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Predictors of disease severity in ulcerative colitis patients from southwestern Ontario

World Journal of Gastroenterology 2010年第2期16卷 232-236页

作者： lee s roth Nilesh Chande Terry Ponich Maya L roth James Gregor Division of Gastroenterology London Health Sciences Centre Victoria Hospital800 Commissioner’s Road EastLondon OntarioN6A 5W9Canada Operational stress Injury Clinic Parkwood HospitalLondonOntarioN6C 5J1Canada

AIM:To understand the demographic characteristics of patients in southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODs:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health sciences Centre south street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo score criteria were collected into a composite. REsULTs:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,Psymptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUsION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators.

关键词： Demographic Disease severity Prognosis Ulcerative colitis

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Deuterium retention in chemically vapor deposited tungsten carbide coatings and hot-rolled tungsten exposed to low-energy deuterium plasma

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Tungsten 2022年第1期4卷 10-19页

作者： Vladimir Kh.Alimov Joachim roth Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of SciencesMoscow 119071Russia Max-Planck-Institut fur Plasmaphysik 85748 GarchingGermany

samples of chemically vapor deposited(CVD)coatings of tungsten carbides W_(45)C_(55)and W_(60)C_(40)and samples of hot-rolled tungsten were exposed to deuterium(D)plasma at sample temperatures ranging from 323 to 813 K,as a result of which the samples were irradiated with D ions with an energy of about 200 eV per D particle at a flux of D particles of about1.1×10^(21)D·m^(-2)·s^(-1)to a fluence of about 2×10^(24)D·m^(-2).The concentration of deuterium in these samples was examined by the D(3 He,p)4 He nuclear reaction.Based on the measured deuterium depth profiles and assuming that these profiles are determined by diffusing D atoms,the diffusion coefficients of deuterium in the CVD tungsten carbide coatings were determined.Using these diffusion coefficients,an estimate of the Arrhenius relation for the diffusion coefficients of deuterium in CVD tungsten carbide coatings was obtained:D=2.5×10^(-3)exp(-1.12 eV/kT)m~2·s^(-1),where T is temperature expressed in Kelvin,and k is the Boltzmann constant.The concentration of trapped deuterium in the bulk of CVD tungsten carbide coatings is practically independent of the stoichiometry of the coatings.It decreases from about 5×10^(-2)to about 7×10^(-4)D/(W+C)with an increase in the deuterium plasma exposure temperature from 373 to 813 K.The concentration of trapped deuterium in hot-rolled tungsten,expressed in units of the D/W atomic ratio,is more than an order of magnitude lower than the concentration of deuterium in tungsten carbides,and also decreases with increasing plasma exposure temperature.

关键词： Chemically vapor deposited tungsten carbides Tungsten Deuterium plasma Deuterium depth profiles Deuterium diffusion coefficients

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Highly N-doped carbon with low graphitic-N content as anode material for enhanced initial Coulombic efficiency of lithium-ion batteries

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Carbon Energy 2023年第2期5卷 236-249页

作者： Yihua Tang Jingjing Chen Zhiyong Mao Christina roth Dajian Wang Department of Electrochemical Process Engineering Universitat BayreuthBayreuthGermany Chair of Electrochemical Process Engineering Bavarian Center for Battery Technology(BayBatt)BayreuthGermany Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjinPR China

N-doped carbons as one of the most prominent anode materials to replace standard graphite exhibit outstanding Li+storage performance.However,N-doped carbon anodes still suffer from low N-doping levels and low initial Coulombic efficiency(ICE).In this study,high N-doped and low graphitic-N carbons(LGNCs)with enhanced ICE were synthesized by taking advantage of a denitrification strategy for graphitic carbon nitride(g-C_(3)N_(4)).In brief,more than 14.5 at%of N from g-C_(3)N_(4)(55.1 at%N)was retained by reacting graphitic-N with lithium,which was subsequently removed.As graphitic-N is largely responsible for the irreversible capacity,the anode's performance was significantly increased.Compared to general N-doped carbons with high graphitic-N proportion(>50%)and low N content(s delivered a low proportion of 10.8%-17.2% within the high N-doping content of 14.5-42.7 at%,leading to an enhanced specific capacity of 1499.9mAh g^(-1) at an ICE of 93.7% for the optimal sample of LGNC(4:1).This study provides a facile strategy to control the N content and speciation,achieving both high Li+storage capacity and high ICE,and thus promoting research and application of N-doped carbon materials.

