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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

The search for the Quantum spin Liquid in Kagome Antiferromagnets

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Chinese Physics Letters 2019年第5期36卷 5-6页

作者： j.-j.Wen Y.s.lee stanford Institute for Materials and Energy sciences SLAC National Accelerator Laboratory Department of Applied Physics Stanford University

A quantum spin liquid (QsL) is an exotic quantum ground state that does not break conventional symmetries and where the spins in the system remain dynamic down to zero temperature. Unlike a trivial paramagnetic state,... 详细信息

关键词： The search for the Quantum spin Liquid in Kagome Antiferromagnets Zn

superplasticity of Ti2448 Alloy with Nanostructured Grains

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journal of Materials science & Technology 2011年第12期27卷 1099-1104页

作者： M.j. Xiao Y.X. Tian G. W. Mao s.j. Li Y.L. Hao R. Yang school of Astronautics Northwestern Polytecllnic University Xi＇an 710072 China - shenyang National Laboratory for Materials science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Ti-24Nb-4Zr-8sn, abbreviated as Ti2448 from its chemical composition in weight percent, is a multifunctional /3 type titanium alloy with body centered cubic （bcc） crystal structure, and its highly localized plastic deformation behavior contributes significantly to grain refinement during conventional cold processing. In the paper, the nanostructured （Ns） alloy with grain size less than 50 nm produced by cold rolling has been used to investigate its superplastic deformation behavior by uniaxial tensile tests at initial strain rates of 1.5 ×10-2, 1.5×10^-3 and 1.6×10-4 s-1 and temperatures of 600,650 and 700℃. The results show that, in comparison with the coarse-grained alloy with size of 50 μm, the Ns alloy has better superplasticity with elongation up to ～275% and ultimate strength of 50-100 MPa. strain rate sensitivity （m） of the Ns alloy is 0.21, 0.30 and 0.29 for 600,650 and 700℃, respectively. These results demonstrate that grain refinement is a valid way to enhance the superplasticity of Ti2448 alloy.

关键词： Titanium alloy bcc crystal superplasticity Nanostructured grain

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Forging strength-ductility unity in a high entropy steel

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journal of Materials science & Technology 2022年第18期113卷 158-165页

作者： s.j.Tsianikas Y.Chen j.jeong s.Zhang Z.Xie school of Mechanical Engineering The University of AdelaideSA 5005Australia Centre for Advanced Thin Film Materials and Devices Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Max-Planck-Institut für Eisenforschung Max-Planck-Straße 1Düsseldorf 40237Germany

Fe_(72.4)Co_(13.9)Cr_(10.4)Mn_(2.7)B_(0.34)high entropy steel was prepared by magnetron *** alloy exhibits a high yield strength of 2.92±0.36 GPa while achieving appreciable plasticity of 13.7±1.9%at the ultimate compressive strength(3.37±0.36 GPa).The distribution of iron and chromium shows an un-usual,characteristic spinodal-like pattern at the nanometer scale,where compositions of Fe and Cr show strong anticorrelation and vary by as much as 20 at.%.The high strength is largely attributable to the compositional modulations,combined with fine grains with body-centered cubic(BCC)crystal structure,as well as grain boundary segregation of interstitial *** impressive plasticity is accommodated by the formation and operation of multiplanar,multicharacter dislocation slips,mediated by coherent in-terfaces,and controlled by shear *** excellent strength-ductility combination is thus enabled by a range of distinctive strengthening mechanisms,rendering the new alloy a potential candidate for safety-critical,load-bearing structural applications.

关键词： Deformation mechanisms Micromechanical testing Compositional fluctuations Body-centered cubic High entropy steel

Fault detection method with PCA and LDA and its application to induction motor

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journal of Central south University 2010年第6期17卷 1238-1242页

作者： jUNG D Y lee s M 王洪梅 KIM j H lee s H Daeho Tech Company Limited Department of Electronics Engineering Inha University school of Mechatronics Changwon National University

A feature extraction and fusion algorithm was constructed by combining principal component analysis(PCA) and linear discriminant analysis(LDA) to detect a fault state of the induction *** yielding a feature vector with PCA and LDA from current signal that was measured by an experiment,the reference data were used to produce matching *** a diagnostic step,two matching values that were obtained by PCA and LDA,respectively,were combined by probability model,and a faulted signal was finally *** the proposed diagnosis algorithm brings only merits of PCA and LDA into relief,it shows excellent performance under the noisy *** simulation was executed under various noisy conditions in order to demonstrate the suitability of the proposed algorithm and showed more excellent performance than the case just using conventional PCA or LDA.

