少卫生与妇幼保健学系

过去十几年的研究表明,双酚A与17β-雌二醇相比具有轻度的雌激素活性。在动物模型中,双酚A已被证实具有多种不利影响,主要涉及生殖内分泌学。早期研究表明,青春期前暴露于双酚A可以加速母鼠青春期的发动,但降低了生殖数量。双酚A对性早... 详细信息

过去十几年的研究表明,双酚A与17β-雌二醇相比具有轻度的雌激素活性。在动物模型中,双酚A已被证实具有多种不利影响,主要涉及生殖内分泌学。早期研究表明,青春期前暴露于双酚A可以加速母鼠青春期的发动,但降低了生殖数量。双酚A对性早熟的影响仍有争议,动物实验的研究结果外推到人类,由于物种代谢的特异性,因此此结果需要进一步审

关键词：性早熟类固醇代谢女童双酚