关键词： denitrification graphitic carbon nitride graphitic-N lithium-ion batteries N-doped carbon

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Postmortem CT in decedents with sARs-CoV-2 infection.A single institution experience

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Forensic sciences Research 2022年第2期7卷 255-260页

作者： Mariam Thomas Fereidoun Abtin Antoinette roth Catherine Yim Anokh Pahwa Jeremy Paige Odey Ukpo Radiology UCLA Medical Center Olive ViewLos AngelesCAUSA University of California Los Angeles Los AngelesCAUSA Los Angeles Medical Examiner-Coroner’s Office Los AngelesCAUSA

Coronavirus disease 2019(COVID-19)caused by sARs-CoV-2 produced a global pandemic with significant mortality.As autopsies are not routinely performed on all decedents with sARs-CoV-2 infection,postmortem CT(PMCT)may be valuable to provide additional information on the cause of death and risk factors known to be associated with an increased mortality in COVID-19.The purpose of this manuscript is to review the PMCT findings in a series of 42 decedents with sARs-CoV-2 infection from our institution.Retrospective analysis of 42 decedents who had a positive postmortem nasopharyngeal swab for sARs-CoV-2 and had a PMCT were included in this study.Images were reviewed for pulmonary findings seen in COVID-19 and other organ involvement.Of the 42 decedents,although the majority had imaging findings in the lungs that would be consistent with COVID-19 and acute respiratory distress syndrome,in 14%of the decedents the sARs-CoV-2 infection was likely coincidental and the PMCT findings suggested that they died from other pathology.Over half of the decedents that died from COVID-19 had PMCT findings of vascular disease.PMCT is useful to identify pulmonary and extra pulmonary findings in decedents with sARs-CoV-2 infection that can provide additional information,which may be useful for the forensic pathologist to help determine the underlying cause of death.

关键词： Forensic sciences postmortem CT COVID-19 virtual autopsy sARs-CoV-2

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Response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation: A case report

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World Journal of Gastrointestinal Oncology 2023年第10期15卷 1829-1834页

作者： Blake Buzard Lindsey Douglass Beth Gustafson Jennifer Buckley Marc roth Lara Kujtan Dhruv Bansal Cancer Institute St.Luke's HospitalKansasMO 64111United States Department of Medical Oncology University of Missouri-Kansas CityKansasMO 64108United States Department of Hematology/Oncology St.Luke's Cancer InstituteKansasMO 64111United States

BACKGROUND Although common in lung cancer,somatic epidermal growth factor receptor(EGFR)mutations are rarely found in colorectal cancer,occurring in approximately 3%of cases.Treatment with anti-EGFR antibodies is commonplace,but EGFR tyrosine kinase inhibitors are not standard treatments in colorectal cancer.Here we report a case of sustained response to osimertinib in a colorectal cancer patient with an EGFR T790M mutation on cell-free DNA analysis.CAsE sUMMARY A 72-year old woman with a past medical history of post-polio syndrome confined to a wheelchair,scoliosis and hypothyroidism presented with metastatic sigmoid colon adenocarcinoma with hepatic metastases.Next generation sequencing revealed a RAs/RAF wild-type,microsatellite stable,PD-L1 negative malignancy.Mutations in TP3 and APC were also identified,as well as EGFR amplification.Cell-free DNA analysis revealed an EGFR T790M mutation.she was unable to tolerate first-line treatment with panitumumab,5-fluorouracil and leucovorin,progressed on second-line treatment with trifluridine/tipiracil plus bevacizumab,and was unable to tolerate third-line treatment with regorafenib.she was started on fourth-line treatment with off-label osimertinib,with clinical response–decrease in size of hepatic metastases and a pericardial effusion.she remained on treatment with osimertinib for seven months.CONCLUsION This case shows the benefit of multi-gene sequencing assays to identify potential therapeutic options in patients with refractory disease.