关键词： principal component analysis (PCA) linear discriminant analysis (LDA) induction motor fault diagnosis fusionalgorithm

Incorporation of a nanotechnology-based additive in cementitious products for clay stabilisation

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journal of Rock Mechanics and Geotechnical Engineering 2020年第5期12卷 1056-1069页

作者： E.U.Eyo s.Ng’ambi s.j.Abbey school of Energy Construction and EnvironmentFaculty of EngineeringEnvironment and ComputingCoventry UniversityCoventryUK Faculty of Environment and Technology Department of Geography and Environmental ManagementCivil Engineering ClusterUniversity of the West of EnglandBristolUK

The mechanical performances and water retention characteristics of clays,stabilised by partial substitution of cement with by-products and inclusion of a nanotechnology-based additive called RoadCem(RC),are studied in this *** unconfined compression tests and one-dimensional oedometer swelling were performed after 7 d of curing to understand the influence of addition of 1%of RC material in the stabilised soils with the cement partially replaced by 49%,59%and 69%of ground granulated blast furnace slag(GBBs)or pulverised fuel ash(PFA).The moisture retention capacity of the stabilised clays was also explored using the soil-water retention curve(sWRC)from the measured *** confirmed an obvious effect of the use of RC with the obtained strength and swell properties of the stabilised clays suitable for road application at 50%replacement of *** outcome is associated with the in-depth and penetrating hydration of the cementitious materials by the RC and water which results in the production of needle-like matrix with interlocking filaments e a phenomenon referred to as the‘wrapping’*** the other hand,the sWRC used to describe the water holding capacity and corresponding swell mechanism of clays stabilised by a proportion of RC showed a satisfactory *** moisture retention of the RC-modified clays was initially higher but reduced subsequently as the saturation level increased with decreasing *** phenomenon confirmed that clays stabilised by including the RC are water-proof in nature,thus ensuring reduced porosity and suction even at reduced water ***,the stabilised clays with the combination of cement,GGBs and RC showed a better performance compared to those with the PFA included.

关键词： Cement Ground granulated blast furnace slag(GBBs) Fly ash RoadCem(RC) swell stabilisation Unconfined compressive strength soil-water retention curve(sWRC)

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CHILDREN REVIsITED

The World of Chinese 2016年第1期 56-57页

作者： s.j.

What inspired you to create this'Happy Chinese Children'series?There’s a story behind ***,I returned home after a long business trip,and my son showed me a picture he had *** was a good *** was a house under a beautiful blue sky with a bird flying across the *** inside the house was a *** my son said to me,'Dad,I feel that we are less free than the bird.'I was so surprised and touched because at

关键词： picture Happy story behind inspired drawn flying young painting beautiful

Properties of Dispersion Casting of Y2O3 Particles in Hypo,Hyper and Eutectic Binary Al-Cu Alloys

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journal of Materials science & Technology 2008年第1期24卷 57-59页

作者： j.j.Park G.H.Kim s.M.Hong s.H.lee M.K.lee C.K.Rhee Nuclear Nano-Materials Development Lab. Korea Atomic Energy Research Institute （KAERI） 150 Deukjin-dongYuseong-gu Daejeon Korea

In the present work,the dispersion casting of Y-2O-3 particles in aluminum-copper alloy was investigated in terms of microstructural changes with respect to Cu contents of 20 （hypo）,33 （eutectic） and 40 （hyper） wt pct by scanning electron microscopy （sEM） and energy dispersive spectroscopy （EDs）.For the fabrication of Al-Cu alloy dispersed Y-2O-3 ceramic particles,stir casting method was *** case of Al-20 wt pct Cu alloy （hypoeutectic）,sEM images revealed that primary Al was grown up in the *** that,eutectic phase with well dispersed ceramic particles was *** case of eutectic composition,Y-2O-3 particles were uniformly dispersed in the *** the Cu is added into Al up to 40 wt pct （hypereutectic）,primary phase was grown up without any Y-2O-3 ceramic particles in the early stage of ***, eutectic phase was formed with well dispersed ceramic *** can be concluded that Y-2O-3 ceramic particles is mostly dispersed in case of eutectic composition in Al-Cu alloy.

关键词： Dispersion casting Y2O3 particles stir casting Al-Cu alloy