关键词： Colorectal cancer Osimertinib Epidermal growth factor receptor T790M Precision oncology Tyrosine kinase inhibitor Case report

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Leaching of lanthanide and yttrium from a Central Appalachian coal and the ashes obtained at 550-950℃

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Journal of Rare Earths 2022年第5期40卷 807-814,I0005页

作者： Ronghong Lin Yee soong Bret H.Howard Murphy J.Keller Elliot A.roth Ping Wang Evan J.Granite U.s.Department of Energy National Energy Technology Laboratory626 Cochrans Mill RoadP.O.Box 10940PittsburghPA15236United States Keylogic systems.Pittsburgh PA15236United States

In this work,we investigated leaching of lanthanide and yttrium(REY) from a Central Appalachian coal and its ashes obtained at 550-950℃ with the main purpose of understanding the impact of ashing temperature on REY leachability in water,ammonium sulfate,and hydrochloric acid.It is found that the coal contains a negligible amount of water-soluble REY,less than 1% ion-exchangeable REY,and about 28% of HCl-soluble REY.Ashing leads to dramatic changes in REY leachability in both ammonium sulfate and hydrochloric acid solutions,which is believed to be related to transformation and redistribution of organically-associated REY in coal during the ashing process.Ashing temperature significantly affects REY leaching from coal ashes;higher ashing temperature results in lower REY leachability in both solutions.Clay minerals may play a significant role in changing the leachability of REY after ashing.In addition,the results also suggest that the organic matter in the coal is relatively enriched in heavy REY.

关键词： Acid leaching Cation exchange Coal Coal ash Rare earth elements Yttrium

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内辐射带高能质子对磁暴响应的统计研究

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地球物理学报 2023年第2期66卷 455-471页

作者：何兆海徐寄遥王赤戴磊陈涛 Ilan roth 中国科学院国家空间科学中心空间天气学国家重点实验室北京100080 中国科学院大学北京100049 space sciences Laboratory University of CaliforniaBerkeleyCaliforniaUSA

范艾伦卫星-A观测表明内辐射带高能质子通量在磁暴主相期间显著下降,在恢复相时与地磁sYM-H指数同步恢复.磁暴期间内辐射带高能质子通量变化对磁场变化的响应是绝热的吗?基于刘维尔定理和第一和第三绝热不变量守恒,定量地评估了高能质... 详细信息

范艾伦卫星-A观测表明内辐射带高能质子通量在磁暴主相期间显著下降,在恢复相时与地磁sYM-H指数同步恢复.磁暴期间内辐射带高能质子通量变化对磁场变化的响应是绝热的吗?基于刘维尔定理和第一和第三绝热不变量守恒,定量地评估了高能质子在内辐射带中的完全绝热效应.两个事件研究表明,理论计算的绝热效应导致的高能质子通量变化与范艾伦卫星观测结果吻合良好.本文进而对2013-2016年期间发生的67次磁暴事件进行了统计研究.结果发现磁暴主相和恢复相期间,内辐射带高能质子通量变化的90%贡献是完全绝热效应.相空间密度的调查结果也支持这一结论.最后通过对比研究磁暴前后高能质子通量的变化,我们发现大部分磁暴(56/67)期间,绝热效应能解释内辐射带高能质子通量的变化;另外11次磁暴事件中非绝热效应可能起着重要作用.

关键词：内辐射带高能质子完全绝热效应

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Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

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signal Transduction and Targeted Therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil stella Christoph Andrea sauer Lennart Boblitz Julius schmidt sascha David Hans-Martin Jack Edith roth Markus Cornberg Thomas F.schulz Tobias Welte Marius M.Hoper Christine s.Falk Institute of Transplant Immunology MHHDHanoverGermany Department of Pneumology MHHDHanoverGermany Department of Intensive Care Medicine University of ZurichCHZurichSwitzerland Division of Molecular Immunology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Department of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection Medicine CiiM HanoverGermany lnstitute of Virology MHHDHanoverGermany German Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 REsIsT MHHHanoverGermany German Center for Lung Diseases DZL/BREATH MarburgGermany

The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after sARs-CoV-2 infection.To define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical school,we used flow cytometry and proteomics data with unsupervised clustering analyses.In our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of sARs-CoV-2-specific antibodies.The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19.Changes within this sign ature were associated with either disease progression or recovery.In summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature

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sAR polarimetric change detection for flooded vegetation

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International Journal of Digital Earth 2013年第2期6卷 103-114页

作者： B.Brisco A.schmitt K.Murnaghan s.Kaya A.roth Canada Centre for Remote sensing Earth Sciences SectorNatural Resources CanadaOttawaONCanada German remote sensing data center german aerospace centeroberpfaffenhofenwesslinggermany

Due to spatial and temporal variability an effective monitoring system for water resources must consider the use of remote sensing to provide information.synthetic Aperture Radar(sAR)is useful due to timely data acquisition and sensitivity to surface water and flooded vegetation.The ability to map flooded vegetation is attributed to the double bounce scattering mechanism,often dominant for this target.Dong Ting Lake in China is an ideal site for evaluating sAR data for this application due to annual flooding caused by mountain snow melt causing extensive changes in flooded vegetation.A curvelet-based approach for change detection in sAR imagery works well as it highlights the change and suppresses the speckle noise.This paper addresses the extension of this change detection technique to polarimetric sAR data for monitoring surface water and flooded vegetation.RADARsAT-2 images of Dong Ting Lake demonstrate this curvelet-based change detection technique applied to wetlands although it is applicable to other land covers and for post disaster impact assessment.These tools are important to Digital Earth for map updating and revision.

关键词： sAR polarimetry change detection wetlands floods earth observa-tion land cover microwave remote sensing

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UV-LED projection photolithography for high-resolution functional photonic components

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Microsystems & Nanoengineering 2021年第4期7卷 149-159页

作者： Lei Zheng Urs Zywietz Tobias Birr Martin Duderstadt Ludger Overrmeyer Bernhard roth Carsten Reinhardt Hannover Centre for Optical Technologies Leibniz University HannoverHannoverLower Saxony 30167Germany Cluster of Excellence PhoenixD(Photonics Opticsand Engineering-Innovation Across Disciplines)HannoverLower Saxony 30167Germany Laser Zentrum Hannover e.V HannoverLower Saxony 30167Germany Institute of Transport and Automation Technology Leibniz University HannoverGarbsenLower Saxony 30823Germany Bremen University of Applied science BremenBremen 28199Germany

The advancement of micro-and nanostructuring techniques in optics is driven by the demand for continuous miniaturization and the high geometrical accuracy of photonic devices and integrated systems.Here,UV-LED projection photolithography is demonstrated as a simple and low-cost approach for rapid generation of two-dimensional optical micro-and nanostructures with high resolution and accuracy using standard optics only.The developed system enables the projection of structure patterns onto a substrate with 1000-fold demagnification.Photonic devices,e.g.,waveguides and microring resonators,on rigid or flexible substrates with varied geometrical complexity and overall structure dimensions from the nanometer to centimeter scale were successfully prepared.In particular,high-resolution gratings with feature sizes down to 150 nm and periods as small as 400 nm were realized for the first time by this approach.Waveguides made of doped laser active materials were fabricated,and their spontaneous emission was detected.The demonstrated superior performance of the developed approach may find wide applications in photonics,plasmonics,and optical materials science,among others.

关键词： projection resolution optics

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